LOCUS       NM_138846               2089 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus glycoprotein m6b (Gpm6b), mRNA.
ACCESSION   NM_138846 XM_346871
VERSION     NM_138846.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Bang,M.L., Vainshtein,A., Yang,H.J., Eshed-Eisenbach,Y., Devaux,J.,
            Werner,H.B. and Peles,E.
  TITLE     Glial M6B stabilizes the axonal membrane at peripheral nodes of
            Ranvier
  JOURNAL   Glia 66 (4), 801-812 (2018)
   PUBMED   29282769
  REMARK    GeneRIF: Study identified glycoprotein M6B as a Schwann cell
            microvilli component of peripheral nodes of Ranvier. Study detected
            Na(+) channel clusters at heminodes without any associated M6B,
            indicating that it is not required for initial channel clustering;
            showed that absence of M6B results in progressive appearance of
            nodal protrusions of the nodal axolemma, that are often accompanied
            by the presence of enlarged mitochondria.
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Drabek,K., van de Peppel,J., Eijken,M. and van Leeuwen,J.P.
  TITLE     GPM6B regulates osteoblast function and induction of mineralization
            by controlling cytoskeleton and matrix vesicle release
  JOURNAL   J Bone Miner Res 26 (9), 2045-2051 (2011)
   PUBMED   21638316
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Fjorback,A.W., Muller,H.K. and Wiborg,O.
  TITLE     Membrane glycoprotein M6B interacts with the human serotonin
            transporter
  JOURNAL   J Mol Neurosci 37 (3), 191-200 (2009)
   PUBMED   18581270
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Shimokawa,N. and Miura,M.
  TITLE     Rhombex-29, a novel gene of the PLP/DM20-M6 family cloned from rat
            medulla oblongata by differential display
  JOURNAL   J Neurosci Res 62 (1), 1-8 (2000)
   PUBMED   11002282
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Yan,Y., Lagenaur,C. and Narayanan,V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_138846.3.
            
            On Nov 27, 2020 this sequence version replaced NM_138846.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB036421.1, SRR26643298.31580.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               JAXUCZ010000021.1  31732935-31733237   c
            304-490             JAXUCZ010000021.1  31706152-31706338   c
            491-647             JAXUCZ010000021.1  31703356-31703512   c
            648-819             JAXUCZ010000021.1  31698653-31698824   c
            820-893             JAXUCZ010000021.1  31695910-31695983   c
            894-959             JAXUCZ010000021.1  31694425-31694490   c
            960-2089            JAXUCZ010000021.1  31691909-31693038   c
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13-q14"
     gene            1..2089
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /note="glycoprotein m6b"
                     /db_xref="GeneID:192179"
                     /db_xref="RGD:620580"
     exon            1..303
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1040
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /note="Rhombex-29; rhombencephalic expression protein-29
                     kDa"
                     /codon_start=1
                     /product="neuronal membrane glycoprotein M6-b"
                     /protein_id="NP_620201.2"
                     /db_xref="GeneID:192179"
                     /db_xref="RGD:620580"
                     /translation="MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILC
                     FSGVALFCGCGHVALAGTVAILEQHFSTNTSDHALLSEVIQLMQYVIYGIASFFFLYG
                     IILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFM
                     FYNIWSTCEVIKSPQSNGTSGVEQICVDVRQYGIIPWNAFPGKICGSALENICNTNEF
                     YMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF"
     exon            304..490
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
     exon            491..647
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
     exon            648..819
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
     exon            820..893
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
     exon            894..959
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2089
                     /gene="Gpm6b"
                     /gene_synonym="M6b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgacgta tggtcgcctg ctccttggca gctgtcttta tggaccagta ggcagagcga
       61 aattgacgct gacaagactt tcgcgtcttg gaaggcactg taatctactg tagtgaagaa
      121 cagagcctct caatcaggcg ggtggaaata agagagacag aggggagtcc aaaagaaaag
      181 gaagaggagg gggaaaagtg tgtgttgtgg ggaagcaggg aaaagcattt ttggtggatg
      241 gtatgaagcc agccatggaa actgcagccg aggaaaatac tgaacaaagc caagagagaa
      301 aaggttgctt cgaatgctgc atcaagtgtc tgggaggagt tccctatgcc tccctagtgg
      361 ccaccatcct atgtttctcg ggagtcgcct tgttctgtgg ctgtggacat gtggctcttg
      421 caggcaccgt ggcaattctt gagcaacact tctccaccaa caccagtgac catgccttgc
      481 tgagcgaagt gatccaactg atgcagtatg tcatctatgg aatcgcgtcc tttttcttcc
      541 tgtacggtat cattctgctg gcagaaggct tctacaccac aagtgcagtg aaagagctgc
      601 acggtgagtt taaaacaact gcctgtggac gatgcatcag tggaatgttc gtgttcctca
      661 cctatgtgct gggagtggcc tggctgggtg tgttcggctt ttctgcagtg ccagtgttta
      721 tgttctacaa tatctggtca acctgtgaag tcatcaagtc cccacaaagc aatgggacct
      781 cgggtgtgga gcagatctgt gtggatgtcc ggcaatacgg tatcattcct tggaacgctt
      841 tcccaggcaa aatctgtggc tctgccctgg agaacatctg caacaccaat gagttctaca
      901 tgtcctatca tctgttcatt gtggcttgtg ctggagctgg tgccaccgtc attgccctgc
      961 tgatctacat gatggctact acatataact atgcggtttt gaagtttaag agtcgggaag
     1021 actgctgcac taagttctaa attgcataag gccaataagg agctatattt agagagctca
     1081 gctctgtagc gtgaacctca ctgacacttc agactaaagc ggagcctagg tttctgcagt
     1141 tcgctacagt aatttgtaaa tagcttcagt taactcactt tgcatggtag actaaatagg
     1201 acttactgta cgtgaattac aaaagaatgg ggtctgacta ttcccagttt gaaagggatt
     1261 gttatttact gacactggtg agcatccttt gaaaaataat tttcttaaac tctgagcata
     1321 agtatctcta agtgaaatat taacaccttg acacaccgtt tgtttttcca ttttgtttgc
     1381 ttgcttgata accagcctta gcgatggcca agagaacaag tgctgaaggc ggaaaggttg
     1441 aacctagctt tcattttgtc attcctttct agaaaagatt ttgcaagtag agttaaaatt
     1501 aagttgaaaa ggtctttata tcacatggtt ggctcactac caaataaatg ccaagttaga
     1561 caagataaaa atttgaaggc catcacccat ttgatttttc tgaaaaatga ttacatattt
     1621 ttgatacaac accattaagg tctttagaac ccacaaacct gataactttc aatcaccttg
     1681 ctacatagca actgttccct tacaactagg ttcttaaatt acatggaaga ttttcatgaa
     1741 gagaagttgg gcccagatct gagggtctca tctatgttga gaaggaagta tggcatgaga
     1801 aaggagtctg gcctttaagg aaactgagtt gtgcagattt gttttgggca aggggaaaat
     1861 acatgggaag gatgcatgtg ccacagaaac tgtaaagaat gataaggatt ttcatgtgaa
     1921 gtgaacttag aggaaatgaa atattggcag ttataaaagg aagaaaatag ttgctaaaaa
     1981 ttgtttacag actgcatatt tttaattttg gttttgacat tcatttaatt tctccatgtt
     2041 aaatatatac ttctataatc atttacgcaa aataaacatt ttttcacac
//
