LOCUS       NM_138891               3845 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 149 (Gpr149), mRNA.
ACCESSION   NM_138891
VERSION     NM_138891.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3845)
  AUTHORS   Edson,M.A., Lin,Y.N. and Matzuk,M.M.
  TITLE     Deletion of the novel oocyte-enriched gene, Gpr149, leads to
            increased fertility in mice
  JOURNAL   Endocrinology 151 (1), 358-368 (2010)
   PUBMED   19887567
REFERENCE   2  (bases 1 to 3845)
  AUTHORS   De Smet,C., Nishimori,H., Furnari,F.B., Bogler,O., Huang,H.J. and
            Cavenee,W.K.
  TITLE     A novel seven transmembrane receptor induced during the early steps
            of astrocyte differentiation identified by differential expression
  JOURNAL   J Neurochem 81 (3), 575-588 (2002)
   PUBMED   12065666
  REMARK    GeneRIF: induced during early steps of astrocyte differentiation,
            Ieda transcripts were found exclusively in brain and testis. In
            developing rat brain, Ieda expression was first detected at
            embryonic day 16, two days before first appearance of mature
            astrocytes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY030276.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_138891.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY030276.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..3845
                     /gene="Gpr149"
                     /gene_synonym="Ieda"
                     /note="G protein-coupled receptor 149"
                     /db_xref="GeneID:192251"
                     /db_xref="RGD:619890"
     exon            1..1511
                     /gene="Gpr149"
                     /gene_synonym="Ieda"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..2729
                     /gene="Gpr149"
                     /gene_synonym="Ieda"
                     /note="induced early in differentiating astrocytes gene
                     protein; orphan seven transmembrane receptor"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 149"
                     /protein_id="NP_620246.1"
                     /db_xref="GeneID:192251"
                     /db_xref="RGD:619890"
                     /translation="MSFFLSNLTNDSRLWKVSHNSTDLMNSPETLTLSLFCLICLMTL
                     VALVGSIFSLVSLLTMQYRTVVSMLVTSWSVDDLLSVLSVAIFMVLQWPREAPGYFQS
                     LCTTSALLYMCQGLSSNLKATLIVFYNFYTMHRTVVSQSSSWRSGQVLGVALTVWAVS
                     LLLASLPLCGWGVFVRTPWGCLTDCSSPYVLLLFAVYASAFGLLAVLSVPLTHQLLCS
                     EEPPRLHANYQEISRGASTPGTPAAGGRVLCLLPEDVEIPALPGTGSSLSSDMVFAPG
                     QPAASSAGAGKRENLWTPRGSSSFPVSLAQKRFALILALTKVILWLPMMIHMVVKHVV
                     GFQSLPVDMLSFLLTLLASTVTPVFVLSKRWAHLPCGCIINCQPDTYSVAFDGKKSKR
                     KGFEFNLSFQQSYGLYKMTHADYYDDDDENPISYHNPKKYECEATKEPREDNHGVFNT
                     ITVEISTTPPLDSATLTGVNKCTNTDIPEPKQAVSEEKGAFSIKTECAINYGEATSFE
                     GPERRLSHEETQKPDLSDWEWCRSKSERTPRQRSGGGLAIPICAFQGTVSLQAPTGKT
                     LSLSTYEVSAEGQKITPPSKKIEVYRSKSVGHEPNSEESPSTFADTNVKIHLEVLEIC
                     DNDEALDTVSIISNISQSSTKVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSDPDG
                     DINISIPDTVEAHRQNSRRQHQDRDGYQEEIQLLNKAYRKREAESKGN"
     exon            1512..1704
                     /gene="Gpr149"
                     /gene_synonym="Ieda"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..2156
                     /gene="Gpr149"
                     /gene_synonym="Ieda"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..3823
                     /gene="Gpr149"
                     /gene_synonym="Ieda"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcctgtg ctcaggctcc ctatgactct gattctcata ttctctctct ctctctctct
       61 ctctctctct ctctctctct ctctctctct ctctctctct ctctcagctg agacctacct
      121 gacaacctct gcctttgaat ccagctctga gcacagatgc atctttttat ttattgtctc
      181 ccaagtgatt gcatcgacct ggagatcctt cctgggaaag acccacaaca tccacacatg
      241 agcactttgc aatctacctg aggagttcct gctttcctgt ctgaaatttg atggtggaaa
      301 gaagtttttc tttgatttat ttacttaaaa tattgaaaag tttcttactg atgcctgaaa
      361 tgaggcacat ctttaaaaca tgggttgatc agatctttct aacggagact cgtctggacc
      421 aacacatgga acatctagaa aaacttggca ggagaaatga catctgcttt gcaactctca
