LOCUS       NM_022255               4988 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus G-protein coupled receptor 173 (Gpr173), mRNA.
ACCESSION   NM_022255 XM_003752061 XM_039100020
VERSION     NM_022255.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4988)
  AUTHORS   Kalamon,N., Blaszczyk,K., Szlaga,A., Billert,M., Skrzypski,M.,
            Pawlicki,P., Gorowska-Wojtowicz,E., Kotula-Balak,M., Blasiak,A. and
            Rak,A.
  TITLE     Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in
            the hypothalamus, ovary and periovarian adipose tissue in rat model
            of polycystic ovary syndrome
  JOURNAL   Biochem Biophys Res Commun 528 (4), 628-635 (2020)
   PUBMED   32505354
  REMARK    GeneRIF: Levels of the neuropeptide phoenixin-14 and its receptor
            GRP173 in the hypothalamus, ovary and periovarian adipose tissue in
            rat model of polycystic ovary syndrome.
REFERENCE   2  (bases 1 to 4988)
  AUTHORS   Stein,L.M., Tullock,C.W., Mathews,S.K., Garcia-Galiano,D.,
            Elias,C.F., Samson,W.K. and Yosten,G.L.
  TITLE     Hypothalamic action of phoenixin to control reproductive hormone
            secretion in females: importance of the orphan G protein-coupled
            receptor Gpr173
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 311 (3), R489-R496 (2016)
   PUBMED   27440717
  REMARK    GeneRIF: These studies are the first to demonstrate a functional
            relationship between PNX and Gpr173 in reproductive physiology and
            identify a potential therapeutic target for ovulatory dysfunction.
REFERENCE   3  (bases 1 to 4988)
  AUTHORS   Larco,D.O., Cho-Clark,M., Mani,S.K. and Wu,T.J.
  TITLE     The metabolite GnRH-(1-5) inhibits the migration of immortalized
            GnRH neurons
  JOURNAL   Endocrinology 154 (2), 783-795 (2013)
   PUBMED   23321696
REFERENCE   4  (bases 1 to 4988)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000372.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022255.3.
            
            On or before Aug 31, 2022 this sequence version replaced
            XM_039100020.1, NM_022255.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132284
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               JACYVU010000372.1  712488-713162       c
            676-765             JACYVU010000372.1  711789-711878       c
            766-913             JACYVU010000372.1  711490-711637       c
            914-4988            JACYVU010000372.1  688304-692378       c
FEATURES             Location/Qualifiers
     source          1..4988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..4988
                     /gene="Gpr173"
                     /gene_synonym="Sreb3"
                     /note="G-protein coupled receptor 173"
                     /db_xref="GeneID:64021"
                     /db_xref="RGD:620748"
     exon            1..675
                     /gene="Gpr173"
                     /gene_synonym="Sreb3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..765
                     /gene="Gpr173"
                     /gene_synonym="Sreb3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..913
                     /gene="Gpr173"
                     /gene_synonym="Sreb3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..4988
                     /gene="Gpr173"
                     /gene_synonym="Sreb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1011..2132
                     /gene="Gpr173"
                     /gene_synonym="Sreb3"
                     /note="super conserved receptor expressed in brain 3;
