LOCUS       NM_177936               1336 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus G protein-coupled bile acid receptor 1 (Gpbar1),
            mRNA.
ACCESSION   NM_177936
VERSION     NM_177936.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Vanden Brink,H., Vandeputte,D., Brito,I.L., Ronnekleiv,O.K.,
            Roberson,M.S. and Lomniczi,A.
  TITLE     Changes in the Bile Acid Pool and Timing of Female Puberty:
            Potential Novel Role of Hypothalamic TGR5
  JOURNAL   Endocrinology 165 (9) (2024)
   PUBMED   39082696
  REMARK    GeneRIF: Changes in the Bile Acid Pool and Timing of Female
            Puberty: Potential Novel Role of Hypothalamic TGR5.
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Zhan,K., Wu,H., Xu,Y., Rao,K., Zheng,H., Qin,S., Yang,Y., Jia,R.,
            Chen,W. and Huang,S.
  TITLE     The function of the gut microbiota-bile acid-TGR5 axis in
            diarrhea-predominant irritable bowel syndrome
  JOURNAL   mSystems 9 (3), e0129923 (2024)
   PUBMED   38329942
  REMARK    GeneRIF: The function of the gut microbiota-bile acid-TGR5 axis in
            diarrhea-predominant irritable bowel syndrome.
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Han,M., Li,S., Xie,H., Liu,Q., Wang,A., Hu,S., Zhao,X., Kong,Y.,
            Wang,W. and Li,C.
  TITLE     Activation of TGR5 restores AQP2 expression via the HIF pathway in
            renal ischemia-reperfusion injury
  JOURNAL   Am J Physiol Renal Physiol 320 (3), F308-F321 (2021)
   PUBMED   33427060
  REMARK    GeneRIF: Activation of TGR5 restores AQP2 expression via the HIF
            pathway in renal ischemia-reperfusion injury.
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Liang,H., Matei,N., McBride,D.W., Xu,Y., Zhou,Z., Tang,J., Luo,B.
            and Zhang,J.H.
  TITLE     TGR5 activation attenuates neuroinflammation via Pellino3
            inhibition of caspase-8/NLRP3 after middle cerebral artery
            occlusion in rats
  JOURNAL   J Neuroinflammation 18 (1), 40 (2021)
   PUBMED   33531049
  REMARK    GeneRIF: TGR5 activation attenuates neuroinflammation via Pellino3
            inhibition of caspase-8/NLRP3 after middle cerebral artery
            occlusion in rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Zhou,H., Zhou,S.Y., Gillilland,M. 3rd, Li,J.Y., Lee,A., Gao,J.,
            Zhang,G., Xu,X. and Owyang,C.
  TITLE     Bile acid toxicity in Paneth cells contributes to gut dysbiosis
            induced by high-fat feeding
  JOURNAL   JCI Insight 5 (20), 138881 (2020)
   PUBMED   33055426
  REMARK    GeneRIF: Bile acid toxicity in Paneth cells contributes to gut
            dysbiosis induced by high-fat feeding.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Cipriani,S., Mencarelli,A., Chini,M.G., Distrutti,E., Renga,B.,
            Bifulco,G., Baldelli,F., Donini,A. and Fiorucci,S.
  TITLE     The bile acid receptor GPBAR-1 (TGR5) modulates integrity of
            intestinal barrier and immune response to experimental colitis
  JOURNAL   PLoS One 6 (10), e25637 (2011)
   PUBMED   22046243
  REMARK    Erratum:[PLoS One. 2013;8(1).
            doi:10.1371/annotation/55febddb-0209-4a48-9c14-23df882126a2]
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Keitel,V., Donner,M., Winandy,S., Kubitz,R. and Haussinger,D.
  TITLE     Expression and function of the bile acid receptor TGR5 in Kupffer
            cells
  JOURNAL   Biochem Biophys Res Commun 372 (1), 78-84 (2008)
   PUBMED   18468513
  REMARK    GeneRIF: TGR5 is localized in the plasma membrane of isolated
            Kupffer cells and is responsive to bile acids;it may play a
            protective role in obstructive cholestasis preventing excessive
            cytokine production thereby reducing liver injury.
REFERENCE   8  (bases 1 to 1336)
  AUTHORS   Keitel,V., Reinehr,R., Gatsios,P., Rupprecht,C., Gorg,B.,
            Selbach,O., Haussinger,D. and Kubitz,R.
  TITLE     The G-protein coupled bile salt receptor TGR5 is expressed in liver
            sinusoidal endothelial cells
  JOURNAL   Hepatology 45 (3), 695-704 (2007)
   PUBMED   17326144
  REMARK    GeneRIF: This is the first report on the expression of TGR5 in
            sinusoidal endothelial cells. Regulation of eNOS by TGR5 connects
            bile salts with hepatic hemodynamics.
REFERENCE   9  (bases 1 to 1336)
  AUTHORS   Kawamata,Y., Fujii,R., Hosoya,M., Harada,M., Yoshida,H., Miwa,M.,
            Fukusumi,S., Habata,Y., Itoh,T., Shintani,Y., Hinuma,S.,
            Fujisawa,Y. and Fujino,M.
