LOCUS       NM_181771               3129 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 135 (Gpr135), mRNA.
ACCESSION   NM_181771
VERSION     NM_181771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3129)
  AUTHORS   Ruiz-Hernandez,A., Romero-Nava,R., Huang,F., Hong,E. and
            Villafana,S.
  TITLE     Altered function and expression of the orphan GPR135 at the
            cardiovascular level in diabetic Wistar rats
  JOURNAL   J Recept Signal Transduct Res 38 (5-6), 484-491 (2018)
   PUBMED   31038027
  REMARK    GeneRIF: we conclude that the orphan receptor GPR135 is expressed
            in different tissues and its expression tends to be modified due to
            diabetes, besides that it is functional and that it seems to be
            coupled to Gi/o protein which has negative chronotropic and
            inotropic effects, therefore, we do not rule out that it
            participates in the cardiovascular complications associated with
            diabetes.
REFERENCE   2  (bases 1 to 3129)
  AUTHORS   Oishi,A., Karamitri,A., Gerbier,R., Lahuna,O., Ahmad,R. and
            Jockers,R.
  TITLE     Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2
            receptor reciprocally modulate their signaling functions
  JOURNAL   Sci Rep 7 (1), 8990 (2017)
   PUBMED   28827538
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3129)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 29, 2022 this sequence version replaced NM_181771.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY288430.1, SRR21887621.997447.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3129              JAXUCZ010000006.1  96363466-96366594   c
FEATURES             Location/Qualifiers
     source          1..3129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3129
                     /gene="Gpr135"
                     /note="G protein-coupled receptor 135"
                     /db_xref="GeneID:314213"
                     /db_xref="RGD:727844"
     exon            1..3129
                     /gene="Gpr135"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1484
                     /gene="Gpr135"
                     /note="probable G-protein coupled receptor 135"
                     /codon_start=1
                     /product="G-protein coupled receptor 135"
                     /protein_id="NP_861436.1"
                     /db_xref="GeneID:314213"
                     /db_xref="RGD:727844"
                     /translation="MEEQARPPSRPAASATLPGSAHPGGAASTATAAALSFSSVATVT
                     LGNQSDAGRPEAAGSRGPAPLLWHGAAVAAQALVLLLIFLLSSLGNCAVMGVIVKHRQ
                     LRTVTNAFILSLSLSDLLTALLCLPAAFLDLFAPPGDSGPWRSFCAASRFFSSCFGIV
                     STFSVALISLDRYCAIVRPPRDKLGRRRALQLLAGAWLAALGFSLPWELLRAPREPPT
                     PQSFHRCLYRTSPDPAQLGAAYSVGLVVACYLLPFLLMCFCRYHICKTVRLSDVRVRP
                     MTTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAATRQGQTTQAPSLLNVA
                     AVWLTWANGAINPVIYAIRNPNISMFLGRNREEGYRTRNMDVFLPSQGLGFQARSRNR
                     LRNGCANRLGACSRMPSSNPASGSGGEVVMWARKNPVVLFFREDPPDPVMAVYKQHKS
                     ETRDSSI"
ORIGIN      
        1 agtcccgggt ggtgaccgag tcccacccac tccccgcggc tgctgttctg gtcagcacaa
       61 cctttcaccc tgctgcggga tgagcagagc ggcggcctgc ccgggaacct atggaggagc
      121 aggcgcggcc gccgagccgc ccggctgcga gtgcaacctt gccgggtagc gcacatcccg
      181 gaggggcggc ttccacggcc accgcggccg cgctgtcgtt cagctccgta gccaccgtaa
      241 cgctgggaaa ccagagcgat gcgggcaggc cggaggcggc tgggtctcgg ggaccggcac
