LOCUS       NM_133619                814 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glycoprotein hormone subunit alpha 2 (Gpha2),
            mRNA.
ACCESSION   NM_133619
VERSION     NM_133619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 814)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 814)
  AUTHORS   Sun,S.C., Hsu,P.J., Wu,F.J., Li,S.H., Lu,C.H. and Luo,C.W.
  TITLE     Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a
            paracrine regulator to activate the TSH receptor in mammalian ovary
  JOURNAL   J Biol Chem 285 (6), 3758-3765 (2010)
   PUBMED   19955180
  REMARK    GeneRIF: Data indicate that the presence of thyrostimulin in the
            ovary suggests that it may have a primitive function in
            reproduction when it activates ovarian TSHR.
REFERENCE   3  (bases 1 to 814)
  AUTHORS   Nagasaki,H., Wang,Z., Jackson,V.R., Lin,S., Nothacker,H.P. and
            Civelli,O.
  TITLE     Differential expression of the thyrostimulin subunits, glycoprotein
            alpha2 and beta5 in the rat pituitary
  JOURNAL   J Mol Endocrinol 37 (1), 39-50 (2006)
   PUBMED   16901922
  REMARK    GeneRIF: Results describe the differential expression of the
            thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat
            pituitary, and suggest that the thyrostimulin system is
            functionally different from the thyroid-stimulating hormone system.
REFERENCE   4  (bases 1 to 814)
  AUTHORS   Li,C., Hirooka,Y., Habu,S., Takagi,J., Gotoh,M. and Nogimori,T.
  TITLE     Distribution of thyrostimulin in the rat: an immunohistochemical
            study
  JOURNAL   Endocr Regul 38 (4), 131-142 (2004)
   PUBMED   15841792
  REMARK    GeneRIF: Thyrostimulin immunoreactivity was visualized in the
            anterior pituitary, central nervous system, adrenal gland, stomach,
            duodenum, pancreas and testis; findings suggest that thyrostimulin
            is widely distributed [thyrostimulin]
REFERENCE   5  (bases 1 to 814)
  AUTHORS   Hsu,S.Y., Nakabayashi,K. and Bhalla,A.
  TITLE     Evolution of glycoprotein hormone subunit genes in bilateral
            metazoa: identification of two novel human glycoprotein hormone
            subunit family genes, GPA2 and GPB5
  JOURNAL   Mol Endocrinol 16 (7), 1538-1551 (2002)
   PUBMED   12089349
REFERENCE   6  (bases 1 to 814)
  AUTHORS   Nakabayashi,K., Matsumi,H., Bhalla,A., Bae,J., Mosselman,S.,
            Hsu,S.Y. and Hsueh,A.J.
  TITLE     Thyrostimulin, a heterodimer of two new human glycoprotein hormone
            subunits, activates the thyroid-stimulating hormone receptor
  JOURNAL   J Clin Invest 109 (11), 1445-1452 (2002)
   PUBMED   12045258
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF260741.1.
            
            On Nov 2, 2002 this sequence version replaced NM_133619.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF260741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132308 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..814
                     /gene="Gpha2"
                     /gene_synonym="Gpa2; Zsig51"
                     /note="glycoprotein hormone subunit alpha 2"
                     /db_xref="GeneID:171158"
                     /db_xref="RGD:621748"
     exon            1..38
                     /gene="Gpha2"
                     /gene_synonym="Gpa2; Zsig51"
                     /inference="alignment:Splign:2.1.0"
     exon            39..308
                     /gene="Gpha2"
                     /gene_synonym="Gpa2; Zsig51"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..595
                     /gene="Gpha2"
                     /gene_synonym="Gpa2; Zsig51"
                     /note="glycoprotein-alpha 2; thyrostimulin subunit alpha;
                     glycoprotein hormone alpha 2; putative secreted protein
                     ZSIG51; cysteine knot protein"
                     /codon_start=1
                     /product="glycoprotein hormone alpha-2 precursor"
                     /protein_id="NP_598303.1"
                     /db_xref="GeneID:171158"
                     /db_xref="RGD:621748"
                     /translation="MPMAPRVLLFCLLGLAVTEGHGLEAAVPIPGCHLHPFNVTVRSD
                     RHGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSVSQCCTISSLKKVRVWL
                     HCVGNQRGELEIFTARACQCDMCRLSRY"
     exon            309..493
                     /gene="Gpha2"
                     /gene_synonym="Gpa2; Zsig51"
                     /inference="alignment:Splign:2.1.0"
     exon            494..767
                     /gene="Gpha2"
                     /gene_synonym="Gpa2; Zsig51"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggaggca cctggagtct acagttcctg ccggactgag tagctgaggc aaggaagcaa
       61 gcaccccaca cattcccacc caaggcagag aggatcaaca gtgccaccca ggcacacctc
      121 acagtcggaa gacccagaag cctggcttgc tgggggagag acacaactgc aaagacttcc
      181 cttcccaccc actccttttc agatgcccat ggcacctcga gtcttgctct tctgcctgct
      241 gggtctggca gtcactgaag ggcatggcct ggaggcagcc gtcccaatcc caggctgcca
      301 cttgcacccc tttaacgtga cagtgcgaag tgatcgccat ggcacctgcc agggctccca
      361 tgtggcacag gcgtgtgtag gacactgtga gtctagtgct ttcccttctc ggtactctgt
      421 gctggttgcc agtggctatc gacacaacat cacctctgtc tctcagtgct gtaccatcag
      481 cagccttaaa aaggtgaggg tgtggctgca ctgcgtgggg aaccagcgtg gggagctcga
      541 gatcttcacg gctagggcct gccagtgtga tatgtgccgt ctctcccgct actaggcccc
      601 gaagggctca ggcctccagt cctgccactg ataggtcgtg cttctctcag accagccctc
      661 tttggagtct gaagatgggg cttcgcctct gtttacctgg cctcctcagc agtctcactg
      721 ctgctttctc cttcacccct gtcctcaata aagcaggcag tgcttgaaaa aaaaaaaaaa
      781 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
