LOCUS       NM_001100512            3212 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glycosylphosphatidylinositol specific
            phospholipase D1 (Gpld1), mRNA.
ACCESSION   NM_001100512 XM_001070303 XM_214480
VERSION     NM_001100512.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3212)
  AUTHORS   Masuda,S., Fujishima,Y., Maeda,N., Tsugawa-Shimizu,Y., Nakamura,Y.,
            Tanaka,Y., Obata,Y., Fukuda,S., Nagao,H., Kita,S., Nishizawa,H. and
            Shimomura,I.
  TITLE     Impact of glycosylphosphatidylinositol-specific phospholipase D on
            hepatic diacylglycerol accumulation, steatosis, and insulin
            resistance in diet-induced obesity
  JOURNAL   Am J Physiol Endocrinol Metab 316 (2), E239-E250 (2019)
   PUBMED   30457913
  REMARK    GeneRIF: GPI-PLD directly regulates intracellular diacylglycerol
            content in rat primary hepatocytes.
REFERENCE   2  (bases 1 to 3212)
  AUTHORS   Raikwar,N.S., Bowen-Deeg,R.F., Du,X.S., Low,M.G. and Deeg,M.A.
  TITLE     Glycosylphosphatidylinositol-specific phospholipase D improves
            glucose tolerance
  JOURNAL   Metabolism 59 (10), 1413-1420 (2010)
   PUBMED   20153004
REFERENCE   3  (bases 1 to 3212)
  AUTHORS   Tang,J.H., He,W.J., Huang,H., Tan,C.C., Duan,Q., Wang,K.J.,
            Yuan,X.Y. and Zhu,X.J.
  TITLE     Important roles of glycosylphosphatidylinositol (GPI)-specific
            phospholipase D and some GPI-anchored proteins in the pathogenesis
            of hepatocellular carcinoma
  JOURNAL   Clin Biochem 42 (4-5), 400-407 (2009)
   PUBMED   19135435
REFERENCE   4  (bases 1 to 3212)
  AUTHORS   Gray,D.L., O'Brien,K.D., D'Alessio,D.A., Brehm,B.J. and Deeg,M.A.
  TITLE     Plasma glycosylphosphatidylinositol-specific phospholipase D
            predicts the change in insulin sensitivity in response to a low-fat
            but not a low-carbohydrate diet in obese women
  JOURNAL   Metabolism 57 (4), 473-478 (2008)
   PUBMED   18328347
REFERENCE   5  (bases 1 to 3212)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   6  (bases 1 to 3212)
  AUTHORS   Schofield,J.N., Stephens,J.W., Hurel,S.J., Bell,K.M., deSouza,J.B.
            and Rademacher,T.W.
  TITLE     Insulin reduces serum glycosylphosphatidylinositol phospholipase D
            levels in human type I diabetic patients and streptozotocin
            diabetic rats
  JOURNAL   Mol Genet Metab 75 (2), 154-161 (2002)
   PUBMED   11855934
REFERENCE   7  (bases 1 to 3212)
  AUTHORS   LeBoeuf,R.C., Caldwell,M., Guo,Y., Metz,C., Davitz,M.A., Olson,L.K.
            and Deeg,M.A.
  TITLE     Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1)
            characterization
  JOURNAL   Mamm Genome 9 (9), 710-714 (1998)
   PUBMED   9716655
REFERENCE   8  (bases 1 to 3212)
  AUTHORS   Metz,C.N., Zhang,Y.Y., Guo,Y., Tsang,T.C., Kochan,J.P.,
            Altszuler,N. and Davitz,M.A.
  TITLE     Production of the glycosylphosphatidylinositol-specific
            phospholipase D by the islets of Langerhans
  JOURNAL   J Biol Chem 266 (27), 17733-17736 (1991)
   PUBMED   1833386
REFERENCE   9  (bases 1 to 3212)
  AUTHORS   Stieger,S., Diem,S., Jakob,A. and Brodbeck,U.
  TITLE     Enzymatic properties of phosphatidylinositol-glycan-specific
            phospholipase C from rat liver and
            phosphatidylinositol-glycan-specific phospholipase D from rat serum
  JOURNAL   Eur J Biochem 197 (1), 67-73 (1991)
   PUBMED   1849823
  REMARK    Erratum:[Eur J Biochem 1991 Sep 15;200(3):812]
REFERENCE   10 (bases 1 to 3212)
  AUTHORS   Davitz,M.A., Hom,J. and Schenkman,S.