      301 cgctgctttg gcacggggca gcagtggccg cccaggcgct cgtgctcctg ctcatcttct
      361 tactgtctag cctgggaaac tgcgcggtga tgggggtgat cgtgaagcac cggcagctgc
      421 gcacggtcac caacgccttc atcctatcgc tgtccctgtc ggacctgctc actgcgctgc
      481 tctgcttacc cgccgccttc ctcgacctgt ttgcgccgcc gggagactcg gggccctggc
      541 gcagcttctg cgccgccagc cgcttcttca gttcgtgttt cggcatcgtc tccacgttca
      601 gcgtggcgct catctcgctg gaccgctact gcgccatcgt gcggccgccg cgggacaagc
      661 taggccggcg gcgcgcgctg cagctgctgg ccggagcgtg gctggctgcg ctcggcttct
      721 ccctgccctg ggagctgctc cgggcacccc gggagccccc gactccgcag agcttccacc
      781 gctgccttta cagaacctcc ccagaccctg cgcagctggg cgccgcttac agcgtggggc
      841 tggtggtggc ttgctacctg ctgcccttcc tgctgatgtg tttctgccgc taccacatct
      901 gcaagactgt gcgcctgtcg gacgtgcgtg tgcggccgat gaccacctat gcgcgcgtgc
      961 tgcgcttttt cagcgaggtg cgcacggcca ccaccgtgct catcatgatt gtctttgtca
     1021 tctgctgctg gggcccctac tgcttcctgg tgttgttggc tgctacccgg cagggtcaga
     1081 ccacacaggc tccctcgctg ctcaatgtgg cagctgtttg gctgacctgg gccaatggag
     1141 ctatcaaccc ggtcatatat gccatccgca accctaacat ttctatgttc ctaggtcgca
     1201 accgcgaaga gggatatagg actagaaaca tggatgtttt tttgcctagc caaggcctag
     1261 gttttcaggc cagaagtcgc aatcgccttc gaaatggctg tgccaacagg cttggggctt
     1321 gcagcaggat gccttcttcc aaccccgcta gtgggtcagg aggggaagtg gtcatgtggg
     1381 ctcgaaaaaa cccagttgtg ctcttcttcc gagaggatcc accagaccca gttatggcag
     1441 tctacaaaca gcataaatct gaaaccaggg acagtagcat ctaagaaggg ttggggtgga
     1501 ccgcttgtaa tagcaaattt ccacttgtct cattgaatga tgcgggaatc cggggagaat
     1561 cgtttatttc ataaagccaa acatttaaag ctaaaaagac agaagtggga gagttaccgc
     1621 ttcattctca aacataaaag acgtaaaagg acattccctt ttttcaaaag tggccaaagg
     1681 aatgtgaaat gcaaaaatta aaataatctt aaaccacaaa accaagcatt gtaaggtgta
     1741 agtgctaaaa agcaacaaaa aataaaattc acagtttctg aagagctcat gttacaggaa
     1801 tcacactgtg agacaaaaat cactgaactg aacttaacag ttgtattcaa atactgtttg
     1861 ctttgttttg ttttgttttg ttgtttgctt gtttttaacg aacgaaggcc cttagatctg
     1921 attgaaggcc cctgtacttt caccagcatt cggcaaaact tcagattcta gagcctgcac
     1981 gtctgacctg ctctgggtgc ttagagcaga aacatcatta caaagactga ggcactctcc
     2041 ctcccagaat ttttgtgcaa gattttaaac ttagagttta ttttaaacca cttctggatt
     2101 tttgtaaagg tcgtttgata ctagatagaa ctcagcggcc caaagggcaa agtgaacata
     2161 ctgcagctgt ttaaacagaa gtctaatctt atacataaaa accaatgttt cttctaagac
     2221 tattttagcc cccaaattac ctgtcttctt cctgtgctgc ctgtgttctt cctctaacct
     2281 gttcttgttt gatagcttgt agggatacca ctccaaatgt tttaataata ataataataa
     2341 taataataat aataataata ataactttca tactagaaaa tccttctcta ttggggtaac
     2401 ttttttcata gagtccaaac tgtaatttga aatcaaattc tttgaatata gtgagtgatg
     2461 ctaagtatgt atgtaggcat atatgttaca catacatatt atacatgtag taccggtttt
     2521 cctatttagc ctttaactgc caaatgtgat tccaaatgga attctaaaag tagttggaaa
     2581 agtatgacca cgttcttgga atagccacag agtatcctaa gaggaccttc tatttagaag
     2641 gtagagtatg ctttagtagc agacccctgc tgtacaggta tgcttgtgta gaatattata
     2701 gtcatcatta gaaagagaat tgatttgggg ttacaaggca ggataaaagt ctattggcac
     2761 aaggttggag agatacctca agccaactga aaatattttc agaaacttgc aaaaaaaatt
     2821 tatactaact cagaagcaca atctaagctt tgtacatgtg aaatttctca cacagaatgt
     2881 cactttggac tttcttgcct tcctgattct gcttcttttt catccagtat tgcatagctt
     2941 taataagcac tttaaaaagt atgaaaatgc atccgttatg tgaaggcttt gcagatctag
     3001 cctgcgttgc gtaaaatgta aagcatttaa gatattcatt cttacataaa tctctgtgtg
     3061 acaggtgagt gtgcaacact attttgtaat cacagatgga aatagatgat tcctgtcttg
     3121 accagccaa
//
