LOCUS       NM_001109386            1536 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 183 (Gpr183), mRNA.
ACCESSION   NM_001109386 XM_001054002
VERSION     NM_001109386.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Li,J., Lu,E., Yi,T. and Cyster,J.G.
  TITLE     EBI2 augments Tfh cell fate by promoting interaction with
            IL-2-quenching dendritic cells
  JOURNAL   Nature 533 (7601), 110-114 (2016)
   PUBMED   27147029
REFERENCE   2  (bases 1 to 1536)
  AUTHORS   Nevius,E., Pinho,F., Dhodapkar,M., Jin,H., Nadrah,K.,
            Horowitz,M.C., Kikuta,J., Ishii,M. and Pereira,J.P.
  TITLE     Oxysterols and EBI2 promote osteoclast precursor migration to bone
            surfaces and regulate bone mass homeostasis
  JOURNAL   J Exp Med 212 (11), 1931-1946 (2015)
   PUBMED   26438360
REFERENCE   3  (bases 1 to 1536)
  AUTHORS   Rutkowska,A., Preuss,I., Gessier,F., Sailer,A.W. and Dev,K.K.
  TITLE     EBI2 regulates intracellular signaling and migration in human
            astrocyte
  JOURNAL   Glia 63 (2), 341-351 (2015)
   PUBMED   25297897
REFERENCE   4  (bases 1 to 1536)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
REFERENCE   5  (bases 1 to 1536)
  AUTHORS   Gessier,F., Preuss,I., Yin,H., Rosenkilde,M.M., Laurent,S.,
            Endres,R., Chen,Y.A., Marsilje,T.H., Seuwen,K., Nguyen,D.G. and
            Sailer,A.W.
  TITLE     Identification and characterization of small molecule modulators of
            the Epstein-Barr virus-induced gene 2 (EBI2) receptor
  JOURNAL   J Med Chem 57 (8), 3358-3368 (2014)
   PUBMED   24678947
REFERENCE   6  (bases 1 to 1536)
  AUTHORS   Benned-Jensen,T., Smethurst,C., Holst,P.J., Page,K.R., Sauls,H.,
            Sivertsen,B., Schwartz,T.W., Blanchard,A., Jepras,R. and
            Rosenkilde,M.M.
  TITLE     Ligand modulation of the Epstein-Barr virus-induced
            seven-transmembrane receptor EBI2: identification of a potent and
            efficacious inverse agonist
  JOURNAL   J Biol Chem 286 (33), 29292-29302 (2011)
   PUBMED   21673108
REFERENCE   7  (bases 1 to 1536)
  AUTHORS   Hannedouche,S., Zhang,J., Yi,T., Shen,W., Nguyen,D., Pereira,J.P.,
            Guerini,D., Baumgarten,B.U., Roggo,S., Wen,B., Knochenmuss,R.,
            Noel,S., Gessier,F., Kelly,L.M., Vanek,M., Laurent,S., Preuss,I.,
            Miault,C., Christen,I., Karuna,R., Li,W., Koo,D.I., Suply,T.,
            Schmedt,C., Peters,E.C., Falchetto,R., Katopodis,A., Spanka,C.,
            Roy,M.O., Detheux,M., Chen,Y.A., Schultz,P.G., Cho,C.Y., Seuwen,K.,
            Cyster,J.G. and Sailer,A.W.
  TITLE     Oxysterols direct immune cell migration via EBI2
  JOURNAL   Nature 475 (7357), 524-527 (2011)
   PUBMED   21796212
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1536)
  AUTHORS   Liu,C., Yang,X.V., Wu,J., Kuei,C., Mani,N.S., Zhang,L., Yu,J.,
            Sutton,S.W., Qin,N., Banie,H., Karlsson,L., Sun,S. and
            Lovenberg,T.W.
  TITLE     Oxysterols direct B-cell migration through EBI2
  JOURNAL   Nature 475 (7357), 519-523 (2011)
   PUBMED   21796211
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1536)
  AUTHORS   Pereira,J.P., Kelly,L.M., Xu,Y. and Cyster,J.G.
  TITLE     EBI2 mediates B cell segregation between the outer and centre
            follicle
  JOURNAL   Nature 460 (7259), 1122-1126 (2009)
   PUBMED   19597478
REFERENCE   10 (bases 1 to 1536)
  AUTHORS   Benned-Jensen,T. and Rosenkilde,M.M.
