LOCUS       NM_001037359            3526 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 35 (Gpr35), mRNA.
ACCESSION   NM_001037359 XM_006245539 XM_346075
VERSION     NM_001037359.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3526)
  AUTHORS   Wang,D., Wang,W., Bing,X., Xu,C., Qiu,J., Shen,J., Huang,J., Li,J.,
            Liu,P. and Xie,B.
  TITLE     GPR35-mediated kynurenic acid sensing contributes to maintenance of
            gut microbiota homeostasis in ulcerative colitis
  JOURNAL   FEBS Open Bio 13 (8), 1415-1433 (2023)
   PUBMED   37423235
  REMARK    GeneRIF: GPR35-mediated kynurenic acid sensing contributes to
            maintenance of gut microbiota homeostasis in ulcerative colitis.
REFERENCE   2  (bases 1 to 3526)
  AUTHORS   Alkondon,M., Pereira,E.F., Todd,S.W., Randall,W.R., Lane,M.V. and
            Albuquerque,E.X.
  TITLE     Functional G-protein-coupled receptor 35 is expressed by neurons in
            the CA1 field of the hippocampus
  JOURNAL   Biochem Pharmacol 93 (4), 506-518 (2015)
   PUBMED   25542997
  REMARK    GeneRIF: Functional GPR35 receptors were found to be expressed in
            CA1 field of hippocampus neurons.
REFERENCE   3  (bases 1 to 3526)
  AUTHORS   Maravillas-Montero,J.L., Burkhardt,A.M., Hevezi,P.A.,
            Carnevale,C.D., Smit,M.J. and Zlotnik,A.
  TITLE     Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine
            CXCL17
  JOURNAL   J Immunol 194 (1), 29-33 (2015)
   PUBMED   25411203
REFERENCE   4  (bases 1 to 3526)
  AUTHORS   Ronkainen,V.P., Tuomainen,T., Huusko,J., Laidinen,S., Malinen,M.,
            Palvimo,J.J., Yla-Herttuala,S., Vuolteenaho,O. and Tavi,P.
  TITLE     Hypoxia-inducible factor 1-induced G protein-coupled receptor 35
            expression is an early marker of progressive cardiac remodelling
  JOURNAL   Cardiovasc Res 101 (1), 69-77 (2014)
   PUBMED   24095869
REFERENCE   5  (bases 1 to 3526)
  AUTHORS   Jenkins,L., Brea,J., Smith,N.J., Hudson,B.D., Reilly,G.,
            Bryant,N.J., Castro,M., Loza,M.I. and Milligan,G.
  TITLE     Identification of novel species-selective agonists of the
            G-protein-coupled receptor GPR35 that promote recruitment of
            beta-arrestin-2 and activate Galpha13
  JOURNAL   Biochem J 432 (3), 451-459 (2010)
   PUBMED   20919992
  REMARK    GeneRIF: screening assays used to identification of small MW
            agonists; some compounds are species-specific agonists;
            agonists/ligands include zaprinast, cromolyn & dicumarol
REFERENCE   6  (bases 1 to 3526)
  AUTHORS   Ohshiro,H., Tonai-Kachi,H. and Ichikawa,K.
  TITLE     GPR35 is a functional receptor in rat dorsal root ganglion neurons
  JOURNAL   Biochem Biophys Res Commun 365 (2), 344-348 (2008)
   PUBMED   17996730
  REMARK    GeneRIF: We propose that GPR35 modulates nociception and that
            continued study of this receptor will provide additional insight
            into the role of kynurenic acid in pain perception.
REFERENCE   7  (bases 1 to 3526)
  AUTHORS   Guo,J., Williams,D.J., Puhl,H.L. 3rd and Ikeda,S.R.
  TITLE     Inhibition of N-type calcium channels by activation of GPR35, an
            orphan receptor, heterologously expressed in rat sympathetic
            neurons
  JOURNAL   J Pharmacol Exp Ther 324 (1), 342-351 (2008)
   PUBMED   17940199
REFERENCE   8  (bases 1 to 3526)
  AUTHORS   Taniguchi,Y., Tonai-Kachi,H. and Shinjo,K.
  TITLE     Zaprinast, a well-known cyclic guanosine monophosphate-specific
            phosphodiesterase inhibitor, is an agonist for GPR35
  JOURNAL   FEBS Lett 580 (21), 5003-5008 (2006)
   PUBMED   16934253
REFERENCE   9  (bases 1 to 3526)
  AUTHORS   Wang,J., Simonavicius,N., Wu,X., Swaminath,G., Reagan,J., Tian,H.
            and Ling,L.
