LOCUS       NP_001014130             557 aa            linear   ROD 23-MAR-2023
DEFINITION  glypican-4 precursor [Rattus norvegicus].
ACCESSION   NP_001014130 XP_228677
VERSION     NP_001014130.1
DBSOURCE    REFSEQ: accession NM_001014108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 557)
  AUTHORS   White JJ, Mazzeu JF, Coban-Akdemir Z, Bayram Y, Bahrambeigi V,
            Hoischen A, van Bon BWM, Gezdirici A, Gulec EY, Ramond F, Touraine
            R, Thevenon J, Shinawi M, Beaver E, Heeley J, Hoover-Fong J, Durmaz
            CD, Karabulut HG, Marzioglu-Ozdemir E, Cayir A, Duz MB, Seven M,
            Price S, Ferreira BM, Vianna-Morgante AM, Ellard S, Parrish A,
            Stals K, Flores-Daboub J, Jhangiani SN, Gibbs RA, Brunner HG,
            Sutton VR, Lupski JR and Carvalho CMB.
  CONSRTM   Baylor-Hopkins Center for Mendelian Genomics
  TITLE     WNT Signaling Perturbations Underlie the Genetic Heterogeneity of
            Robinow Syndrome
  JOURNAL   Am J Hum Genet 102 (1), 27-43 (2018)
   PUBMED   29276006
REFERENCE   2  (residues 1 to 557)
  AUTHORS   Xiong Y, Zhang Y, Zheng F, Yang Y, Xu X, Wang W, Zhu B and Wang X.
  TITLE     Expression of Glypican-4 in the brains of epileptic patients and
            epileptic animals and its effects on epileptic seizures
  JOURNAL   Biochem Biophys Res Commun 478 (1), 241-246 (2016)
   PUBMED   27425250
  REMARK    GeneRIF: According to behavioral studies, downregulation of Gpc4 by
            Gpc4 siRNA decreased spontaneous seizure frequency, while
            upregulation of Gpc4 by recombinant Gpc4 overexpression led to a
            converse result. These findings support the hypothesis that
            increased expression of Gpc4 in the brain is associated with
            epileptic seizures.
REFERENCE   3  (residues 1 to 557)
  AUTHORS   Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, Chung GY,
            Condomitti G, Kim HM, Kim H, de Wit J, Park KS, Tabuchi K and Ko J.
  TITLE     PTPsigma functions as a presynaptic receptor for the
            glypican-4/LRRTM4 complex and is essential for excitatory synaptic
            transmission
  JOURNAL   Proc Natl Acad Sci U S A 112 (6), 1874-1879 (2015)
   PUBMED   25624497
  REMARK    GeneRIF: GPC-4 showed strong (nanomolar) affinity and heparan
            sulfate-dependent interaction with the Ig domains of PTPsigma in
            rat brain synapses.
REFERENCE   4  (residues 1 to 557)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (residues 1 to 557)
  AUTHORS   de Wit J, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC,
            Vennekens KM, Yates JR 3rd and Ghosh A.
  TITLE     Unbiased discovery of glypican as a receptor for LRRTM4 in
            regulating excitatory synapse development
  JOURNAL   Neuron 79 (4), 696-711 (2013)
   PUBMED   23911103
REFERENCE   6  (residues 1 to 557)
  AUTHORS   Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ and Beachy
            PA.
  TITLE     Dally-like core protein and its mammalian homologues mediate
            stimulatory and inhibitory effects on Hedgehog signal response
  JOURNAL   Proc Natl Acad Sci U S A 107 (13), 5869-5874 (2010)
   PUBMED   20231458
REFERENCE   7  (residues 1 to 557)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (residues 1 to 557)
  AUTHORS   Trinidad JC, Specht CG, Thalhammer A, Schoepfer R and Burlingame
            AL.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   9  (residues 1 to 557)
  AUTHORS   Hagihara K, Watanabe K, Chun J and Yamaguchi Y.
  TITLE     Glypican-4 is an FGF2-binding heparan sulfate proteoglycan
            expressed in neural precursor cells
  JOURNAL   Dev Dyn 219 (3), 353-367 (2000)
   PUBMED   11066092
REFERENCE   10 (residues 1 to 557)
  AUTHORS   Siebertz B, Stocker G, Drzeniek Z, Handt S, Just U and Haubeck HD.
  TITLE     Expression of glypican-4 in haematopoietic-progenitor and
            bone-marrow-stromal cells
  JOURNAL   Biochem J 344 Pt 3 (Pt 3), 937-943 (1999)
   PUBMED   10585884
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081962.1.
            
            On Apr 20, 2005 this sequence version replaced XP_228677.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081962.1, SRR8487227.176117.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     Protein         1..557
                     /product="glypican-4 precursor"
                     /calculated_mol_wt=60395
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2186
     Region          24..550
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..557
                     /gene="Gpc4"
                     /coded_by="NM_001014108.1:516..2189"
                     /db_xref="GeneID:317322"
                     /db_xref="RGD:1359399"
ORIGIN      
        1 marlgllall ctlaalsasl laaepksksc sevrrlyvsk gfnkndaply eingdhlkic
       61 sqdytccsqe meekyslqsk ddfqtvvseq cnhlqaifas rykkfdeffk ellenaeksl
      121 ndmfvktygh lymqnselfk dlfvelkryy vagnvnleem lndfwarlle rmfrlvnsqy
      181 hftdeylecv skyteqlkpf gdvprklklq vtrafvaart faqglavard vvnrvsvvnp
      241 taqctqallk miycshcrgl vtvkpcynyc snimrgclan qgdldlewnn fidamlmvae
      301 rlegpfnies vmdpidvkis daimnmqdns vqvsqkvfqg cgppkplpag risrsisesa
      361 fsarfrpyhp eqrpttaagt sldrlvtdvk eklkqakkfw sslpstvcnd ermaagnene
      421 ddcwngksks rylfavtgng lanqgnnpev qvdtskpdil ilrqimalrv mtskmknayn
      481 gndvdffdis dessgegsgs gceyqqcpse feynatdhsg ksanekadsa ggapaeakpy
      541 llaalcilfl avqgewr
//