  TITLE     Structural motifs of importance for the constitutive activity of
            the orphan 7TM receptor EBI2: analysis of receptor activation in
            the absence of an agonist
  JOURNAL   Mol Pharmacol 74 (4), 1008-1021 (2008)
   PUBMED   18628402
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473951.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001054002.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB748127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663601, SAMN13663608
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     gene            1..1536
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="G protein-coupled receptor 183"
                     /db_xref="GeneID:679975"
                     /db_xref="RGD:1598095"
     exon            1..54
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..1536
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1154
                     /gene="Gpr183"
                     /gene_synonym="Ebi2"
                     /note="Epstein-Barr virus induced gene 2
                     (lymphocyte-specific G protein-coupled receptor);
                     EBV-induced G-protein coupled receptor 2; epstein-Barr
                     virus-induced G-protein coupled receptor 2"
                     /codon_start=1
                     /product="G-protein coupled receptor 183"
                     /protein_id="NP_001102856.1"
                     /db_xref="GeneID:679975"
                     /db_xref="RGD:1598095"
                     /translation="MANNFTTPLAASHGNNCDLYAHHSTARILMPLHYSLVFIIGLVG
                     NLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIVYYALGFDWRIGDALCRI
                     TALLFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGICVFVWILVFAQTL
                     PLLLKPMSKQEADKTTCMEYPNFEGTASLPWILLGACLLGYVLPLAIILLCYSQICCK
                     LFRTAKQNPLTEKSGVNKKALNTIILIIGVFVLCFTPYHVAIMQHMVKTLYAPGALGC
                     GVRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSA
                     PEENSREMTESQMMIHSKASNGR"
ORIGIN      
        1 cagtctgggc aaacacagac ggccaccttg gaggctctag ccaccctctg atactaactc
       61 tgaccactgc ggatacagaa atggctaaca attttactac accactggca gcttctcacg
      121 gcaataactg tgatctctat gcacaccaca gcacggccag gatattaatg cctctgcatt
      181 atagcctggt cttcatcatt ggtctggtgg gaaacttgtt ggccttagtt gtcattgttc
      241 aaaatagaaa aaaaatcaac tcaaccactc tctattcaat gaacttggtg atttccgaca
      301 tcctgtttac cacagcttta cctacgcgga tagtctacta tgccctgggt tttgactgga
      361 ggattggtga tgccctgtgc cggataactg ctctgttgtt ctacatcaac acgtatgcag
      421 gtgtgaactt catgacttgt ttgagcatag accgattctt tgccgtggtg caccctctgc
      481 gctacaacaa gattaaaaga attgaatatg caaagggcat ttgtgtattt gtctggattt
      541 tggtgtttgc tcaaacactg ccactgctcc tcaaacccat gtctaagcag gaggcagaca
      601 agactacttg catggaatat ccaaattttg aagggacagc atctctcccg tggattctgc
      661 tcggagcctg cctgctaggc tacgtgctgc ctcttgccat cattctcctg tgctactctc
      721 agatctgctg caaactcttc aggactgcca agcagaaccc actgaccgag aaatctggtg
      781 tgaacaaaaa ggctctcaac acgatcatcc tcatcatcgg cgtgttcgtc ttgtgcttca
      841 cgccctacca cgtggccatt atgcagcaca tggtgaagac tctctacgcc cccggagccc
      901 tcggctgtgg ggtgagacac tccttccaga tctctctgca cttcacagtg tgcctgatga
      961 acttcaactg ctgcatggac cctttcatat acttctttgc atgtaaaggg tacaagagaa
     1021 aggtcatgaa gatgctcaaa cgtcaagtga gcgtgtcaat ctccagtgca gtgaggtcag
     1081 cccctgagga gaactcacgg gaaatgacgg agtcacagat gatgatccac tccaaggcct
     1141 ccaatgggag gtaaaggtgc ttgggccctc acagcacagc aagctgcagg gcaggcgggc
     1201 tctgcctacc aactgttctg ctcccaacca ggatgccttc cagttgtcct ctctgggcag
     1261 gactacccac tgccacctca ccagccagcg cactgacatc cagaccagac caaggaaaca
     1321 gcaaaagcaa gttctacttc ataaatgaaa cagaatatac aaaggaaggc tatcgtaata
     1381 cgtctccatg taaaaagaaa tgctgtgtga aattaccatt tcttgccaat agcgtggcaa
     1441 aagaaagaag actgattgca ctgtatatat tgccagtgta aaaatgttaa tactctaata
     1501 tatgtaacat atttcctaat ttacaccttt cacttt
//