                     probable G-protein coupled receptor 173-like"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 173"
                     /protein_id="NP_071591.1"
                     /db_xref="GeneID:64021"
                     /db_xref="RGD:620748"
                     /translation="MANTTGEPEEVSGALSLPSASAYVKLVLLGLIMCVSLAGNAILS
                     LLVLKERALHKAPYYFLLDLCLADGIRSAICFPFVLASVRHGSSWTFSALSCKIVAFM
                     AVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVF
                     DVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMK
                     PVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMD
                     EVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAA
                     VNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAPREPYCVM"
ORIGIN      
        1 cgtccatccc ctccccaaca ccacctctgc tgctgcctct ggctgtggac ctgcacctct
       61 tctccatcct cgccaggccc ggagagtggg gttagcctgg atgagagtgt gcccctaacc
      121 tgaggccctc ccaggccatg gctcatgtgt tcccagggag gagtccagga ccctgagcat
      181 ctgctagaag cttggcagag gccccgctgg gaccgtgtct tctgaggaca aaaggctgcg
      241 gccagcaggc agactgggtg gggggtgggg ggggtggggg aaccggtagc taagcaggca
      301 gaacagtagc ggagccagcg ctggccccct cccagactgg cggtggcatg aagatggggg
      361 tgggagtgtg tagtgggaga agcacctacc aggaccccca cctgcccact acttgggcat
      421 cccaaagctg tgtgctgccc acctggtgtt ccccaaaatc tccagctcta ccaagtgcac
      481 ccctctggca cctgcttctc ttgctgccag cgatttagac caaccaggct gtatccacgg
      541 caacagaagc aggagtgtca ctggctgcca gatcactgag ggtcccacaa tgtggcctgg
      601 gctgtggttt atccgggatg acacagagtg agcctccttc ctgaattcca agacagtcct
      661 gctaagaaaa cccagtctct acctacaggt aacatacttt tgctcactca ccctggaaga
      721 tgtgtcccag ctagtgggag gaagctgcta taggaataga ggaagatacc catattgtgt
      781 ttgggacctc cagatctatg acacagtagc cagaggtccc tgtatctgga ggtgcaggaa
      841 aacctggtat atggagaaca tggattctac tagggacacg gctcctaact actagctcgc
      901 aactttagtg gaggtgtagc tcagcaagaa aactgatgga gtccgccagg gcccatcaaa
      961 tactgaactg gccgatcccc tagggttagg ggtagccctt acccctcagt atggccaaca
     1021 ccaccggaga gcccgaagag gtgagcggcg cactgtccct gccatcagca tcggcttatg
     1081 tgaagctggt gctgctggga ctgatcatgt gtgtaagcct ggcaggcaat gccatcttgt
     1141 ccctgctggt gctcaaggag cgtgccctgc acaaggctcc ttactacttt ctgctggacc
     1201 tgtgcctagc cgatggcata cgctctgcca tctgcttccc ctttgtactg gcttctgtgc
     1261 gccatggctc ctcgtggacc ttcagtgcac tcagctgtaa gattgtggcc tttatggctg
     1321 tgctcttttg cttccatgcg gccttcatgc tgttctgcat cagcgtcacc cgctacatgg
     1381 ccatcgccca ccaccgcttc tatgccaagc gcatgacact ctggacatgc gcagctgtca
     1441 tctgcatggc ctggaccttg tctgtggcca tggctttccc acctgtcttt gatgtgggca
     1501 cctacaagtt tatccgagag gaggaccagt gcatctttga gcatcgctac ttcaaagcaa
     1561 atgacactct gggctttatg cttatgttgg ctgtgctcat ggcagccaca catgctgtct
     1621 atggcaagct gctactcttc gagtatcgtc accgcaagat gaagccagtg cagatggtgc
     1681 ccgccatcag ccaaaactgg acattccatg gccctggggc taccggccag gctgctgcca
     1741 actggatcgc tggctttggc cgtgggccca tgccaccaac tctgctgggt atccggcaga
     1801 atgggcatgc agctagccgg cggctactgg gcatggacga ggtcaagggt gaaaagcagc
     1861 tgggccgaat gttctacgcg attacactgc tcttcctgct cctctggtca ccatacattg
     1921 tggcctgcta ctggcgagtg tttgtgaaag cctgcgctgt gccccaccgc tacctggcca
     1981 ctgctgtttg gatgagcttc gcccaggctg ctgtcaaccc aatcgtctgc ttcctgctta
     2041 acaaggacct caagaagtgc ctgaggactc atgccccttg ctggggcaca ggaggtgccc
     2101 cagctcccag agaaccctac tgtgtcatgt gaagcaagcc agtaggtgat aggcaggggg
