LOCUS       NM_017274               2646 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus glycerol-3-phosphate acyltransferase,
            mitochondrial (Gpam), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017274
VERSION     NM_017274.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Cattaneo,E.R., Pellon-Maison,M., Rabassa,M.E., Lacunza,E.,
            Coleman,R.A. and Gonzalez-Baro,M.R.
  TITLE     Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic
            germ cells and incorporates arachidonic acid into triacylglycerols
  JOURNAL   PLoS One 7 (8), e42986 (2012)
   PUBMED   22905194
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Guha,P., Aneja,K.K., Shilpi,R.Y. and Haldar,D.
  TITLE     Transcriptional regulation of mitochondrial glycerophosphate
            acyltransferase is mediated by distal promoter via ChREBP and
            SREBP-1
  JOURNAL   Arch Biochem Biophys 490 (2), 85-95 (2009)
   PUBMED   19682972
  REMARK    GeneRIF: ChREBP and SREBP-1 bind to the mtGPAT distal promoter.
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Karlsson,E.A., Wang,S., Shi,Q., Coleman,R.A. and Beck,M.A.
  TITLE     Glycerol-3-phosphate acyltransferase 1 is essential for the immune
            response to infection with coxsackievirus B3 in mice
  JOURNAL   J Nutr 139 (4), 779-783 (2009)
   PUBMED   19193813
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Rodriguez-Calvo,R., Barroso,E., Serrano,L., Coll,T., Sanchez,R.M.,
            Merlos,M., Palomer,X., Laguna,J.C. and Vazquez-Carrera,M.
  TITLE     Atorvastatin prevents carbohydrate response element binding protein
            activation in the fructose-fed rat by activating protein kinase A
  JOURNAL   Hepatology 49 (1), 106-115 (2009)
   PUBMED   19053045
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Onorato,T.M. and Haldar,D.
  TITLE     Casein kinase II stimulates rat liver mitochondrial
            glycerophosphate acyltransferase activity
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1091-1096 (2002)
   PUBMED   12207885
  REMARK    GeneRIF: Casein kinase II stimulates rat liver mitochondrial
            glycerophosphate acyltransferase activity
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Park,H., Kaushik,V.K., Constant,S., Prentki,M., Przybytkowski,E.,
            Ruderman,N.B. and Saha,A.K.
  TITLE     Coordinate regulation of malonyl-CoA decarboxylase,
            sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase
            by AMP-activated protein kinase in rat tissues in response to
            exercise
  JOURNAL   J Biol Chem 277 (36), 32571-32577 (2002)
   PUBMED   12065578
  REMARK    GeneRIF: Gpam regulation in rats in response to exercise
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Balija,V.S., Chakraborty,T.R., Nikonov,A.V., Morimoto,T. and
            Haldar,D.
  TITLE     Identification of two transmembrane regions and a cytosolic domain
            of rat mitochondrial glycerophosphate acyltransferase
  JOURNAL   J Biol Chem 275 (41), 31668-31673 (2000)
   PUBMED   10924502
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Ganesh Bhat,B., Wang,P., Kim,J.H., Black,T.M., Lewin,T.M.,
            Fiedorek,F.T. Jr. and Coleman,R.A.
  TITLE     Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and
            characterization of the cDNA and expressed protein
  JOURNAL   Biochim Biophys Acta 1439 (3), 415-423 (1999)
   PUBMED   10446428
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Lee,Y., Hirose,H., Zhou,Y.T., Esser,V., McGarry,J.D. and Unger,R.H.
  TITLE     Increased lipogenic capacity of the islets of obese rats: a role in
            the pathogenesis of NIDDM
  JOURNAL   Diabetes 46 (3), 408-413 (1997)
   PUBMED   9032096
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF021348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF021348.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2646
                     /gene="Gpam"
                     /note="glycerol-3-phosphate acyltransferase,
                     mitochondrial"
                     /db_xref="GeneID:29653"
                     /db_xref="RGD:61847"
     exon            1..126
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            127..261
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2646
                     /gene="Gpam"
                     /EC_number="2.3.1.15"
                     /note="GPAT; GPAT-1"
                     /codon_start=1
                     /product="glycerol-3-phosphate acyltransferase 1,
                     mitochondrial"
                     /protein_id="NP_058970.1"
                     /db_xref="GeneID:29653"
                     /db_xref="RGD:61847"
                     /translation="MEESSVTIGTIDVSYLPNSSEYSLGRCKHTNEDWVDCGFKPTFF
                     RSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHR
                     GWLARRLSYILFVQERDVHKGMFATSITDNVLNSSRVQEAIAEVAAELNPDGSAQQQS
                     KAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAAT
                     ETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFI
                     RRRLDETPDGRKDILYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSV
                     VVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKN
                     YGYVRVDFAQPFSLKEYLEGQSQKPVSAPLSLEQALLPAILPSRPDAAAAEHEDMSSN
                     ESRNAADEAFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVED
                     FFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSV
                     FELNFYSNGVLHVFIMEAIIACSIYAVQNKRGSGGSAGGLGNLISQEQLVRKAASLCY
                     LLSNEGTISLPCQTFYQVCQETVGKFIQYGILTVAEQDDQEDVSPGLAEQQWNKKLPE
                     PLNWRSDEEDEDSDFGEEQRDCYLKVSQAKEHQQFITFLQRLLGPLLEAYSSAAIFVH
                     TFRGPVPESEYLQKLHRYLLTRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQK
                     RASVLELSTTFLPQGSRQKLLEYILSFVVL"
     exon            262..384
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            385..458
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            459..572
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            573..719
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            720..816
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            817..953
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1053
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1266
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1380
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1466
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1582
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1653
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1918
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2061
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2139
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2280
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2470
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2529
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2646
                     /gene="Gpam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgaataag cctctggagg agctgctgaa tcacccccgc cccaggctgt cttctgaagc
       61 tgtctgggga tagctttgct aatcaactga ctggaaataa ttccagacac cacatcaagg
      121 atacagctca tgttttgttt gggacttcca cgttgagtca tggaggagtc ttcagtgaca
      181 attggcacaa tagacgtttc ttatctgccc aattcatcag aatacagcct tggccgatgt
      241 aaacacacga atgaggactg ggttgactgt ggcttcaaac ctaccttctt cagatccgca
      301 acgctgaaat ggaaggagag cctcatgagc cggaagaggc ccttcgtggg aaggtgttgc
      361 tattcatgca cgcctcagag ctgggaaagg tttttcaacc ccagtatccc atctctgggt
      421 ttgcggaatg ttatttatat caatgaaact cacacaaggc accgaggatg gctggcaaga
      481 cggctttctt acatcctttt tgttcaagag cgcgatgtcc acaagggcat gtttgccacc
      541 agtatcactg acaatgtact gaatagcagc agagtccaag aggcaattgc tgaagtggct
      601 gcagaattga acccggatgg atctgcccag cagcagtcca aagccatcca gaaagtgaaa
      661 aggaaagcca ggaagatcct ccaggaaatg gttgctacag tctcccccgg gatgatcagg
      721 ctgactggct gggtgttact aaagctcttc aacagcttct tctggaacat tcagattcac
      781 aagggtcaac ttgagatggt gaaagctgca actgagacga atctgccgct cttgtttctg
      841 ccggtgcaca gatcccacat cgactacctg ctgctcacct tcatcctctt ctgccacaac
      901 atcaaagctc catacatcgc ctcgggcaac aacctcaaca tccccatctt cagtaccttg
      961 attcacaagc ttgggggctt tttcataaga cggaggcttg acgaaactcc agatggacgc
     1021 aaagacattc tgtacagagc gttgctccat gggcatatag ttgaactcct ccgacagcag
     1081 cagttcctgg agatcttcct ggaaggcacc cgctcccgca gtggcaagac ctcctgtgcc
     1141 cgggccgggc tcctgtcagt ggtagtggat actctgtcat ccaacaccat ccctgacatc
     1201 ctggtcatcc ctgtgggcat ctcgtatgat cggataatcg aaggtcacta caatggtgaa
     1261 cagttgggca agcccaagaa gaatgaaagt ctctggagtg tggcaagagg cgttatcaga
     1321 atgctgcgga aaaactacgg ctatgtccga gtggactttg cacagccatt ttctttgaag
     1381 gaatatttag aaggccaaag tcagaaacct gtatctgctc ccctctcttt ggagcaagca
     1441 ctgttaccag caatccttcc ttcaagacct gatgctgctg ctgccgaaca tgaagacatg
     1501 tccagtaatg agtcgagaaa cgcggcagac gaagccttcc gaaggaggct gatcgcaaac
     1561 ctggcggagc acattctctt caccgccagc aagtcctgcg ctatcatgtc cacccacatt
     1621 gtggcctgcc tgctcctcta cagacacagg cagggaatcc acctctccac gctggtggaa
     1681 gacttctttg tgatgaagga ggaagtccta gctcgggatt ttgacctggg cttctccggg
     1741 aattcagaag atgtagtcat gcatgctatt cagcttctgg ggaactgtgt cacaatcacc
     1801 cacactagca ggaaggatga attctttatt actcccagca caactgtccc gtccgtcttt
     1861 gaactcaact tctacagcaa tggggtactt catgtcttta tcatggaagc catcatagct
     1921 tgcagcattt atgcagtcca gaataagagg ggttccggag ggtctgccgg aggccttggc
     1981 aacctgatca gccaggagca gctggtgcgg aaggccgcca gcctgtgcta ccttctctct
     2041 aatgaaggta ccatttctct gccctgccag acattttacc aggtttgtca agagacagta
     2101 ggaaagttca tccagtacgg aattctcaca gtggcagagc aagatgacca ggaagatgtc
     2161 agtcctggcc ttgcagagca gcagtggaac aagaagcttc cggagcctct gaactggaga
     2221 agtgacgaag aagatgagga cagtgacttt ggtgaggagc agcgtgattg ctacctgaag
     2281 gtgagccagg ccaaggagca ccagcaattc atcacctttc tgcagaggct tctggggccc
     2341 ctgctagaag cctacagctc tgctgccatc tttgtccaca ccttccgcgg cccagtcccg
     2401 gagtctgagt acctgcagaa gctgcacagg taccttctca ccaggacgga gaggaacgtc
     2461 gcggtgtacg ctgagagtgc cacatactgt cttgtgaaga atgctgtgaa aatgtttaag
     2521 gacatcgggg ttttcaaaga gaccaagcag aagcgagcgt ctgtcttaga actgagcacc
     2581 actttcctac ctcagggcag ccggcagaag ctcctggaat acattctgag cttcgtggtg
     2641 ctgtag
//
