LOCUS       NM_001071777            5505 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 17 (Gpr17), mRNA.
ACCESSION   NM_001071777 XM_006254604
VERSION     NM_001071777.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5505)
  AUTHORS   He,L., Yang,H., Feng,J., Wei,T., Huang,Y., Zhang,X. and Wang,Z.
  TITLE     Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the
            regeneration and repair of myelin sheath post-periventricular
            leukomalacia (PVL)
  JOURNAL   Bioengineered 12 (1), 7314-7324 (2021)
   PUBMED   34569901
  REMARK    GeneRIF: Knockdown of G protein-coupled receptor-17 (GPR17)
            facilitates the regeneration and repair of myelin sheath
            post-periventricular leukomalacia (PVL).
REFERENCE   2  (bases 1 to 5505)
  AUTHORS   Braune,M., Scherf,N., Heine,C., Sygnecka,K., Pillaiyar,T.,
            Parravicini,C., Heimrich,B., Abbracchio,M.P., Muller,C.E. and
            Franke,H.
  TITLE     Involvement of GPR17 in Neuronal Fibre Outgrowth
  JOURNAL   Int J Mol Sci 22 (21), 11683 (2021)
   PUBMED   34769111
  REMARK    GeneRIF: Involvement of GPR17 in Neuronal Fibre Outgrowth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5505)
  AUTHORS   Mao,F.X., Chen,H.J., Qian,L.H. and Buzby,J.S.
  TITLE     GPR17 plays a role in ischemia-induced endogenous repair of
            immature neonatal cerebral White matter
  JOURNAL   Brain Res Bull 161, 33-42 (2020)
   PUBMED   32387084
  REMARK    GeneRIF: GPR17 plays a role in ischemia-induced endogenous repair
            of immature neonatal cerebral White matter.
REFERENCE   4  (bases 1 to 5505)
  AUTHORS   Zhao,B., Wang,H., Li,C.X., Song,S.W., Fang,S.H., Wei,E.Q. and
            Shi,Q.J.
  TITLE     GPR17 mediates ischemia-like neuronal injury via microglial
            activation
  JOURNAL   Int J Mol Med 42 (5), 2750-2762 (2018)
   PUBMED   30226562
  REMARK    GeneRIF: These findings suggested that GPR17 may mediate
            ischemialike neuronal injury and microglial activation in vitro;
            however, the protective effects on ischemic neuronal injury might
            depend upon microglial activation.
REFERENCE   5  (bases 1 to 5505)
  AUTHORS   He,Y., Lv,B., Huan,Y., Liu,B., Li,Y., Jia,L., Qu,C., Wang,D., Yu,H.
            and Yuan,H.
  TITLE     Zhenbao pill protects against acute spinal cord injury via
            miR-146a-5p regulating the expression of GPR17
  JOURNAL   Biosci Rep 38 (1) (2018)
   PUBMED   29187582
  REMARK    GeneRIF: Zhenbao pill could inhibit neuronal apoptosis by
            regulating miR-146a-5p/GPR17 expression, and then promoting the
            recovery of spinal cord function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5505)
  AUTHORS   Zhao,B., Zhao,C.Z., Zhang,X.Y., Huang,X.Q., Shi,W.Z., Fang,S.H.,
            Lu,Y.B., Zhang,W.P., Xia,Q. and Wei,E.Q.
  TITLE     The new P2Y-like receptor G protein-coupled receptor 17 mediates
            acute neuronal injury and late microgliosis after focal cerebral
            ischemia in rats
  JOURNAL   Neuroscience 202, 42-57 (2012)
   PUBMED   22155652
  REMARK    GeneRIF: GPR17 might mediate acute neuronal injury and late
            microgliosis after focal cerebral ischemia
REFERENCE   7  (bases 1 to 5505)
  AUTHORS   Fumagalli,M., Daniele,S., Lecca,D., Lee,P.R., Parravicini,C.,
            Fields,R.D., Rosa,P., Antonucci,F., Verderio,C., Trincavelli,M.L.,
            Bramanti,P., Martini,C. and Abbracchio,M.P.
  TITLE     Phenotypic changes, signaling pathway, and functional correlates of
            GPR17-expressing neural precursor cells during oligodendrocyte
            differentiation
  JOURNAL   J Biol Chem 286 (12), 10593-10604 (2011)
   PUBMED   21209081
  REMARK    GeneRIF: Phenotypic changes, signaling pathway, and functional
            correlates of GPR17-expressing neural precursor cells during
            oligodendrocyte differentiation.
