LOCUS       NM_001108646            2873 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 162 (Gpr162), mRNA.
ACCESSION   NM_001108646 XM_001064191 XM_342757
VERSION     NM_001108646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2873)
  AUTHORS   Caruso,V., Sreedharan,S., Carlini,V.P., Jacobsson,J.A., Haitina,T.,
            Hammer,J., Stephansson,O., Crona,F., Sommer,W.H., Riserus,U.,
            Lannfelt,L., Marcus,C., Heilig,M., de Barioglio,S.R.,
            Fredriksson,R. and Schioth,H.B.
  TITLE     mRNA GPR162 changes are associated with decreased food intake in
            rat, and its human genetic variants with impairments in glucose
            homeostasis in two Swedish cohorts
  JOURNAL   Gene 581 (2), 139-145 (2016)
   PUBMED   26827797
  REMARK    GeneRIF: Study provides a characterization of GPR162 in mouse brain
            as well as detailed mRNA expression in a panel of rat tissues
            complementing a specie-specific mapping of the receptor and shows
            its functional implication in food intake-related behavior.
REFERENCE   2  (bases 1 to 2873)
  AUTHORS   Ruiz-Hernandez,A., Sanchez-Munoz,F., Rodriguez,J.,
            Calderon-Zamora,L., Romero-Nava,R., Huang,F., Hong,E. and
            Villafana,S.
  TITLE     Expression of orphan receptors GPR22 and GPR162 in
            streptozotocin-induced diabetic rats
  JOURNAL   J Recept Signal Transduct Res 35 (1), 46-53 (2015)
   PUBMED   24937127
  REMARK    GeneRIF: orphan receptors GPR22 and GPR162 are expressed in a
            different way in heart, kidney, brain and aorta of diabetic and
            non-diabetic rats.  We conclude that orphan receptors could be
            involved in the development of diabetes complications.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342757.3, XM_001064191.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2873
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2873
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /note="G protein-coupled receptor 162"
                     /db_xref="GeneID:362436"
                     /db_xref="RGD:1307437"
     exon            1..246
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /inference="alignment:Splign:2.1.0"
     exon            247..1539
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /inference="alignment:Splign:2.1.0"
     CDS             673..2439
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /EC_number="1.14.11.7"
                     /note="gene rich cluster, A"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 162"
                     /protein_id="NP_001102116.1"
                     /db_xref="GeneID:362436"
                     /db_xref="RGD:1307437"
                     /translation="MARGGLGAEEASLRSNALSWLACGLLALLANAWIILSISAKQQK
                     HKPLELLLCFLAGTHILMAAVPLTTFAVVQLRRQASSDYDWNESICKVFVSTYYTLAL
                     ATCFTVASLSYHRMWMVRWPVNYRLSNAKKQALHAVMGIWMVSFILSTLPSIGWHNNG
                     ERYYARGCQFIVSKIGLGFGVCFSLLLLGGIVMGLVCVAITFYQTLWARPRRARQARR
                     AGGSVGAKAGGLGGLGTRPAFEVPAIVVEDTRGKRRSSLDGSESAKTSLQVTNLVSAI
                     VFLYDSLTGVPILVVSFFSLKSDSAPPWMVLAVLWCSMAQTLLLPSFIWSCERYRADV
                     RTVWEQCVAIMSEDDGDDDGACDDYTDGRVCKIRFDANGATGSGSRDPTQVKLLPGRH
                     MLFPPLERVHYLQVPLSRRLSHDETNVFSTPRAPGSFLHKWSSSDDIRILPAQSRALG
                     GPPEYPGQRLRIEDEEDEEEAEGGGLASLRQFLESGVLGSGGGPPRGPGFFREEITTF
                     IDETPLPSPTASPGPSPRRPRPLGFSPRRLSLGSPESRAVGLPLGLSAGRRCSLTGSE
                     GSSRAWGRPWGPGNPIFPQLTL"
     exon            1540..1729
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1887
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2873
                     /gene="Gpr162"
