LOCUS       NM_133298               2320 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus glycoprotein nmb (Gpnmb), mRNA.
ACCESSION   NM_133298
VERSION     NM_133298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Hou,X., Xiao,S., Xu,X., Qin,M., Cheng,X. and Xu,X.
  TITLE     Glycoprotein Non-metastatic Melanoma Protein B (GPNMB) Protects
            Against Neuroinflammation and Neuronal Loss in Pilocarpine-induced
            Epilepsy via the Regulation of Microglial Polarization
  JOURNAL   Neuroscience 551, 166-176 (2024)
   PUBMED   38782114
  REMARK    GeneRIF: Glycoprotein Non-metastatic Melanoma Protein B (GPNMB)
            Protects Against Neuroinflammation and Neuronal Loss in
            Pilocarpine-induced Epilepsy via the Regulation of Microglial
            Polarization.
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Li,X., Xu,J., Su,W., Su,L., Chen,X., Yang,J., Lin,X. and Yang,L.
  TITLE     GPNMB Modulates Autophagy to Enhance Functional Recovery After
            Spinal Cord Injury in Rats
  JOURNAL   Cell Transplant 33, 9636897241233040 (2024)
   PUBMED   38400732
  REMARK    GeneRIF: GPNMB Modulates Autophagy to Enhance Functional Recovery
            After Spinal Cord Injury in Rats.
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Zheng,Y., Huang,C., Yang,X. and Zhang,Z.
  TITLE     Altered expression of glycoprotein non-metastatic melanoma protein
            B in the distal sciatic nerve following injury
  JOURNAL   Int J Mol Med 45 (6), 1909-1917 (2020)
   PUBMED   32236569
  REMARK    GeneRIF: Altered expression of glycoprotein nonmetastatic melanoma
            protein B in the distal sciatic nerve following injury.
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Ma,J., Baker,A.R., Calabro,A. and Derwin,K.A.
  TITLE     Exploratory study on the effect of osteoactivin on muscle
            regeneration in a rat volumetric muscle loss model
  JOURNAL   PLoS One 12 (4), e0175853 (2017)
   PUBMED   28426701
  REMARK    GeneRIF: objective of this study is to investigate the potential
            regenerative effect of OA embedded and delivered via a cross-linked
            gelatin hydrogel within a volumetric tibialis anterior muscle
            defect in a rat model
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Jarve,A., Muhlstedt,S., Qadri,F., Nickl,B., Schulz,H., Hubner,N.,
            Ozcelik,C. and Bader,M.
  TITLE     Adverse left ventricular remodeling by glycoprotein nonmetastatic
            melanoma protein B in myocardial infarction
  JOURNAL   FASEB J 31 (2), 556-568 (2017)
   PUBMED   28148779
  REMARK    GeneRIF: This is the first experimental study to show that GPNMB
            adversely influences myocardial remodeling.
REFERENCE   6  (bases 1 to 2320)
  AUTHORS   Onaga,M., Ido,A., Hasuike,S., Uto,H., Moriuchi,A., Nagata,K.,
            Hori,T., Hayash,K. and Tsubouchi,H.
  TITLE     Osteoactivin expressed during cirrhosis development in rats fed a
            choline-deficient, L-amino acid-defined diet, accelerates motility
            of hepatoma cells
  JOURNAL   J Hepatol 39 (5), 779-785 (2003)
   PUBMED   14568261
  REMARK    GeneRIF: results indicate that osteoactivin is a novel factor
            involved in the progression of hepatocellular carcinoma via
            stimulation of tumor invasiveness and metastatic potential
REFERENCE   7  (bases 1 to 2320)
  AUTHORS   Bandari,P.S., Qian,J., Yehia,G., Joshi,D.D., Maloof,P.B.,
            Potian,J., Oh,H.S., Gascon,P., Harrison,J.S. and Rameshwar,P.
