LOCUS       NM_030828               3493 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus glypican 1 (Gpc1), mRNA.
ACCESSION   NM_030828
VERSION     NM_030828.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3493)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3493)
  AUTHORS   Mahmoud,M., Mayer,M., Cancel,L.M., Bartosch,A.M., Mathews,R. and
            Tarbell,J.M.
  TITLE     The glycocalyx core protein Glypican 1 protects vessel wall
            endothelial cells from stiffness-mediated dysfunction and disease
  JOURNAL   Cardiovasc Res 117 (6), 1592-1605 (2021)
   PUBMED   32647868
  REMARK    GeneRIF: The glycocalyx core protein Glypican 1 protects vessel
            wall endothelial cells from stiffness-mediated dysfunction and
            disease.
REFERENCE   3  (bases 1 to 3493)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 3493)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 3493)
  AUTHORS   Zeng,Y., Waters,M., Andrews,A., Honarmandi,P., Ebong,E.E., Rizzo,V.
            and Tarbell,J.M.
  TITLE     Fluid shear stress induces the clustering of heparan sulfate via
            mobility of glypican-1 in lipid rafts
  JOURNAL   Am J Physiol Heart Circ Physiol 305 (6), H811-H820 (2013)
   PUBMED   23851278
  REMARK    GeneRIF: These data suggest that fluid shear stress induced the
            cell junctional clustering of lipid rafts with their anchored
            glypican-1 and associated HS.
REFERENCE   6  (bases 1 to 3493)
  AUTHORS   Ronca,F., Andersen,J.S., Paech,V. and Margolis,R.U.
  TITLE     Characterization of Slit protein interactions with glypican-1
  JOURNAL   J Biol Chem 276 (31), 29141-29147 (2001)
   PUBMED   11375980
REFERENCE   7  (bases 1 to 3493)
  AUTHORS   Asundi,V.K., Keister,B.F. and Carey,D.J.
  TITLE     Organization, 5'-flanking sequence and promoter activity of the rat
            GPC1 gene
  JOURNAL   Gene 206 (2), 255-261 (1998)
   PUBMED   9469940
REFERENCE   8  (bases 1 to 3493)
  AUTHORS   Karthikeyan,L., Flad,M., Engel,M., Meyer-Puttlitz,B., Margolis,R.U.
            and Margolis,R.K.
  TITLE     Immunocytochemical and in situ hybridization studies of the heparan
            sulfate proteoglycan, glypican, in nervous tissue
  JOURNAL   J Cell Sci 107 (Pt 11), 3213-3222 (1994)
   PUBMED   7699018
REFERENCE   9  (bases 1 to 3493)
  AUTHORS   Litwack,E.D., Stipp,C.S., Kumbasar,A. and Lander,A.D.
  TITLE     Neuronal expression of glypican, a cell-surface
            glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan,
            in the adult rat nervous system
  JOURNAL   J Neurosci 14 (6), 3713-3724 (1994)
   PUBMED   8207484
REFERENCE   10 (bases 1 to 3493)
  AUTHORS   Karthikeyan,L., Maurel,P., Rauch,U., Margolis,R.K. and
            Margolis,R.U.
