LOCUS       NP_001164066             376 aa            linear   ROD 31-MAR-2024
DEFINITION  probable G-protein coupled receptor 132 [Rattus norvegicus].
ACCESSION   NP_001164066 XP_001073056 XP_234574
VERSION     NP_001164066.1
DBSOURCE    REFSEQ: accession NM_001170595.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 376)
  AUTHORS   Ikeno,Y., Konno,N., Cheon,S.H., Bolchi,A., Ottonello,S.,
            Kitamoto,K. and Arioka,M.
  TITLE     Secretory phospholipases A2 induce neurite outgrowth in PC12 cells
            through lysophosphatidylcholine generation and activation of G2A
            receptor
  JOURNAL   J Biol Chem 280 (30), 28044-28052 (2005)
   PUBMED   15927955
  REMARK    GeneRIF: The neuritogenic effect of sPLA2 is mediated by generation
            of LPC and subsequent activation of G2a (G protein-coupled receptor
            132).
REFERENCE   2  (residues 1 to 376)
  AUTHORS   Weng,Z., Fluckiger,A.C., Nisitani,S., Wahl,M.I., Le,L.Q.,
            Hunter,C.A., Fernal,A.A., Le Beau,M.M. and Witte,O.N.
  TITLE     A DNA damage and stress inducible G protein-coupled receptor blocks
            cells in G2/M
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12334-12339 (1998)
   PUBMED   9770487
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000006.1.
            
            On or before May 22, 2010 this sequence version replaced
            XP_001073056.2, XP_234574.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The extent of this transcript is supported by
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.27544.1,
                                           SRR26643290.24272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     Protein         1..376
                     /product="probable G-protein coupled receptor 132"
                     /note="G protein-coupled receptor G2a"
                     /calculated_mol_wt=41682
     Region          48..315
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          73..94
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          111..133
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          156..172
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          193..216
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          237..259
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          283..308
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..376
                     /gene="Gpr132"
                     /gene_synonym="G2a"
                     /coded_by="NM_001170595.1:146..1276"
                     /db_xref="GeneID:314480"
                     /db_xref="RGD:1310817"
ORIGIN      
        1 mrseptnatg natavtstlq ttsvptscht lsyeesrvvl vavysvvcml glpancltaw
       61 ltllqvlqrn vlavylfcls lcellyistm plwiiyiqnq hkwslgqqac kvtayiffcn
      121 iytsilllcc iscdrymavv yalesrghrh qrtavtisac vvilvglvny pvfdmkveds
      181 fcfeplgids riagyyylrf tfgfavplgv laftnhqifr siklsdslsa aqknkvkrsa
      241 iavvtiflvc fapyhvvlli kaasfsfyeg drdavcdfen rlytvstvfl clstvnsvad
      301 piiyvlatdh srqevcriht gwkkwstktd vtylkdseet hsptalmnay tfpstvhlpg
      361 sqpvelgslg sageta
//
