LOCUS       NM_207592               2130 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glucose-6-phosphate isomerase (Gpi), mRNA.
ACCESSION   NM_207592 XM_214908
VERSION     NM_207592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Mojzikova,R., Koralkova,P., Holub,D., Saxova,Z., Pospisilova,D.,
            Prochazkova,D., Dzubak,P., Horvathova,M. and Divoky,V.
  TITLE     Two novel mutations (p.(Ser160Pro) and p.(Arg472Cys)) causing
            glucose-6-phosphate isomerase deficiency are associated with
            erythroid dysplasia and inappropriately suppressed hepcidin
  JOURNAL   Blood Cells Mol Dis 69, 23-29 (2018)
   PUBMED   28803808
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Keighren,M.A., Flockhart,J.H. and West,J.D.
  TITLE     Survival of glucose phosphate isomerase null somatic cells and germ
            cells in adult mouse chimaeras
  JOURNAL   Biol Open 5 (5), 596-610 (2016)
   PUBMED   27103217
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Tian,K., Zhong,W., Zheng,X., Zhang,J., Liu,P., Zhang,W. and Liu,H.
  TITLE     Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes
            Proliferation of Articular Chondrocytes through Activation of AKT
            and Smad2/3
  JOURNAL   Sci Rep 5, 15101 (2015)
   PUBMED   26459914
  REMARK    GeneRIF: Neuroleukin/Autocrine Motility Factor Receptor Pathway
            Promotes Proliferation of Articular Chondrocytes through Activation
            of AKT and Smad2/3
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Wang,Y., Ha,S.W., Zhang,T., Kho,D.H., Raz,A. and Xie,Y.
  TITLE     Polyubiquitylation of AMF requires cooperation between the gp78 and
            TRIM25 ubiquitin ligases
  JOURNAL   Oncotarget 5 (8), 2044-2051 (2014)
   PUBMED   24810856
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Merkle,S. and Pretsch,W.
  TITLE     A glucosephosphate isomerase (GPI) null mutation in Mus musculus:
            evidence that anaerobic glycolysis is the predominant energy
            delivering pathway in early post-implantation embryos
  JOURNAL   Comp Biochem Physiol B 101 (3), 309-314 (1992)
   PUBMED   1582174
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Malini,T. and Vanithakumari,G.
  TITLE     Comparative study of the effects of beta-sitosterol, estradiol and
            progesterone on selected biochemical parameters of the uterus of
            ovariectomised rats
  JOURNAL   J Ethnopharmacol 36 (1), 51-55 (1992)
   PUBMED   1501493
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Kozak,C., Nichols,E. and Ruddle,F.H.
  TITLE     Gene linkage analysis in the mouse by somatic cell hybridization:
            assignment of adenine phosphoribosyltransferase to chromosome 8 and
            alpha-galactosidase to the X chromosome
  JOURNAL   Somatic Cell Genet 1 (4), 371-382 (1975)
   PUBMED   1235912
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   Nichols,E.A. and Ruddle,F.H.
  TITLE     Polymorphism and linkage of glutathione reductase in Mus musculus
  JOURNAL   Biochem Genet 13 (5-6), 323-329 (1975)
   PUBMED   1180875
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062005.1.
            
            On Aug 30, 2004 this sequence version replaced XM_214908.2.
            
            Summary: This gene encodes a member of the glucose phosphate
            isomerase protein family. A similar protein in human and mouse has
            been identified as a moonlighting protein based on its ability to
            perform mechanistically distinct functions. In the cytoplasm, the
            gene product functions as a glycolytic enzyme (glucose-6-phosphate
            isomerase) that interconverts glucose-6-phophsate and
            fructose-6-phosphate. Extracellularly, the protein (also referred
            to as neuroleukin) functions as a neurotrophic factor that promotes
            survival of skeletal motor neurons and sensory neurons, and as a
            lymphokine that induces immunoglobulin secretion. The protein is
            also referred to as autocrine motility factor based on an
            additional function as a tumor-secreted cytokine and angiogenic
            factor. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062005.1, SRR8487226.141163.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: inferred from conservation
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2130
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /note="glucose-6-phosphate isomerase"
                     /db_xref="GeneID:292804"
                     /db_xref="RGD:2727"
     exon            1..188
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1743
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /EC_number="5.3.1.9"
                     /note="autocrine motility factor"
                     /codon_start=1
