LOCUS       NM_001170326            7200 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 158 (Gpr158), mRNA.
ACCESSION   NM_001170326 XM_225625
VERSION     NM_001170326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7200)
  AUTHORS   Patricia da Silva,E., da Silva Feltran,G., Alexandre Alcantara Dos
            Santos,S., Cardoso de Oliveira,R., Assis,R.I.F., Antonio Justulin
            Junior,L., Carleto Andia,D., Zambuzzi,W.F., Latini,A. and Foganholi
            da Silva,R.A.
  TITLE     Hyperglycemic microenvironment compromises the homeostasis of
            communication between the bone-brain axis by the epigenetic
            repression of the osteocalcin receptor, Gpr158 in the hippocampus
  JOURNAL   Brain Res 1803, 148234 (2023)
   PUBMED   36634900
  REMARK    GeneRIF: Hyperglycemic microenvironment compromises the homeostasis
            of communication between the bone-brain axis by the epigenetic
            repression of the osteocalcin receptor, Gpr158 in the hippocampus.
REFERENCE   2  (bases 1 to 7200)
  AUTHORS   Orlandi,C., Posokhova,E., Masuho,I., Ray,T.A., Hasan,N., Gregg,R.G.
            and Martemyanov,K.A.
  TITLE     GPR158/179 regulate G protein signaling by controlling localization
            and activity of the RGS7 complexes
  JOURNAL   J Cell Biol 197 (6), 711-719 (2012)
   PUBMED   22689652
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 18, 2009 this sequence version replaced XM_225625.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.70070.1,
                                           SRR26360176.1643394.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1605              JAXUCZ010000017.1  88742823-88744427
            1606-1711           JAXUCZ010000017.1  88776680-88776785
            1712-1814           JAXUCZ010000017.1  88948359-88948461
            1815-2038           JAXUCZ010000017.1  88964497-88964720
            2039-2107           JAXUCZ010000017.1  89003970-89004038
            2108-2217           JAXUCZ010000017.1  89093747-89093856
            2218-2456           JAXUCZ010000017.1  89123591-89123829
            2457-2595           JAXUCZ010000017.1  89138334-89138472
            2596-2701           JAXUCZ010000017.1  89143324-89143429
            2702-2848           JAXUCZ010000017.1  89147191-89147337
            2849-7200           JAXUCZ010000017.1  89148307-89152658
FEATURES             Location/Qualifiers
     source          1..7200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..7200
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /note="G protein-coupled receptor 158"
                     /db_xref="GeneID:291352"
                     /db_xref="RGD:1305841"
     exon            1..1605
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     CDS             704..4324
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /note="probable G-protein coupled receptor 158;
                     metabotropic glycine receptor"
                     /codon_start=1
                     /product="metabotropic glycine receptor precursor"
                     /protein_id="NP_001163797.1"
                     /db_xref="GeneID:291352"
                     /db_xref="RGD:1305841"
                     /translation="MGAMAYSLLLCLLLAHLGLGEVGASLDPSERPDSSRERTSRGKQ
                     HGQQLPRASAPDPSIPWSRSTDGTILAQKLAEEVPMDVASYLYTGDFHQLKRANCSGR
                     YELAGLPGKSPSLASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQAL
                     VRSLLEGEPSISRAAITFSTESLSTPAPQVFLQATREESRILLQDLSSSAHHLANATL
                     ETEWFHGLRRKWRPHLHRRGSNQGPRGLGHSWRRRDGLGGDRSHVKWSPPFLECENGS
                     YKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNN
                     SECMPIKGLGFVLGAYQCVCKAGFYHPRVFSVNNFQRRGPDHHFSGSTKDVSEEAHVC
                     LPCREGCPFCADDRPCFVQEDKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRAS
                     GLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWVRLLGFATVYGTVTLKLHRVLK
                     VFLSRTAQRIPYMTGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSD
                     NLTFNMCLIDRWDYMTAVAEFLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELIIT
                     AIFHTIRFVLASRLQPDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEA
                     YEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHL
                     QKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGTDHSAAKGTGLVRKNPTESSGN
                     TGRPKEESLKNRVFSLKKSHSTYDHVRDQTDESSSLPTESQEEEVTENSTLESLSSKK
                     LTQKVKEDSEAESTESVPLVCKSASAHNLSSEKKPGHPRTSMLQKSLSVIASAKEKTL
                     GLAGKTQTLVMEDRAKSQKPQPKDRETNRKYSNSDNTETKDSGCPNSNHTEELRKPQK
                     SGIMKQQRVNLPTANPDASSSTTQIKDNFDIGEVCPWEVYDLTPGPVPSEPKAQKHVS
                     IAASEVEQNPASFSKEKSHHKPKAAEGLYQANHKSIDKTEVCPWESHGQSPLEDENRL
                     ISKTPVLPGRAREENGSQLYTTNMCAGQYEELPPKAVASKVENENLNQMGDQEKQTSS
                     SVDIIPGSCISSNNSPQPLTSRAEVCPWEFEPLEQPNAERIVALPASSALSASKIPGP
                     RK"
     exon            1606..1711
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1814
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2038
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2107
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2217
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2456
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2595
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2701
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2848
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..7200
                     /gene="Gpr158"
                     /gene_synonym="mGlyR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccctag aagggtttgg ttgcggccaa gctgtctctt taaactggtt tcatctgaga
       61 gcagggagag gcagcggtgc ggtttgtggt aagggctcca gttaaccagc tgcctggcag
      121 tctggactcc agagacacaa acgtcttcaa agaaaacctg ggttccttgg gactcgccgc
      181 tgagctcgcg gcgtggatct gtgtgcgcgc tttcatctcg gggcgaaagg gtcgaggagg
      241 ggccacagcc aggaggcggg aacgacctgc caagggtgag atgatggagc agcgtcttca
      301 gtggccgcgg tggcagcatc agcagcatca gcagcatcag caccagctct tgaacacacc
      361 tcaatgagag cggcggtgga agcggctgag cagaaagacg taagccggct aactatagct
      421 gccggggatg taacctgttt ggctcaaggc tgcgaggtgc gtaatcccga gccgacccat
      481 tgtggagcgg gacacagcca gcattgccac aggtgatttg ggtctgtgac ggcagctgaa
      541 ccagctgggc caatttcaaa acattcttat tttaaagtcc atctggactg ggctccacct
      601 ggagaaggaa gcctctcccc caaaagtctt actggtgata aattaaggac cgaaatttac
      661 aaagtgactc ctccggttat ctcctctctt ctgtgctaga cagatgggag ccatggctta
      721 ctctttactc ctctgcctcc tgctcgctca tctgggattg ggagaggttg gtgccagcct
      781 cgacccttca gaacggccag attcttctcg agagaggact tcgaggggga agcagcacgg
      841 tcagcagctg ccgcgagcct ctgccccgga cccctctatt ccctggagcc gctccacaga
      901 cggcaccatc ttggcacaaa aactagccga ggaggtgccc atggacgtgg cctcttacct
      961 ctatactggg gacttccacc agctgaagag agccaactgc tcaggccgct atgagttggc
     1021 gggcctgccg gggaagtcac cgtccctagc cagctcccat ccttccttgc acggggcgct
     1081 ggacactctg acacacgcca ccaacttcct caacatgatg ttgcagagca ataagtctcg
     1141 ggagcagacc gtgcaggatg acctgcagtg gtaccaggct ttggtgcgaa gtctcctgga
     1201 gggagagccc agcatctccc gggcggccat caccttcagc accgagtcgc tgtccacgcc
     1261 cgccccgcaa gtcttcctcc aggccacccg tgaggagagt cgcatcctgc tgcaggacct
