LOCUS       NM_001106722            4537 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 22 (Gpr22), mRNA.
ACCESSION   NM_001106722 XM_001073380 XM_234041
VERSION     NM_001106722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4537)
  AUTHORS   Chang,C.C., Chen,C.H., Hsu,S.Y. and Leu,S.
  TITLE     Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac
            injury in mice with acute myocardial infarction
  JOURNAL   BMC Cardiovasc Disord 24 (1), 287 (2024)
   PUBMED   38816768
  REMARK    GeneRIF: Cardiomyocyte-specific overexpression of GPR22 ameliorates
            cardiac injury in mice with acute myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4537)
  AUTHORS   Ruiz-Hernandez,A., Sanchez-Munoz,F., Rodriguez,J.,
            Calderon-Zamora,L., Romero-Nava,R., Huang,F., Hong,E. and
            Villafana,S.
  TITLE     Expression of orphan receptors GPR22 and GPR162 in
            streptozotocin-induced diabetic rats
  JOURNAL   J Recept Signal Transduct Res 35 (1), 46-53 (2015)
   PUBMED   24937127
  REMARK    GeneRIF: orphan receptors GPR22 and GPR162 are expressed in a
            different way in heart, kidney, brain and aorta of diabetic and
            non-diabetic rats.  We conclude that orphan receptors could be
            involved in the development of diabetes complications.
REFERENCE   3  (bases 1 to 4537)
  AUTHORS   Adams,J.W., Wang,J., Davis,J.R., Liaw,C., Gaidarov,I., Gatlin,J.,
            Dalton,N.D., Gu,Y., Ross,J. Jr., Behan,D., Chien,K. and Connolly,D.
  TITLE     Myocardial expression, signaling, and function of GPR22: a
            protective role for an orphan G protein-coupled receptor
  JOURNAL   Am J Physiol Heart Circ Physiol 295 (2), H509-H521 (2008)
   PUBMED   18539757
  REMARK    GeneRIF: Demonstrate GRR22 expression in rat heart.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_234041.4, XM_001073380.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4537
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..4537
                     /gene="Gpr22"
                     /note="G protein-coupled receptor 22"
                     /db_xref="GeneID:298944"
                     /db_xref="RGD:1310848"
     exon            1..415
                     /gene="Gpr22"
                     /inference="alignment:Splign:2.1.0"
     exon            416..1392
                     /gene="Gpr22"
                     /inference="alignment:Splign:2.1.0"
     CDS             1307..2716
                     /gene="Gpr22"
                     /note="probable G-protein coupled receptor 22"
                     /codon_start=1
                     /product="G-protein coupled receptor 22"
                     /protein_id="NP_001100192.1"
                     /db_xref="GeneID:298944"
                     /db_xref="RGD:1310848"
                     /translation="MSKLSMTSCINLWKTTMVSQKAHKATANRGNTNCSKRMCFSPVL
                     EINMQSESNVTVRDDIEDIDTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVL
                     YCMKSNLISSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLERNTALICCFHEACVS
                     FASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMTSIWIFSFFSFLIPFIEVNF