  TITLE     Hematopoietic growth factor inducible neurokinin-1 type: a
            transmembrane protein that is similar to neurokinin 1 interacts
            with substance P
  JOURNAL   Regul Pept 111 (1-3), 169-178 (2003)
   PUBMED   12609765
REFERENCE   8  (bases 1 to 2320)
  AUTHORS   Bachner,D., Schroder,D. and Gross,G.
  TITLE     mRNA expression of the murine glycoprotein (transmembrane) nmb
            (Gpnmb) gene is linked to the developing retinal pigment epithelium
            and iris
  JOURNAL   Brain Res Gene Expr Patterns 1 (3-4), 159-165 (2002)
   PUBMED   12638126
REFERENCE   9  (bases 1 to 2320)
  AUTHORS   Shikano,S., Bonkobara,M., Zukas,P.K. and Ariizumi,K.
  TITLE     Molecular cloning of a dendritic cell-associated transmembrane
            protein, DC-HIL, that promotes RGD-dependent adhesion of
            endothelial cells through recognition of heparan sulfate
            proteoglycans
  JOURNAL   J Biol Chem 276 (11), 8125-8134 (2001)
   PUBMED   11114299
REFERENCE   10 (bases 1 to 2320)
  AUTHORS   Safadi,F.F., Xu,J., Smock,S.L., Rico,M.C., Owen,T.A. and
            Popoff,S.N.
  TITLE     Cloning and characterization of osteoactivin, a novel cDNA
            expressed in osteoblasts
  JOURNAL   J Cell Biochem 84 (1), 12-26 (2001)
   PUBMED   11746512
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF184983.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF184983.2, BC061725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132281, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..2320
                     /gene="Gpnmb"
                     /note="glycoprotein nmb"
                     /db_xref="GeneID:113955"
                     /db_xref="RGD:71008"
     exon            1..184
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1833
                     /gene="Gpnmb"
                     /note="transmembrane glycoprotein NMB; osteoactivin;
                     glycoprotein (transmembrane) nmb"
                     /codon_start=1
                     /product="transmembrane glycoprotein NMB precursor"
                     /protein_id="NP_579832.1"
                     /db_xref="GeneID:113955"
                     /db_xref="RGD:71008"
                     /translation="MESLCGVLVFLLLAAGLPLQAAKRFRDVLGHEQYPDHMRENNQL
                     RGWSSDENEWDEQLYPVWRRGEGRWKDSWEGGRVQAALTSDSPALVGSNITFVVNLVF
                     PRCQKEDANGNIVYERNCRSDLELASDPYVYNWTTGADDEDWEDNTSQGQHLRFPDGK
                     PFPRPHGRKKWNFVYVFHTLGQYFQKLGQCSARVSINTVNLTVGPQVMEVIVFRRHGR
                     AYIPISKVKDVYVITDQIPIFVTMYQKNDRNSSDETFLRDLPIFFDVLIHDPSHFLNY
                     SAISYKWNFGDNTGLFVSNNHTLNHTYVLNGTFNFNLTVQTAVPGPCPSPTPSPSSST
                     SPSPASSPSPTLSTPSPSLMPTGYKSMELSDISNENCRINRYGYFRATITIVDGILEV
                     NIIQVADVPIPTLQPDNSLMDFIVTCKGATPTEACTIISDPTCQIAQNRVCSPVAVDE
                     LCLLSVRRAFNGSGTYCVNFTLGDDASLALTSALISIPGKDLGSPLRTVNGVLISIGC
                     LAMFVTMVTILLYKKHKTYKPIGNCTRNVVKGKGLSVFLSHAKAPFSRGDREKDPLLQ
                     DKPWML"
     exon            185..337
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            338..481
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            482..655
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            656..814
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1174
