LOCUS       NM_001130547            2080 bp    mRNA    linear   ROD 15-JAN-2024
DEFINITION  Rattus norvegicus glycosylphosphatidylinositol anchored high
            density lipoprotein binding protein 1 (Gpihbp1), mRNA.
ACCESSION   NM_001130547 XM_001074228 XM_216955
VERSION     NM_001130547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Yuan C, Xu Y, Lu G, Hu Y, Mao W, Ke L, Tong Z, Xia Y, Ma S, Dong X,
            Xian X, Wu X, Liu G, Li B and Li W.
  TITLE     AAV-mediated hepatic LPL expression ameliorates severe
            hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient
            mice and rats
  JOURNAL   Mol Ther 32 (1), 59-73 (2024)
   PUBMED   37974401
  REMARK    GeneRIF: AAV-mediated hepatic LPL expression ameliorates severe
            hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient
            mice and rats.
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB,
            Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG,
            Jorgensen TJD, Fong LG and Ploug M.
  TITLE     A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine
            regulates lipoprotein lipase
  JOURNAL   Proc Natl Acad Sci U S A 115 (26), E6020-E6029 (2018)
   PUBMED   29899144
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Chiu AP, Wan A, Lal N, Zhang D, Wang F, Vlodavsky I, Hussein B and
            Rodrigues B.
  TITLE     Cardiomyocyte VEGF Regulates Endothelial Cell GPIHBP1 to Relocate
            Lipoprotein Lipase to the Coronary Lumen During Diabetes Mellitus
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (1), 145-155 (2016)
   PUBMED   26586663
  REMARK    GeneRIF: Cardiomyocyte VEGF activates EC Notch signaling,
            facilitating GPIHBP1-mediated translocation of LPL across EC and
            regulating LPL-derived fatty acid delivery to the cardiomyocytes.
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Davies BS, Beigneux AP, Barnes RH 2nd, Tu Y, Gin P, Weinstein MM,
            Nobumori C, Nyren R, Goldberg I, Olivecrona G, Bensadoun A, Young
            SG and Fong LG.
  TITLE     GPIHBP1 is responsible for the entry of lipoprotein lipase into
            capillaries
  JOURNAL   Cell Metab 12 (1), 42-52 (2010)
   PUBMED   20620994
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel
            AW, Bensadoun A, Kastelein JJ, Fong LG, Dallinga-Thie GM and
            Beigneux AP.
  TITLE     Chylomicronemia with low postheparin lipoprotein lipase levels in
            the setting of GPIHBP1 defects
  JOURNAL   Circ Cardiovasc Genet 3 (2), 169-178 (2010)
   PUBMED   20124439
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Sonnenburg WK, Yu D, Lee EC, Xiong W, Gololobov G, Key B, Gay J,
            Wilganowski N, Hu Y, Zhao S, Schneider M, Ding ZM, Zambrowicz BP,
            Landes G, Powell DR and Desai U.
  TITLE     GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition
            by angiopoietin-like 3 and angiopoietin-like 4
  JOURNAL   J Lipid Res 50 (12), 2421-2429 (2009)
   PUBMED   19542565
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J,
            Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ,
            Fong LG, Dallinga-Thie GM and Young SG.
  TITLE     Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind
            lipoprotein lipase
  JOURNAL   Arterioscler Thromb Vasc Biol 29 (6), 956-962 (2009)
   PUBMED   19304573
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Gin P, Beigneux AP, Davies B, Young MF, Ryan RO, Bensadoun A, Fong
            LG and Young SG.
  TITLE     Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to
            GPIHBP1 containing a G56R amino acid substitution
  JOURNAL   Biochim Biophys Acta 1771 (12), 1464-1468 (2007)
   PUBMED   17997385
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X,
            Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford
            K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun
            A and Young SG.
  TITLE     Glycosylphosphatidylinositol-anchored high-density
            lipoprotein-binding protein 1 plays a critical role in the
            lipolytic processing of chylomicrons
  JOURNAL   Cell Metab 5 (4), 279-291 (2007)
   PUBMED   17403372
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y,
            Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J,
            Fujino T and Yamamoto TT.
