LOCUS       NM_001007013            1557 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glycoprotein hormone subunit beta 5 (Gphb5),
            mRNA.
ACCESSION   NM_001007013 XM_345688
VERSION     NM_001007013.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   van Zeijl,C.J., Surovtseva,O.V., Wiersinga,W.M., Boelen,A. and
            Fliers,E.
  TITLE     Transient hypothyroxinemia in juvenile glycoprotein hormone subunit
            B5 knock-out mice
  JOURNAL   Mol Cell Endocrinol 321 (2), 231-238 (2010)
   PUBMED   20223276
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Nagasaki,H., Wang,Z., Jackson,V.R., Lin,S., Nothacker,H.P. and
            Civelli,O.
  TITLE     Differential expression of the thyrostimulin subunits, glycoprotein
            alpha2 and beta5 in the rat pituitary
  JOURNAL   J Mol Endocrinol 37 (1), 39-50 (2006)
   PUBMED   16901922
  REMARK    GeneRIF: Results describe the differential expression of the
            thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat
            pituitary, and suggest that the thyrostimulin system is
            functionally different from the thyroid-stimulating hormone system.
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Macdonald,L.E., Wortley,K.E., Gowen,L.C., Anderson,K.D.,
            Murray,J.D., Poueymirou,W.T., Simmons,M.V., Barber,D.,
            Valenzuela,D.M., Economides,A.N., Wiegand,S.J., Yancopoulos,G.D.,
            Sleeman,M.W. and Murphy,A.J.
  TITLE     Resistance to diet-induced obesity in mice globally overexpressing
            OGH/GPB5
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2496-2501 (2005)
   PUBMED   15699348
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Li,C., Hirooka,Y., Habu,S., Takagi,J., Gotoh,M. and Nogimori,T.
  TITLE     Distribution of thyrostimulin in the rat: an immunohistochemical
            study
  JOURNAL   Endocr Regul 38 (4), 131-142 (2004)
   PUBMED   15841792
  REMARK    GeneRIF: Thyrostimulin immunoreactivity was visualized in the
            anterior pituitary, central nervous system, adrenal gland, stomach,
            duodenum, pancreas and testis; findings suggest that thyrostimulin
            is widely distributed [thyrostimulin]
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Nakabayashi,K., Matsumi,H., Bhalla,A., Bae,J., Mosselman,S.,
            Hsu,S.Y. and Hsueh,A.J.
  TITLE     Thyrostimulin, a heterodimer of two new human glycoprotein hormone
            subunits, activates the thyroid-stimulating hormone receptor
  JOURNAL   J Clin Invest 109 (11), 1445-1452 (2002)
   PUBMED   12045258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 29, 2022 this sequence version replaced NM_001007013.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY437504.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN09345329, SAMN09345330 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000006.1  99870196-99870308   c
            114-315             JAXUCZ010000006.1  99869093-99869294   c
            316-1557            JAXUCZ010000006.1  99865691-99866932   c
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1557
                     /gene="Gphb5"
                     /gene_synonym="Gpb5"
                     /note="glycoprotein hormone subunit beta 5"
                     /db_xref="GeneID:366668"
                     /db_xref="RGD:1359264"
     exon            1..113
                     /gene="Gphb5"
                     /gene_synonym="Gpb5"
                     /inference="alignment:Splign:2.1.0"
     exon            114..315
                     /gene="Gphb5"
                     /gene_synonym="Gpb5"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..504
                     /gene="Gphb5"
                     /gene_synonym="Gpb5"
                     /note="glycoprotein-beta 5; glycoprotein hormone beta 5"
                     /codon_start=1
                     /product="glycoprotein hormone beta-5 precursor"
                     /protein_id="NP_001007014.1"
                     /db_xref="GeneID:366668"
                     /db_xref="RGD:1359264"
                     /translation="MKLVYLVLGTAALLLGGSDSVLSSSSGNLHTFVGCAVREFTFVA
                     KKPGCRGLRITTDACWGRCETWEKPILEPPYIEAYHRVCTYNETRQVTVKLPNCAPGV
                     DPFYTYPMAVRCDCGACSTATTECETI"
     exon            316..1557
                     /gene="Gphb5"
                     /gene_synonym="Gpb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagaaggg agagagactt acccagaata aactttcttc actcattgaa acttttgaaa
       61 gcctggggca cgagtctcag ctctccaaga agagttgatt ccagcaagat cagcatgaag
      121 ctggtatacc ttgtccttgg tactgcggcc ctccttctgg gtggctctga ctctgtcctc
      181 agcagctcca gcgggaacct acacactttt gtgggatgtg ctgtgaggga attcactttt
      241 gtggccaaga agccaggctg caggggactt cggatcacca cagatgcctg ctggggtcgc
      301 tgtgagacct gggagaaacc cattctggag cctccctaca tagaagccta tcatcgagtg
      361 tgtacctaca atgagaccag acaggtgacg gtgaagctgc ctaactgtgc ccctggagtc
      421 gaccccttct acacctaccc tatggctgtc cgatgtgact gcggggcatg ttccactgcc
      481 accactgagt gtgagaccat ctgaagccag cacagtcatg gctggtggcc caagcttcat
      541 acatccacgg ctcccaggaa tctatctgct ttaacccctg cagtcagtta gggccagccc
      601 aagttacctg ccttcctcta cccagcttag gcaccaggtc caggtgcagc acgcttaggt
      661 tgaaaatgta aaacaatatt ggcccttccc cgagaataat ccctctgctt catagtctgc
      721 aaatttgttt tcttcctgct tgacttttgg aacatgaatt gtatgttgcg accctccccc
      781 aggttctgtt gctactgtcc gcttgtttga aggggttggg tatcattaag cggtggaaag
      841 cctttaaatc ttcacattct gatgctgagc tcggtctgga tttatgatta aagggcaaag
      901 gatgatcaaa accaaagagc gttcttcctg gcacatgagg ctgcccatcc gcgagcgttc
      961 tttcagagca ccccatttcc ctttgaaccc agtgatttac caaaacaaga ggcaaggaca
     1021 gcccagacag ttaggaaaag gtgttttgat gtggctgatt catctctcaa gcaaaattct
     1081 ctcaagatcc tcagggaagt gtctgcttgc caatcaaaaa caaacaaaca aacaacagac
     1141 ctcacaaagt accattagga gctatcattt aggtttaaaa ccaccagata ctaactaaat
     1201 tccctggtcg agtgcttccc ccacagccac agtgaggtga ccagttacag atgcccttcc
     1261 ctgtttagta cattttaaat caattagtca gttagactca gaatcctgag tgtttgtggc
     1321 agtaaggtgg ccctgcctgc tcagagggga caggtgtgcc cgcctggcac tcgattgctt
     1381 tttctgaagt cttacggcag ctgcttttgt ggccttcttt ttaaactcca attttatgca
     1441 ctcatattta gttttggtat ttagggggtt gagtttccct ttgttcactt ttatatgcca
     1501 ggagcacatg atgtcaataa agtgtggtct ctgtcattgg aattcatgca aactttc
//
