LOCUS       NM_057201               3079 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 37 (Gpr37), mRNA.
ACCESSION   NM_057201
VERSION     NM_057201.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3079)
  AUTHORS   Kunihiro,J., Nabeka,H., Wakisaka,H., Unuma,K., Khan,M.S.I.,
            Shimokawa,T., Islam,F., Doihara,T., Yamamiya,K., Saito,S.,
            Hamada,F. and Matsuda,S.
  TITLE     Prosaposin and its receptors GRP37 and GPR37L1 show increased
            immunoreactivity in the facial nucleus following facial nerve
            transection
  JOURNAL   PLoS One 15 (12), e0241315 (2020)
   PUBMED   33259479
  REMARK    GeneRIF: Prosaposin and its receptors GRP37 and GPR37L1 show
            increased immunoreactivity in the facial nucleus following facial
            nerve transection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3079)
  AUTHORS   Islam,F., Khan,M.S.I., Nabeka,H., Shimokawa,T., Yamamiya,K. and
            Matsuda,S.
  TITLE     Age- and sex-associated changes in prosaposin and its receptors in
            the lacrimal glands of rats
  JOURNAL   Histol Histopathol 35 (1), 69-81 (2020)
   PUBMED   31215019
  REMARK    GeneRIF: Age- and sex-associated changes in prosaposin and its
            receptors in the lacrimal glands of rats.
REFERENCE   3  (bases 1 to 3079)
  AUTHORS   Islam,F., Khan,M.S.I., Nabeka,H., Saito,S., Li,X., Shimokawa,T.,
            Yamamiya,K., Kobayashi,N. and Matsuda,S.
  TITLE     Prosaposin and its receptors are differentially expressed in the
            salivary glands of male and female rats
  JOURNAL   Cell Tissue Res 373 (2), 439-457 (2018)
   PUBMED   29656342
  REMARK    GeneRIF: The present findings indicate that PSAP and its receptors,
            GPR37 and GPR37L1, are expressed in the major salivary glands of
            rats and their immunoreactivities differ considerably with age and
            sex.
REFERENCE   4  (bases 1 to 3079)
  AUTHORS   Dutta,P., O'Connell,K.E., Ozkan,S.B., Sailer,A.W. and Dev,K.K.
  TITLE     The protein interacting with C-kinase (PICK1) interacts with and
            attenuates parkin-associated endothelial-like (PAEL)
            receptor-mediated cell death
  JOURNAL   J Neurochem 130 (3), 360-373 (2014)
   PUBMED   24749734
  REMARK    GeneRIF: PICK1 interacts with parkin and our data showed that PICK1
            reduces PAELR expression levels in transiently transfected
            heterologous cells
REFERENCE   5  (bases 1 to 3079)
  AUTHORS   Meyer,R.C., Giddens,M.M., Schaefer,S.A. and Hall,R.A.
  TITLE     GPR37 and GPR37L1 are receptors for the neuroprotective and
            glioprotective factors prosaptide and prosaposin
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9529-9534 (2013)
   PUBMED   23690594
REFERENCE   6  (bases 1 to 3079)
  AUTHORS   Murakami,T., Shoji,M., Imai,Y., Inoue,H., Kawarabayashi,T.,
            Matsubara,E., Harigaya,Y., Sasaki,A., Takahashi,R. and Abe,K.
  TITLE     Pael-R is accumulated in Lewy bodies of Parkinson's disease
  JOURNAL   Ann Neurol 55 (3), 439-442 (2004)
   PUBMED   14991825
REFERENCE   7  (bases 1 to 3079)
  AUTHORS   Nakahara,T., Kuroki,T., Ohta,E., Kajihata,T., Yamada,H.,
            Yamanaka,M., Hashimoto,K., Tsutsumi,T., Hirano,M. and Uchimura,H.
  TITLE     Effect of the neurotoxic dose of methamphetamine on gene expression
            of parkin and Pael-receptors in rat striatum
  JOURNAL   Parkinsonism Relat Disord 9 (4), 213-219 (2003)
   PUBMED   12618056
  REMARK    GeneRIF: expression of Pael-R genes in the nigro-striatal pathway
            may have significant implication for pathophysiology and treatment
            of parkinson disease.
REFERENCE   8  (bases 1 to 3079)
  AUTHORS   Imai,Y., Soda,M., Hatakeyama,S., Akagi,T., Hashikawa,T.,
            Nakayama,K.I. and Takahashi,R.