  TITLE     Cloning of a major heparan sulfate proteoglycan from brain and
            identification as the rat form of glypican
  JOURNAL   Biochem Biophys Res Commun 188 (1), 395-401 (1992)
   PUBMED   1417860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030828.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02896.1, BC061572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               JAXUCZ010000009.1  100843645-100844029
            386-544             JAXUCZ010000009.1  100864746-100864904
            545-936             JAXUCZ010000009.1  100866283-100866674
            937-1102            JAXUCZ010000009.1  100867324-100867489
            1103-1233           JAXUCZ010000009.1  100868378-100868508
            1234-1353           JAXUCZ010000009.1  100868633-100868752
            1354-1487           JAXUCZ010000009.1  100868845-100868978
            1488-1663           JAXUCZ010000009.1  100869171-100869346
            1664-3493           JAXUCZ010000009.1  100869629-100871458
FEATURES             Location/Qualifiers
     source          1..3493
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..3493
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /note="glypican 1"
                     /db_xref="GeneID:58920"
                     /db_xref="RGD:61853"
     exon            1..385
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1896
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /note="GPI-anchored cell surface heparan sulfate
                     proteoglycan"
                     /codon_start=1
                     /product="glypican-1 precursor"
                     /protein_id="NP_110455.2"
                     /db_xref="GeneID:58920"
                     /db_xref="RGD:61853"
                     /translation="MELRARGWWLLCAAAALVACARGDPASKSRSCSEVRQIYGAKGF
                     SLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANHSRMELETALHDSSRALQATLAT
                     QLHGIDDHFQRLLNDSERTLQDAFPGAFGDLYTQNTRAFRDLYAELRLYYRGANLHLE
                     ETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGDAPRELRLRATRAFV
                     AARSFVQGLGVASDVVRKVAQVPLAPECSRAVMKLVYCAHCRGVPGARPCPDYCRNVL
                     KGCLANQADLDAEWRNLLDSMVLITDKFWGPSGAENVIGSVHMWLAEAINALQDNKDT
                     LTAKVIQGCGNPKVNPHGSGPEEKRRRGKLALQEKSSTGTLEKLVSEAKAQLRDIQDY
                     WISLPGTLCSEKMAMSPASDDRCWNGISKGRYLPEVMGDGLANQINNPEVEVDITKPD
                     MTIRQQIMQLKIMTNRLRGAYGGNDVDFQDASDDGSGSGSGGGCPDDACGRRVSKKSS
                     SSRTPLTHALPGLSEQEGQKTSAATRPEPHYFFLLFLFTLVLAAARPRWR"
     exon            386..544
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            545..936
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1102
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1233
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1353
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1487
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1663
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..3493
                     /gene="Gpc1"
                     /gene_synonym="HSPG M12; HSPGM12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgactga gtggccggac ctcgcgcctc gcgcctcgcg ccccgcgctg cagccgcagc
       61 cggcttttgt tgtctccgcc tcctcggctg ccgccgcctc tggaccacga gcggcgcgcg
      121 ctgggacctt ggctctgccc ttcgcgcaga ctgggctgag cgggccggcc gggatccagg
      181 gaggcgcgca cgggcggccg gggagccgcg ggccccgcca tggagctccg ggcccgaggc
      241 tggtggctgc tgtgcgcggc cgccgcgcta gtcgcctgcg cccgcgggga ccccgccagc
      301 aagagccgga gctgcagcga agtccgccag atctacgggg ctaagggctt tagcctgagc
      361 gacgtgcccc aggcagagat ctcgggagag cacctgcgga tctgccccca gggctacacc
      421 tgctgcacca gtgagatgga ggagaacctg gccaaccaca gccggatgga gctggagacc