  TITLE     Purification of a glycosyl-phosphatidylinositol-specific
            phospholipase D from human plasma
  JOURNAL   J Biol Chem 264 (23), 13760-13764 (1989)
   PUBMED   2760042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ308109.1, CO393645.1, CO571976.1 and CO571457.1.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_214480.2, XM_001070303.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ308109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1945              AJ308109.1         1-1945
            1946-2216           CO393645.1         491-761
            2217-2786           CO571976.1         46-615
            2787-3212           CO571457.1         23-448              c
FEATURES             Location/Qualifiers
     source          1..3212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..3212
                     /gene="Gpld1"
                     /note="glycosylphosphatidylinositol specific phospholipase
                     D1"
                     /db_xref="GeneID:291132"
                     /db_xref="RGD:631371"
     exon            1..108
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..2543
                     /gene="Gpld1"
                     /EC_number="3.1.4.50"
                     /note="phosphatidylinositol-glycan-specific phospholipase
                     D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D;
                     glycoprotein phospholipase D;
                     glycosyl-phosphatidylinositol-specific phospholipase D;
                     glycosylphosphatidylinositol phospholipase D"
                     /codon_start=1
                     /product="phosphatidylinositol-glycan-specific
                     phospholipase D precursor"
                     /protein_id="NP_001093982.1"
                     /db_xref="GeneID:291132"
                     /db_xref="RGD:631371"
                     /translation="MSVGRLWSGLLLLLLFFCSRSSSCGLSTHVEIGHRALQFLQLQD
                     GRINYKELLLEHQDAYQAGTVFPDAFYPSICKQGKFHEVSESTHWTPFLNASIHYIRE
                     NYPLPWEKDTEKLVAFLFGVTSHMVADVSWHSLGIEQGFLRTMGAIDFYDSYSEAHSA
                     GDFGGDVLSQFEFNFNYLSRRWYVPIQDLLRIYDNLYGRKVITKNVIVDCTYLQFLEM
                     HGEMLAVSKLYSTYSTKSPFLVEQFQDYFLGGLDDMAFWSTNIYRLTSFMLENGTSDC
                     NLPENPLFISCDGRKNHTLSSSKVQKNDFHRNLTMFISKDIRKNLNYTERGVFYSTGS
                     WAPESVTFMYQTLERNLRMMFTGNSQTALKHVSSPSASYTLSVPYARLGWVMASADLN
                     QDGHGDLVVGAPGYSHPGRFQIGRVYIIYGNDLGLPPIDLDLDKEAHGVLEGFQPSGR
                     FGSALAVLDFNKDGLPDLAVGAPSVGSGQLTYNGSVYVYYGSQQGRLSSSPNITISCK
                     DTYCNLGWALLAADADGDGQHDLVISSPFAPGGGKQRGIVAAFYSHPRRNDKESLTLD
                     EADWKVNGEEDFSWFGYSLHGVTVANRSLLLIGSPTWKNISRMARSSHQKNQEKKSLG
                     RVYGYFPPNRQREITISGDKAMGKLGTSLSSGYVRVNGTLTQVLLVGAPTHDDVSKMA
                     FLTMTLHQGGATRMYELAPEKTQPALLSTFSGDRRFSRFGSVLHLTDLDDDGLDEIIM
                     AAPLRITDVTSGLLGGEDGRVYIYNGMHTTLGDVTGKCKSWMTPCPEEKAQYVLISPE
                     ASSRFGSSLVSVRSKERNQVVVAAGRSSWGARLSGALHVYSFSSD"
     exon            109..164
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..243
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..341
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..452
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..501
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..556
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..664
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..692
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..832
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..898
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1022
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1162
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1349
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1460
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1535
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1692
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1834
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1943
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2037
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2217
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2378
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2405