  TITLE     CHIP is associated with Parkin, a gene responsible for familial
            Parkinson's disease, and enhances its ubiquitin ligase activity
  JOURNAL   Mol Cell 10 (1), 55-67 (2002)
   PUBMED   12150907
REFERENCE   9  (bases 1 to 3079)
  AUTHORS   Imai,Y., Soda,M., Inoue,H., Hattori,N., Mizuno,Y. and Takahashi,R.
  TITLE     An unfolded putative transmembrane polypeptide, which can lead to
            endoplasmic reticulum stress, is a substrate of Parkin
  JOURNAL   Cell 105 (7), 891-902 (2001)
   PUBMED   11439185
REFERENCE   10 (bases 1 to 3079)
  AUTHORS   Leng,N., Gu,G., Simerly,R.B. and Spindel,E.R.
  TITLE     Molecular cloning and characterization of two putative G
            protein-coupled receptors which are highly expressed in the central
            nervous system
  JOURNAL   Brain Res Mol Brain Res 69 (1), 73-83 (1999)
   PUBMED   10350639
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087946.1, BC087728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1732              JAXUCZ010000004.1  55124689-55126420   c
            1733-3079           JAXUCZ010000004.1  55104355-55105701   c
FEATURES             Location/Qualifiers
     source          1..3079
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3079
                     /gene="Gpr37"
                     /gene_synonym="Ednrbl"
                     /note="G protein-coupled receptor 37"
                     /db_xref="GeneID:117549"
                     /db_xref="RGD:619848"
     exon            1..1732
                     /gene="Gpr37"
                     /gene_synonym="Ednrbl"
                     /inference="alignment:Splign:2.1.0"
     CDS             740..2551
                     /gene="Gpr37"
                     /gene_synonym="Ednrbl"
                     /note="probable G-protein coupled receptor 37; G-protein
                     coupled receptor CNS1; G protein-coupled receptor 37
                     (endothelin receptor type B-like); prosaposin receptor
                     GPR37"
                     /codon_start=1
                     /product="prosaposin receptor GPR37 precursor"
                     /protein_id="NP_476549.1"
                     /db_xref="GeneID:117549"
                     /db_xref="RGD:619848"
                     /translation="MPAPGAPLSRTSRLLLLLLFKVSVSAALSFVPEPRNGTCLGESC
                     SPLIPRRSRDAGGPRNSARDALRVHVPREKLEAEVRGATSWDLPPPRGGDTGVIEEAA
                     ASGPLGPPTKPPGAWRWKGAQGKEPSGHLGRREPTDSQLFRQTSERGEMSSKRDEIPQ
                     GSQEHSVKTEPEPRDLFYWPRKTGQLQGSHYRPSAVHEGRTLAPPGRALPQNGSADDW
                     VPDQGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIV
                     CHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVAS
                     LGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQ
                     LSKEDLGFSGQAPAERCVIKISPDLPDTIYVLALTYDGARLWWYFGCYFCLPTLFTIT
                     CSLVTARKIRKAEKASTRGNKRQIHLESQMNCTVVALTILYGFCIIPENICNIVTAYM
                     ATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCRPFSRAFMECCCCCCEECIQKSS
                     TVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC"
     exon            1733..3079
                     /gene="Gpr37"
                     /gene_synonym="Ednrbl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctactccac gccttctccg ccagtgtact atgcgcagcc accggcgcca tccgcttgtc
       61 aactttgagc tgaaggagca gcaactttga cagtggccgc gggtttctaa tctggcttct
      121 ccttggcaac agtctcttcg aaagtcgagt taaacgaggc aagagtttcc tctgagcacc
      181 cttgttgcct tgtttgcaac gggtcccccg ccagccgaga gtgggattgt gacagccagt
