LOCUS       NM_053930                947 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus glycoprotein Ib platelet subunit beta (Gp1bb),
            mRNA.
ACCESSION   NM_053930
VERSION     NM_053930.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 947)
  AUTHORS   Boeckelmann,D., Hengartner,H., Greinacher,A., Nowak-Gottl,U.,
            Sachs,U.J., Peter,K., Sandrock-Lang,K. and Zieger,B.
  TITLE     Patients with Bernard-Soulier syndrome and different severity of
            the bleeding phenotype
  JOURNAL   Blood Cells Mol Dis 67, 69-74 (2017)
   PUBMED   28131619
REFERENCE   2  (bases 1 to 947)
  AUTHORS   Luo,S.Z. and Li,R.
  TITLE     Specific heteromeric association of four transmembrane peptides
            derived from platelet glycoprotein Ib-IX complex
  JOURNAL   J Mol Biol 382 (2), 448-457 (2008)
   PUBMED   18674540
REFERENCE   3  (bases 1 to 947)
  AUTHORS   Strassel,C., Nonne,C., Eckly,A., David,T., Leon,C., Freund,M.,
            Cazenave,J.P., Gachet,C. and Lanza,F.
  TITLE     Decreased thrombotic tendency in mouse models of the
            Bernard-Soulier syndrome
  JOURNAL   Arterioscler Thromb Vasc Biol 27 (1), 241-247 (2007)
   PUBMED   17095718
REFERENCE   4  (bases 1 to 947)
  AUTHORS   Watanabe,R., Ishibashi,T., Saitoh,Y., Shichishima,T., Maruyama,Y.,
            Enomoto,Y., Handa,M., Oda,A., Ambo,H., Murata,M. and Ikeda,Y.
  TITLE     Bernard-soulier syndrome with a homozygous 13 base pair deletion in
            the signal peptide-coding region of the platelet glycoprotein
            Ib(beta) gene
  JOURNAL   Blood Coagul Fibrinolysis 14 (4), 387-394 (2003)
   PUBMED   12945881
REFERENCE   5  (bases 1 to 947)
  AUTHORS   Perrault,C., Moog,S., Rubinstein,E., Santer,M., Baas,M.J., de la
            Salle,C., Ravanat,C., Dambach,J., Freund,M., Santoso,S.,
            Cazenave,J.P. and Lanza,F.
  TITLE     A novel monoclonal antibody against the extracellular domain of
            GPIbbeta modulates vWF mediated platelet adhesion
  JOURNAL   Thromb Haemost 86 (5), 1238-1248 (2001)
   PUBMED   11816713
REFERENCE   6  (bases 1 to 947)
  AUTHORS   Berndt,M.C., Shen,Y., Dopheide,S.M., Gardiner,E.E. and Andrews,R.K.
  TITLE     The vascular biology of the glycoprotein Ib-IX-V complex
  JOURNAL   Thromb Haemost 86 (1), 178-188 (2001)
   PUBMED   11487006
  REMARK    Review article
REFERENCE   7  (bases 1 to 947)
  AUTHORS   Toda,S., Kajii,Y., Sato,M. and Nishikawa,T.
  TITLE     Reciprocal expression of infant- and adult-preferring transcripts
            of CDCrel-1 septin gene in the rat neocortex
  JOURNAL   Biochem Biophys Res Commun 273 (2), 723-728 (2000)
   PUBMED   10873671
REFERENCE   8  (bases 1 to 947)
  AUTHORS   Kunishima,S., Lopez,J.A., Kobayashi,S., Imai,N., Kamiya,T.,
            Saito,H. and Naoe,T.
  TITLE     Missense mutations of the glycoprotein (GP) Ib beta gene impairing
            the GPIb alpha/beta disulfide linkage in a family with giant
            platelet disorder
  JOURNAL   Blood 89 (7), 2404-2412 (1997)
   PUBMED   9116284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Mar 27, 2006 this sequence version replaced NM_053930.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227461.1, BF546915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000011.1  95882561-95882635
            76-947              JAXUCZ010000011.1  95882867-95883738
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..947
                     /gene="Gp1bb"
                     /note="glycoprotein Ib platelet subunit beta"
                     /db_xref="GeneID:116727"
                     /db_xref="RGD:621050"
     exon            1..75
                     /gene="Gp1bb"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..686
                     /gene="Gp1bb"
                     /note="platelet glycoprotein Ib beta chain; GPIbB;
                     GPIb-beta; glycoprotein Ib (platelet), beta polypeptide;
                     GP-Ib beta; glycoprotein Ib, beta polypeptide;
                     glycoprotein Ib platelet beta subunit"
                     /codon_start=1
                     /product="platelet glycoprotein Ib beta chain precursor"
                     /protein_id="NP_446382.1"
                     /db_xref="GeneID:116727"
                     /db_xref="RGD:621050"
                     /translation="MGSRPRGALSLLLLLLAPPSRPASGCPAPCRCSETRVDCGRRGL
                     TWASLPAAFPPDTTELVLTDNNLTALPPGLLDTLPALRRVHLGANPWRCDCRLLPLRA
                     WLAGRPEREFYRDLRCVAPLALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVL
                     GLLHALLLALLLSRLRRLRAQARARSTREFSLTAPLVAESAGGGAS"
     exon            76..947
                     /gene="Gp1bb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggagtcag gcaggctctc gggccaacgc cactccagaa cgaagtaggc ctccatcctc
       61 tcgccatggg ctcccggccg cgcggggcgc tgagcctgct gcttctgctg ctagcgccgc
      121 ccagccgccc agcctctggc tgtcccgcgc catgccgctg ctctgagacg cgcgtggact
      181 gcgggcgccg cgggctgacc tgggcctcgc tgccggctgc cttccctccc gacactacag
      241 aattggtgct gaccgacaac aacctgacgg cgctgccgcc cgggcttctg gatacgctgc
      301 cggcgctgcg cagagtgcac ctgggcgcta acccatggcg ctgcgactgt cgcttattgc
      361 cgctgcgcgc ctggctggcc ggccgccctg agcgcgagtt ctaccgcgac ctgcgctgtg
      421 tcgcgcctct ggcgctgcgt ggccgcttgc tgccctacgt ggcggaggat gagctgcggg
      481 ccgcatgcgc gcccggccta ctttgctggg gagctctggt ggcgcagcta gcgctgctgg
      541 tcctcgggct gctacacgcg ctgctgctgg cactcctact gagtcgcctg cggaggctac
      601 gcgcgcaggc gcgcgctcgc tccacccgcg agttctcact cacagccccg ctggtggccg
      661 agtcggccgg aggtggtgca tcttaagaaa ggacaggcgc agagcaacga cgacctgcaa
      721 attttacagg tccctgctgg aggaccctcc gccttcacct ggatcggcct tggcctctat
      781 ccttgcccaa cttcccagac ccaagctctg caagcctgaa tccacatggg gtcaaactgc
      841 tgccagtact accagaatga ggcaaccttg agtcttcaga gcctagagtg ctggagcagt
      901 ccagtctcct gccagactcc gcactgaata aacctttctc ctcctca
//