      481 gcactccacg acagcagccg tgccctgcag gctacgctgg ccacccagct gcatggcatc
      541 gatgaccact tccagcgcct gctgaatgac tcggagcgta cactgcagga tgcttttccc
      601 ggggcctttg gggacctgta cacgcagaac actcgggcct tccgggacct gtatgctgag
      661 ctgcgtctct actaccgagg ggccaaccta caccttgagg agacactggc cgagttctgg
      721 gcacggctgc tggagcgtct cttcaagcag ctgcaccccc agctgctgct gcccgatgac
      781 tatctggact gcctgggcaa gcaggcagag gcactgcggc cgtttgggga tgcccctcga
      841 gaactgcgcc tgagggccac ccgtgctttt gtggcggcac gatcctttgt gcagggcctg
      901 ggtgtggcca gtgacgtagt ccgaaaggtg gcccaggttc ctctggcccc agaatgttct
      961 cgggctgtca tgaagttggt ctactgtgcc cattgccggg gagtccctgg tgcccggccc
     1021 tgtcccgact attgccgaaa tgtgctcaaa ggctgccttg ccaaccaggc cgacctggat
     1081 gccgagtgga ggaacctcct ggactccatg gtgctcatca ctgacaagtt ctggggcccg
     1141 tcgggtgcgg agaatgtcat tggcagtgtg catatgtggc tggcggaggc catcaacgcc
     1201 ctccaggaca acaaggacac actcacagct aaggtcatcc agggctgcgg aaaccccaag
     1261 gtcaatcccc atggctctgg gcctgaggag aagcgtcgcc gtggcaaact ggcactgcag
     1321 gagaagtcct ccacaggtac tctggaaaag ctggtctctg aggccaaggc ccagctccga
     1381 gacattcagg actactggat cagcctccca gggacactgt gtagtgagaa gatggccatg
     1441 agtcctgcca gcgatgaccg ctgctggaat gggatttcca agggccggta cctacctgag
     1501 gtgatgggtg atgggctggc caaccagatc aacaaccctg aagtggaggt ggacatcacc
     1561 aagccggata tgaccatccg gcagcagatc atgcagctca agatcatgac caaccgttta
     1621 cgtggcgcct acggtggcaa tgatgtggac ttccaggatg ccagtgatga cggcagtggc
     1681 tccggcagcg gtggcggatg cccagatgac gcctgtggcc ggagggtcag caagaagagc
     1741 tccagctccc ggaccccctt gacccatgcc ctccccggct tgtcagaaca ggagggacag
     1801 aagacctcgg ccgccactcg cccagagcct cactacttct ttctgctctt cctgttcacc
     1861 ttggtccttg ctgcagccag gcccaggtgg cggtaactgc cccctagccc aaaggactgt
     1921 cttggccaaa acatgcaaca gaccatattt aattcccttg gccttcgagg cccagggcag
     1981 gataaggaga cagtagctct gagtgctggg gcagggtgca tggggttctg gccttcctgg
     2041 gtctggccac gcctgtcacc ctagctttta attttgtatc aggtcagctg cgagccagtg
     2101 tccccaaaag ccatgtattt cagggacctc aggggcacct ctggctgcac actcctcccc
     2161 taccctcctg caccacccca gaagctcacg aggccaacca gaagggcggc tattagctac
     2221 aacccatcgg agacctcaag tgagcctgtg ccttcctctc ctgcctcttc ccgctgggga
     2281 ctccccacca gaccccatgg gccacagatg tcagaaattg aggcccatcc cgcagctccc
     2341 caggaagcct gcaagggatg ccagtatgtc gctgaccagg ctctggcagg gccttcaagt
     2401 ttatgcatga taccttctcc tcagaagaag ctctgcagcc aggatcccaa cacacaccag
     2461 accaggaccc tgtgccactg tggagctcag tgaatctggt tctcaaagaa gacccactgt
     2521 ggggttcctc tagtgtgaca taggtgaggt ggcagctggc aaggccgcac taggctgcca
     2581 cactgtttgc cccctcagat gggctcataa agactggcct tgagggtcca catgaagagc
     2641 ctcacttcag gggaatagcc ggccacgtct agcccctatc ccacttagaa aggtcacctg
     2701 gccacgggga tgctgggtgg ctggtgaaac ttaagctcag ggtcagtggg acctggcact
     2761 gcaggtcaag aggacgcctg ggccccttcc tgacccaggc agctctgcag gagctggggg
     2821 agcattgaca gtcaagggct tttatagaca tgcacattca gaccctcggt gtccttgtcc
     2881 actgagtgct gcatctcatc gcatctcaat cttcattgac agcactggag aggctcgggg
     2941 caccacttgg agcctggtat cccgcagcct tgagacctgg gggcacctgg cttaccaagg
     3001 ttgccaaggc tccatcttcc cttccagggc cttggggatg ctaagttgct gtatccagga
     3061 agacagtggt cctcacatgc agaaggcctg ggaaaaggct gcttgtcgct tttttttttt
     3121 cctttctttt tgtcactggg ttagagaggc tcccgccagc acagcaccaa ggcctgccca
     3181 gtagtcaggt ctcctggtcc aggatgggtg tgctctgtag ttggtctgtg ggtttcttag
     3241 gcccatgccc tgagcacatt cacccagcca catccctgct agtgacactc aggcaggggc
     3301 actgggagcc agacctgggc tctggcatca acgagtgcct aggtgtcagg acagcggcac
     3361 ccatgctgta cagggcagcc aggatagtgg ccaagctact gtgtcctttc tccatgaggc
     3421 tccctgtcac tcggtgccag tgggtaatgt gtgttctttg agtccttata tgaattaaag
     3481 gctggagacc tac
//