  TITLE     Kynurenic acid as a ligand for orphan G protein-coupled receptor
            GPR35
  JOURNAL   J Biol Chem 281 (31), 22021-22028 (2006)
   PUBMED   16754668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Oct 19, 2022 this sequence version replaced
            XM_006245539.4, NM_001037359.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494,
                              SAMN06680412 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000009.1  100974580-100974740
            162-3526            JAXUCZ010000009.1  100983621-100986985
FEATURES             Location/Qualifiers
     source          1..3526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..3526
                     /gene="Gpr35"
                     /note="G protein-coupled receptor 35"
                     /db_xref="GeneID:367315"
                     /db_xref="RGD:1309404"
     exon            1..161
                     /gene="Gpr35"
                     /inference="alignment:Splign:2.1.0"
     exon            162..3526
                     /gene="Gpr35"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1092
                     /gene="Gpr35"
                     /codon_start=1
                     /product="G-protein coupled receptor 35"
                     /protein_id="NP_001032436.2"
                     /db_xref="GeneID:367315"
                     /db_xref="RGD:1309404"
                     /translation="MNNTNCSILPWPAAVNHVFTIYLVLLLVLGLLLNGLALWVFCYR
                     MHQWTETRVYMTNLAVADVCLLCSLPFVLYSLKYSTSDTPICQLSQGIYLVNRYMSIS
                     LVTAIAVDRYVAVRHPLRARELRSPRQAGAVCVALWVIVVTSLVLRWRLGIQEGGFCF
                     SSQNRYNFSTTAFSLLGFYLPLAIVVFCSLQVVTALARRPATDVGQVEATQKATRMVW
                     ANLAVFIICFLPLHLILTVQVSLNLHTCAARNIFSRALTITAKLSDINCCLDAICYYY
                     MAKEFQDASLPATASSTPHKSQDTQSLSLT"
ORIGIN      
        1 taaagggcaa agaggctcta atgaggcaga aactgtcatg tgggcagcaa ccacggtccc
       61 attccactgc gtcagagggg gttccacaga ggtgtctggc agcactaaaa ctgagcagca
      121 cttggggaag gccagcctgg agtagaagag cattgcctga gccctaggac catgaacaat
      181 acaaattgta gcatcctccc gtggcctgct gcagtcaacc acgtcttcac catctacttg
      241 gtcttgctgc tggtgctggg cctgctgctc aatggcctgg cactctgggt attctgctat
      301 cgcatgcacc agtggacgga gacccgagtc tatatgacca acctggctgt ggctgacgtc
      361 tgcctgctct gctccttgcc attcgtgctg tactccctga aatacagtac ttcggacaca
      421 cccatctgcc agctctcaca gggcatctac ctggtcaaca ggtacatgag cataagcttg
      481 gtcaccgcca ttgctgtgga ccgctatgtg gcagtgcggc atcccctgcg tgcccgtgag
      541 ctgcggtccc cacggcaggc tggagcagtg tgtgtggccc tctgggtgat agtggtcacc
      601 tccctggtac tgcgctggcg cctggggata caggagggtg gcttctgctt cagcagccaa
      661 aatcggtaca acttcagcac cactgccttc tcgctgctgg gattctacct gccgctggcc
      721 atagtggtct tctgctcttt gcaggttgtg actgcgttgg cccgaaggcc agccactgac
      781 gtggggcagg tggaggccac tcagaaggcc acccgcatgg tctgggccaa cttggccgtg
      841 tttatcatct gcttcctgcc cctgcatttg atcctgacag tgcaggtctc cctgaacctc
      901 cacacctgcg ctgcccgaaa catcttcagc cgtgccctga caatcacagc caagctctca
      961 gacatcaact gctgcctgga tgccatctgt tactactaca tggccaaaga gttccaggat
