LOCUS       NM_053302               1908 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 182 (Gpr182), mRNA.
ACCESSION   NM_053302
VERSION     NM_053302.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Gao,H., Liebenthal,D.A., Yallampalli,U. and Yallampalli,C.
  TITLE     Adrenomedullin promotes rat trophoblast stem cell differentiation
  JOURNAL   Biol Reprod 91 (3), 65 (2014)
   PUBMED   25061099
  REMARK    GeneRIF: Data suggest that stimulation of
            adrenomedullin/adrenomedullin receptor signaling enhances
            trophoblast stem cell differentiation; this stimulation involves
            CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor
            activity-modifying protein 2).
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Geissler,B., Plank,C., Hartner,A., Amann,K., Struwe,F.G.,
            Hilgers,K.F., Rascher,W. and Dotsch,J.
  TITLE     Effects of adrenomedullin on the glomerular adrenomedullin system
            in a rat model of anti-thy1 glomerulonephritis
  JOURNAL   Nephron Exp Nephrol 115 (3), e80-e88 (2010)
   PUBMED   20431304
  REMARK    GeneRIF: study demonstrates that glomerular gene expression of ADM
            and its receptors are downregulated during anti-Thy1
            glomerulonephritis
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Li,Y.Y., Li,L., Hwang,I.S., Tang,F. and O,W.S.
  TITLE     Coexpression of adrenomedullin and its receptors in the
            reproductive system of the rat: effects on steroid secretion in rat
            ovary
  JOURNAL   Biol Reprod 79 (2), 200-208 (2008)
   PUBMED   18401014
  REMARK    GeneRIF: The presence of ADM and the gene expression of ADM and its
            receptor components in the female reproductive system suggest a
            paracrine effect of ADM on ovarian steroidogenesis.
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Ross,G.R., Yallampalli,U. and Yallampalli,C.
  TITLE     Cyclic AMP-independent CGRP8-37-sensitive receptors mediate
            adrenomedullin-induced decrease of CaCl2-contraction in pregnant
            rat mesenteric artery
  JOURNAL   J Vasc Res 45 (1), 33-44 (2008)
   PUBMED   17898545
  REMARK    GeneRIF: Adrenomedullin inhibits CaCl(2)-induced contraction,
            without affecting calcium influx, through a CGRP(8-37)-sensitive
            receptor, but not using the cyclic adenosine monophosphate pathway,
            probably through activation of protein phosphatases.
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Rebuffat,P., Macchi,C., Malendowicz,L.K. and Nussdorfer,G.G.
  TITLE     Up-regulation of adrenomedullin receptor gene expression in
            activated local stem cells during rat adrenal regeneration
  JOURNAL   Int J Mol Med 20 (6), 855-858 (2007)
   PUBMED   17982694
  REMARK    GeneRIF: Data indicate that the adrenomedullin receptor subtypes
            AM1-R and AM2-R are up-regulated in enucleated adrenals, and that
            this effect depends on the increased local production of AM.
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Dotsch,J., Schoof,E., Schocklmann,H.O., Brune,B., Knerr,I., Repp,R.
            and Rascher,W.
  TITLE     Nitric oxide increases adrenomedullin receptor function in rat
            mesangial cells
  JOURNAL   Kidney Int 61 (5), 1707-1713 (2002)
   PUBMED   11967020
  REMARK    GeneRIF: Nitric oxide increases adrenomedullin receptor function in
            rat mesangial cells
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Makino,I., Honda,K., Makino,Y., Okano,I., Kangawa,K., Kamiya,H.,
            Shibata,K. and Kawarabayashi,T.
  TITLE     Phenotypic changes of adrenomedullin receptor components, RAMP2,
            and CRLR mRNA expression in cultured rat vascular smooth muscle
            cells
  JOURNAL   Biochem Biophys Res Commun 288 (3), 515-520 (2001)
   PUBMED   11676473
  REMARK    GeneRIF: The increase in functional adrenomedullin receptor during
            phenotypic change may in part contribute to the development of
            vascular lesions
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Kapas,S., Catt,K.J. and Clark,A.J.
  TITLE     Cloning and expression of cDNA encoding a rat adrenomedullin
            receptor
  JOURNAL   J Biol Chem 270 (43), 25344-25347 (1995)
   PUBMED   7592696
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Eva,C. and Sprengel,R.
  TITLE     A novel putative G protein-coupled receptor highly expressed in
            lung and testis
  JOURNAL   DNA Cell Biol 12 (5), 393-399 (1993)
   PUBMED   8390839
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Harrison,J.K., Barber,C.M. and Lynch,K.R.
  TITLE     Molecular cloning of a novel rat G-protein-coupled receptor gene
            expressed prominently in lung, adrenal, and liver
  JOURNAL   FEBS Lett 318 (1), 17-22 (1993)
   PUBMED   8382168
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129072.1.
