LOCUS       NM_001106958            1612 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus G protein-coupled receptor 143 (Gpr143), mRNA.
ACCESSION   NM_001106958 XM_001064908 XM_228848
VERSION     NM_001106958.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Nakano M, Koga M, Hashimoto T, Matsushita N, Masukawa D, Mizuno Y,
            Uchimura H, Niikura R, Miyazaki T, Nakamura F, Zou S, Shimizu T,
            Saito M, Tamura K, Goto T and Goshima Y.
  TITLE     Right ventricular overloading is attenuated in
            monocrotaline-induced pulmonary hypertension model rats with a
            disrupted Gpr143 gene, the gene that encodes the
            3,4-l-dihydroxyphenyalanine (l-DOPA) receptor
  JOURNAL   J Pharmacol Sci 148 (2), 214-220 (2022)
   PUBMED   35063136
  REMARK    GeneRIF: Right ventricular overloading is attenuated in
            monocrotaline-induced pulmonary hypertension model rats with a
            disrupted Gpr143 gene, the gene that encodes the
            3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Masukawa D, Nakamura F, Koga M, Kamiya M, Chen S, Yamashita N, Arai
            N and Goshima Y.
  TITLE     Localization of ocular albinism-1 gene product GPR143 in the rat
            central nervous system
  JOURNAL   Neurosci Res 88, 49-57 (2014)
   PUBMED   25108060
  REMARK    GeneRIF: the unique distribution pattern of gene OA1 product GPR143
            in the rat central nervous system central nervous system
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Hiroshima Y, Miyamoto H, Nakamura F, Masukawa D, Yamamoto T,
            Muraoka H, Kamiya M, Yamashita N, Suzuki T, Matsuzaki S, Endo I and
            Goshima Y.
  TITLE     The protein Ocular albinism 1 is the orphan GPCR GPR143 and
            mediates depressor and bradycardic responses to DOPA in the nucleus
            tractus solitarii
  JOURNAL   Br J Pharmacol 171 (2), 403-414 (2014)
   PUBMED   24117106
  REMARK    GeneRIF: gpr143 acted as a functional receptor for DOPA in the
            nucleus tractus solitarii
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Giordano F, Bonetti C, Surace EM, Marigo V and Raposo G.
  TITLE     The ocular albinism type 1 (OA1) G-protein-coupled receptor
            functions with MART-1 at early stages of melanogenesis to control
            melanosome identity and composition
  JOURNAL   Hum Mol Genet 18 (23), 4530-4545 (2009)
   PUBMED   19717472
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Palmisano I, Bagnato P, Palmigiano A, Innamorati G, Rotondo G,
            Altimare D, Venturi C, Sviderskaya EV, Piccirillo R, Coppola M,
            Marigo V, Incerti B, Ballabio A, Surace EM, Tacchetti C, Bennett DC
            and Schiaffino MV.
  TITLE     The ocular albinism type 1 protein, an intracellular G
            protein-coupled receptor, regulates melanosome transport in pigment
            cells
  JOURNAL   Hum Mol Genet 17 (22), 3487-3501 (2008)
   PUBMED   18697795
  REMARK    Erratum:[Hum Mol Genet. 2017 Aug 1;26(15):3028-3029. PMID:
            28854565]
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   Lopez VM, Decatur CL, Stamer WD, Lynch RM and McKay BS.
  TITLE     L-DOPA is an endogenous ligand for OA1
  JOURNAL   PLoS Biol 6 (9), e236 (2008)
   PUBMED   18828673
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Piccirillo R, Palmisano I, Innamorati G, Bagnato P, Altimare D and
            Schiaffino MV.
  TITLE     An unconventional dileucine-based motif and a novel cytosolic motif
            are required for the lysosomal and melanosomal targeting of OA1
  JOURNAL   J Cell Sci 119 (Pt 10), 2003-2014 (2006)
   PUBMED   16621890
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Innamorati G, Piccirillo R, Bagnato P, Palmisano I and Schiaffino
            MV.
  TITLE     The melanosomal/lysosomal protein OA1 has properties of a G
            protein-coupled receptor
  JOURNAL   Pigment Cell Res 19 (2), 125-135 (2006)
   PUBMED   16524428
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C,
            Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C and
            Ballabio A.
