LOCUS       NM_153727               2143 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 3 (Gpr3), mRNA.
ACCESSION   NM_153727 XM_006239006
VERSION     NM_153727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Tanaka,S., Shimada,N., Shiraki,H., Miyagi,T., Harada,K., Hide,I.
            and Sakai,N.
  TITLE     GPR3 accelerates neurite outgrowth and neuronal polarity formation
            via PI3 kinase-mediating signaling pathway in cultured primary
            neurons
  JOURNAL   Mol Cell Neurosci 118, 103691 (2022)
   PUBMED   34871769
  REMARK    GeneRIF: GPR3 accelerates neurite outgrowth and neuronal polarity
            formation via PI3 kinase-mediating signaling pathway in cultured
            primary neurons.
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Godlewski,G., Jourdan,T., Szanda,G., Tam,J., Cinar,R.,
            Harvey-White,J., Liu,J., Mukhopadhyay,B., Pacher,P., Ming Mo,F.,
            Osei-Hyiaman,D. and Kunos,G.
  TITLE     Mice lacking GPR3 receptors display late-onset obese phenotype due
            to impaired thermogenic function in brown adipose tissue
  JOURNAL   Sci Rep 5, 14953 (2015)
   PUBMED   26455425
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Tanaka,S., Miyagi,T., Dohi,E., Seki,T., Hide,I., Sotomaru,Y.,
            Saeki,Y., Antonio Chiocca,E., Matsumoto,M. and Sakai,N.
  TITLE     Developmental expression of GPR3 in rodent cerebellar granule
            neurons is associated with cell survival and protects neurons from
            various apoptotic stimuli
  JOURNAL   Neurobiol Dis 68, 215-227 (2014)
   PUBMED   24769160
  REMARK    GeneRIF: This study demonstrate for the first time that the
            expression of GPR3 modulates the viability of cultured P7 rat CGNs
            and mediates an antiapoptotic effect in various apoptosis-inducing
            models using rat cerebellar granule neurons.
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Yang,C.R., Wei,Y., Qi,S.T., Chen,L., Zhang,Q.H., Ma,J.Y., Luo,Y.B.,
            Wang,Y.P., Hou,Y., Schatten,H., Liu,Z.H. and Sun,Q.Y.
  TITLE     The G protein coupled receptor 3 is involved in cAMP and cGMP
            signaling and maintenance of meiotic arrest in porcine oocytes
  JOURNAL   PLoS One 7 (6), e38807 (2012)
   PUBMED   22685609
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Zhang,B., Wei,Q., Shi,S., Dong,F., Shi,F. and Xu,Y.
  TITLE     Immunolocalization and expression pattern of Gpr3 in the ovary and
            its effect on proliferation of ovarian granulosa cells in pigs
  JOURNAL   J Reprod Dev 58 (4), 410-419 (2012)
   PUBMED   22498817
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Hinckley,M., Vaccari,S., Horner,K., Chen,R. and Conti,M.
  TITLE     The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP
            signaling and maintenance of meiotic arrest in rodent oocytes
  JOURNAL   Dev Biol 287 (2), 249-261 (2005)
   PUBMED   16229830
  REMARK    GeneRIF: the cAMP levels required for maintaining meiotic arrest in
            mouse and rat oocytes are dependent on the expression of Gpr3
            and/or Gpr12
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Mehlmann,L.M., Saeki,Y., Tanaka,S., Brennan,T.J., Evsikov,A.V.,
            Pendola,F.L., Knowles,B.B., Eppig,J.J. and Jaffe,L.A.
  TITLE     The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian
            oocytes
  JOURNAL   Science 306 (5703), 1947-1950 (2004)
   PUBMED   15591206
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Uhlenbrock,K., Gassenhuber,H. and Kostenis,E.
  TITLE     Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and
            gpr12 family of constitutively active G protein-coupled receptors
  JOURNAL   Cell Signal 14 (11), 941-953 (2002)
   PUBMED   12220620
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   Iismaa,T.P., Kiefer,J., Liu,M.L., Baker,E., Sutherland,G.R. and
            Shine,J.