            
            On Jan 10, 2007 this sequence version replaced NM_053302.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1908
                     /gene="Gpr182"
                     /gene_synonym="Admr"
                     /note="G protein-coupled receptor 182"
                     /db_xref="GeneID:29307"
                     /db_xref="RGD:61903"
     exon            1..139
                     /gene="Gpr182"
                     /gene_synonym="Admr"
                     /inference="alignment:Splign:2.1.0"
     exon            140..1353
                     /gene="Gpr182"
                     /gene_synonym="Admr"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1352
                     /gene="Gpr182"
                     /gene_synonym="Admr"
                     /note="adrenomedullin receptor; NOW; G10D"
                     /codon_start=1
                     /product="G-protein coupled receptor 182"
                     /protein_id="NP_445754.2"
                     /db_xref="GeneID:29307"
                     /db_xref="RGD:61903"
                     /translation="MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELN
                     ENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSL
                     PVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQR
                     HQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSA
                     TILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIAVFVICWLPYHVTMLL
                     LTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRY
                     LPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHAIRNVQASSLPPNTSPTL
                     CNSIAS"
     exon            1354..1899
                     /gene="Gpr182"
                     /gene_synonym="Admr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctacttc ccgcaggcaa gcagagctgc ctgaagccag caacagagcc tgctccacaa
       61 agctgcctct gcagcctcct ggtggctcac agccccatcc ataggctctc ccggacaggt
      121 gctccccaga gaaatccaga cactagctgg ccctcatgtc agtcataccc agctccaggc
      181 cggtctccac cttggcacct gacaatgatt ttagagagat ccacaactgg acagagctgc
      241 tccatctctt caaccaaacc ttttctgatt gccacatgga actcaatgag aacaccaaac
      301 aagtggtcct ctttgtcttc tacctggcca tctttgtggt agggttagtg gagaacgtcc
      361 tggtgatatg tgtcaactgc cgccgctcag gccgggtggg gatgctgaac ttatacatcc
      421 tcaacatggc cgtcgcggac ctgggcatca tcctgtctct gcctgtttgg atgctggagg
      481 tcatgctgga gtacacctgg ctctggggca gcttctcctg tcgcttcatt cattatttct
      541 accttgccaa catgtacagc agcatcttct tcctcacctg cctcagcatt gaccgctacg
      601 tcaccctcac caatacctct ccctcctggc agcgccacca gcaccgaata cggagggccg
      661 tgtgcgcagg cgtctgggtc ctctccgcca tcatcccact gcctgaggtg gtacatatcc
      721 agctgctgga tggctccgag cccatgtgcc tcttcctagc accttttgaa acgtacagcg
      781 cctgggccct ggcagtggcc ctgtcggcta ccatcctggg cttcctactg ccttttcctc
      841 tcatcgcagt gtttaatatc ctgtcagcct gccggcttcg gaggcaaggg cagacagaga
      901 gcaggcgcca ctgtctgttg atgtgggctt acatagctgt ctttgtcatc tgctggctgc
      961 cctaccacgt gactatgctg ctgctcactc tgcacacaac ccacatcttc cttcactgca
     1021 acctggttaa cttcctctac ttcttctacg aaatcattga ctgcttctcc atgctacact
     1081 gtgtcgccaa ccccatcctc tacaactttc tcagcccgag cttccggggc cgactgctga
     1141 gccttgtggt ccgttacctt cccaaggagc aggccagggc agcaggcggt cgagcctcct
     1201 cttcatcttc cacccagcac tccatcatca ttaccaaaga gggcagcctg cccgctgcag
     1261 cggatctgca cacccacgcc atcagaaacg tgcaggcctc ctctctgcct ccgaacacct
     1321 cacctacact ctgcaattcc atagccagct aagctcacta tgcaagttgt gaggacaaga
     1381 ggccagaggc caaggaccca ggaggctccg gcaggacgtt ccgtagctgt gcctcatccc
     1441 tggccctgag ttcgataaat caagggggtg aggattacag ccagctgggt cttgggcagg
     1501 cacccggcag ctggctcagc aggatggctc ctccacccag tcatccagga aatgtggctc
     1561 catttccctg tggcatcctc ccctccccca actcatcctg ccccctcctc ccctaaagcg
     1621 gaggcctcct cacaaatgac ctccctctcc aagggagata cagccactag tgattccacg
     1681 cccatcttat ttctccagat cttggcaatg tcagggaaca gccattcttc agaggacacc
     1741 ttgggagctg ctgtaggtac tcctcctccc atgcagggag aggggaggcc aaagactgat
     1801 ttccagaaca ctacagttga gttctctcta gtcgagcctt tcccgagtcc ccctacccaa
     1861 caatctgtct attaaaacta tggaaaaaaa aaaaaaaaaa aaaaaaaa
//
