LOCUS       NM_001037295            1542 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 12 (Gpr12), transcript
            variant 1, mRNA.
ACCESSION   NM_001037295
VERSION     NM_001037295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Lu,X., Zhang,N., Dong,S. and Hu,Y.
  TITLE     Involvement of GPR12 in the induction of neurite outgrowth in PC12
            cells
  JOURNAL   Brain Res Bull 87 (1), 30-36 (2012)
   PUBMED   21985983
  REMARK    GeneRIF: These findings indicate that GPR12 may play a role in
            neurite outgrowth during PC12 cell differentiation.
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Hinckley,M., Vaccari,S., Horner,K., Chen,R. and Conti,M.
  TITLE     The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP
            signaling and maintenance of meiotic arrest in rodent oocytes
  JOURNAL   Dev Biol 287 (2), 249-261 (2005)
   PUBMED   16229830
  REMARK    GeneRIF: the cAMP levels required for maintaining meiotic arrest in
            mouse and rat oocytes are dependent on the expression of Gpr3
            and/or Gpr12
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Ignatov,A., Lintzel,J., Hermans-Borgmeyer,I., Kreienkamp,H.J.,
            Joost,P., Thomsen,S., Methner,A. and Schaller,H.C.
  TITLE     Role of the G-protein-coupled receptor GPR12 as high-affinity
            receptor for sphingosylphosphorylcholine and its expression and
            function in brain development
  JOURNAL   J Neurosci 23 (3), 907-914 (2003)
   PUBMED   12574419
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Song,Z.H., Modi,W. and Bonner,T.I.
  TITLE     Molecular cloning and chromosomal localization of human genes
            encoding three closely related G protein-coupled receptors
  JOURNAL   Genomics 28 (2), 347-349 (1995)
   PUBMED   8530049
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Saeki,Y., Ueno,S., Mizuno,R., Nishimura,T., Fujimura,H., Nagai,Y.
            and Yanagihara,T.
  TITLE     Molecular cloning of a novel putative G protein-coupled receptor
            (GPCR21) which is expressed predominantly in mouse central nervous
            system
  JOURNAL   FEBS Lett 336 (2), 317-322 (1993)
   PUBMED   8262253
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Eidne,K.A., Zabavnik,J., Peters,T., Yoshida,S., Anderson,L. and
            Taylor,P.L.
  TITLE     Cloning, sequencing and tissue distribution of a candidate G
            protein-coupled receptor from rat pituitary gland
  JOURNAL   FEBS Lett 292 (1-2), 243-248 (1991)
   PUBMED   1840531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001037295.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61496.1, BC127447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000012.1  13637324-13637518
            196-1542            JAXUCZ010000012.1  13638154-13639500
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1542
                     /gene="Gpr12"
                     /gene_synonym="Gpcr12"
                     /note="G protein-coupled receptor 12"
                     /db_xref="GeneID:80840"
                     /db_xref="RGD:68333"
     exon            1..195
                     /gene="Gpr12"
                     /gene_synonym="Gpcr12"
                     /inference="alignment:Splign:2.1.0"
     exon            196..1542
                     /gene="Gpr12"
                     /gene_synonym="Gpcr12"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1215
                     /gene="Gpr12"
                     /gene_synonym="Gpcr12"
                     /note="R334"
                     /codon_start=1
                     /product="G-protein coupled receptor 12"
                     /protein_id="NP_001032372.1"
                     /db_xref="GeneID:80840"
                     /db_xref="RGD:68333"
                     /translation="MNEDPKVNLSGLPRDCIEAGTPENISAAVPSQGSVVESEPELVV
                     NPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAGLGLIINFV
                     FAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVM
                     LVMLWGTSTCLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSISFLFMFALMLQLYI
                     QICKIVMRHAHQIALQHHFLATSHYVTTRKGISTLALILGTFAACWMPFTLYSLIADY
                     TYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPNTLSQRARSPSDV
                     "
ORIGIN      
        1 ctgcgacctg cgggggcgcg cgcagcctcg tggggttctc gcggatgcgc gccgggcggg
       61 gagcgcgcag ggcggagagc cgggcgcgag cgacgcagct cacctgccgc gggcgccacc
      121 acggacgtgc cacgcgggtg gccctcgcta ttcggcagca ccgaaggagc cccccctcgg
      181 tctgggcgtg ccaagaggac aggggttaaa atgaacgaag acccgaaggt caatttaagc
      241 gggctgcctc gggactgtat agaagctggt actccggaga acatctcagc cgctgtcccc
      301 tcccagggct ctgttgtgga gtcagaaccc gagctcgttg tcaacccctg ggacattgtc
      361 ttgtgcagct caggaaccct catctgctgt gaaaatgccg tcgtggtcct tatcatcttc
      421 cacagcccca gcctgcgagc acccatgttc ctgctgatag gcagcctggc tcttgcagac
      481 ctgctggctg gtctgggact catcatcaat tttgtttttg cctacctgct tcagtcagaa
      541 gccaccaagc tggtcacaat tggactcatt gtcgcctctt tctctgcctc tgtctgcagt
      601 ttgctggcta tcactgtgga ccgctacctc tcgctgtatt acgccctgac gtaccactcc
      661 gagaggaccg tcacctttac ctatgtcatg ctagtgatgc tctggggaac ttccacctgc
      721 ctggggctgc tgcctgtcat gggctggaac tgcctgaggg acgagtccac ctgcagcgtg
      781 gtcagacccc tcactaagaa caacgccgcc attctctcca tctccttcct cttcatgttc
      841 gcactgatgc tccaactcta catccagatt tgtaagattg tgatgaggca cgcccatcag
      901 atagccctgc agcaccactt cctggctacg tcgcactacg tgactacccg gaaagggatc
      961 tccaccctgg ctctcatcct ggggaccttt gccgcctgct ggatgccttt taccctctat
     1021 tccttgatcg ccgattacac ctacccctcc atctacacct acgccaccct cctgcccgcc
     1081 acgtacaatt ccatcatcaa ccctgtcata tatgctttca gaaaccaaga gatccagaaa
     1141 gccctctgcc tcatctgctg tgggtgcatc cctaacacgc tgtcccagag agcacgctct
     1201 cccagcgatg tgtagcagcg ttctccccac aggacgctgg ctctactaag cgccccactg
     1261 cccagggcag ccggtgactt cctcccctta aattctttgc actggatctc acaggcagaa
     1321 gcaacgatat cttttagact agtgttggca gtggaaatca tgttaccagt gttttaaaaa
     1381 actcaacttc tcggcttagc attctgttgt ttggtttggg agttaggagt tgtttgtttg
     1441 tttgtttgtt tggagggtgt agtggcacct catgtggccg taaaattata cacaagtctc
     1501 aggattttta acctagactt gaaaataaat cagttttaaa gg
//
