LOCUS       NM_133573               1279 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus G protein-coupled estrogen receptor 1 (Gper1),
            mRNA.
ACCESSION   NM_133573
VERSION     NM_133573.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Zhang,Y.Q., Sun,T., Zhao,Z., Fu,J., Yang,L., Xu,Y., Zhao,J.F.,
            Tang,X.L., Liu,A. and Zhao,M.G.
  TITLE     Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion
            Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling
            Pathway
  JOURNAL   Neuromolecular Med 26 (1), 33 (2024)
   PUBMED   39138706
  REMARK    GeneRIF: Activation of GPR30 Ameliorates Cerebral
            Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through
            Nrf2/GPX4 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1279)
  AUTHORS   Grubic Kezele,T., Omrcen,H., Baticic,L., Sucurovic,S. and Zoricic
            Cvek,S.
  TITLE     Joint Inflammation Correlates with Joint GPR30 Expression in Males
            and Hippocampal GPR30 Expression in Females in a Rat Model of
            Rheumatoid Arthritis
  JOURNAL   Int J Mol Sci 25 (14), 7864 (2024)
   PUBMED   39063107
  REMARK    GeneRIF: Joint Inflammation Correlates with Joint GPR30 Expression
            in Males and Hippocampal GPR30 Expression in Females in a Rat Model
            of Rheumatoid Arthritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1279)
  AUTHORS   Azizian,H., Farhadi,Z., Bader,M., Alizadeh Ghalenoei,J.,
            Ghafari,M.A. and Mahmoodzadeh,S.
  TITLE     GPER activation attenuates cardiac dysfunction by upregulating the
            SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats
  JOURNAL   PLoS One 18 (12), e0293630 (2023)
   PUBMED   38134189
  REMARK    GeneRIF: GPER activation attenuates cardiac dysfunction by
            upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal
            diabetic rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1279)
  AUTHORS   Hu,J., Huang,Y., Gao,F., Sun,W., Liu,H., Ma,H., Yuan,T., Liu,Z.,
            Tang,L., Ma,Y., Zhang,X., Bai,J. and Wang,R.
  TITLE     Brain-derived estrogen: a critical player in maintaining cognitive
            health of aged female rats, possibly involving GPR30
  JOURNAL   Neurobiol Aging 129, 15-27 (2023)
   PUBMED   37257405
  REMARK    GeneRIF: Brain-derived estrogen: a critical player in maintaining
            cognitive health of aged female rats, possibly involving GPR30.
REFERENCE   5  (bases 1 to 1279)
  AUTHORS   Xu,X., Wang,J., Guo,X., Chen,Y., Ding,S., Zou,G., Zhu,L., Li,T. and
            Zhang,X.
  TITLE     GPR30-mediated non-classic estrogen pathway in mast cells
            participates in endometriosis pain via the production of FGF2
  JOURNAL   Front Immunol 14, 1106771 (2023)
   PUBMED   36845134
  REMARK    GeneRIF: GPR30-mediated non-classic estrogen pathway in mast cells
            participates in endometriosis pain via the production of FGF2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1279)
  AUTHORS   Sakamoto,H., Matsuda,K., Hosokawa,K., Nishi,M., Morris,J.F.,
            Prossnitz,E.R. and Kawata,M.
  TITLE     Expression of G protein-coupled receptor-30, a G protein-coupled
            membrane estrogen receptor, in oxytocin neurons of the rat
            paraventricular and supraoptic nuclei
  JOURNAL   Endocrinology 148 (12), 5842-5850 (2007)
   PUBMED   17872373
  REMARK    GeneRIF: Results suggest that GPR30 may serve primarily as a
            nongenomic transducer of estrogen actions in the
            hypothalamo-neurohypophyseal system.
REFERENCE   7  (bases 1 to 1279)
  AUTHORS   Funakoshi,T., Yanai,A., Shinoda,K., Kawano,M.M. and Mizukami,Y.
  TITLE     G protein-coupled receptor 30 is an estrogen receptor in the plasma
            membrane
  JOURNAL   Biochem Biophys Res Commun 346 (3), 904-910 (2006)
   PUBMED   16780796
  REMARK    GeneRIF: GPR30, a transmembrane receptor for estrogen, is localized
            to the plasma membrane of CA2 pyramidal neuronal cells of the
            hippocampus in rat brain
REFERENCE   8  (bases 1 to 1279)
  AUTHORS   Revankar,C.M., Cimino,D.F., Sklar,L.A., Arterburn,J.B. and
            Prossnitz,E.R.
  TITLE     A transmembrane intracellular estrogen receptor mediates rapid cell
            signaling
  JOURNAL   Science 307 (5715), 1625-1630 (2005)
   PUBMED   15705806
REFERENCE   9  (bases 1 to 1279)
  AUTHORS   Thomas,P., Pang,Y., Filardo,E.J. and Dong,J.
