LOCUS       NM_001079710            1357 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 18 (Gpr18), mRNA.
ACCESSION   NM_001079710 XM_001053946
VERSION     NM_001079710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1357)
  AUTHORS   Narasimhan,M., Mahimainathan,L., Reddy,P.H. and Benamar,K.
  TITLE     GPR18-NAGly system in periaqueductal gray and chronic neuropathic
            pain
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (12), 165974 (2020)
   PUBMED   32949767
  REMARK    GeneRIF: GPR18-NAGly system in periaqueductal gray and chronic
            neuropathic pain.
REFERENCE   2  (bases 1 to 1357)
  AUTHORS   Wrobel,A., Szopa,A., Serefko,A. and Poleszak,E.
  TITLE     A Novel Alternative in the Treatment of Detrusor Overactivity? In
            Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and
            GPR18 Cannabinoid Receptors
  JOURNAL   Molecules 25 (6), 1384 (2020)
   PUBMED   32197469
  REMARK    GeneRIF: A Novel Alternative in the Treatment of Detrusor
            Overactivity? In Vivo Activity of O-1602, the Newly Synthesized
            Agonist of GPR55 and GPR18 Cannabinoid Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1357)
  AUTHORS   Wang,X., Sumida,H. and Cyster,J.G.
  TITLE     GPR18 is required for a normal CD8alphaalpha intestinal
            intraepithelial lymphocyte compartment
  JOURNAL   J Exp Med 211 (12), 2351-2359 (2014)
   PUBMED   25348153
REFERENCE   4  (bases 1 to 1357)
  AUTHORS   Penumarti,A. and Abdel-Rahman,A.A.
  TITLE     The novel endocannabinoid receptor GPR18 is expressed in the
            rostral ventrolateral medulla and exerts tonic restraining
            influence on blood pressure
  JOURNAL   J Pharmacol Exp Ther 349 (1), 29-38 (2014)
   PUBMED   24431468
  REMARK    GeneRIF: The role of a novel cannabinoid receptor GPR18, espressed
            in the rostral ventrolateral medulla, in central blood pressure
            control.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128782.1.
            
            On Dec 11, 2006 this sequence version replaced XM_001053946.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128782.1, CO570572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     gene            1..1357
                     /gene="Gpr18"
                     /note="G protein-coupled receptor 18"
                     /db_xref="GeneID:679957"
                     /db_xref="RGD:1304889"
     exon            1..187
                     /gene="Gpr18"
                     /inference="alignment:Splign:2.1.0"
     exon            188..1333
                     /gene="Gpr18"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1217
                     /gene="Gpr18"
                     /note="NAGly receptor"
                     /codon_start=1
                     /product="N-arachidonyl glycine receptor"
                     /protein_id="NP_001073178.1"
                     /db_xref="GeneID:679957"
                     /db_xref="RGD:1304889"
                     /translation="MAIPSNRDQLALSNGSHPEEYKIAALVFYSCIFLIGLLVNVTAL
                     WVFSCTTKKRTTVTIYMMNVALLDLVFILSLPFRMFYYAKGEWPFGDYFCHILGALVV
                     FYPSLALWLLALISADRYMAIVQPKYAKELKNTGKAVLACVGVWIMTLTTTVPLLLLD
                     EDPDKASSPATCLKISDIIHLKAVNVLNFTRLIFFFLIPLFIMIGCYVVIIHSLLRGQ
                     TSKLKPKVKEKSIRIIVTLLLQVLACFVPFHICFALLMLQGEENSYSPWGAFTTFLMN
                     LSTCLDVVLYYIVSKQFQARVISVMLYRNYLRSVRRKSVRSGSLRSLSNMNSEML"
ORIGIN      
        1 aaagggcaga gcagtgctca gagcccagca gaccagcccc gccatcggta ctacatctca
       61 gcaaccctcc aacaggacca gccgcagagg caaaggaaaa caattcaaag acactatctg
      121 cctaacacag gcaggccact gcacactctt tccagcacct cgcagacagc cctttgacgg
      181 acaggagttt ctacgtacca tggggaccag cctgctgtaa gatggccatc ccgagcaatc
      241 gcgaccagct tgctctttcc aatggttcac acccagagga atacaaaatc gcagccctgg
      301 tcttctacag ctgcatcttc ctgattgggc tgcttgttaa tgtcactgcc ctatgggttt
      361 tcagctgtac gaccaagaaa agaaccaccg taaccatcta catgatgaac gtcgcactgc
      421 tggacttagt atttatactg agtctaccct ttcggatgtt ttactatgca aaaggcgagt
      481 ggccatttgg agactacttc tgccacattc ttggggccct ggtggtgttt tacccaagcc
      541 ttgctctgtg gcttcttgct ctcattagtg ctgacagata catggccata gtacagccga
      601 aatacgccaa ggaactcaag aacactggca aggcggtgct cgcgtgtgtg ggggtctgga
      661 taatgaccct gaccaccact gtccctctgc tactgctcga tgaagaccca gataaggcct
      721 cctccccggc cacctgcctg aagatctccg acatcatcca cttaaaagct gtcaatgtgc
      781 ttaacttcac gcgactcata tttttcttcc tgatccctct gttcatcatg atcgggtgct
      841 acgtggtcat cattcacagc ctcctccgcg ggcagacgtc taagctgaag cccaaggtca
      901 aggagaagtc catacggatc atcgtcacgc tcctgctgca ggtgcttgcc tgcttcgtgc
      961 ccttccacat ctgttttgct ctcctgatgc tacaggggga ggagaacagc tacagcccct
     1021 ggggagcctt caccaccttc ctcatgaacc tcagcacgtg tctcgacgtc gttctctact
     1081 acattgtttc caaacagttc caggctcgag tcatcagtgt catgctgtac cgcaattacc
     1141 ttcgcagtgt gcgcagaaaa agtgtccggt caggcagtct acggtcactt agcaacatga
     1201 acagtgaaat gctttgagtc agagcaagct gactgtcttc aatctcttta aaattctttt
     1261 tctatctact ctcaggtgaa ccagcattca atattatcca gtccctgctc taataaagag
     1321 aaataataat aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