  TITLE     A G protein-coupled receptor responsive to bile acids
  JOURNAL   J Biol Chem 278 (11), 9435-9440 (2003)
   PUBMED   12524422
  REMARK    GeneRIF: TGR5 is implicated in the suppression of macrophage
            functions by bile acids
REFERENCE   10 (bases 1 to 1336)
  AUTHORS   Maruyama,T., Miyamoto,Y., Nakamura,T., Tamai,Y., Okada,H.,
            Sugiyama,E., Nakamura,T., Itadani,H. and Tanaka,K.
  TITLE     Identification of membrane-type receptor for bile acids (M-BAR)
  JOURNAL   Biochem Biophys Res Commun 298 (5), 714-719 (2002)
   PUBMED   12419312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 18, 2022 this sequence version replaced NM_177936.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX534229.1, SRR26360190.2907689.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680422
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000009.1  83309895-83310078
            185-1336            JAXUCZ010000009.1  83311246-83312397
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..1336
                     /gene="Gpbar1"
                     /gene_synonym="M-BAR; Tgr5"
                     /note="G protein-coupled bile acid receptor 1"
                     /db_xref="GeneID:338443"
                     /db_xref="RGD:631400"
     exon            1..184
                     /gene="Gpbar1"
                     /gene_synonym="M-BAR; Tgr5"
                     /inference="alignment:Splign:2.1.0"
     exon            185..1336
                     /gene="Gpbar1"
                     /gene_synonym="M-BAR; Tgr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1216
                     /gene="Gpbar1"
                     /gene_synonym="M-BAR; Tgr5"
                     /note="membrane-type receptor for bile acids; G
                     protein-coupled receptor"
                     /codon_start=1
                     /product="G-protein coupled bile acid receptor 1"
                     /protein_id="NP_808797.1"
                     /db_xref="GeneID:338443"
                     /db_xref="RGD:631400"
                     /translation="MMSHNTTELSAIPRGVQELSLVLASLIVIANLLLALGIVLDRHL
                     RSPPAGCFFLSLLLAGLLTGLALPTLPGLWNRSHQGYWSCLLLHLAPNFCFLSLLANL
                     LLVHGERYMAVLQPLRPHGSVRLALFLTWISSLLFASLPALGWNHWSPGANCSSQAIF
                     PAPYLYLEVYGLLLPAVGATALLSVRVLATAHHQLREIRRLERAVCRDAPSTLARALT
                     WRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPVTLLSLISLGSASAAVVP
                     VAMGLGDQRYTAPWRTAAQRWLQVLRGRPKRANPGPSTAYHSSSQCSTDLDLN"
ORIGIN      
        1 aggagcccag gccaggccag agtctgagca ggcaaacctg gttcctgctg tccccagcat
       61 agaagcacca tgcactcatt gaccaggaca cccggcatgg ccccaagacc tacaagagtg
      121 gctgctgtga ctctttgatc ctcagaggaa gagctagcaa gcactacctg ttcctaacag
      181 ccatgcatgc tggctgcagc tccggaccct ccatgcgcca agacccatga tgtcacacaa
      241 caccactgag ctgtcagcca ttcccagagg ggttcaggag ctttccctgg tcctggcaag
      301 cctcatcgtc atcgccaacc tgctcctggc cctaggcatt gtcctggacc gccacttacg
      361 cagcccacct gctggctgct tctttctaag cctactacta gctgggctac tcacagggtt
      421 ggcactgccc acgctgcctg ggctatggaa taggagccat caggggtact ggtcctgcct
      481 ccttctccac ttggccccca acttttgttt cctctccctg cttgccaatc tgctgctggt
      541 gcatggggaa cgctacatgg cagtgttgca gccactccgg ccccatggga gtgtgcggct
      601 agccctgttc ctcacctgga tcagctccct gctctttgcc agcctgcctg ctctgggctg
      661 gaaccactgg agtcctggtg ccaactgcag ctcccaggct atcttcccag ccccctacct
      721 ttacctcgaa gtctatgggc tcctgctgcc cgctgtgggg gccactgccc ttctctctgt
      781 ccgagtgttg gccactgccc accaccagct gcgggagatc cgcagactgg agcgggcggt
      841 gtgccgtgat gcaccctcaa ccctagcgag ggctctcacc tggaggcagg ctagggcaca
      901 ggcaggagcc acactgctct ttttgctgtg ttgggggccc tatgtggcca cattgctcct
      961 gtcagtcttg gcctatgagc ggcggccacc actagggcct gtaactctgt tatctctcat
     1021 ctcattgggc agtgccagtg ctgcagttgt gcctgtggcc atgggtctgg gtgatcagcg
     1081 ctacacggcc ccctggagga cagctgccca aaggtggcta caagtgcttc gaggaagacc
     1141 caagagggcc aatccaggcc ccagcactgc ctaccactcc agtagccaat gcagcactga
     1201 cttggacttg aattagggaa acagtagcta ctgctgcctc ccaggacaca catctatctc
     1261 atagtgcccc acttctttgg cttggagccc ttgctccatg agacctcacc cagaccaaat
     1321 aaatctctgg ccacca
//
