LOCUS       NM_022215               2848 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glycerol-3-phosphate dehydrogenase 1 (Gpd1),
            mRNA.
ACCESSION   NM_022215
VERSION     NM_022215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2848)
  AUTHORS   Orr,A.L., Quinlan,C.L., Perevoshchikova,I.V. and Brand,M.D.
  TITLE     A refined analysis of superoxide production by mitochondrial
            sn-glycerol 3-phosphate dehydrogenase
  JOURNAL   J Biol Chem 287 (51), 42921-42935 (2012)
   PUBMED   23124204
  REMARK    GeneRIF: These results clarify the maximum rate and mechanism of
            superoxide production by mGPDH.
REFERENCE   2  (bases 1 to 2848)
  AUTHORS   Rauchova,H., Mracek,T., Novak,P., Vokurkova,M. and Soukup,T.
  TITLE     Glycerol-3-phosphate dehydrogenase expression and oxygen
            consumption in liver mitochondria of female and male rats with
            chronic alteration of thyroid status
  JOURNAL   Horm Metab Res 43 (1), 43-47 (2011)
   PUBMED   20886417
  REMARK    GeneRIF: GPDH expression was significantly increased in the
            hyperthyroid and decreased in the hyporthyroid status in both
            sexes.
REFERENCE   3  (bases 1 to 2848)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2848)
  AUTHORS   Mracek,T., Pecinova,A., Vrbacky,M., Drahota,Z. and Houstek,J.
  TITLE     High efficiency of ROS production by glycerophosphate dehydrogenase
            in mammalian mitochondria
  JOURNAL   Arch Biochem Biophys 481 (1), 30-36 (2009)
   PUBMED   18952046
  REMARK    GeneRIF: high efficiency of mGPDH-dependent ROS production in
            mammalian mitochondria with a low content of mGPDH and suggest its
            endogenous inhibition in BAT.
REFERENCE   5  (bases 1 to 2848)
  AUTHORS   Ying,W.
  TITLE     NAD+/NADH and NADP+/NADPH in cellular functions and cell death:
            regulation and biological consequences
  JOURNAL   Antioxid Redox Signal 10 (2), 179-206 (2008)
   PUBMED   18020963
  REMARK    Review article
REFERENCE   6  (bases 1 to 2848)
  AUTHORS   Daikoku,T., Shinohara,Y., Shima,A., Yamazaki,N. and Terada,H.
  TITLE     Dramatic enhancement of the specific expression of the heart-type
            fatty acid binding protein in rat brown adipose tissue by cold
            exposure
  JOURNAL   FEBS Lett 410 (2-3), 383-386 (1997)
   PUBMED   9237667
REFERENCE   7  (bases 1 to 2848)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   8  (bases 1 to 2848)
  AUTHORS   Dobson,D.E., Groves,D.L. and Spiegelman,B.M.
  TITLE     Nucleotide sequence and hormonal regulation of mouse
            glycerophosphate dehydrogenase mRNA during adipocyte and muscle
            cell differentiation
  JOURNAL   J Biol Chem 262 (4), 1804-1809 (1987)
   PUBMED   3027100
REFERENCE   9  (bases 1 to 2848)
  AUTHORS   Preston,S.L. and McMorris,F.A.
  TITLE     Normal myelin composition and phospholipid synthesis in
            adrenalectomized rats with reduced brain myelin and glycerol
            3-phosphate dehydrogenase activity
  JOURNAL   J Neurochem 45 (6), 1771-1778 (1985)
   PUBMED   2997397
REFERENCE   10 (bases 1 to 2848)
  AUTHORS   Kozak,L.P. and Ratner,P.L.
  TITLE     Genetic regulation of translatable mRNA levels for mouse
            sn-glycerol-3-phosphate dehydrogenase during development of the
            cerebellum
  JOURNAL   J Biol Chem 255 (16), 7589-7594 (1980)
   PUBMED   6105153
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088396.1.
