LOCUS       NM_001024241            4648 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus G protein-coupled receptor 139 (Gpr139), mRNA.
ACCESSION   NM_001024241 XM_219399
VERSION     NM_001024241.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4648)
  AUTHORS   Wang,L., Dugovic,C., Yun,S., White,A., Lord,B., Dvorak,C., Liu,C.,
            Lovenberg,T. and Bonaventure,P.
  TITLE     Putative role of GPR139 on sleep modulation using pharmacological
            and genetic rodent models
  JOURNAL   Eur J Pharmacol 882, 173256 (2020)
   PUBMED   32531213
  REMARK    GeneRIF: Putative role of GPR139 on sleep modulation using
            pharmacological and genetic rodent models.
REFERENCE   2  (bases 1 to 4648)
  AUTHORS   Kononoff,J., Kallupi,M., Kimbrough,A., Conlisk,D., de Guglielmo,G.
            and George,O.
  TITLE     Systemic and Intra-Habenular Activation of the Orphan G
            Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol
            Drinking and Hyperalgesia in Alcohol-Dependent Rats
  JOURNAL   eNeuro 5 (3) (2018)
   PUBMED   29971251
  REMARK    GeneRIF: These results provide robust preclinical evidence that G
            protein-coupled receptor 139 (GPR139)activation reverses key
            addiction-like behaviors in dependent animals, suggest that GPR139
            may be a novel target for the treatment of alcohol use disorder,
            and demonstrate that GPR139 is functionally relevant in regulating
            mammalian behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4648)
  AUTHORS   Liu,C., Bonaventure,P., Lee,G., Nepomuceno,D., Kuei,C., Wu,J.,
            Li,Q., Joseph,V., Sutton,S.W., Eckert,W., Yao,X., Yieh,L.,
            Dvorak,C., Carruthers,N., Coate,H., Yun,S., Dugovic,C.,
            Harrington,A. and Lovenberg,T.W.
  TITLE     GPR139, an Orphan Receptor Highly Enriched in the Habenula and
            Septum, Is Activated by the Essential Amino Acids L-Tryptophan and
            L-Phenylalanine
  JOURNAL   Mol Pharmacol 88 (5), 911-925 (2015)
   PUBMED   26349500
REFERENCE   4  (bases 1 to 4648)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I., Urny,J. and Schaller,H.C.
  TITLE     Characterisation and differential expression of two very closely
            related G-protein-coupled receptors, GPR139 and GPR142, in mouse
            tissue and during mouse development
  JOURNAL   Neuropharmacology 50 (4), 512-520 (2006)
   PUBMED   16378626
REFERENCE   5  (bases 1 to 4648)
  AUTHORS   Matsuo,A., Matsumoto,S., Nagano,M., Masumoto,K.H., Takasaki,J.,
            Matsumoto,M., Kobori,M., Katoh,M. and Shigeyoshi,Y.
  TITLE     Molecular cloning and characterization of a novel Gq-coupled orphan
            receptor GPRg1 exclusively expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 331 (1), 363-369 (2005)
   PUBMED   15845401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 13, 2022 this sequence version replaced NM_001024241.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1769406.1,
                                           SRR26360176.1313323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               JAXUCZ010000001.1  182953676-182953942 c
            268-4648            JAXUCZ010000001.1  182909476-182913856 c
FEATURES             Location/Qualifiers
     source          1..4648
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..4648
                     /gene="Gpr139"
                     /note="G protein-coupled receptor 139"