                     FSLQSGNAWENKTLLCVSTSEYYTELGMYYHLLVQIPIFFFTVIVMLITYTKILQALN
                     IRIGTRFSTGQKKKARKKKTISLTTHETTDMSQSSGGRNVVFGVRTSVSVIIALRRAV
                     KRHRERRERQKRVFKMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMA
                     YGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPMPNNAVIHNSWIDPKRNKKV
                     TYEDSEIREKCLVPQVVTD"
     exon            1393..4537
                     /gene="Gpr22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagtgggg agaagcgaca aggtaggctg tcactctgca aaagctgctc gagcaggctt
       61 ccctctccag agcagtgccc ttccttttca gaaagcctgg atccgaatgc tgtctctgga
      121 gacaagaagc cttcagtatg ctaaattact ttcactacgt attttcaaat gcttatcgag
      181 tccacagtgg gaagagtgag cgtctgctgc agcctcgaag cagcactaca cattctatac
      241 attagcaggg ctgctcaaac aatggcacag taaagataca ttttcattaa ggtcgtttgg
      301 aagagatttt tatgaccttc ttcccccagc cctgtacttt caaatgaaca gaatgaatca
      361 atcaaaactg gaaatgcttc aactccatcg ggaactggtc aaatctttag cagagggccc
      421 acaactaatt caatatacac aactggcaat ttgaagaatg caactgatta agaggctccc
      481 tggctctctg aaccacaaac tactagatat tcttgtaacg catgatttta agacactaag
      541 gagttaaagc ctcagcttag ctgtgctgga acagaacaag ctgacagcat cccaagacga
      601 tgctacatag aataaccatg aaaagagaaa aatagacctg taaaacctgg agaccaactg
      661 gagagtggtt taaaaggaag atctcacact ttaagatagc agaattatgg acactattga
      721 ttctgcaaga aacagtgaag caaaaacttc aaaaaggaga atgtcatgat gtaccagcaa
      781 gcaaaatgaa gctgtagcaa gtgtttcctg cacgattcag atattcatat caattggtat
      841 gactaataga gttttccatc tgaccaatta tgcatcctct tctaatgaga acaaaccgaa
      901 ttaaatagca gatggctttt atcaaaagag catgtactgg atttataata taaagcaaac
      961 tatgtgatca agaaatcatt ccaaaataat gagaagcgct gcagaagcag cctgagaaca
     1021 aacgggtctc taagtgcgtt ttaggagctg ggagcattat gtctcctttt ctgttttcac
     1081 ggattctgga aaatagacac gatcatatat ttcttcaaaa agaaaatgca atttctatca
     1141 tttgatgaag tttcatttgc ctgaaaatta tgtgctgttc tttagaaatc cgtcagtcac
     1201 ctaaatctca cgattcacaa gtgaagtact caaacagcaa atgaatgaat ttctacaaga
     1261 cgtgaaataa aacacagcca ctccactgtt accaggaaaa aaattcatgt caaaattgtc
     1321 aatgacatca tgtatcaatt tgtggaaaac taccatggtg agccaaaagg cccataaagc
     1381 aacagcgaac aggggaaata ccaactgctc caaaagaatg tgtttttctc ctgttctgga
     1441 aatcaacatg cagtctgaat caaacgtcac ggtgcgagat gacattgagg acatcgatac
     1501 caatatgtac caaccactgt catacccatt aagctttcaa gtgtctctca ctggatttct
     1561 catgttagaa attgtgctgg ggcttggtag caaccttacc gtactggtac tttactgcat
     1621 gaaatccaac ttaatcagct ctgtcagtaa cattatcaca atgaatctcc atgtacttga
     1681 tgtaataatc tgtgtgggat gtattcctct aaccatagtg atccttctgc tctcactgga
     1741 gaggaacact gctctcatct gctgtttcca cgaagcttgt gtttcttttg caagtgtttc
     1801 cacagcaatc aacgtttttg ctattactct ggacagatat gacatctctg taaaacctgc
     1861 aaacagaatt ctgacaatgg gcagagctgt gatgctaatg acgtccattt ggattttttc
     1921 tttcttctca ttcctgattc ccttcattga agtcaatttt ttcagccttc aaagtggaaa
     1981 tgcgtgggaa aacaagacac tgctgtgtgt cagcacaagt gagtactaca ctgagctcgg