  TITLE     Isolation and chromosomal localization of a novel human
            G-protein-coupled receptor (GPR3) expressed predominantly in the
            central nervous system
  JOURNAL   Genomics 24 (2), 391-394 (1994)
   PUBMED   7698767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Dec 2, 2020 this sequence version replaced
            XM_006239006.3, NM_153727.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.29400.1,
                                           SRR26360194.2320198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000005.1  150698407-150698526 c
            121-2143            JAXUCZ010000005.1  150695406-150697428 c
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2143
                     /gene="Gpr3"
                     /gene_synonym="Gpcr3"
                     /note="G protein-coupled receptor 3"
                     /db_xref="GeneID:266769"
                     /db_xref="RGD:628686"
     exon            1..120
                     /gene="Gpr3"
                     /gene_synonym="Gpcr3"
                     /inference="alignment:Splign:2.1.0"
     exon            121..2143
                     /gene="Gpr3"
                     /gene_synonym="Gpcr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1115
                     /gene="Gpr3"
                     /gene_synonym="Gpcr3"
                     /note="G protein-coupled receptor R4"
                     /codon_start=1
                     /product="G-protein coupled receptor 3"
                     /protein_id="NP_714949.2"
                     /db_xref="GeneID:266769"
                     /db_xref="RGD:628686"
                     /translation="MMWGAGRSMAWFSAGSGSVNVSIDPAEEPTGPATLLPSPRAWDV
                     VLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAADFCI
                     GSPEMSLVLVGVLATAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVW
                     VGALGLGLVPVLAWNCRDGLTTCGVVYPLSKNHLVVLAIVFFMVFGIMLQLYAQICRI
                     VCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDANSPPL
                     YTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSPSDV"
ORIGIN      
        1 gtgactcacg ccgcgtctcc cgcggccgcg ggggcttctc ggggtccgca cacaccttcc
       61 tctgccagaa cctgagtgga ggctccccgc ggcccggccg cacccggtcc tgagccacgg
      121 gtaccatgat gtggggtgca ggaagatcca tggcctggtt ctcagccggc tcaggcagtg
      181 tgaatgtgag catagaccca gcagaggaac ctacaggccc agctacactg ctgccctctc
      241 ccagggcctg ggatgtggtg ctgtgcatct caggcaccct ggtgtcctgc gagaatgctc
      301 tggtggtggc catcattgtg ggcacgcctg ccttccgcgc ccccatgttc ctgctggtgg
      361 gcagcttggc cgtagcagac ctgctggcag gcctgggcct ggtcctgcac ttcgctgctg
      421 acttctgtat tggctcacca gagatgagct tggtgctggt tggcgtgcta gcaacggcct
      481 ttactgccag catcggcagc ctgctggcca tcaccgttga ccgctacctt tccctgtaca
      541 acgccctcac ctactactca gagacaacag taactcgaac ctacgtgatg ctggccttgg
      601 tgtgggtggg tgccctgggc ctggggctgg ttcccgtgct ggcctggaac tgccgggatg
      661 gcctgaccac gtgcggcgta gtctatccac tctccaagaa ccatctggtg gttctggcca
      721 tcgtcttctt catggtgttt ggcatcatgc tacagctcta tgcccagatc tgccgcattg
      781 tttgccgcca cgcccagcag atcgccctcc aacgacacct gctgcctgcc tcccactacg
      841 tggccacccg caagggcatc gccacattgg ccgtggtgct tggcgccttt gccgcctgtt
      901 ggttgccctt cactgtctac tgcctcctgg gagacgccaa ctctcctcct ctctacacct
      961 accttaccct gctccctgcc acttacaact ccatgatcaa cccggtcatt tacgccttcc
     1021 gcaaccaaga cgtgcagaag gtgctgtggg ccatctgctg ctgctgttct acttccaaga
     1081 tcccattccg gtcccggtcc cctagtgatg tctagtttga tcctggtgga tctgtggttt
     1141 tgactaccgt agaacttcag aaggttaggt ccgccagggc ttagttccaa ccacccctcc
     1201 cccacccagt cccacgccct taagacccag ctggttctgg agttctagga cattgggtgt
     1261 tttgggatct tgttcaagat tcctgcaggg gccgagccca gctgactgca tggctctaga
     1321 atgttccaga tggtcagggt cccactcaga aatgtctcac agcccaaagt ggtttgcaat
     1381 tccagaatgc tgggaatttt acagtaccat tccaagtcct tgatcttcct tcccagaaac
     1441 ttgaccttga tcattgttgc ttttgacttt cgaagctccg gagtcggagg ttaatcactt
     1501 agttgcctag atgagagaga aagatttatc tatatatatg gacatacaaa gaaggtatat
     1561 ttattgttta tttatttatt tatttataaa ttatgggtgg taagggaaaa agaaagagac
     1621 cctcacctag aaatctagtt cataccaggg tatccccagc ctccacgacc ccgtttctga
     1681 cctcagttcc tggagtgggg gatggaaaaa gagaaaacac gtattttgtt atttttgctt
     1741 attttttatc agagaaatca tagaaaccag agcctcctcc ccaggcccgc actgctcggg
     1801 tttgcaaggg gaacacacca gcctctggtt ttttattttt ttaagaagcc atcacctgag
     1861 caaccgagaa ttcctctgcg ctgaggcccg gcttccctct ggtggccatt tgggggaatt
     1921 gcaactcggc gaggcagtcg ggattgtaaa acgcaccccc ccatctccac tccagcctgg
     1981 ctttcagcgc cacagccatg gcctgggggc caggccttac cctgaggtgc ccgagaggag
     2041 gcggggcaga gccagtatcc ccccagccct ctgccaattg gggtatggcc cccagtgcat
     2101 tcctgttcag tccccaaccc tactcaataa aaatggtttt ttt
//