     1021 gcgtccttgc cggccacagc ctctagcaca ccccacaaga gccaagatac tcagagcctg
     1081 agcctcacct agaagaagtg aacatgtgcc atgagccaga ggaacctgtg atatatgagc
     1141 aaggagactc caaatcagcc tgaacccgct gtgcggtttg agcactctag gagacccagt
     1201 tggtctggag aagctgtatc tgcccctctg aaaggaccac aggattctaa tgtccgactt
     1261 gagggaccct ggactgagac cacatacctg ccaccccaga tcgagaaccc ctgggcacca
     1321 gaatgtggcc ttaatagcta gccaccgagt ttagctctcc cctggagttg gtcctggcaa
     1381 ggtcctctgt catccagatg caagtgatga gaggcaaata agggacatac agctcagaga
     1441 gccaggagac atcttcccag aggaccctct aatggctgtt tccttttcct acctctaaac
     1501 ttcacaccac atgtagggtt aagcagaagg gcagcggctg tgatctggaa ggctgtcccc
     1561 taaggcccat gactgtcagt gttgatacag ctctggagac ccagcgctca caaagtcacg
     1621 ctcagcagta acacccctgt tgctgtcctg agccactttc agtatttcca ttctgtggtg
     1681 ggcctgttgg tcactgaggc cagtggctgt gggaggggtc tactggagtt tgtagtgagg
     1741 aagctggata tttggtttgg tacctgcact ctctaaggat gtggccccag gtggcaaggg
     1801 gtttaggagt aaagtatcag ccccaaagcc agcccaaagc cagagcgcat ttggaggtgt
     1861 agtagccctg ggcttctccc tctgtgcttt gattttggtc ttggcccaaa tgctgcagcc
     1921 atacccagag ccagagcccc tccagctcag aggagagggc tgtccctccc cattctccac
     1981 ccctttatcc aaggcctact gcctaactga ctcccccccc cccttttttt tgtatgacct
     2041 attctataaa accaaaagtc tgctcatctt ccagacacca aagaaaggat tccatccaag
     2101 tataaattgg caaaccggtt tactggtatt gctgacaaaa gcatggtggc tctttgggtg
     2161 ctccgttact gagaagcccc actcagcata ggtgacaatc cccaaactgc accactagat
     2221 taccaatccc catggctaag gtgtgaggga gccgtggctg caaccctagg cctgctgacc
     2281 ctcatctccc tgtcagagat tgctaacagc ttcacgatca tcacctggct taccacagta
     2341 gtggttcgct tgtttcttgg ttcgcctgag ggtgttcaga ggatcgcagc agcagcagca
     2401 ttcctgctca cagctgatca gcatcctagg ccccacccac tctcctccag ttctcacatt
     2461 ccctccactc tctcttttgc aatattaccc gaaccttcac cttggaaggg atgatgtatc
     2521 tatatgatat caaaatatat aatacacacg tgtgtgccta tgattctttt ctgagtctta
     2581 tgcctctaga caacagacac ctaagtagct tgactgagag aaacaaagca tcaggagggg
     2641 gaagggcccc cgcaatgctc cctagtgtgc tgtagtgggt tccccgtcca tggtaccagc
     2701 agagcaccct gccttgatgc acatggcaca ctaccttcct caggtaacct cagctttaga
     2761 ggaaaaatcc catgtccccg tgggctaggc ttggccatct gttcagatga tgcagaagac
     2821 ctggggtgga aaatgaagga gtctttacac aaaatatgca aaattagcat cctaaaaata
     2881 tgagaaagtt aaatggctca tctggcaaag gtgccagcga ccgagcctga caacctaagc
     2941 tcagtccctg gaaccaacat ggtgggagga gagaaccata tagcacaagt tgttctctgg
     3001 ccccaacata taccccagag gaaaaaaaaa caaatgtcaa aataaatagt gcactagaaa
     3061 aacctgttgg caaagaggaa ggctgaaccc cataccgctg ttggccaagg ccaattagaa
     3121 cgagtgtcag aggcactgga gtaagtgctg gaaaactcca ggacatctgg aggtaacctg
     3181 tgacttgtta aagactgcat ttggcaaagc attcgtgaga agtttgtgct atataaataa
     3241 cttcctcaaa gcctactctg tgtaccggct agttttgttt tgtttcgtca acttgacaca
     3301 agctagagtc ctctgaaaaa agggaaccag ccacgattgg gaaaattctt ctgtaagact
     3361 ggcctgtagg cagtcctgtt tctttaatga gtaagcaatg tgggctctgt tcataatagc
     3421 cagaaactgg aaacaaccta gatgtccctc aacagaagaa tggataaaga aagtgtactt
     3481 ctacacggag gaatattgcc cacccgttta aaaaggggca tcatta
//
