LOCUS       NM_001109062            1815 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 146 (Gpr146), mRNA.
ACCESSION   NM_001109062 XM_001065344 XM_573364
VERSION     NM_001109062.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Jiang,Y., Huang,J., Xia,Y., Sun,Z., Hu,P., Wang,D., Liu,Y., Tao,T.
            and Liu,Y.
  TITLE     Hypoxia activates GPR146 which participates in pulmonary vascular
            remodeling by promoting pyroptosis of pulmonary artery endothelial
            cells
  JOURNAL   Eur J Pharmacol 941, 175502 (2023)
   PUBMED   36638952
  REMARK    GeneRIF: Hypoxia activates GPR146 which participates in pulmonary
            vascular remodeling by promoting pyroptosis of pulmonary artery
            endothelial cells.
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Martin,J.H., Aitken,R.J., Bromfield,E.G., Cafe,S.L.,
            Sutherland,J.M., Frost,E.R., Nixon,B. and Lord,T.
  TITLE     Investigation into the presence and functional significance of
            proinsulin C-peptide in the female germlinedagger
  JOURNAL   Biol Reprod 100 (5), 1275-1289 (2019)
   PUBMED   30715203
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Yosten,G.L., Kolar,G.R., Redlinger,L.J. and Samson,W.K.
  TITLE     Evidence for an interaction between proinsulin C-peptide and GPR146
  JOURNAL   J Endocrinol 218 (2), B1-B8 (2013)
   PUBMED   23759446
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474012.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_573364.2, XM_001065344.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: EX488971.1, BF523104.1 [ECO:0000331]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1815
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /note="G protein-coupled receptor 146"
                     /db_xref="GeneID:498153"
                     /db_xref="RGD:1560731"
     exon            1..101
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /inference="alignment:Splign:2.1.0"
     exon            102..1815
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1126
                     /gene="Gpr146"
                     /gene_synonym="RGD1560731"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 146"
                     /protein_id="NP_001102532.1"
                     /db_xref="GeneID:498153"
                     /db_xref="RGD:1560731"
                     /translation="MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLFYLGAGVPVGLGYN
                     ALLVLANLASKNSMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHV
                     TLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFS
                     SLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTP
                     LDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLVSRGRTVEGHYLGILQVAK
                     DLAKFLAFSSSSVTPLLYRYINKAFPSKLRRLVKKIHCGRRHCSPDPAGIQQVMAQA"
ORIGIN      
        1 gtgtacacag cccccgcggc gtgcgcgccg tgagctccgt tgcctcctgc aagcccagct
       61 gcccgcccgc ggccggtgag cgggccgccg cccagcgagc gctgcgaagc tggggtgagc
      121 tgccatgtgg agctgtggcc cactcaacag cacagcgtgg gctgaggagc cgctgtgccg
      181 gaacctgcgc ctggggctgt gggtcctctc actgttctac ctgggggcag gtgtccctgt
      241 gggcttaggc tacaatgctc ttttggtgct ggccaatctg gccagcaaga acagcatgac
      301 catgcctgat gtgtacttcg tgaacatggc tgtggcgggg ctggtgctca cagcactggc
      361 acctgcgtac ctgctgggtc ctgcccactc caggtgggcc ctgtggagcc tcagcagcga
      421 ggcccatgtg acactgctca tcctgttcaa cgtggcttcc ctggtgacca tgtactccac
      481 tgcactgctg agtcttgact actacatcga gcgtgccctg ccgcgtacct acatggctag
      541 tgtgtacaac acccggcacg tgtgtggctt cgtctgggga ggggcagtgc tcaccagctt
      601 ttcctccctg ctcttctata tctgcagtca tgtgtcttct agaattgccg agtgtgcccg
      661 gatgcagaac acggaggcag ccgacgccat ccttgtgctc attggctacg tggtgccagg
      721 tctggctgtg ttgtatgccc tggcactcat ctcaaggatt gggaaggaag acacacccct
      781 ggaccaggac accagcaggc tggacccctc agtgcacagg ctgctggtgg ccactgtgtg
      841 cacacagttt ggcctctgga caccttacta cctgagcctg gggcacacag tgctagtgtc
      901 acggggaagg accgtggagg ggcattatct gggcatccta caggttgcta aggacctggc
      961 aaagttcttg gccttctcaa gcagttctgt gacgccgctg ctctaccgtt acatcaacaa
     1021 agccttcccc agcaagctcc ggcgcctggt gaaaaagata cactgtgggc gccgccactg
     1081 ctcccccgac cctgcgggga tacagcaggt gatggcccag gcgtagctga ccctctctgg
     1141 gccgacgtcc aaggagaggg cctgaccatg aggaacacta aaactcaact ggacgcatag
     1201 cactttgttc cccaagcaca tggtgcttcc aacccaaaag acacgccgaa gccagagtag
     1261 cacagcaggg catttctctt gacattttct gtgttttccc ctaaaagacc aatcttggtc
     1321 ttaagctgca ttgtggaaag cagaggtgcc ttctgtgaag aggctgcttc taactaaccc
     1381 tcaccatccc acccacggtg tgtgcctttc tcccaggggc atcttcaagg tccatgtcct
     1441 caaaagcagg ctgacctttg gtttccctga tatttggact ttctaaatga agcgatgaaa
     1501 tctaaagcca gtatttatac tccatattga tatgatactt gattctccta ttattttttt
     1561 aaatagaaag aagtgttaga aaaataccta gtattaagaa gaaggcagtt caggggaaca
     1621 cggctgtcgc aaataccagt gttacagctt gaggacagga cagtgtgtca aacctgtggc
     1681 agctccacag ccactgctga cagtgacagc tatggtgcac tggccctgtc cccacccaca
     1741 catctggcac ctctcctcta ctgcgtgagg atcttagtat aggtctgtct tcccaatgct
     1801 tccacatatg cacat
//