     1321 gtcctcctcc gctcaccacc tggctaacgc cactctggag accgagtggt tccacgggct
     1381 tcggcgaaag tggaggcccc acttgcaccg ccgcggctcc aatcaggggc cacggggcct
     1441 gggccacagc tggcggcgca gggatgggct tggcggggac aggagccatg tcaagtggtc
     1501 tccacctttt ctggagtgcg agaatgggag ttacaagccc gggtggctgg tcactctctc
     1561 tgctgccttc tacgggcttc aacctaacct ggtcccggaa ttcaggggcg tgatgaaagt
     1621 tgatataaat cttcagaaag tggacattga ccaatgttcg agtgatggct ggttttcagg
     1681 aacccacaaa tgtcacctta acaactcaga gtgtatgcca atcaaaggcc taggattcgt
     1741 gctcggagcc tatcagtgcg tttgcaaagc aggattctat catccccgtg tcttctcagt
     1801 gaacaacttt cagagaagag gtccagatca ccatttttca ggaagcacaa aggatgtgtc
     1861 agaagaagcc cacgtctgcc tgccctgccg agaaggctgc cccttctgtg ctgatgaccg
     1921 cccatgtttt gtccaggagg ataagtacct gcgtctcgcc atcatctcct tccaagccct
     1981 gtgtatgctg ctggactttg tcagcatgct ggtggtctac cacttccgca aagcaaagag
     2041 catcagggca tctggcctca tcttgttgga aacaatactc tttggctctc tgcttcttta
     2101 ctttccggtt gttattctgt actttgagcc aagtacattt cgttgtattc tcctgaggtg
     2161 ggttcgtctt ctcggttttg cgacagttta tggaactgtg accctcaagc ttcacagggt
     2221 tttgaaggta ttcctttcaa gaacagcaca aagaatccca tatatgactg gcggtcgggt
     2281 catgaggatg ctggcagtaa tagtcttggt agtgttttgg tttctggttg gctggacttc
     2341 ttctatgtgc cagaacttgg agcgggatat cttgcttgtt ggccaagggc aaacatctga
     2401 taacctcacc ttcaatatgt gcctcattga ccgctgggat tacatgacag cagttgctga
     2461 atttttattc ctcctgtggg gcatttatct ctgctatgca gtgcggactg tgccgtcagc
     2521 attccatgag ccacgctaca tggctgtcgc agtgcacaac gagctcatca tcactgctat
     2581 attccacaca atcagattcg tgcttgcttc gaggcttcag cctgactgga tgctgatgct
     2641 gtactttgca cacactcact tgactgtgac agtcaccatc gggctgcttc tgattccaaa
     2701 gttttcacac tcaagcaata atccccgtga tgacatcgcc acagaagcgt atgaagatga
     2761 gttggacatg ggtcgttctg gatcctacct gaacagcagc atcaattcag cctggagcga
     2821 gcacagtcta gatccagaag acattcggga tgagctgaag aaactctatg cccagttaga
     2881 gatatacaaa cgtaagaaga tgatcacaaa caacccccac ctccagaaaa agcggtgctc
     2941 caagaagggc ttaggccggt ccatcatgag gcgtatcact gagatcccag agacggtcag
     3001 caggcagtgc tccaaagagg acaaggaggg cacagatcac agtgcagcca aagggacagg
     3061 ccttgtccgg aagaacccta ctgagtcctc agggaacaca gggagaccca aggaggagtc
     3121 cctgaaaaac cgggtctttt ctctcaagaa atcccatagc acatatgacc atgtaagaga
     3181 ccaaactgat gaatccagca gcctgcccac agagagccag gaggaggagg tcacggaaaa
     3241 ttcaaccttg gagtcgctgt caagtaaaaa actgacacaa aaagtcaaag aagatagcga
     3301 ggccgagtcc acagagtcag tgcccttggt ctgcaagtca gccagtgctc acaacctcag
     3361 ctctgaaaag aagcccgggc acccacgcac atctatgtta cagaagtcgc tcagtgtcat
     3421 tgcaagtgcc aaggagaaga cactagggct ggctggtaaa acccagactt tagttatgga
     3481 agaccgagct aagtcccaga aacctcagcc aaaagataga gagacaaaca ggaagtactc
     3541 aaattccgat aacacagaga ctaaagattc tggctgccca aactctaatc acacagagga
     3601 gctaagaaag ccccagaaat ctgggattat gaaacagcag agggtcaacc tccccactgc
     3661 caatcctgac gcgagctcca gcaccaccca gataaaggac aattttgata ttggagaagt
     3721 gtgcccttgg gaggtttatg acctgacccc cggtcctgtg ccttcagaac caaaagctca
     3781 aaaacacgta tcaattgcag cttcggaagt ggaacaaaac ccagcttctt tttcgaagga
     3841 gaagtcccac cacaagccta aggcagctga aggtctctac caagccaatc acaagagcat
     3901 agacaagaca gaggtgtgcc cctgggagag ccacggtcag tcccctttgg aagatgagaa
     3961 tcgtctgatt tctaagactc cagttctccc agggagagcc agagaagaga atggaagtca
     4021 gttgtacaca accaatatgt gtgctgggca atatgaagaa ctgcccccca aagccgtagc
     4081 atcaaaagta gagaatgaaa atctcaacca aatgggagac caggagaaac agacatcttc
     4141 ttctgtggat atcatccctg gctcctgtat ctcgagtaat aactcccctc aacccttaac
     4201 gtcacgagcc gaagtgtgtc cctgggagtt cgagccccta gaacaaccaa atgctgaaag