      241 cccctagtgg aggggacttg tttttctttt tctctagaga cctttactag cgactggata
      301 aagcagtacc gagaaaggac gtaaatagca gagcaactgt taccaagaag acagccacca
      361 cccaaagcct gggaggaacg ccgggtttcc tccaggctgc gcccagtcgc aacattaggg
      421 aacaatcagg tggtgttcgc aacttttcaa ggtcagcctg ttggatctgt tatttctttc
      481 ggacccttcg ggtgcacaga gcttggatta gatttggctg ggaaatgctc aggacacgaa
      541 accttgaagg attgtaggga tgtgttgagg acaccgtcct tccccgactg ccctgtaccc
      601 tgccctccca gcagtcttca gctcccctcc actagccagc ggtgagtatg tgacatgtgc
      661 ctaactctct gcaccaagtt tggcagcagg tgtcggtgct aaggtagagc caggatacta
      721 ggtgcgccct cgcggagcca tgccagcccc gggcgcgcct ctctctcgca catcgcggct
      781 gctgctcctt ctgctgttca aggtttctgt ctctgctgcc ctgagctttg tccctgagcc
      841 caggaatgga acttgtttgg gggagagctg ttccccactg attccacgtc gcagcaggga
      901 tgccggggga cctaggaatt cagcaagaga tgctctgcga gtccatgtgc ccagagaaaa
      961 gctggaagca gaggtgagag gggcgacctc ctgggacctc ccaccaccca ggggcggtga
     1021 cacaggtgtg attgaagagg cagcggcttc tgggcccttg ggacctccaa ccaagccacc
     1081 aggtgcctgg agatggaaag gagcccaggg taaagaacca tccggacatt tggggagaag
     1141 ggagcccacg gactcccaac tcttccgtca aacctctgag agaggagaga tgagttccaa
     1201 gcgcgacgag attccccagg gcagccagga gcacagtgtg aaaacagaac ctgaacccag
     1261 agatcttttt tactggccac gaaaaacagg acaactccag ggttcccatt acaggccttc
     1321 agcggtacac gaaggaagaa cccttgctcc cccaggcagg gcgctacctc aaaacgggtc
     1381 tgcagatgac tgggtccctg accaaggggg tccacgccgt ggaaatagca ctaaccgacg
     1441 cgtgagactg aagaacccct tctacccatt gacccaggaa tcctatggag cctatgctgt
     1501 catgtgctta tctgtggtga tctttgggac cggcatcatt ggtaacttgg cagtgatgtg
     1561 catcgtgtgt cacaattact acatgaggag catctccaat tctctcttgg ccaacctcgc
     1621 tttctgggac tttctcatca tcttcttctg cctccccttg gtcatcttcc atgagttgac
     1681 caagaagtgg cttttggaag atttctcctg caagatcgtg ccctatatcg aggtagcttc
     1741 tctgggtgtc actaccttca ccttatgtgc actgtgcata gatcgcttcc gggctgccac
     1801 caacgtccag atgtactatg aaatgattga aaattgttct tccaccactg ccaaacttgc
     1861 agttatctgg gttggcgctc tgctcttggc acttccggaa gttgtcctcc gccagctgag
     1921 taaggaggat ttgggcttta gtggccaggc tcctgcagaa cggtgtgtca taaagatctc
     1981 tcccgattta ccggacacca tctatgtttt ggctctcact tatgatggcg cacggctctg
     2041 gtggtatttc ggctgctact tttgtctgcc cacacttttc accatcacct gctctctagt
     2101 gaccgctcgg aagatccgca aggcggagaa agccagtacc cgtgggaaca agcggcagat
     2161 ccatctagag agccagatga actgcacagt ggtggctctg accattttat atggattttg
     2221 catcatcccc gagaatatct gcaacatcgt cactgcctac atggccacgg gtgtctctca
     2281 gcagaccatg gacctcctca acatcatcag ccagttcctt ttgttcttca agtcctgcgt
     2341 cacccctgta ctcctcttct gcctctgcag gcccttcagc agggccttca tggagtgctg
     2401 ctgttgctgc tgcgaggagt gcatccagaa gtcttccact gtgaccagtg atgacaacga
     2461 caacgagtac accacagagc tggagttgtc gcccttcagc accatccgca gagagatgtc
     2521 cacctttgcc tctgtgggga ctcactgctg aaggaacggc ttggttagct cagattcctt
     2581 cgattttcat agcctgtgaa aatttttact ccatattttt ccttacaggg gaacaatgca
     2641 aacattttga aaagcaagta gagggagaca tattaactac tctagaactg attttgcaga
     2701 ttaatatttg tgctctggga aaaaaaagtt tctatttagt tatgtaagaa gaaggcagtc
     2761 aacagtctca gatcattttt cctgctctgg tgctaatatt ttattcaaga gtcattgcac
     2821 cttaaccata ttaattgttc gatttctttc tttttctttc ttttgaaaac atagtcgttg
     2881 tatattgaag aagggcctgg gattttgcta gttattttgt ttttgagttg tgaccgaaag
     2941 tacattgtat ctgaaatgat ttggttttgt cccagccatg aaacttagca ccaaataaac
     3001 tccccatcct tctttaacct gactgtcaat ctacttttaa ccaagactca ataaattttt
     3061 aattgcctta aatacacaa
//