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2456
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..3188
                     /gene="Gpld1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaatgacaa catgtctgta ggcaggctgt ggtctggcct gctgctcctg ctgctttttt
       61 tctgctctag aagttcatct tgtggtctct caacacatgt agaaatagga cacagggctc
      121 tgcagttcct tcagcttcaa gatggacgca ttaactacaa agagctgctc ttagaacacc
      181 aggatgcata tcaggcaggg acggtgtttc ctgatgcctt ttaccctagc atctgcaaac
      241 aaggaaaatt ccatgaagtg tctgagagta ctcactggac tccatttctt aatgccagca
      301 ttcattatat tcgggagaac taccctctgc cctgggagaa ggacacagag aagttggtgg
      361 ctttcttgtt tggagtcacc tcccacatgg tcgctgatgt cagctggcac agcctgggta
      421 ttgaacaagg gttcctcagg acaatgggag ctattgattt ttacgactct tattctgagg
      481 ctcattcggc tggtgatttt ggaggagatg tgttgagcca gtttgaattt aattttaatt
      541 acctctcacg gcgctggtac gtgcccatcc aagatcttct gagaatttat gataatctct
      601 acggtcggaa agtcatcacc aagaatgtca ttgttgattg cacatacctt cagttcctgg
      661 aaatgcacgg ggagatgcta gctgtttcca agctctattc cacatactct acgaagtccc
      721 catttctggt ggaacagttc caagactatt tcctcggagg tctagatgac atggccttct
      781 ggtccacgaa catttaccgt ttgaccagct ttatgctgga gaacgggacc agtgactgca
      841 acctgcctga gaaccctctg ttcatctcct gtgatggtag gaagaaccac accctcagca
      901 gctcaaaagt gcagaaaaat gattttcaca ggaatttgac catgtttata agtaaagaca
      961 tcaggaaaaa cctcaactac acagaaagag gcgtgttcta cagcacaggc tcctgggccc
     1021 cggaatccgt aacctttatg taccagactc tggagaggaa cctgaggatg atgtttactg
     1081 gcaactctca gacagctctg aagcatgtct ccagtccctc tgcctcctac accctgtctg
     1141 tcccctatgc caggctcggc tgggtcatgg cctcagctga cctcaaccag gatgggcacg
     1201 gcgacctcgt ggtgggtgca ccaggctaca gccaccctgg ccgcttccag atcgggcggg
     1261 tgtacatcat ctatggcaat gatttgggcc tgccccccat cgacctggac ttagacaagg
     1321 aggctcatgg ggtcctggag ggcttccagc cttcaggtcg ctttggctca gctttggcag
     1381 tgctggactt caacaaggat gggctgcctg atctggctgt gggtgctccc tccgtgggct
     1441 cagggcagct cacctacaat ggctctgtgt atgtctacta tggttcccag caagggaggt
     1501 tgtcttcttc ccctaacatc accatctcct gcaaggacac ctactgtaat ttgggctggg
     1561 ctctcttggc agcagacgca gatggagatg gccagcatga tctggtgatc agttcacctt
     1621 ttgcaccagg tggagggaag cagagaggaa ttgtggctgc cttttattca caccccagac
     1681 ggaacgacaa agagtcactg actttggacg aagctgactg gaaggtgaac ggggaggagg
     1741 acttctcatg gtttggatac tcccttcatg gggtcacagt ggcaaacaga agcctgctgc
     1801 tgattgggag cccgacctgg aagaatatca gcaggatggc acgctcaagc caccaaaaga
     1861 accaagagaa aaagagcctg ggaagggtgt atggctactt ccccccaaac cggcagaggg
     1921 aaatcactat ctcgggagat aaggcaatgg gaaagctggg tacatccctg tccagtggtt
     1981 atgtgagggt gaatggcacc ctaacccaag tcctgctggt tggagcccct actcatgatg
     2041 acgtgtctaa aatggcattc ctaaccatga ccctgcacca gggtggagcc actcggatgt
     2101 acgagctagc ccctgagaag acacagcctg ctctgctcag caccttcagc ggagaccgac
     2161 gtttttctcg atttggtagt gttctacacc tgacagacct ggatgacgat ggcttagatg
     2221 aaatcatcat ggctgcccca ctgaggataa cagatgtcac ttctggactg cttgggggag
     2281 aagatgggcg agtgtacatt tataatggca tgcataccac cttaggtgat gtgacaggca
     2341 aatgcaagtc ctggatgact ccatgtccag aggagaaggc ccagtatgtg ctaatttctc
     2401 cagaggcaag ttcaaggttt gggagctcac tggtgtctgt gcggtctaag gaaaggaacc
     2461 aagtggtcgt tgctgctgga aggagttctt ggggagcccg gctctctggg gcacttcacg
     2521 tctacagctt cagctcagat tgaagatgtc atctcctaat cagcccgtct cttcagcaag
     2581 tcatctccat gatggccaaa gtagttctcc agaggagctc tggtgaaacc tgacagaggt
     2641 ggggctcctg gacagccagg ctacccggaa atgcggtcag ctctgtgtgg acactggatg
     2701 agagggagca gcaggctttg agggcaagtc cctctaaagt gcttttgaat cctctgagct
     2761 tgctgcctgt gcgtgggact ttatcaaccc accccctttt ctgcggcatt acctgcctct
     2821 ctagtgtaga aagggtgtag ttagctctta acattctcca tataattgct cctataaaat
     2881 ccttcttcgt ggtggctggt cctatttgga tcttaaatgt accccaaatc tatgttgaag
     2941 gcttggccct tagcttaaag aaggtaggaa ctgaagtggg tctttgtcgg aggaagttat
     3001 gttactgggg tgtatcagga ccccaggtcc ttccttgcct ctccactgcc agttgctgtg
     3061 aaatgagcag ctctcctccg ccatgacata gtgcttcttt cccagcccca aagcaaaggg
     3121 ccaagcaccc tggagctgac ttggctgaaa ctgagccaaa ataaacattt cctcttttta
     3181 ggctgttaaa aaaaaaaaaa aaaaaaaaaa aa
//