  TITLE     Expression cloning and characterization of a novel
            glycosylphosphatidylinositol-anchored high density
            lipoprotein-binding protein, GPI-HBP1
  JOURNAL   J Biol Chem 278 (9), 7344-7349 (2003)
   PUBMED   12496272
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_001074228.1, XM_216955.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM074338.1, FM085308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2080
                     /gene="Gpihbp1"
                     /gene_synonym="RGD1564237"
                     /note="glycosylphosphatidylinositol anchored high density
                     lipoprotein binding protein 1"
                     /db_xref="GeneID:300027"
                     /db_xref="RGD:1564237"
     exon            1..90
                     /gene="Gpihbp1"
                     /gene_synonym="RGD1564237"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..749
                     /gene="Gpihbp1"
                     /gene_synonym="RGD1564237"
                     /note="GPI-anchored HDL-binding protein 1"
                     /codon_start=1
                     /product="glycosylphosphatidylinositol-anchored high
                     density lipoprotein-binding protein 1 precursor"
                     /protein_id="NP_001124019.1"
                     /db_xref="GeneID:300027"
                     /db_xref="RGD:1564237"
                     /translation="MKALRAVLLILLLSGQPGSSWAQEAGDVDLELERYSYDDDGDDD
                     DDDDEEEEEEETNMIPGSRDRAPPLQCYFCQVLHSGESCNETQSCSSSKPFCITVISH
                     GKTDTGVLTTYSMWCTDTCQPIVKTVDSTQMTQTCCQSTLCNIPPWQSPQIHNPLGGR
                     ADSPLKGGTRHPQGDRFSHPQVVKVTHPQSDGAHLSKGGKANQPQGNGAGFPAGWSKF
                     GNVVLLLTFLTSLWASGA"
     exon            91..234
                     /gene="Gpihbp1"
                     /gene_synonym="RGD1564237"
                     /inference="alignment:Splign:2.1.0"
     exon            235..354
                     /gene="Gpihbp1"
                     /gene_synonym="RGD1564237"
                     /inference="alignment:Splign:2.1.0"
     exon            355..2080
                     /gene="Gpihbp1"
                     /gene_synonym="RGD1564237"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggactgc accagtggac agaacagcct gagtcaggat gaaagctctc agggctgtcc
       61 tcctgatctt gctactcagt ggacagccag ggagcagctg ggcacaagaa gctggcgatg
      121 tggacctgga gctagagcgc tacagctacg atgatgacgg tgatgacgat gatgacgatg
      181 atgaagaaga ggaagaggag gagaccaaca tgatccctgg cagcagggac agagcaccgc
      241 ctctacagtg ctacttctgc caagtgcttc acagcgggga gagctgcaac gagacacaga
      301 gctgctccag cagcaagccc ttctgtatca cagtcatctc ccatggcaaa actgacacag
      361 gtgtcctgac gacctactcc atgtggtgta ctgatacctg ccagcccatc gtgaagacag
      421 tggacagcac ccaaatgacc cagacctgtt gccagtccac actctgcaat attccaccct
      481 ggcagagccc ccaaatccac aaccctctgg gtggccgggc agacagcccc ttgaagggtg
      541 ggaccagaca tcctcaaggt gacaggttta gccaccccca ggttgtcaag gttactcatc
      601 ctcagagcga tggggctcac ttgtctaagg gtggcaaggc taaccagccc cagggaaatg
      661 gggccggatt ccctgcaggc tggagcaaat ttggtaacgt agttctcctg ctcaccttcc
      721 tcaccagtct gtgggcatca ggggcctaaa gacccgtcct cccccaacca ggacccttca
      781 gcctttcctc cctgacaacc agcttcagag aataaacttg aatgtctttt gccatctagc
      841 cagttgctac tccttcggcc attccctgcc ctcagtttca ccctcaggcc tccttgcctt
      901 cttctcttct cagcccgtgg gtgggtaaca tgtcagcctc agatctggct gtctgttgcc
      961 tgtgctgtgg ggacgttcag cctacagggg ccccatctgc tcagctacgc agaaaaaata
     1021 acaagcctca aaggctcatt ctcatcttga atttgccagc acgaaattct ccccgctaga
     1081 gccaccatct agagaaaatc agcccttacg tgtggggtgc agggtgagcc tccagagacc
     1141 tgaagggagg aggtgttgga aggaaaccaa gagtgttgca gggctgaaat acaatggctg
     1201 cagctaaggg agggagggag gcagagaggg taaggaaggc ctggctgctc agtaggggat
     1261 tcttcagctg tggcctggca cagaaatcca tcctcttctg ggttctagaa cctctcttct
     1321 agcgtaggcc tccaagagga tgctgggagc acaagatgga ccacacatct gggaaatgtc
     1381 acagagcccc aagaactcct taggcagaga aatagatggg actcccatcc ctgcctgggg
     1441 gcatgggtac cttctctggt gaggagaggc ccctaggagg tagcatctcc ttgagtcatc
     1501 agggaacctg gcttcttggc aggagggccc atctttgact gagtacagct cctttggctg
     1561 agctcttggc ttccgtgact gcatcaagct agacctccac cagcagctgg tgccagagca
     1621 gatctctggg gtaggaaaaa gaccatgccc ggaccactgc tccactgctg acttggatag
     1681 aactcagttt cccccacttg tgcaacaagc agacggcttg agggactccc aggtccacag
     1741 tagctcagcg ttgcaaaact agaagtctag agtccttgcc taaaagctga gtttgtttgt
     1801 tggcatgcaa taagaaatcc ctattctagc ttatctctcc tgttcctgtt aataaagcat
     1861 ctgtgccaag ccaggctgta caaggccaga gctcttgagt ggaggaggca cctcttcctc
     1921 tgtccccttt ctccttcctg ctgactggaa ctcagcagcc ctttctacca caaggaagca
     1981 ccatgcagtg gcaaggggac atgggagaag gttctggaac accagtaaac aaggcattgc
     2041 accgtgtacc tcaggagggg aagtaaactc ccttgttgaa
//