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="NP_997475.1"
                     /db_xref="GeneID:292804"
                     /db_xref="RGD:2727"
                     /translation="MAALTRNPEFQKLLEWHRANSANLKLRELFEADPERFNHFSLNL
                     NTNHGHILLDYSKNLVNKEVLHMLVDLAKSRGVEAARDNMFSGLKINSTEDRAVLHVA
                     LRNRSNRSIMMDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKAITDIINIGIGGS
                     DLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLANLNPESSLFIIASKTFTTQET
                     ITNAETAKEWFLQAAKDPSAVAKHFVALSTNTDKVKEFGIDPKNMFEFWDWVGGRYSL
                     WSAIGLSIALHVGFDHFEQLLSGAHWMDQHFMKTPLDKNAPVLLALLGIWYINFYGCE
                     THAMLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDYQTGPIVWGEPGTNGQHAFY
                     QLIHQGTKMIPCDFLIPVQTQHPIRNGLHHKILLANFLAQTEALMKGKSPEEARKELQ
                     AAGKSPEELEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIIWDIN
                     SFDQWGVELGKQLAKKIEPELDGSSAVTSHDSSTNGLIGFIKLQRDTKID"
     exon            189..279
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            280..348
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            349..468
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            469..552
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            553..699
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            700..771
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            772..816
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            817..870
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            871..931
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            932..975
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1128
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1258
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1335
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1464
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1540
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1607
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..2014
                     /gene="Gpi"
                     /gene_synonym="Amf; Gpi1; Nlk; Pgi; Phi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgccgct cctctttcct tcctcttccg tgcacgtact gctccgtgta cttctcgggt
       61 cccgccatgg ctgcgctcac ccggaacccg gagttccaga agctgctgga gtggcaccgg
      121 gcgaactctg ccaacctcaa gctgcgcgaa ctttttgagg cagatccgga gcgcttcaac
      181 cacttcagct tgaacctcaa caccaaccat ggacatattc tgttggatta ctccaagaac
      241 cttgtgaaca aggaggtgtt gcacatgctg gtggacctgg ccaagtccag aggcgtggag
      301 gccgcgcggg acaacatgtt cagtggtttg aagatcaact ccaccgagga ccgggcggtg
      361 ctgcacgtgg cccttcggaa ccggtccaac agatccatca tgatggacgg caaagacgtg
      421 atgccagagg tcaacaaggt gctggacaag atgaagtctt tctgccagcg ggtccggagt
      481 ggtgactgga aagggtacac cggcaaagct atcacggaca tcatcaacat cggcattgga
      541 ggctccgacc tgggacccct catggtgact gaagctctca agccttactc taaaggaggt
      601 cccagagtct ggtttgtctc caacattgat gggacccaca ttgccaaaac attggccaac
      661 ctgaaccctg agtcttccct ctttataatc gcctccaaga ccttcaccac ccaggagacc
      721 atcaccaacg cagagactgc caaagagtgg tttctccaag ctgcgaagga tccgtctgca
      781 gttgcaaagc actttgttgc cctgtctacg aacacggaca aagtgaagga gtttggaatt
      841 gaccctaaaa acatgttcga gttctgggat tgggtaggtg gccgctactc gctgtggtca
      901 gccattggac tctccatcgc actgcatgtg ggttttgacc actttgaaca gctgctgtcc
      961 ggggctcact ggatggacca gcacttcatg aagacgcccc tggataagaa tgcccccgtc
     1021 ctgctggctc tcctgggcat ctggtatatc aacttctacg gctgtgagac ccacgccatg
     1081 ctgccctatg accagtacat gcaccgcttt gctgcctatt tccagcaggg tgacatggaa
     1141 tccaatggaa agtacatcac caagtctgga gcccgggttg actaccagac aggccccatt
     1201 gtgtgggggg agccagggac caacggtcaa catgcattct accagcttat ccaccaaggc
     1261 accaagatga taccctgtga tttcctcatc cctgttcaga cccagcaccc catacggaat
     1321 ggtctgcatc acaagatcct cctggccaac ttcttggccc agactgaggc cctgatgaag
     1381 gggaagtcgc cagaagaggc caggaaggag ctccaggctg ccggaaagag cccagaagaa
     1441 ctggagaaac tcttgccaca caaggtcttt gaaggaaacc ggccgaccaa ctcaattgtg
     1501 tttaccaagc taacaccctt cattctggga gcactgattg ccatgtatga gcacaagatc
     1561 ttcgttcagg gcatcatctg ggacatcaac agcttcgacc agtggggagt ggagctgggg
     1621 aagcagctgg ccaagaaaat tgagccagag ctggacggca gctctgccgt aacctcccat
     1681 gactcctcca ctaatggact gatcggcttc atcaagctgc agcgcgacac caaaatagat
     1741 taagcccagc cgcggccctc ctgacttcgt gtcccttctc gcctatgcac tgcatggtcc
     1801 tgcccctccc tgcccagagt gcgtaccacc ggacttggac cacgaggctt ttgggagaag
     1861 ctggtctgga gctgctgtcc gccccctctg tgcaccctcc ccctgttgaa gcaggcggaa
     1921 gggctctgat gctgacgcca tgttgttctg acctgtattc acatcccagc tagaataaag
     1981 acacccagag gaggcatggg ctcagcctct caagaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
