LOCUS       NM_178105               3346 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glycoprotein m6a (Gpm6a), transcript variant 1,
            mRNA.
ACCESSION   NM_178105
VERSION     NM_178105.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Alzuri,S.E., Rosas,N.M., Hlavacova,N., Jezova,D. and Fuchsova,B.
  TITLE     Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in
            the hippocampus of chronically stressed rats
  JOURNAL   J Neurochem 165 (4), 603-621 (2023)
   PUBMED   36943192
  REMARK    GeneRIF: Role of miR-124-3p in regulatory mechanisms of Gpm6a
            expression in the hippocampus of chronically stressed rats.
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Aparicio,G.I., Leon,A., Gutierrez Fuster,R., Ravenscraft,B.,
            Monje,P.V. and Scorticati,C.
  TITLE     Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in
            Rat Dorsal Root Ganglion Neurons
  JOURNAL   Biomolecules 13 (4), 594 (2023)
   PUBMED   37189342
  REMARK    GeneRIF: Endogenous Glycoprotein GPM6a Is Involved in Neurite
            Outgrowth in Rat Dorsal Root Ganglion Neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Formoso,K., Garcia,M.D., Frasch,A.C. and Scorticati,C.
  TITLE     Evidence for a role of glycoprotein M6a in dendritic spine
            formation and synaptogenesis
  JOURNAL   Mol Cell Neurosci 77, 95-104 (2016)
   PUBMED   27793698
  REMARK    GeneRIF: Overexpression of M6a is accompanied by an increase in
            spine density, particularly in mature spines.
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Alvarez Julia,A., Frasch,A.C. and Fuchsova,B.
  TITLE     Neuronal filopodium formation induced by the membrane glycoprotein
            M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated
            kinase 1 (Pak1)
  JOURNAL   J Neurochem 137 (1), 46-61 (2016)
   PUBMED   26809475
  REMARK    GeneRIF: Formation of filopodia by membrane glycoprotein M6a
            (Gpm6a) requires actin regulator coronin-1a (Coro1a), known to
            regulate plasma membrane localization and activation of Rac1 and
            its downstream effector Pak1.
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Formoso,K., Garcia,M.D., Frasch,A.C. and Scorticati,C.
  TITLE     Filopodia formation driven by membrane glycoprotein M6a depends on
            the interaction of its transmembrane domains
  JOURNAL   J Neurochem 134 (3), 499-512 (2015)
   PUBMED   25940868
  REMARK    GeneRIF: we analyzed the functional contribution of transmembrane
            domains (TMDs) of the neuronal membrane glycoprotein M6a
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Cooper,B., Werner,H.B. and Flugge,G.
  TITLE     Glycoprotein M6a is present in glutamatergic axons in adult rat
            forebrain and cerebellum
  JOURNAL   Brain Res 1197, 1-12 (2008)
   PUBMED   18241840
  REMARK    GeneRIF: M6a is an axonal component of glutamatergic neurons and
            that it is localized to distinct sites of the axonal plasma
            membrane of pyramidal and granule cells
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Wu,D.F., Koch,T., Liang,Y.J., Stumm,R., Schulz,S., Schroder,H. and
            Hollt,V.
  TITLE     Membrane glycoprotein M6a interacts with the micro-opioid receptor
            and facilitates receptor endocytosis and recycling
  JOURNAL   J Biol Chem 282 (30), 22239-22247 (2007)
   PUBMED   17548356
REFERENCE   8  (bases 1 to 3346)
  AUTHORS   Alfonso,J., Fernandez,M.E., Cooper,B., Flugge,G. and Frasch,A.C.
  TITLE     The stress-regulated protein M6a is a key modulator for neurite
            outgrowth and filopodium/spine formation
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17196-17201 (2005)
   PUBMED   16286650
  REMARK    GeneRIF: M6a plays an important role in neurite outgrowth and
            filopodium/spine formation and may be, at least in part,
            responsible for plastic alterations found in the hippocampus of
            chronically stressed animals
REFERENCE   9  (bases 1 to 3346)
  AUTHORS   Mukobata,S., Hibino,T., Sugiyama,A., Urano,Y., Inatomi,A.,
            Kanai,Y., Endo,H. and Tashiro,F.