REFERENCE   8  (bases 1 to 5505)
  AUTHORS   Maekawa,A., Xing,W., Austen,K.F. and Kanaoka,Y.
  TITLE     GPR17 regulates immune pulmonary inflammation induced by house dust
            mites
  JOURNAL   J Immunol 185 (3), 1846-1854 (2010)
   PUBMED   20574000
  REMARK    Erratum:[J Immunol. 2010 Oct 1;185(7):4506]
REFERENCE   9  (bases 1 to 5505)
  AUTHORS   Daniele,S., Lecca,D., Trincavelli,M.L., Ciampi,O., Abbracchio,M.P.
            and Martini,C.
  TITLE     Regulation of PC12 cell survival and differentiation by the new
            P2Y-like receptor GPR17
  JOURNAL   Cell Signal 22 (4), 697-706 (2010)
   PUBMED   20056144
  REMARK    GeneRIF: Gpr17 acts as a neurotrophic regulator for neuronal-like
            cells and interacts with endogenous uracil derivatives,
            cysteinyl-leukotrienes, and nerve growth factor in the signalling
            pathways involved in neuronal survival and differentiation.
REFERENCE   10 (bases 1 to 5505)
  AUTHORS   Ciana,P., Fumagalli,M., Trincavelli,M.L., Verderio,C., Rosa,P.,
            Lecca,D., Ferrario,S., Parravicini,C., Capra,V., Gelosa,P.,
            Guerrini,U., Belcredito,S., Cimino,M., Sironi,L., Tremoli,E.,
            Rovati,G.E., Martini,C. and Abbracchio,M.P.
  TITLE     The orphan receptor GPR17 identified as a new dual uracil
            nucleotides/cysteinyl-leukotrienes receptor
  JOURNAL   EMBO J 25 (19), 4615-4627 (2006)
   PUBMED   16990797
  REMARK    GeneRIF: GPR17, a Gi-coupled orphan receptor at intermediate
            phylogenetic position between P2Y and CysLT receptors, is
            specifically activated by both families of endogenous ligands.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Oct 5, 2022 this sequence version replaced
            XM_006254604.4, NM_001071777.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.73028.1,
                                           SRR26360194.1718161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               JAXUCZ010000018.1  23856992-23857381   c
            391-5505            JAXUCZ010000018.1  23850460-23855574   c
FEATURES             Location/Qualifiers
     source          1..5505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5505
                     /gene="Gpr17"
                     /note="G protein-coupled receptor 17"
                     /db_xref="GeneID:767613"
                     /db_xref="RGD:1589785"
     exon            1..390
                     /gene="Gpr17"
                     /inference="alignment:Splign:2.1.0"
     exon            391..5505
                     /gene="Gpr17"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..1431
                     /gene="Gpr17"
                     /note="UDP/CysLT receptor"
                     /codon_start=1
                     /product="uracil nucleotide/cysteinyl leukotriene
                     receptor"
                     /protein_id="NP_001065245.1"
                     /db_xref="GeneID:767613"
                     /db_xref="RGD:1589785"
                     /translation="MDGLETALPSLTDNASLAYSEQCGQETPLENMLFACFYLLDFIL
                     AFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEI
                     PCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVA
                     VAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRS
                     LRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCSAQRALA
                     LGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLS
                     ARSEL"
ORIGIN      
        1 gtgtctgtca actcccgcca aagaccccca cccggcccgg cccttgccca ctcccaggct
       61 cccaggacag tcacacactt ggcctctgtg atgctcagtg gcctggctgg ggggtggggg
      121 catgcacggt ctgaggacac actggaatat tcagtatgtg ctccgtggaa gcagccccag
      181 ctggaggagc agcctacccc acaaaggacc cctcaggaat gaagtagctt ttcaggttca
      241 ggggagcgtc ggactctcct gctcgcctta aatagtcaag ccttccttct acagctacaa
      301 ggagcccacc tggagaccca cccgcggctg ctcacagctc acctgcttcc ctggtctcct
      361 ttcctttctt tcctgggtca tctgcaagag acttctgcct tcagccacaa gatggatggc
      421 ctcgagacag ccctaccgag tctgactgac aatgcctccc tggcttactc tgaacaatgt
      481 ggccaagaga cgcccctgga gaacatgctc ttcgcctgct tctacctcct ggacttcatc
      541 ctagcttttg tgggcaacgc tctggccctc tggcttttca tctgggatca caagtcaggc
      601 actccggcca acgtgttcct aatgcacctg gctgtggccg acttgtcctg tgtgctggtc
      661 ctgcctaccc ggttggttta tcacttctct ggcaatcact ggccttttgg ggaaatcccg
      721 tgccgactca ctggcttcct cttctacctg aatatgtacg ccagcatcta cttcctcacc
      781 tgcatcagtg ctgaccggtt cctggccatt gtgcacccag tcaagtccct caagcttcga
      841 agacctctct atgcccacct ggcctgcgcc ttcctgtgga tcgtggtggc cgtggctatg
      901 gccccactgc tagtgagtcc gcagactgtg cagaccaacc acacggttgt ctgcctgcaa
      961 ctgtaccggg agaaggcctc ccatcatgcc ctggcttccc tggctgtggc ttttaccttc
     1021 cccttcatca ccacggtcac ctgctacctg ctgatcattc gcagcctccg ccagggtccc
     1081 cgtatagaga agcacctcaa gaataaagcc gtccgcatga ttgctatggt tctggccatc
     1141 ttcctgattt gttttgtgcc ctaccacatc caccgttcag tctatgtgct tcactaccgc
     1201 ggtggtggga cttcgtgctc agctcagcgt gccctggccc tagggaaccg gatcacctcc
     1261 tgcctcacca gcctcaacgg ggccctggat ccagtcatgt acttctttgt ggctgagaaa
     1321 ttccgccacg ccttgtgcaa cttgctctgc agcaaacgac tcacaggtcc tcctcccagc
     1381 tttgaaggga aaaccaacga gagctccctg agcgctcggt ctgagctgtg agcccgagct
     1441 gggcgagcct cggggaggtc ctgtcaccgg gccagctgta cactgttgca ggaagactgg
     1501 ctattgactg gggtacacgc taccagagcc agctaaagaa gtctatcttc cctcactact
     1561 tcctgagcaa acaaacggaa gcgccaggag ttctcgccct gctccaaggc ctcaactgca
     1621 aggccatcca gtctgagcaa atctatccag agggaggact aactacgggg ctgcctgccc
     1681 acccctccac aggactggat tggcctggct tctgcacagc tctcagacac tcagtgactt
     1741 cactggtgct aaatagggaa gggagccaca gggacatttc tggaacaatg ggaatctttc
     1801 ttctctacta aacttctagc ttctttgata ctacagatgc ccacagacac aaagccctac
     1861 agaataaccc agagacaagc tgcccaaggt ccaggagaag aggcagcaca aatgccaatg
     1921 gaactggatg gacgtttaat atttcctttg aagtgtatgg tatatcgaat attgtttaag
     1981 gtgctttgcc cccatgatct ctgtctgagt ttaggggaca cagactctaa tgacagccac
     2041 atgtgagtat atttcagact ggctgcttgt aagcccagca aatagagttc tggactccgc
     2101 ccctcttgca accgtgtccc cacacctgcc tcaagcgctg tcccgagctt ctcaacacaa
     2161 tgtggtcttg tcagacatat ggacaccatt agagcccact gcaggcaggg agcctaatgt
     2221 gtgaacttgt ctccagctac acccagaagg gacatcctga gccccgctcc ctcccaagag
     2281 gcttctgcag ccctggctgc ctgggtctga gctgttgaac ttgttagtgt gtgatgactg
     2341 ctctaatgcg tcccctttcg tacttgtttg taatactctt aaacataatt gagtcttaag
     2401 atgaaggaaa taatcgtgct ggttcaacat gacacatgat gtcctccccc tgaaagtctt
     2461 gtctcttcca cccacgaatg actgagtagg acaacacccc cttgttgtgg ttctgtggcc
     2521 ttgtggcagg tctgcccagg cagacctgga gctgtgcatc atggagttga ttgccattct
     2581 aggttaaggg ggctctcgaa cttgtccctc cagctgcacc ctgcctatca ctagaggaac
     2641 cccaagatga ccctgatgct cagaactgct tttatccagt gccggtctgg ccacccccac
     2701 agcccctcac caagacaacc tgctgaatac aaggccgtgc cagccaggac caacacgagg