                     /db_xref="GeneID:293545"
                     /db_xref="RGD:1311729"
     exon            1..267
                     /gene="Gpr139"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1202
                     /gene="Gpr139"
                     /note="g(q)-coupled orphan receptor GPRg1"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 139"
                     /protein_id="NP_001019412.1"
                     /db_xref="GeneID:293545"
                     /db_xref="RGD:1311729"
                     /translation="MEHTHAHLAANSSACGLGFVPVVYYSFLLCLGLPANILTVIILS
                     QLVARRQKSSYNYLLALAAADILVLFFIVFVDFLLEDFILTMQMPPIPDKIIEVLEFS
                     SIHTSIWITVPLTVDRYIAVCHPLKYHTVSYPARTRKVILSVYITCFLTSIPYYWWPN
                     IWTEDYISTSMHHVLVWIHCFTVYLVPCSIFFILNSIIVYKLRRKSNFRLRGYSTGKT
                     TAILFTITSIFATLWAPRIIMILYHLYGAPIQNPWLVHIMLDVANMLALLNTAINFFL
                     YCFISKRFRTMAAATLKALFKCQKQPVQFYTNHNFSITSSPWISPANSHCIKMLVYQY
                     DKHGKPIKVSP"
     exon            268..4648
                     /gene="Gpr139"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagagaac ggagctgcct atctaggagg gcaggtgcgc agccactcga ggacaccagc
       61 cagggctgga agcgggtccc gcggcgcggc gatcctcccc agggctgcct ggtccccagc
      121 cgcttggcag ctgcgccgag cccagcccgg cgaggggcgc gctcatggag cacacgcacg
      181 cccacctcgc tgcgaatagc tcagcttgcg gcttgggctt cgtgccggtg gtctactaca
      241 gcttcttgtt gtgcctcggg ttaccagcaa atatcttgac agtcatcatc ctctctcaac
      301 tggtagccag aagacagaag tcctcctaca actatcttct ggcacttgct gctgccgaca
      361 tcttggtcct ctttttcatc gtctttgtgg atttcttgtt agaagacttc attttgacca
      421 tgcagatgcc tccgatccct gacaagatca tagaagtgct agagttctcc tccatccaca
      481 cttctatttg gattacagtc cccttaacag ttgataggta tatcgcagtc tgtcacccac
      541 tcaaatacca cacagtttcc tacccagcca ggacccggaa agtcattctg agtgtttata
      601 ttacctgctt cctgactagc atcccctact actggtggcc taacatctgg actgaagact
      661 acatcagtac ctccatgcat catgtccttg tctggatcca ctgcttcacc gtgtacctgg
      721 tgccctgctc catcttcttc atcttgaact caatcattgt gtacaagctt aggagaaaga
      781 gtaatttccg cctccgtggc tattccactg gcaagaccac tgccatcttg tttaccatca
      841 cctccatctt tgctaccctc tgggcccccc gcatcatcat gattctctac cacctctacg
      901 gagcacccat ccagaaccct tggctggtcc acattatgtt ggatgttgcc aacatgctgg
      961 ctcttctgaa cacagccatc aacttcttcc tctactgctt catcagcaag cgcttccgta
     1021 ccatggcagc tgctacactc aaggccttgt tcaagtgcca gaagcagcct gtacagttct
     1081 acaccaacca taacttttcc ataacaagta gtccctggat ctcaccagca aactcacact
     1141 gcatcaaaat gttggtgtac cagtatgaca aacatgggaa gcctataaaa gtatccccgt
     1201 gaccccacag ggctggcact tgtgcctgcg tgtaatctgt ttccagaaga gagggtatcc
     1261 catcctctgg ttgaacagct ctccttaaga gtgctaacct gatttccagt ctccacagac
     1321 tgagccgctc tcagactggc agatgagaag aaatggaaga gaagaaagga gagcatgaat
     1381 cttggtgttt taggggtttt tttcttcttt tttatgcact cattttcaca aaatcacact
     1441 gacagccaaa gttcctgctg gcttgaagac accattggca cttataaatg ccatcatatt
     1501 gtgaccaata aagaccatgg tagagaagta attagtgctg gtaccatcca tagtcactag
     1561 gaaccagcca ctcatgtgtg tggtccatcc agccaccatg gtgtgtagct gagccacaat
     1621 cttcttccaa gagttgaggt cacccatcat atccctgtgc cattgtcagc agctaacagg
     1681 gctgactgat tttgggattc ttttcaaagg tgcccttcgt cctagacaga gttgtggtct
     1741 ccaagtggcc ctggcaactc tggctgcaga agacaacatg gggaaaggga cgtgtcacat
     1801 cccatccaaa ctcctgctgt gccggaatgt ctatggggag gctccaaacc aacatgacta