                     /gene_synonym="Grca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagactggcc aacggctccc taaccccagg ctcgcaggcc gatgacccta ggagacaggg
       61 gcctcgaggg gcctcaaact agcgtgccgc gggctgagcc cgagaggccg ggctgggggg
      121 agggaggccc ggagggaggg agcgaaggaa ggaggagggc tggcgagctg gagccggcag
      181 gcggcgggag cccgggcgag cctcgtcggg agtgcgtctc ctcagcagag caggacacaa
      241 ccagagcttg tccaggtgac tgagctccac ccctgtgcac caagacaccc acccgcactg
      301 gtcaagcctc actggacaag agacccggaa gtcccagcat gagattcaga gctccccagc
      361 cagcttcata gatggggaag cagcctgctt gcctccccgg tcaattacag ggataattaa
      421 gaaagagccc cacccaatat ggagactgag ggctaccacc tctattgatt ctctgccttc
      481 tgccctgccc tgcccacctg accttagctg gtcaatgcta tgctgagaag gaaggaagac
      541 ttggggtcag cttgcctggc tacagggcaa ggatcgtggg catcatgggg gtttgcgtga
      601 gcggggctcc agggtgagac ctagcccccg cccccaggaa ttcaaggggg tgggggtggg
      661 gccaaggata gaatggctcg gggtgggttg ggggcagaag aggcctccct acgctcaaac
      721 gcattgtcct ggctggcctg cgggctgctg gccctgctgg ccaacgcctg gatcatcctc
      781 agcatctcgg ccaaacagca gaagcacaag ccactggagc tgctgctctg cttcctggcg
      841 ggcacacata tactcatggc cgctgtgccc cttaccacct tcgctgtggt acagctccgg
      901 cgccaggcct cctctgacta tgactggaac gagagcatct gcaaggtctt tgtgtccacc
      961 tactacacgc tggccctggc cacctgcttc acggtcgcct cgctctccta ccaccgcatg
     1021 tggatggtgc gctggcccgt taactaccgc ctcagcaacg ccaagaagca ggcactgcac
     1081 gccgtcatgg gcatctggat ggtcagcttt atcctgtcca cgctgccctc catcggctgg
     1141 cacaacaacg gggagcgcta ctacgcccga ggctgccagt tcatagtctc caagattggc
     1201 ctgggctttg gtgtctgctt cagcctcttg ctccttgggg gcattgtcat ggggttggtc
     1261 tgtgtggcca tcacgttcta tcagacactg tgggcccggc cccggagggc tcggcaagcc
     1321 cggagagcgg ggggcagcgt gggagccaag gcaggtgggc tggggggctt gggtacccgg
     1381 ccagcttttg aggtgccagc catcgtggtg gaggacaccc gagggaagcg gcggtcctcg
     1441 ctggatggct ctgaatctgc caagacatcc ttgcaggtca ccaacttggt cagcgccatc
     1501 gtctttctct atgactcgct cacgggggtg cccatcttgg tggtgagctt cttctccttg
     1561 aagtcagact cagccccgcc atggatggtc ctggctgtgc tgtggtgctc catggcacag
     1621 acgttgctcc tgccctcctt catctggtcc tgtgagcgct accgtgcaga tgtgcgcaca
     1681 gtgtgggagc agtgtgtggc catcatgtcc gaggatgacg gtgatgacga tggcgcctgt
     1741 gatgactaca cagacggccg cgtgtgcaaa attcgctttg atgctaatgg agccacaggg
     1801 tcagggagtc gggaccccac ccaggtgaaa ctgctgccgg gtcggcacat gctcttccca
     1861 ccccttgaga gagtacacta tttacaggtt cctttgtccc gccggttatc ccatgatgag
     1921 accaacgtct tttctactcc tcgggcacca ggctccttcc tgcacaagtg gtcatcgtct
     1981 gatgatatcc ggatcctccc agcccagagc agagcccttg gaggtcctcc agaatacccg
     2041 ggacagagac tcaggataga ggatgaggag gacgaggaag aggctgaagg tgggggctta
     2101 gccagccttc gacagtttct agaaagtggg gttctggggt caggtggggg acccccacga
     2161 ggtcctggtt ttttccggga ggagatcacc accttcatcg atgagacacc tctgccttct
     2221 ccaactgcat caccaggacc ctctcctcgt aggcctaggc cgctgggctt ttcacctcga
     2281 cgactctccc ttgggtctcc tgagagccga gctgttggac ttcctttggg gttaagtgca
     2341 ggaagacgct gttcccttac agggagtgaa gggagttcaa gggcttgggg aagaccctgg
     2401 gggccaggca accccatctt cccccagttg accctgtaag gccatgggtg agtgagtttg
     2461 cctcattctg gccctgagtc tatggcagct gcctccaggg agatgggggg ctacatctgg
     2521 gctctagagc cccagctctc tcccatccaa gtgaccagat acccaactca cccgtcttca
     2581 cccttagcaa aatgtattaa aaggctgaag tgttgccgtg gaaaccttgg tgttcagcga
     2641 ctgcggtggc aaatgggtca gtggcttggg cgagggagaa tggctcacag aggacaaaat
     2701 ggagaaaggg caggaggaag agatacagaa agagacagcc caacatgcag gcaggagaaa
     2761 tgggcttagg agagactgat cctgaggtgg agcatggggc acttgagtgt gttagtttga
     2821 agtgggaagg atccttgttc aaattagtaa aggcgctcaa tcctcatctc ccc
//