     2761 ccatgcgcct cttggatgaa atagcaaagg gacaagatca ctgcaggctg tgacaggagg
     2821 gacagagggg acaaagaccc agacagtctc atgacaagct ggagggtctc tgaaagtcag
     2881 cactgccttt cctggcacag gggatgcaga agtagacttg ggtcagagga ggaaaaattt
     2941 gtagctcaat ttgggacctg ttgtgttaga atctcaaatg gagatgccac accggtggga
     3001 gaactgagca aaggagagat ccggaggaga tccctggatt gtccagatgt accactaaga
     3061 ggcccaggac tttatcttca aaggcaggca tggactcggg cctaaagaac atcctcgtgc
     3121 agagggagag gctgagggaa actaacacaa cagagaaatc ttactgggag aggatgtgtt
     3181 tcaccccagg gagggtcctg ctgtgagagc actcagagag gtcaaggggg agcctggtga
     3241 tacccaggtt cggcttcagt cacagagaag gtcaaaggtg gtactggatg ctcccccata
     3301 gctttcccaa gcaggtgaga gactggctca ttgctgccgg gaaggtatat aacccacagg
     3361 gagagaggca ggggtgagaa gaaaaggtaa ggcctcctgg aagggggact gccagagtac
     3421 cagggaggta tacagtcctg aatttggagt caattgggca acctggttaa ggggtgtccc
     3481 tccaatatcc tccagccgtg tgaatgtagg gaggaaggca gacagatggg gtcggcatgg
     3541 tgcggtagcg gatgggatgt caggggtaat tgggatttat caacttaaaa ctcctcatcc
     3601 atccgtagcc actcaaggcc cttcaggcct gctgccccct aaggaccacc ccttgtccag
     3661 agggagctct gtctgtcctt acgctcctgc ctccatcctt atcctgcggg ctgtgttctc
     3721 cctctagcag ggacaggaca aggcccacag ccggatcagt agaggacgct gcagagccta
     3781 ctaggcagga cgaaggcact tagagtggtg gcaggagatc ctcctctctg cccacggctg
     3841 ccgctggctc acctgcctgc gttcttcaca aagcccaggt cagccagctc cacgtcgcac
     3901 agctcacagc ggaagcagcc cggatgccag ttggcgttca tggccttgat cacgcggccg
     3961 atgacaaact cacctgggag aggagagacc tcagctacca gggcacactc cccagccgtg
     4021 ggtatccccc aagccctatg tacccagtgc tcctcccgtg tagcctgtct aagcacccct
     4081 cttttagggg tcagaagagc aatgctcagg aagacagact gagggcatca ggagaagtcc
     4141 ccaggcaaag gaatgccagt accacctgtt accccacttg tcccctcccc acttgctaag
     4201 tacagtcagt caccagctct taccacagaa tccgcagcat ggagcgaaca gcatttggaa
     4261 gtcgtgttca cagtacttcc ggccctcaaa ctgcaaacgg gggccacaga aaaaaggcac
     4321 gcaagtcatt cagcacctca caagctttta caccctagta aatagcaggg gtctggggtc
     4381 ctgagaaggg aggcttctaa agctagctgg agcaggggtc tagcccatgc cacttagcag
     4441 agtgcaaagt cgtggagggt ggggcgggtt tcacagagat actgagggtc cgaggccagc
     4501 tcttggggat tctgctgtct gctgagggag aggggacctg tgggtcctga ccacaggccg
     4561 agctgaggtg ggagcggtgc tggggaagga agggtcaaat cttgcgttct atgtgctact
     4621 ccattcttca catctgacca gctcagttcc cccaaagact acaaaagacc cacagaggga
     4681 agacggagga aaggattctc agggaggccc tggggaattg gggtgacaaa gaaaaagcac
     4741 agccgtgctt cagtcagcca ctgtcctgta ccgtccccaa gaatgaccaa agcttgcctt
     4801 gcctttctct cccttaacaa tttgctttct taagaaaaat ctggggctgg ggatgtagat
     4861 cggttcatag agtacctgac atgcataaag gtcttggttt ggttcacaga attgtgggaa
     4921 tggtagtgca tatctgtaat ctcagcactg ggcagatgga gacaggatgc accagacgtt
     4981 caaagtcatc tttgacaact tccttcccct aaagtcacat gcagctctcc actgtgaggg
     5041 aggcaggggc ttgaattcct tcagcagcaa tatctcccag acacctactg ggctgggctt
     5101 ggctgtggtc taaatctcct agcagaactc tgctcaaccc tctgatgcct ctccagccag
     5161 caactcttgg gagcctggaa agtgactgga gatcctcacc tgaccacata tccacatcag
     5221 tcagtcaacg atgccgactg ctgacaactc tcggagagtc cagccccctc aagctttggt
     5281 cccctctcca ctgcagccca gaggagtgac agccagtgct taaccagctc tgggggaggc
     5341 aacagaggcc ttgccagacg ctgtggtgta aatctttctt ccaaactgat gtcaccacac
     5401 agatgaaaat aatctcagat gcataaacgg gaaagtctaa caaataacgg gaagtcggtg
     5461 tcttatgtac ttgttatcat catttttaat aaagtactat atcta
//