     1861 tgtcccttag acttggggtc taaggtgtag ttttctattt gccatattgt atagatttta
     1921 tgtctcctct aaaacaaaga ccctgccctg gtgtgtgggg ggaaaggaga aattcttgag
     1981 cccagaaaaa caaaaaatca agcccactct tgccactgtt tcgattcatc accatatcag
     2041 ctgtttgcga tccttgcatt caaaatcatc ttgctgtggc actatacacg cctcctggag
     2101 aagcctttta tgtgtcaagt tgttattcct gctccttgct tgctcaagcc ctcacctata
     2161 tcgctttact tgaagtgact tcttaactgg agatactagt cgggaggtta gaaaactgca
     2221 gctcttctgg agggaaggga gtgtatagca cccaccaaaa cccagctggc attgctgtgt
     2281 aagacccaaa gtacaaacaa actggagggg tggttgtgcc aaccactgct atgtcctttg
     2341 atgtaagtag ctgagtcagg aaggggtgcc agttatcagt aaagctgttt aacttggatg
     2401 cttcaaagat actaaaattt attattttcc cctttcctgt tcaagttaag aagaaatctc
     2461 ggatgtggat aggggcttcc ctgagagtgt agacatataa aacacaggta tagacacaac
     2521 tatactaaac tgttatgtgg tgtgctttaa aaggatgtcc acactagagt tcctctcatt
     2581 ttatttctgc cccttttcaa gatatctgaa accatccctg gtttagaaga aatcctctaa
     2641 aatgattttt gaaattgcat aatattggtg ccaaactaaa cagagtcacc tgaaacactt
     2701 ggtttgattt gtcctgcatt ttctctctaa gttggagggc atgtccctat caccttaagg
     2761 ggttctgcaa caaaggaatg ggaaggaaag acccctgaag caacacgagt cccaaacttc
     2821 caccagggcc attcaatact aacccagtgc aatcggaggc tgtattgttc ctatccctgt
     2881 taaatggctt atgggagagt ctcgccaaac ccagtagtta gattctgaag tcagtacaaa
     2941 agtgaatgac cttatggggc tgtggttcct gtggttcccc agggaaaatg acctttgaac
     3001 atccaggaag ttgcattttg ctccagcatt gggatgggtt gccggtactt tgattgaaga
     3061 taatacagat gtttaggggg tgtgtcctat tattgtgaag tatctgagaa catcaggact
     3121 acctggatac aggaagccac acccactgaa aagtctgcag aagttactca cgtaagagat
     3181 gatctaagtt ctagcatcca tctcgcttgc tccccagagc atatactcca tgagcgaaat
     3241 gtgagcaaat cctccacatc tcttgaatcg catttctttc tttttctccc caagcatgtg
     3301 aaattgaatg tatgttcatt agctgtgtgt atgatacaat tccattgcac ttccccccgt
     3361 aagtaaacat taaccaaagg ctacctacgc cgagtatata ttatgtgtgt gtgcttattt
     3421 attttttaaa atgcatatct ctgaaaatgt tagtttgagc tatagataaa tgattcaaag
     3481 tgcaatatct ataaaggtta agcaattcct ttttgagaat gtacacaaga tgaacaacag
     3541 tgagtctctg actctcaatg ctgcctgctc tgtgtttttt aattgtatgt aaaacaatta
     3601 attatttaaa gctgggtgtg tactgggaat gctttctcca gacactcatt tatgactttt
     3661 cgtagcagga gaggttctat tagtaggtat ggcagcatct ctttcttctg actacattcc
     3721 tatttctcta agcaattttt caaactaatc catagaagca ctccagagag ttgctgtatc
     3781 ttctgtttaa aatacacatg gatacccttt tggttaggtt gctatatatc atagcctata
     3841 tatgtatata tgtatacata tgtatgtatg tatatatata ctaaagttta agattttaag
     3901 atttcaggaa aatattcatt tattattgat attaataata acaagcaatg atgaagatgc
     3961 tttcatttta actttaaaaa ttgtaagcct tttctttcag gccaggtttg gaagatgaag
     4021 cccgtcacat aaacagctgc tgctaagggc aaacacctta gcctgggttt ttgtggtgct
     4081 tctttcaaag actgttcatt atcacctcca ttgctgtatg atttgtgtcc ttggacatgg
     4141 ttgacagtgc cacacatgta catgctgagt ctttttctta gcaactggaa gcctggggaa
     4201 agagataagg gggacagcag acaaaccata agagataagc catgtgaatg aatgaacatc
     4261 cctgttccaa ccaccttgca ataggaaagg gttattttgc acagatggtg tctacttgtc
     4321 caatgtgggg aaccctttgg aaatgcatta atgactctaa tgttgacgac tactactgtt
     4381 ctgaggttac caccgaaaaa cagtaaatgt tcatattttc ttaaatagat aatatattgt
     4441 gtttggacta gtttgtattc taataaattc taatatggtg cacacttggt gtttgctatt
     4501 tgcatatatg ttcaaccaac tgcagaatgc tggtttttat tcatattatt tttaattgat
     4561 aaatcataat tgtatacagg tatggagtgc agtgtgatgt tttgatatgt gtattaaatg
     4621 tgcaatgatt aaaccgagca aattaaca
//