     2161 aaagtcatga tcaccatact ggggccaaca ggggaagggt gggacccata cagaagcctt
     2221 tttttttttt ttttgagctt cagtccaggc tctcaaacta tccataactg aggcattttg
     2281 ccaacacctc gctagggttg gaaacggggt gaagaactgg aaaagaggca tttctagttt
     2341 tgtggggcgt gtcccgcagc ctctccactt ctacaatctc cttttcccat gccttccctt
     2401 ccttcccttc cctttccctt tcccttctcc tatctttcta aaataacaat tcagtaaatg
     2461 aaaacaaact gaaaatgcag ggtttttaat aataacagct gaggaaacag gctttcttgc
     2521 ttaaaatgtc cccccttttg acactgtcaa gaaatgggaa atttctactg taaaatagat
     2581 tcccagagat cttattgccc cctgggctcc catttaccct ccccttctaa atcctttagc
     2641 aagacttgga tgtttaggaa atattgactt aagtcttcag acaagaggga ccaaataggg
     2701 tgctgtattc cttgggagca aggatgttta aattgctatg ttgtgtgcaa tgttgttttt
     2761 ggctaacctt gatccaaagc ccgatctcca acccctccct accatgtcca tactttgaag
     2821 gtgtttcttg aggctctgtt tgagaagaca agagcataca aagaagggcc tccatgatgt
     2881 gcccaggcta gatgaagtgc agaatgagag atgtgctcct caaccaaaat ataccaaact
     2941 tagctacatt cactcaagct tcctcttgac tcccctaacc tttccaccta ggaatatata
     3001 tccactttag tccccactag ggatgatgtg ggtatatgct gacaggaaaa gtcatccatg
     3061 gaagtatagg gagatagttg aactctccag aggagctaga gtccagactg tgaggtcaga
     3121 gctaaattca accccacaac tgtctcttgg gttcacacta ctccccccaa agtgaaaatt
     3181 tctttggggg ccttggtcac caatagttat ccagacttca aggcactgtg gatttgaatc
     3241 cattcctgct tgacctcttc tttttgtccc ttcctaactt cacagtcctt gagcccctcc
     3301 ttggttgggc cccaagcatc gttcccagaa gtttttcttt ctccatccac tcctaccaat
     3361 gtccaaagtg gagcagacta cacccaaatt gcaaagctgg aaggtctcaa gccttttctc
     3421 catggacaga gaccaacttc aaggccagtt ctatagactg gtgaaccaag ttggaattct
     3481 ttgcctaagt ttgggacagt ggtgtctcca tcccttttcc ttccttataa gctcctgtca
     3541 gaaactccac ctctacccca agataggcac tgaactgagg aagtcttgac ccaaaagcaa
     3601 tgaagggggc actctaggca gaagagatat tgtgaccctg gttgtggagt ggccctggaa
     3661 aagcgagcca gaggagctaa gaggctggga acatgtgttt ggggtggggc tattctctca
     3721 gtgatgatga taggaatgcc tttctgaggg ctggggtgca aagaccaagg tgggagggca
     3781 aatagggtag actcgggagg gttttcctcc atttcccttt tctaactgcc tggattcatc
     3841 attggatttt gtaaatggaa aaagtgaaat gaacaatgtt atattggatg ttctctctct
     3901 ctctctctct ctctctctct ctctctctct ctctctgtgt gtgtgtgtgt gtgtgtgtgt
     3961 gtacgtgtgt gtgcccacgc acacacatgc gcccctgcac acatctttgt ctatgtcttc
     4021 tatctgtgta tgatcacgtg gggaggtatg attgaatgag atagtgtgtg tctgtgtgac
     4081 tttgtgtggg taagaacccc tgaggaaaac ttgcctagtg cacagatgtg agcaaataca
     4141 tatatgtgaa gaaataaagt acaacacaca cacacacaca cacacacaca cacacactgg
     4201 agaggagaca aaacttagta tgtgcctgca gcaggaaata gagtgcttag gagatggaac
     4261 ctgaaatttt ttatgtatgt atgtgtcaag agagtcaact cccatctcat aaggttgtct
     4321 tcccttggcc cagcttctga gcaccaggta aggagagaat actttagaac tccatctctt
     4381 cccagtgtct ggagattcag tcctcaccca aaattcaaac aaggtatttc ttaaattgga
     4441 ccatcatgga aataggaact gggaatggag gaggagtcaa acatgaaggt aatggggtta
     4501 agaaatggcc ccctgcaatg taatggcttt tagaggaact gctcagccta aactggaagt
     4561 tcttcttaag gttccactgt atacagctgg gactttgttc agctttgact aaattcagaa
     4621 ggaaagatgg cataaaaaaa aaaaagcccg agtctagggg tctacccaac tggcctactc
     4681 cctaggcact caattaattt actatttatt tatttattcc ttcaggtgca cagaattgaa
     4741 ctgaccctat tcctcagttc ttagcatact atatcatcat tggtccatgc aaggtcctgt
     4801 tattattttg ctttgtcccc ttcatcaccc atccctgatc ccatccttcc caatcccaca
     4861 taggcaccac tcttatgtac ttaatgtgtg tccttccaaa ccaccgttca tgtgtttatt
     4921 tacttatgtg tatctgtgga aaatatatga tattgatgtg ttttaattta cataaacagt
     4981 attgtact
//