  TITLE     M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal
            differentiation
  JOURNAL   Biochem Biophys Res Commun 297 (4), 722-728 (2002)
   PUBMED   12359212
  REMARK    GeneRIF: M6a acts as a nerve growth factor-gated Ca(2+) channel in
            neuronal differentiation.
REFERENCE   10 (bases 1 to 3346)
  AUTHORS   Roussel,G., Trifilieff,E., Lagenaur,C. and Nussbaum,J.L.
  TITLE     Immunoelectron microscopic localization of the M6a antigen in rat
            brain
  JOURNAL   J Neurocytol 27 (9), 695-703 (1998)
   PUBMED   10447243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 23, 2021 this sequence version replaced NM_178105.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088862.1, SRR26360172.67833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               JAXUCZ010000016.1  43487205-43487812   c
            609-801             JAXUCZ010000016.1  43398838-43399030   c
            802-958             JAXUCZ010000016.1  43388857-43389013   c
            959-1112            JAXUCZ010000016.1  43382361-43382514   c
            1113-1189           JAXUCZ010000016.1  43379016-43379092   c
            1190-1255           JAXUCZ010000016.1  43378409-43378474   c
            1256-3346           JAXUCZ010000016.1  43374385-43376475   c
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..3346
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /note="glycoprotein m6a"
                     /db_xref="GeneID:306439"
                     /db_xref="RGD:631368"
     exon            1..608
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..1408
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal membrane glycoprotein M6-a"
                     /codon_start=1
                     /product="neuronal membrane glycoprotein M6-a isoform 1"
                     /protein_id="NP_835206.1"
                     /db_xref="GeneID:306439"
                     /db_xref="RGD:631368"
                     /translation="MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFC
                     GCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVE
                     GFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWT
                     ICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVAL
                     AGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNA
                     YT"
     exon            609..801
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
     exon            802..958
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1112
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1189
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1255
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..3346
                     /gene="Gpm6a"
                     /gene_synonym="M6a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaatgaatc tgactgggtg agcagaaact actgcagcag aaagacagga tgagaatctg
       61 ggctttccca ctgtggtagc aatgggggga attatgggtt ggtggtccgc ttcatgctag
      121 gaggacaccc ctccatctgt tcacagttca gcctgcttcc agtttaaagc cgagatttca
      181 acacaaacct caatttcttt cccccatttt aaatgcaaag cgaggcttgt gaatcacagt
      241 gcctctgctc ctagcatcca gacccctttc cactccccct cccaaaatta tccggctgtt
      301 tgtttgagta cctgcttact gtggcacaca ataggcagct ttgagaagaa aaattgataa
      361 tcttcacgga agagtaattt gaatgaaatt acacttgaca gccagcctct aagcaaacaa
      421 gaggcgcgag ggagcttcag ctaagctcca aggacttgcc caagccactg ctgctggagc
      481 tgcccaggga aaaaaagcac tcgctttttt taacatctaa ttgagctttt gactaattcc