      481 cgctctgagg aaatcatcag actcgtttga agagggaaat taaaatatta aggaaaatgt
      541 cgttcttcct cagcaactta acaaatgact ctagactgtg gaaagtaagt cataattcta
      601 cggaccttat gaattcgcca gaaactctga ctctttctct cttttgcctg atctgtttaa
      661 tgactctcgt agctctggta ggcagcattt tctcactggt ttctctgctc accatgcagt
      721 acagaactgt tgtgtctatg cttgtgacct cttggtctgt ggatgatctc ttgagcgtct
      781 tgtcagtggc catcttcatg gttttgcagt ggccaagaga ggcaccgggc tacttccagt
      841 ctctgtgtac cacctctgcc ttactgtata tgtgccaggg cctctccagc aacttgaagg
      901 cgactcttat agtcttctac aacttttata cgatgcacag gacagtggtg agtcagtcaa
      961 gctcctggcg atcaggacag gtactcggtg tggctttaac cgtgtgggca gtcagcctgc
     1021 tgctggcctc gctcccgctg tgcggctggg gtgtcttcgt gcgcacgcct tggggctgcc
     1081 tgaccgactg ctccagccca tacgtgctgc tcctcttcgc ggtgtacgct tccgctttcg
     1141 ggctcctggc ggttctttct gtccctctca ctcaccagct gctgtgttca gaggagccgc
     1201 caagactcca tgccaactac caggaaattt ctcgtggcgc ctctactcct gggacccctg
     1261 ctgctggggg aagagtgctc tgtctgttgc cagaggatgt tgaaatccct gctctgccag
     1321 gcactgggag ctccctgagc tccgacatgg tgtttgcacc gggtcagcct gctgcctcta
     1381 gcgctggagc cggcaagcga gagaatctct ggactccccg tggctcgagc agcttccccg
     1441 tgagcctggc acagaagcgc tttgctttga tcctagcgct gactaaagtc atcctctggc
     1501 tgcctatgat gatccacatg gtggtaaaac acgtggtggg gtttcagagc cttccggtcg
     1561 atatgctcag ctttctacta accctgctgg ccagcactgt aacaccagtg tttgtcttgt
     1621 ctaaacgatg ggcccacttg ccttgtggct gcatcatcaa ctgccagcct gacacctact
     1681 ccgttgcatt cgatgggaaa aagtcaaaga ggaaaggctt tgaattcaat ttatcgttcc
     1741 aacaaagtta tggactctat aagatgacac atgcagatta ctatgacgat gatgatgaaa
     1801 atcccatatc ctaccacaac ccaaagaaat atgagtgtga agctacaaag gagcctcggg
     1861 aagacaacca cggtgtgttc aataccatca cagtagaaat cagcaccacg ccaccgctgg
     1921 acagcgccac actgaccggt gtcaacaagt gcaccaacac ggatatccct gagcccaaac
     1981 aggccgtgag cgaagaaaag ggtgcctttt ctattaaaac agaatgtgct attaactatg
     2041 gagaagccac ctcgtttgaa ggtccagaga gacgactgtc ccatgaggag actcagaaac
     2101 cagatctttc agactgggag tggtgcagga gtaagtcaga acgaacacct cgccagcgtt
     2161 ctggtggtgg gctggctatt cccatttgtg cgttccaagg gactgtgtct ctccaagcac
     2221 caactgggaa aaccctctct ctttctactt atgaggtcag tgcagaaggg caaaagataa
     2281 ccccgccctc taagaaaata gaagtctatc gatctaaaag tgttggccat gaaccgaact
     2341 cagaagagtc tccctccacg tttgcagaca ccaacgtaaa aatacacttg gaagttcttg
     2401 aaatttgtga caacgatgag gctttagaca ctgtgtcaat catcagcaac atcagccagt
     2461 cctctacaaa agttcggtct ccttctctgc gctactcacg gaaggaaaac aggtttgtct
     2521 catgcgactt aggagaaact gcctcctact ccctcttctt acccacaagt gatcctgacg
     2581 gagatatcaa catctctatc ccagacacag tggaggcaca cagacagaac agcaggcggc
     2641 agcatcaaga cagggatggc taccaggaag agatccagtt gttaaacaaa gcctacagga
     2701 aaagagaagc agaaagcaag ggtaactagg aagtaccgag tctatagagg tcagaatggc
     2761 tctgcaatct tagactgtaa aacttaccat agtcccgaga ctaatttccc acttccttct
     2821 aaccacatgt tcgcataacc tttcctggtt tcctagtttg tattttttgg atgacctgcc
     2881 atagtgcatt tcacatgtta ctcaaagatc atacactgtg gtaactgaac acttttgtgt
     2941 ctgatttcta aaaatctttc taaaccaaat cttgacttag tttgatattt tgcctgtttg
     3001 tctaataaat ccactattct cgtgcatgca tttttgtacc catgctgctt ttttactgca
     3061 aaagagaaaa gagatgttcg ggcaatagaa aaaaattaca cccaaactct gagttgtatt
     3121 tggatatgga tttatatcta gccaaaggac cttattctag tttctgcttt agctgttcag
     3181 tggtctagga ggtatattct tttgtaaaaa ggcaaattag cctctaagtg gaactttgga
     3241 aatatgtgta ttcctagtct atcgtaattt catttgttgt tacaaaatac aagtagttta
     3301 gtaagtgctt ctgcttgtct ttcttcgact ggagattggg agaaattctg tcacattaag
     3361 ttctgggagc tagggcaaca atcttctggc taaaacagag gaagacaccg aagtctaaca
     3421 aaaagctccc gtgttaaaga ttgagaagac tcgctttgcc attcttgatg catagaaatt
     3481 tttacttcaa atatcgttct tgattaagta ctttcagttt ttttctttta aaaatgtatt
     3541 atagcaaaca ataaaacaag tctatacata tatcattgaa tgatggcaag gagtccatga
     3601 ccagattaat ttctccaaac accttatcgg cacactgcta atgtatattt taaaattctg
     3661 atcctttaaa atcgctttat tctaatgttt ctataaacat actatatatg ttacctatat
     3721 atgttattta caaaagtcat tgtcgttgta tgtgctctga gattgtgtat acctgcagtt
     3781 caggcccata tgatgtttac agattaaatg aattatattt aaaaaaaaaa aaaaaaaaaa
     3841 aaaaa
//