     2041 gatgtactat cacctcctag ttcagatccc catcttcttc ttcacagtta tcgtgatgct
     2101 gatcacatac accaagatac tccaggctct taatatccgg ataggcacta gattctcaac
     2161 aggccagaag aagaaagccc ggaagaaaaa gacaatctct ctaaccacac atgagaccac
     2221 agacatgtcg caaagcagtg gtgggaggaa tgtcgtattt ggtgtgagaa cttcagtttc
     2281 tgtaataatt gccctccggc gagccgtgaa acgacaccgg gaacgacgag agaggcagaa
     2341 aagagtcttc aaaatgtcgt tattgattat ttctacattt cttctctgtt ggacaccaat
     2401 ttctgtttta aataccacca ttttatgttt aggcccaagt gaccttttag taaaattaag
     2461 attgtgtttt ctagtcatgg cttatggaac aactatattc catcctctcc tgtatgcatt
     2521 caccagacaa aaatttcaaa aggtcttaaa aagtaagatg aaaaagcgag ttgtttccat
     2581 agttgaagct gatcccatgc ctaataacgc tgtaatacac aactcatgga tagatcctaa
     2641 aagaaacaaa aaggttacct acgaagacag tgaaataaga gagaaatgtt tagtacctca
     2701 ggttgtcaca gactagagag aagtctcagc ttcaccaaat acattcagaa gagttttaaa
     2761 tttaaattgt aaaaatgaat tactgccaaa tgtaagagaa aacattctag gtattggtta
     2821 tgttgtaaaa tttcaatgtg aatgtcaact agattaggtc atatatactc aatttcttca
     2881 ttatttaatg tatttgttgc atggcagttt gttaaaaaat aataccatgt gtatattttg
     2941 tcaatattat gtccatcaga agatatccat gtaagtcata ttttctaaag aataaatacg
     3001 tagccttaaa acagtgtata actttaaaat gtaactgaca caggtatcta cgtttttaaa
     3061 aacaatgtat gaagtctatt atttctaaga cacaaactac agatatattt atatgatgac
     3121 aagttgcata aaatatttaa cacaaaagat cataggctca aaaaaatcaa agcaagattt
     3181 tctgtaccat tatgctatgt ttctgatatg accgacttgt tataatattt taacaaaata
     3241 atgaactata tataaatctt attctttctt ttgaatgtag gaaatacaga ctatattagt
     3301 atttcaaaat catgagtcaa tgaataaata cttgtacatg cacaccaaaa tagggaaact
     3361 ttaaagttca agtttactat aaaaagaaaa gagtttgaat tctattacag ggtaatatgc
     3421 ctgtaataca aatgaaccaa caatagaggg agggaagaag gcgacagtaa caccagcctt
     3481 attcctcctt cctcattttg cctgattcta caccaaatgt cctaggttaa aaaaaaatac
     3541 tggtcttcaa aagctgcaat aaagtaattt ctcacttaac tctacgattt tgtacacaag
     3601 aggttagcca tacaaagagg aagactgagc agaagaagag gaccatttct gtcactgtag
     3661 aaaagcctaa cacagccaga tgtttctaat tttagacaca gagcaactta catgaggtag
     3721 aatttataca acagttcctt cccagccttc aaaatacagt ggctctgttt ccagtctcca
     3781 ggagattaag ccaataataa attgtgtcac gtttctgttc caccaccatg taacccaagc
     3841 atttttctct taaatcctca attcctgcta gaaaatgatt actaattgta attatagatt
     3901 gctattttca tagcagacaa gaatttttac ttgttataat aatttgccaa tgcatagtaa
     3961 taccaaaact tagcaacaac ttatttaaaa taggtaagta cccactatat gtaactggat
     4021 agcttgacaa taattattct atattttaaa tactatattt actaaatgaa gtaacatact
     4081 ttttaaattt aaatgctcat gttaaacaac tcaatataca tcacttttta tacgagggtg
     4141 agattcacca atcaacttta ctgactagcc tagtccctag ggaaatgact gtgatacagg
     4201 agcttgaaat cactaagctt tctgggaaat taaactgatt cgtttctgat tataatgcta
     4261 gagtgtcaaa acttggcaaa agcccacttt ccttctgctt tatgaagttt aaaaaatgct
     4321 gcagtttgag aaattgtagc ataatcaaat aaactttatt tttgaaacct aaaattaaaa
     4381 cttaatggtg ttaagaattt tttcactcaa taaatacatt tgacctacaa tatatcctaa
     4441 catcttaatt acaactttta gtgaattttg tacttagact tccaagcata agttaaaata
     4501 ctaacaccta gatttacaaa atcttaattt taaaaac
//