     4261 aatcgtagct ttacccgcct cctctgcttt aagtgcaagt aagatacccg ggccacggaa
     4321 ataggaagtc caggacactt tcaaaatgta ccaccctggg aagaaaaggg gtaatcccga
     4381 gtttgataaa aatagatctg aaaatcaaac gttaccaagg aatctttgtt agcctaggga
     4441 aacatggcac atggtgcggt aaggtgaagg caagggctgg agaaggccag aaaaaggcag
     4501 taatgtgtgc ctccagccat gaaaaaccag atcaacactg ggggacagct tagcatttca
     4561 gcctgttaaa gggacatttc cctgtctgtc tttacaagtg ggattgaatg gccccaagca
     4621 agattcacca ggaggcatgg aagacagggg catggatttt atgatggata aacttagatg
     4681 cacgtgactg taattctaag tagtcgactg aaaagacctt catcacctat ttaaccttgg
     4741 tagcactgct aacttaatgc accccagtac cttttatata cacgattgct ctcattttct
     4801 taaaatctgt gtgtgtcagt aaattgttgt gtctcctatt caagcattcc agattgtata
     4861 atttttgcaa ataactttga tattatgtga cacaacacat ttatgcaatc tgcagctact
     4921 caattgtcat tgcaacctac caaatacctg ctgtcatcta ccaagtgcgg ttgattcttg
     4981 gagtacagta agctttctct ggcttaggaa gccataactg ttatgatgaa aacttttagt
     5041 ttgggccatg gtttatatag tgaagttggg tttgactcct ttgtttccca tcatggcttg
     5101 ttgtgtgatg tcttaatttt ttttttgaaa cataagttga gttgcttgtt ctacacttct
     5161 tgtagggact ccaaagcttt actaatcttg gagatgaagt ggtcctactt agtcatatgt
     5221 ctcagtaagt taaggacaac ttactcattg tttgttccaa gtcagagcta gatttcccca
     5281 atgcatcgcc cttcttaact ctttcagtat ttcacattag catttcctaa ggaagaagct
     5341 gaatgagaaa actgtgctgt ccattgttac caacagaaga ggccagctct aggaacgccc
     5401 tgaggataag agtatactgc aggtccagga attgcctttc atgacaaata cagaaaggta
     5461 gctcctaata gcactttcaa gggattattt ttataaagag aaaaaataat gatagcatca
     5521 agatcattga atggatatat ttttattatg catactgaag ataatgatat tttaaattac
     5581 cttaaactat ttattctcat aaacttttat tcattgcttc atctgggtac agaacttgct
     5641 gggctcaaat cccaaagaga ttttataacc tgatttactc aaagcccata ggtatgagtt
     5701 ctttatgctc cccagtacca gaactcacaa gcccttcaaa ctgtccttgc aagccacctc
     5761 gctaaaatgt aaagcctaag attggtctgc agatatcaaa gcatatctta gagaacttgc
     5821 tgcattctat gctgatcact agaatgagga ccctgagctg ctgacttagc tctgaggatt
     5881 gtgatcttga aatgagtctc taaaatccag gcacaattta tctaaggatg aatcacttaa
     5941 aactacatcc caggcttgat ttttctccca tcataaacac tgaacaacca cttatgtgac
     6001 caagacattt ccatccgaag gaacagtttt acctttgctg aaccccaagg agaatttgct
     6061 aggaggatgc aggaggggag gaggagtcag gaggtagaca caaggctgtg cctgtgcttt
     6121 gagtctatca tcaaactttt ctcagtgttt acttttgtac tcagcaggaa gcaagcactt
     6181 gaggaattgg cagagttggg catcaattgc ccttgcccat ttgcttgctt catccattac
     6241 tcaggttggt ggggtaggtt tgaaaagcta cagaggtttt cttgttacct gctgccttca
     6301 ttaacccatc atccccacct ttccaatcaa agcctatcta ctctgtgact tttagacttc
     6361 tcttctgagg agcatttgtg aacttggctt agagtttgta gactcatgta cttgttccac
     6421 ttgtgtctga ggtctgttag cactagattt gcttctgaga attaagcagg taactgtcac
     6481 tgactttcat tgcactttag gatgaccctg cttgacctgt ggctcacaga agatttgcca
     6541 aattataccg tagtgacagg ctgcccaccc ccaatagatt attctccacc atcacaaatc
     6601 agcacaaatg cctagggtct ttcctagagc ttcattttca tgactcgtca ccaaaagaaa
     6661 ttggactctg tcattctgga agctcttttc ccaggctgag aacaatagaa agtacgtaca
     6721 gtgtgaaggt ctcacaaaca tttactaggt tgtcctttca atgcatgtgc aggctgcacc
     6781 ctgtcattgt tttactccag tgtttataaa taagtagatt tatatctgtc ttaatacaag
     6841 tgtatatttt atgcaagaat taaatgcttt acaacataaa ttattactcc acctctcgta
     6901 agcttcggtg gcaatacgga ttgaaccccg acagttgtct tgtatttgct tcctaggttt
     6961 ctgcatgcaa gtggtgatag gtaggactga cgatacactg cctttgactt ctagcactta
     7021 gcagccgaga gttgtagagt caacaaagct ataagtctct tcacttaacc tgtggttctt
     7081 ctaaaactat tatccgaatc tacagcatcc caccatggaa tatttggtaa tttatgttgt
     7141 gatgtgttgc agcatgtaaa taactataac ttctctgcaa taaacattta tatgaaaatg
//