      541 gtgcaccaga ttctcctgaa gaaaggtagc catggaagag aatatggaag aaggacagac
      601 acaaaaaggg tgttttgagt gctgcattaa atgcctggga ggtattccct atgcttctct
      661 gattgctacc atcctgctgt atgcaggcgt tgccctgttc tgtggctgtg gtcatgaagc
      721 cctttctgga acagtcaaca ttctgcagac ctactttgag atggcaagaa ctgctggaga
      781 cacactggat gtttttacca tgattgatat ctttaagtat gtgatctacg gcattgcggc
      841 tgctttcttt gtctatggca ttttactgat ggtggaaggt ttcttcacaa ctggggccat
      901 caaagatctc tatggggact tcaaaatcac cacctgtggc agatgtgtga gcgcttggtt
      961 tatcatgctg acatacctct tcatgttggc ctggctggga gtcacagctt ttacctcact
     1021 gccagtgtac atgtatttca acgtgtggac catctgccgg aatactacac tcgtggaggg
     1081 agcaaatctc tgcttggacc ttcgtcagtt tgggattgtg acaattggag aggaaaagaa
     1141 aatttgtact gtctctgaga acttcctgag gatgtgtgaa tctactgagc tgaacatgac
     1201 cttccacttg ttcattgtgg cccttgctgg agcaggagca gcagttattg ctatggttca
     1261 ctaccttatg gttctgtctg ccaactgggc ctatgtgaaa gatgcctgcc ggatgcagaa
     1321 gtatgaagac atcaagtcaa aggaggagca agagcttcat gacattcatt ccacccgctc
     1381 caaagagcgg ctcaatgcat acacataaat aagtttcatt gttccttccc atttgaatgc
     1441 attggtgttt aattaagggc catccaacca tccaatctgt gaaaagcaaa acaaagagtg
     1501 cttctcatca aagatatgta gggtgactaa tgaatcacct gagtataact ctttcctggt
     1561 tagcattcaa tctcctaatt tgttaaattg gaatagccaa ctctcttcta caagctccta
     1621 ttcagtcttt tgttttaact ctcaaactga tttagttatt ctgtaagatc aaagatatta
     1681 acattgtcac atgcaaatac ttgtttgatt tttaatcacc tcccacatat cacacataac
     1741 acttttttca ttgtttctta tgttttgaaa gagaaaatag ctttttatac attttagttt
     1801 tgatttcagt aactagttta actacaggta accttcaaag ggaccattgt acattatgaa
     1861 caagtgacag aaatgacatc atgatcactc ttcttgatat gggaatctag tctggagatc
     1921 agtggccaca tggctattgg ccctggttaa tgttttcatc aatctaaggt gcaatttcta
     1981 aatttataag ggtaggttaa aaaaagtgct tcttatcttt gttaacattg tatttttttc
     2041 tttgatgtac ttaaaaggta tttctctgat tactcatgtt tatgttgtga gcatgtagaa
     2101 acagtaatgc taatgcatgg ccagttgcct ttctaagatt gtgacactgg gcttaccttt
     2161 taaagtttag tatagaaaca attatcatgg aaataactac tgtggactgt tggagaatga
     2221 tctttttgtg acttatgcag tggctggatt ggatctttta atatgctaat gtggaaaatt
     2281 aattaccttt atgaaggtgg tatcttaaac ataagcacac taaaccctca agacttgttt
     2341 tacccactta aaacttttaa tggattgcac ctctgtaagc tatttcttaa aatgtgtatg
     2401 atatatttga aaagacttcc attaatataa tagctttgct tgcagccttc caatctatgt
     2461 tggtttacct gtagtgtttt ctaaagggtg gtcagaggcc actagagaat gtattgtttt
     2521 ggagtgtagt gatatatttt gtggttttat ttcaagtaag tcattttaac cgaatgttca
     2581 ttcatattca tttataagaa gtacctatat cagaccaatt ttaaaagaaa aacaatcagt
     2641 attaatggac caaatttcgt gtttgtttta acctggactc tcttttgatt atttctaatg
     2701 ctacaagaat gctgtgaatg tcatttaaaa taatgatgta gcctgacaag aaattctgtc
     2761 agtgtataaa cctaggtagt attgtgcact gatttgacca ttgtgaaatc ctccttcagt
     2821 gtaagtgcat tcccaataaa atttattgag tgaaacaatc tttgtacaac tactagtcat
     2881 gcatcatcag taattttaca agttcttgta gtaggtaggg ggtattacta gcgttatctg
     2941 tggcatgatt atgcattctg taatattaat tttggggtcc ttttgctttt ttaacactta
     3001 gattatctta atggttcaac attttttctg acatatgcag tattaaagat attcagcaaa
     3061 agtattaatg ggcttcttta aattctatat tatagtgttt cagttctgtg tctacagtgt
     3121 gtaatgattt ttaaaactgt cttttaaatt tatgtagtga tgttgacatt ttggctttta
     3181 tttctggttt tagagtttgt attttcatgg agtgctttgt agcaggcatt acaagtaatc
     3241 tgttttgtac ataaatgtgc caacagcttg atggtggcgt ttttgaaatg tagaacaaag
     3301 tgcttgcaaa atgtaataaa tactcttgtg tactttgtgt atttaa
//
