LOCUS       NM_001399408            1297 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 137B (Gpr137b),
            transcript variant 2, mRNA.
ACCESSION   NM_001399408 XM_006254372
VERSION     NM_001399408.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Urso,K., Caetano-Lopes,J., Lee,P.Y., Yan,J., Henke,K., Sury,M.,
            Liu,H., Zgoda,M., Jacome-Galarza,C., Nigrovic,P.A., Duryea,J.,
            Harris,M.P. and Charles,J.F.
  TITLE     A role for G protein-coupled receptor 137b in bone remodeling in
            mouse and zebrafish
  JOURNAL   Bone 127, 104-113 (2019)
   PUBMED   31173907
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Gan,L., Seki,A., Shen,K., Iyer,H., Han,K., Hayer,A., Wollman,R.,
            Ge,X., Lin,J.R., Dey,G., Talbot,W.S. and Meyer,T.
  TITLE     The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1
            localization and activity
  JOURNAL   Nat Cell Biol 21 (5), 614-626 (2019)
   PUBMED   31036939
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Islam,Z., Inui,T. and Ishibashi,O.
  TITLE     Gpr137b is an orphan G-protein-coupled receptor associated with M2
            macrophage polarization
  JOURNAL   Biochem Biophys Res Commun 509 (3), 657-663 (2019)
   PUBMED   30595385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 7, 2022 this sequence version replaced XM_006254372.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.50628.1,
                                           SRR26643295.55382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               JAXUCZ010000017.1  93025482-93025911   c
            431-480             JAXUCZ010000017.1  93005619-93005668   c
            481-703             JAXUCZ010000017.1  93000744-93000966   c
            704-853             JAXUCZ010000017.1  92998674-92998823   c
            854-982             JAXUCZ010000017.1  92997450-92997578   c
            983-1107            JAXUCZ010000017.1  92995652-92995776   c
            1108-1297           JAXUCZ010000017.1  92995226-92995415   c
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1297
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /note="G protein-coupled receptor 137B"
                     /db_xref="GeneID:289287"
                     /db_xref="RGD:1307342"
     exon            1..430
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1243
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transmembrane 7 superfamily member 1; integral membrane
                     protein GPR137B"
                     /codon_start=1
                     /product="integral membrane protein GPR137B isoform 2"
                     /protein_id="NP_001386337.1"
                     /db_xref="GeneID:289287"
                     /db_xref="RGD:1307342"
                     /translation="MEAPPWEPVRNDSLPPTLSPAVPPYVKLGLTAVYTAFYALLFVF
                     IYAQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFRDFVAANSFSPFVFWLL
                     YCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLT
                     CAVLVKTGDWDRKVIVSVRVAINDTLFVLCAISLSICLYKISKMSLANIYLESKGSSV
                     CQVTAIGVTVILLYTSRACYNLFILSFSQIKNVHSFDYDWYNVSDQADLKSQLGDAGY
                     IVFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSD
                     DDLAWNIAPQGLQGRISPSLPRESQSICCSNHSVEHDLGHPGRHLGSSSKAREYMNNY
                     Q"
     exon            431..480
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..703
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..853
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..982
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1107
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1297
                     /gene="Gpr137b"
                     /gene_synonym="Tm7sf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgggtac cggggagcga acggatgcga gccccgatga agctcgagcg gccccagcct
       61 gatggaggcg cctccgtggg agccggtgcg caatgattcc ctgcctccca cgctgagccc
      121 cgcggtgccg ccctacgtga agctcggcct caccgcggtc tacaccgctt tctacgcgct
      181 tctcttcgtg ttcatctatg cacagctctg gctggtgctg cgctaccgtc acaagcggct
      241 cagctaccag agcgtcttcc tctttctttg cctcttctgg gcctcgctgc gtactgtgct
      301 cttctccttt tacttccgag acttcgtggc ggccaactcg ttcagccctt tcgtcttctg
      361 gctgctctac tgcttcccgg tgtgtctaca gttcttcacc ctcacgctca tgaacttgta
      421 cttcacgcag gtgattttca aggccaagtc aaaatattct ccagaattac tcaaatacag
      481 gttacccctc tacctggcct cacttttcat tagccttgtt ttcctgttgg tgaatctgac
      541 ctgcgctgtg ctggtgaaga ctggagactg ggacaggaag gttatcgtct ctgtgagagt
      601 ggccatcaat gacacactct ttgtgctgtg tgccatctct ctctccatct gcctctacaa
      661 aatctccaag atgtccttgg ccaacatcta cttggaatca aagggctcct ccgtgtgtca
      721 ggtaactgcc attggtgtca ccgtcatctt gctctacacc tctcgggcct gctacaacct
      781 attcatcttg tcattttctc agatcaagaa cgtccattcc tttgattatg actggtacaa
      841 tgtatcagac caggcagatc tgaagagcca gctgggtgat gccggctaca tagtgtttgg
      901 cgtggtgctt ttcgtgtggg agctcttacc caccactttg gtggtttatt tcttccgagt
      961 cagaaatccc acgaaggatc ttaccaatcc tgggatggtc cccagccatg gatttagtcc
     1021 cagatcttac ttctttgaca acccccgaag atatgacagt gatgatgatc ttgcctggaa
     1081 cattgcccct cagggacttc agggaaggat ctctccgagc ctacccagag agagccagag
     1141 catttgctgc tcgaatcact cagtggaaca tgacctggga catccaggca gacaccttgg
     1201 atcctcttct aaagccagag aatatatgaa caattatcag tagagtatat attatgagaa
     1261 ccaaaatttg tcattcttag ttatttacta agatatt
//