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1273
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1376
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1585
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1679
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..2308
                     /gene="Gpnmb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtatttcata aaacagagag gatcgcagga ggccggcact ctgactcctg gtggatggga
       61 ctagggagtc agagtcaagc cctgactggc tgagggcggg cgctccgagt cagcatggaa
      121 agtctctgcg gggtcctggt atttctgctg ctggctgcag gactgccgct ccaggcggcc
      181 aagcggttcc gtgatgtgct gggccatgag cagtatccgg atcacatgag ggagaacaac
      241 caattacgtg gctggtcttc agatgaaaat gaatgggatg aacagctgta tccagtgtgg
      301 aggaggggag agggcagatg gaaggactcc tgggaaggag gccgtgtgca ggcagcccta
      361 accagtgatt caccggcctt ggtgggttcc aatatcacct tcgtagtgaa cctggtgttc
      421 cccagatgcc agaaggaaga tgccaacggc aatatcgtct atgagaggaa ctgcagaagt
      481 gatttggagc tggcttctga cccgtatgtc tacaactgga ccacaggggc agacgatgag
      541 gactgggaag acaacaccag ccaaggccag cacctcaggt tccccgacgg gaagcccttc
      601 cctcgccccc acggacggaa gaaatggaac ttcgtctacg tcttccacac acttggtcag
      661 tattttcaaa agctgggtca gtgttcagca cgagtttcta taaacacagt caacttgaca
      721 gttggccctc aggtcatgga agtgattgtc tttcgaagac acggccgggc atacattccc
      781 atctccaaag tgaaagacgt gtatgtgata acagatcaga tccctatatt cgtgaccatg
      841 taccagaaga atgaccggaa ctcgtctgat gaaaccttcc tcagagacct ccccattttc
      901 ttcgatgtcc tcattcacga tcccagtcat ttcctcaact actctgccat ttcctacaag
      961 tggaactttg gggacaacac tggcctgttt gtctccaaca atcacacttt gaatcacacg
     1021 tatgtgctca atggaacctt caactttaac ctcaccgtgc aaactgcagt gccgggacca
     1081 tgcccctcac ccacaccttc gccttcttct tcgacttctc cttcgcctgc atcttcgcct
     1141 tcacccacat tatcaacacc tagtccctct ttaatgccta ctggctacaa atccatggag
     1201 ctgagtgaca tttccaatga aaactgccga ataaacagat atggttactt cagagccacc
     1261 atcacaattg tagatggaat cctagaagtc aacatcatcc aggtagcaga tgtcccaatc
     1321 cccacactgc agcctgacaa ctcactgatg gacttcattg tgacctgcaa aggggccact
     1381 cccacggaag cctgtacgat catctctgac cccacctgcc agatcgccca gaacagggtg
     1441 tgcagcccgg tggctgtgga tgagctgtgc ctcctgtccg tgaggagagc cttcaatggg
     1501 tccggcacgt actgtgtgaa tttcactctg ggagacgatg caagcctggc cctcaccagc
     1561 gccctgatct ctatccctgg caaagaccta ggctcccctc tgagaacagt gaatggtgtc
     1621 ctgatctcca ttggctgcct ggccatgttt gtcaccatgg ttaccatctt gctgtacaaa
     1681 aaacacaaga cgtacaagcc aataggaaac tgcaccagga acgtggtcaa gggcaaaggc
     1741 ctgagtgttt ttctcagcca tgcaaaagcc ccgttctccc gaggagaccg ggagaaggat
     1801 ccactgctcc aggacaagcc atggatgctc taagtcttca ctctcacttc tgactgggaa
     1861 cccactcttc tgtgcatgta tgtgagctgt gcagaagtac atgactggta gctgttgttt
     1921 tctacggatt attgtaaaat gtatatcatg gtttagggag tgtagttaat tggcatttta
     1981 gtgaagggat gggaagacag tatttcttcg catctgtatt gtggttttta tactgttaat
     2041 agggtgggca cattgtgtct gaagggggag ggggaggtca ctgctactta aggtcctagg
     2101 ttaactggga gaggatgccc caggctcctt agatttctac acaagatgtg cctgaaccca
     2161 gctagtcctg acctaaaggc catgcttcat caactctatc tcagctcatt gaacatacct
     2221 gagcgcctga tggaattata atggaaccaa gcttgttgta tggtgtgtgt gtgtacataa
     2281 gatactcatt aaaaagacag tctattaaaa aaaaaaaaaa
//