  TITLE     Identity of an estrogen membrane receptor coupled to a G protein in
            human breast cancer cells
  JOURNAL   Endocrinology 146 (2), 624-632 (2005)
   PUBMED   15539556
REFERENCE   10 (bases 1 to 1279)
  AUTHORS   Bonini,J.A., Anderson,S.M. and Steiner,D.F.
  TITLE     Molecular cloning and tissue expression of a novel orphan G
            protein-coupled receptor from rat lung
  JOURNAL   Biochem Biophys Res Commun 234 (1), 190-193 (1997)
   PUBMED   9168987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_133573.3.
            
            On Nov 26, 2020 this sequence version replaced NM_133573.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U92802.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1279              JAXUCZ010000012.1  20331791-20333069   c
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1279
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="G protein-coupled estrogen receptor 1"
                     /db_xref="GeneID:171104"
                     /db_xref="RGD:619845"
     exon            1..1279
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1173
                     /gene="Gper1"
                     /gene_synonym="Gper; Gpr30; GPR41"
                     /note="mER; chemokine receptor-like 2; membrane estrogen
                     receptor; G-protein coupled receptor 30; G-protein coupled
                     receptor 41; chemoattractant receptor-like 2"
                     /codon_start=1
                     /product="G-protein coupled estrogen receptor 1"
                     /protein_id="NP_598257.2"
                     /db_xref="GeneID:171104"
                     /db_xref="RGD:619845"
                     /translation="MAATTPAQDVGVEIYLGPVWPAPSNSTPLALNLSLALREDAPGN
                     LTGDLSEHQQYVIALFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLA
                     AADLILVADSLIEVFNLDEQYYDIAVLCTFMSLFLQINMYSSVFFLTWMSFDRYLALA
                     KAMRCGLFRTKHHARLSCGLIWMASVSATLVPFTAVHLRHTEEACFCFADVREVQWLE
                     VTLGFIVPFAIIGLCYSLIVRALIRAHRHRGLRPRRQKALRMIFAVVLVFFICWLPEN
                     VFISVHLLQWAQPGDTPCKQSFRHAYPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDK
                     LRLYVAQKTSLPALNRFCHATLKAVIPDSTEQSDVKFSSAV"
ORIGIN      
        1 ttctgtgacc ctttcagcaa gtcctgaaag cttctacggg aagccatggc tgcaactact
       61 ccagcacaag atgttggcgt agagatctac ctaggtcccg tgtggccagc cccttccaac
      121 agcacccctc tggccctcaa cctgtccctg gcgctgcggg aagatgcccc ggggaacctc
      181 actggggacc tctctgaaca tcagcaatat gtgatcgctc tcttcctctc ctgcctctac
      241 accatcttcc tcttccccat cggctttgtg ggcaacatcc tcatcttggt ggtgaacatc
      301 agcttccggg agaagatgac tatcccagac ctgtacttca tcaacctggc agcggccgac
      361 ctcatcctgg tggccgactc cctgatcgag gtgttcaacc tggacgagca gtactacgat
      421 atcgccgtgc tctgcacctt catgtccctc ttcctgcaga tcaacatgta cagcagcgtc
      481 ttcttcctca cctggatgag cttcgacagg tacctggcgc tggccaaagc catgcgctgt
      541 ggcctcttcc gcaccaagca ccacgcgcgg ctcagctgtg gcctcatctg gatggcctca
      601 gtgtccgcca cgctggtgcc cttcacggcc gtgcatctgc ggcacaccga ggaggcctgc
      661 ttctgctttg ccgatgtcag ggaggtgcag tggctggagg tcacgctggg cttcattgtg
      721 cccttcgcca tcatcggcct gtgctattcc ctcatcgtgc gggccctcat ccgggcccac
      781 aggcatcgtg gcctgcgccc acgcaggcag aaagccctga ggatgatctt cgcagtggtc
      841 cttgtcttct tcatctgctg gctgccggag aacgtcttca tcagcgtcca cctactgcag
      901 tgggcgcagc caggggacac tccctgcaag cagtctttcc gtcatgccta ccccttgaca
      961 ggccacatag tcaacctggc agccttctcc aacagctgcc tgaatcccct catctatagc
     1021 ttcctgggag agaccttcag ggacaagctc aggctgtatg tggcgcagaa gacgagcctg
     1081 ccagctctca accgcttctg ccatgccacg ctcaaggcag tcataccaga cagcacggag
     1141 cagtcagatg tcaagttcag cagtgctgta tgagaggtac ctcctagagg aaaacggaca
     1201 ggggagcagg cgtgcccagg agctgcacac tcctagcaca ggtggtgggc gagctgagcc
     1261 atgtcatact ctaaacccc
//