            
            On Jan 12, 2005 this sequence version replaced NM_022215.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088396.1, AB002558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2848
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /note="glycerol-3-phosphate dehydrogenase 1"
                     /db_xref="GeneID:60666"
                     /db_xref="RGD:621381"
     exon            1..53
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1062
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /EC_number="1.1.1.8"
                     /note="glycerol-3-phosphate dehydrogenase [NAD+],
                     cytoplasmic; GPD-C; GPDH-C; glycerol 3-phosphate
                     dehydrogenase; glycerol-3-phosphate dehydrogenase 1
                     (soluble)"
                     /codon_start=1
                     /product="glycerol-3-phosphate dehydrogenase [NAD(+)],
                     cytoplasmic"
                     /protein_id="NP_071551.2"
                     /db_xref="GeneID:60666"
                     /db_xref="RGD:621381"
                     /translation="MAGKKVCIVGSGNWGSAIAKIVGSNASQLAHFDPRVTMWVFEED
                     IGGRKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAATGADILVFVVPHQFIGKIC
                     DQLKGHLKANTIGISLIKGIDEGPNGLKLISEVIGESLGIPMSVLMGANIASEVAEEK
                     FCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLG
                     FGDNTKAAVIRLGLMEMIAFAKLFCSGSVSSATFLESCGVADLITTCYGGRNRKVAEA
                     FARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKFPLFTAVYKVCYEGQP
                     VGEFICCLQNHPEHM"
     exon            54..231
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            232..372
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            373..511
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            512..624
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            625..858
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            859..965
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            966..2825
                     /gene="Gpd1"
                     /gene_synonym="Gpd3; GPDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcagca ccatggctgg caagaaagtc tgcatcgtag gctccggcaa ctggggctca
       61 gccattgcca agatcgtggg tagtaatgcc agccaactgg cacactttga tccacgggtg
      121 accatgtggg tgtttgagga agacatcggg ggcagaaagt taactgagat catcaacacg
      181 caacacgaga atgtgaaata cctgccgggg cacaagctgc cccctaatgt ggtggctgtc
      241 ccagatgtcg tccaggctgc aacaggtgct gacatcctgg tttttgtggt accccatcag
      301 ttcattggca agatctgtga ccagctcaag ggccacttga aagccaatac tattggcata
      361 tctcttatta aggggataga cgagggcccc aatggactga aactcatctc tgaagtgatt
      421 ggggagagcc ttggcatccc tatgagcgtg ctgatggggg ccaacattgc cagtgaggtg
      481 gctgaagaga agttctgtga gacgaccatt ggctgcaagg accctgctca gggacagctc
      541 ctgaaggagc tgatgcaaac acccaacttc cgcatcaccg tggtacaaga ggtggacaca
      601 gtggagatct gtggggcctt gaagaatata gtggctgttg gggctggctt ctgtgacggg
      661 cttggcttcg gtgacaacac caaggcggca gtgatccggc tggggctcat ggagatgatc
      721 gccttcgcca agctcttctg cagtggctct gtgtcctccg ccaccttcct ggagagctgt
      781 ggggtcgctg acctcatcac gacctgctac ggggggcgga accgcaaggt ggcagaggcc
      841 ttcgctcgca ccggaaagtc cattgagcag ctggagaaag agatgctgaa cgggcagaag
      901 ctacaggggc cccagacagc ccgggagctg cacagcatcc tccaacacaa gggcctcgtg
      961 gacaagtttc ccttgttcac cgcggtgtac aaagtgtgct atgagggcca gccagtgggt
     1021 gagttcatct gctgcctgca gaaccaccca gagcacatgt gaattcggcc agagcccaag
     1081 acagacagcg cctttgcccc aagggagaca agcagaagcg tgtgacacca ccagtctcca
     1141 ggacttccca tccagcagag tcctctctga aggaccctgg ggacaggagg ctgtggggct
     1201 cggccacata cctggagatt gctgtggaac ctgcggcctc tcgcagaacc acaccacgct
     1261 tcctccacgt cctctgggag gtgtggaacc aagccccaat gctgcctgct ctaggggtgc
     1321 agttggggga agggaaggcg ccaagtcaag ggttgctggt tactgcctca cacacactgg
     1381 gaatctgtcc cgttaagtga ctgaagaagt tctttagcca caggaaagat gaggcaaggg
     1441 ctgccaaggg aagggtctgg acgcctgagc tgatgcagac cccagagacc cttttggccg
     1501 acctctgcta ggccccacgc agcatcaatg atctcactgt ttgctaacaa aatacaaagc
     1561 tctcaaacaa ctcccttcta acttctccta gcaacatttg ccacctcaga agcctctgct
     1621 tccccttcct ccaggctact ctggcacaag agagctccac actggcattt ctggccccgg
     1681 ggcctccatt cttcccagag acttcctggt ccctagagct ttgccaggac ctccccaccc
     1741 tgtgtgacct ttccgagctc tcccttgctg cacccagctg ccagcaccct ctttggggag
     1801 caggaactca atctgctgac agagctacac ttcttcatag caggctcaga tggctcaggc
     1861 tcccctgacc ttctgatttg tccacctccc tagtcaggag ctctggctat gagaagcgcc
     1921 agccagcccc tccaactgct gacgccttta aaaaaggcat ccgaacccca tatctttctt
     1981 ctcagggttg tccccatcac tgacttcatg tctaacagaa tgtaggattc atagcttatc
     2041 ttccacagct ccttcaaccc gtattcttga ctctaccctt tcctcttgcc caagccagtg
     2101 tgtctttccg ctgttttcaa acagccagag cgctaccaag tatctgtata ggcttggagc
     2161 caaggagcag ctcaaggttc agcaggtttc cacaatggtt ggtgggcctt gaaaggccaa
     2221 agccagctgc ccttgggaca aggtcctcat gagaccataa gcacagcaca catcaggagc
     2281 tggggaactc gagggaagaa acaattgaaa agagcctgcc ctggggtgag ggaaagcagc
     2341 agggggatgg gagtatgcct tgtactggcc cctttccaag gtttggtggc agcaggagaa
     2401 tgtcacagat cagcagcctg gagccctagc tataaatagt ctccgggagc tgagaggttt
     2461 ctccctccac caggggtctc catttcgcgt gtggcagcaa ctggcacacg gtgtctctgg
     2521 ccagcttgct attaaactaa cacatcggag tgccaggccc ctctccgctc ctagccttta
     2581 agaattcagt cttatcaatg aaggtcagag ccattgggaa aggtgaagtg ggggagccct
     2641 gtcatcgatc ccaactgggt cggaaccctc ccacgcatga ctcaattcag agctgtttcc
     2701 caggaggctg gggcgggatg cagacagatt ccaacacctt aacctatgtt tgctcagtca
     2761 actgtgaatc tgaggccttc tgtcaggcca cttgtctacc caataaagtg tgttttttcc
     2821 agaaaaaaaa aaaaaaaaaa aaaaaaaa
//