  TITLE     Ocular albinism: evidence for a defect in an intracellular signal
            transduction system
  JOURNAL   Nat Genet 23 (1), 108-112 (1999)
   PUBMED   10471510
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474014.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064908.1, XM_228848.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071,
                              SAMN16676789 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..1612
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /note="G protein-coupled receptor 143"
                     /db_xref="GeneID:302619"
                     /db_xref="RGD:1565799"
     exon            1..316
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1284
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /codon_start=1
                     /product="G-protein coupled receptor 143"
                     /protein_id="NP_001100428.1"
                     /db_xref="GeneID:302619"
                     /db_xref="RGD:1565799"
                     /translation="MASPRLGIFCCPSWDAATQLVLTFQPRVFHALCLGSGALRLVLG
                     LLQLLTGRRSVGHRAPATTPAASVHILRAATACDLLGCLGIVIRSTVWIAYPEFIENI
                     SNMNGTDIWPTAFCVGSAMWIQLLYSACFWWLFCYAVDVYLVIRRSAGRSTILLYHIM
                     AWGLPVLLCVEGAVMLYYPSVSRCERGLDHAIPHYVTTYLPLMLVLVANPILFHKTVI
                     SVASLLKGRKGVYTENERLMGAVIKTRFFKIMLVLIACWLSNIINECLLFYLEMQPDT
                     HGGSLKRIQNAARTTWFIMGILNPSQGLLLSLAFYGWTGCSLDVHAPKMVIQWETMTA
                     SAAEGTYQTPEGSCVPHQNPRKVVCVGGHTSDEVLSILSEGSDASTVEIHTATGSHNI
                     KEVDSISQAQGDL"
     exon            317..426
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            427..521
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            522..614
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            615..724
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            725..833
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            834..951
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1189
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1612
                     /gene="Gpr143"
                     /gene_synonym="RGD1565799"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagcacc tgaccaggaa aagctgtggg ttctgcagac cagagaccgg tccgtgagca
       61 agaccaatgg cctccccgcg cctgggaatc ttctgctgcc cttcgtggga tgcagccaca
      121 cagctggtgc tgaccttcca accgcgggtg ttccatgcgc tgtgtctggg cagcggcgcc
      181 ctccgcctgg tgcttggcct ccttcagctc ctaacagggc gccgatctgt tggtcacagg
      241 gcgcctgcga caaccccagc agcctcagtc cacatccttc gtgctgccac cgcctgtgat
      301 ttgcttggct gcctgggaat cgttatcagg tccacagtgt ggatagccta cccagaattc
      361 attgaaaaca tttccaatat gaatggaaca gacatttggc ctactgcttt ctgtgtcggg
      421 agtgcaatgt ggatccagct gttgtacagt gcctgcttct ggtggctctt ctgctatgca
      481 gttgatgtat acttggtgat caggagatca gcaggacgga gcaccatcct gctgtaccac
      541 atcatggcct ggggcctgcc tgtgctgctc tgtgtggaag gtgcagtcat gctttattac
      601 ccttctgtgt ccaggtgtga gagaggcctg gaccatgcca tcccccatta tgtcaccaca
      661 tacttgccac ttatgcttgt ccttgtggcc aacccgatcc tgtttcacaa gacagtgatt
      721 tcagtggcct ctttactgaa aggacgaaaa ggtgtttata cagagaatga gagattgatg
      781 ggggccgtga tcaagacccg gtttttcaaa ataatgctgg tgttaattgc atgttggttg
      841 tccaatatca tcaatgaatg tcttttgttc taccttgaaa tgcaaccaga tacccatgga
      901 ggctctctga aacgcatcca gaatgcagcc aggaccacat ggtttattat gggaatattg
      961 aatccatctc aaggacttct cttgtctctg gccttctatg gctggacagg atgcagcctg
     1021 gatgtccatg ctcccaagat ggtgattcag tgggaaacaa tgactgcctc ggctgctgag
     1081 ggcacatatc agacccctga gggttcctgt gtgccccatc aaaaccccag gaaggtggtg
     1141 tgtgttgggg ggcacacttc tgatgaggtg ctgagtattt tgtctgaagg ttcggatgct
     1201 agcactgttg aaatccatac tgcaactggg tcccacaaca taaaggaagt tgactccatt
     1261 tcccaagccc agggggatct ctgaatggat gggatggggg ccagacatcc ctgtttttca
     1321 ggttctgtgt cttgttgttt tggattgtgt tcttgccttc cttcctatca cagtgctgcc
     1381 atgatgtagc atccttcaaa ttccactttg gtcaccatag aggagctcac tgaggatggc
     1441 ctttatgctg ggagaaacaa cacaccagaa cttggacatg gaaaatttcc tctagaacat
     1501 tcagtgtcac ctcttgactt ttaattaccc cttggacttt tactaaggcc agttgtagtg
     1561 cttaagtgcc agacccaaat tcttgagaaa atagttaaat aaagtcattg tg
//
