LOCUS       NM_001191885            1261 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus glycerol-3-phosphate dehydrogenase 1 like
            (Gpd1l), mRNA.
ACCESSION   NM_001191885 XM_343498
VERSION     NM_001191885.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Liu,M., Sanyal,S., Gao,G., Gurung,I.S., Zhu,X., Gaconnet,G.,
            Kerchner,L.J., Shang,L.L., Huang,C.L., Grace,A., London,B. and
            Dudley,S.C. Jr.
  TITLE     Cardiac Na+ current regulation by pyridine nucleotides
  JOURNAL   Circ Res 105 (8), 737-745 (2009)
   PUBMED   19745168
  REMARK    GeneRIF: Mutations of GPD1-L may downregulate Na(v)1.5 by altering
            the oxidized to reduced NAD(H) balance.
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Valdivia,C.R., Ueda,K., Ackerman,M.J. and Makielski,J.C.
  TITLE     GPD1L links redox state to cardiac excitability by PKC-dependent
            phosphorylation of the sodium channel SCN5A
  JOURNAL   Am J Physiol Heart Circ Physiol 297 (4), H1446-H1452 (2009)
   PUBMED   19666841
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   London,B., Michalec,M., Mehdi,H., Zhu,X., Kerchner,L., Sanyal,S.,
            Viswanathan,P.C., Pfahnl,A.E., Shang,L.L., Madhusudanan,M.,
            Baty,C.J., Lagana,S., Aleong,R., Gutmann,R., Ackerman,M.J.,
            McNamara,D.M., Weiss,R. and Dudley,S.C. Jr.
  TITLE     Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L)
            decreases cardiac Na+ current and causes inherited arrhythmias
  JOURNAL   Circulation 116 (20), 2260-2268 (2007)
   PUBMED   17967977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_343498.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211779.1, FQ217318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               JAXUCZ010000008.1  123498697-123498948 c
            253-430             JAXUCZ010000008.1  123488850-123489027 c
            431-571             JAXUCZ010000008.1  123485839-123485979 c
            572-710             JAXUCZ010000008.1  123483514-123483652 c
            711-823             JAXUCZ010000008.1  123480035-123480147 c
            824-1057            JAXUCZ010000008.1  123471645-123471878 c
            1058-1164           JAXUCZ010000008.1  123470565-123470671 c
            1165-1261           JAXUCZ010000008.1  123469282-123469378 c
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1261
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /note="glycerol-3-phosphate dehydrogenase 1 like"
                     /db_xref="GeneID:363159"
                     /db_xref="RGD:1560123"
     exon            1..252
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1261
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /EC_number="1.1.1.8"
                     /note="glycerol-3-phosphate dehydrogenase 1 like 1"
                     /codon_start=1
                     /product="glycerol-3-phosphate dehydrogenase 1-like
                     protein"
                     /protein_id="NP_001178814.1"
                     /db_xref="GeneID:363159"
                     /db_xref="RGD:1560123"
                     /translation="MAAAPLKVCIVGSGNWGSAVAKIIGSNVKNLQKFSSTVKMWVFE
                     ETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLGEAVQDADLLVFVIPHQFIHK
                     ICDEITGRVPKKAVGITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAA
                     EKFCETTIGSKVLQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDG
                     LCCGDNTKAAVIRLGLMEMIAFAKIFCKGQVSTATFLESCGVADLITTCYGGRNRKVA
                     EAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYEG
                     RPVTQMLSCLQSHPEHI"
     exon            253..430
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            431..571
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            572..710
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            711..823
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1057
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1164
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1261
                     /gene="Gpd1l"
                     /gene_synonym="Gpd1l1; RGD1560123"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctaggcgc ctaggcgggt ggcggtggcc attggcggac aggagggcgg ggcggggtcg
       61 cccggagcgg ctatactagg ccgttccagt ggaggtgagc agccggcccg ggaggcactg
      121 tgtgtgctgc agcgatccgg cttgcagcag cgatccggct tggccctggg aggaaggctg
      181 tgtacagcag ctacccggct tggccatggc agcggcgcct ctgaaagtgt gcatcgtggg
      241 ctccgggaac tggggatcag ctgttgcaaa aatcatcgga agcaatgtga agaacctgca
      301 gaagttctcc tccacggtca agatgtgggt cttcgaagag actgtgaacg ggaggaagtt
      361 gacagacatc atcaacaatg accacgaaaa tgtgaaatat ctcccgggac acaagctacc
      421 agaaaatgtg gtcgctgtcc caaatctcgg cgaagccgtg caggacgcag acctgttggt
      481 gttcgttatc ccccaccagt tcattcacaa gatctgcgat gagatcacgg gcagggtgcc
      541 caagaaggcc gtgggaatca ccctcatcaa gggtatagat gagggcccgg acgggctgaa
      601 gctcatctcc gacatcatcc gggagaagat ggggattgac atcagtgtgc tgatgggggc
      661 caacatcgcc agcgaggtcg ctgcggagaa gttctgcgag accaccattg gcagcaaagt
      721 gttgcagaac ggccttctct tcaaagagct gctgcagacg cccaatttca gaatcacggt
      781 ggtggatgat gcagacaccg tggaactctg cggtgctctt aagaacattg ttgctgtggg
      841 agccggcttc tgcgatggcc tctgctgtgg ggacaacacc aaggcagccg tcatccgcct
      901 gggcctcatg gaaatgatcg ctttcgccaa gatcttctgt aagggccagg tgtccacggc
      961 caccttcttg gagagctgcg gggtggccga cctcatcacc acctgctacg gagggcggaa
     1021 ccgcaaggtg gcagaagcct tcgccaggac cgggaagacc atcgaagagc tggagaagga
     1081 gctgctgaac ggacagaagc tccagggacc tcagacctct gcggaggtgt accgcatcct
     1141 caagcagaag gggctgctgg acaagtttcc cctcttcact gccgtgtatc agatctgcta
     1201 tgaaggcaga cctgtcaccc agatgctgtc ctgcctgcag agccacccgg agcacatctg
     1261 a
//
