LOCUS       NM_001109654            2677 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glycoprotein Ib platelet subunit alpha (Gp1ba),
            mRNA.
ACCESSION   NM_001109654 XM_001080712
VERSION     NM_001109654.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2677)
  AUTHORS   Zhang,H., Zhang,S., Zhang,J., Zhou,R., Nie,Y., Ren,S., Li,J.,
            Feng,K., Ji,F., Kong,G. and Li,Z.
  TITLE     Improvement of human platelet aggregation post-splenectomy with
            paraesophagogastric devascularization in chronic hepatitis B
            patients with cirrhotic hypersplenism
  JOURNAL   Platelets 31 (8), 1019-1027 (2020)
   PUBMED   31851564
REFERENCE   2  (bases 1 to 2677)
  AUTHORS   Yamaguchi,T., Fushida,S., Kinoshita,J., Okazaki,M., Ishikawa,S.,
            Ohbatake,Y., Terai,S., Okamoto,K., Nakanuma,S., Makino,I.,
            Nakamura,K., Miyashita,T., Tajima,H., Takamura,H., Ninomiya,I. and
            Ohta,T.
  TITLE     Extravasated platelet aggregation contributes to tumor progression
            via the accumulation of myeloid-derived suppressor cells in gastric
            cancer with peritoneal metastasis
  JOURNAL   Oncol Lett 20 (2), 1879-1887 (2020)
   PUBMED   32724431
REFERENCE   3  (bases 1 to 2677)
  AUTHORS   Kallianpur,A.R., Bradford,Y., Mody,R.K., Garman,K.N., Comstock,N.,
            Lathrop,S.L., Lyons,C., Saupe,A., Wymore,K., Canter,J.A.,
            Olson,L.M., Palmer,A. and Jones,T.F.
  TITLE     Genetic Susceptibility to Postdiarrheal Hemolytic-Uremic Syndrome
            After Shiga Toxin-Producing Escherichia coli Infection: A Centers
            for Disease Control and Prevention FoodNet Study
  JOURNAL   J Infect Dis 217 (6), 1000-1010 (2018)
   PUBMED   29216383
REFERENCE   4  (bases 1 to 2677)
  AUTHORS   Rossaint,J., Kuhne,K., Skupski,J., Van Aken,H., Looney,M.R.,
            Hidalgo,A. and Zarbock,A.
  TITLE     Directed transport of neutrophil-derived extracellular vesicles
            enables platelet-mediated innate immune response
  JOURNAL   Nat Commun 7, 13464 (2016)
   PUBMED   27845343
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2677)
  AUTHORS   Denes,A., Pradillo,J.M., Drake,C., Sharp,A., Warn,P., Murray,K.N.,
            Rohit,B., Dockrell,D.H., Chamberlain,J., Casbolt,H., Francis,S.,
            Martinecz,B., Nieswandt,B., Rothwell,N.J. and Allan,S.M.
  TITLE     Streptococcus pneumoniae worsens cerebral ischemia via interleukin
            1 and platelet glycoprotein Ibalpha
  JOURNAL   Ann Neurol 75 (5), 670-683 (2014)
   PUBMED   24644058
REFERENCE   6  (bases 1 to 2677)
  AUTHORS   Koskela,S., Partanen,J., Salmi,T.T. and Kekomaki,R.
  TITLE     Molecular characterization of two mutations in platelet
            glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome
            families
  JOURNAL   Eur J Haematol 62 (3), 160-168 (1999)
   PUBMED   10089893
REFERENCE   7  (bases 1 to 2677)
  AUTHORS   Ware,J., Russell,S. and Ruggeri,Z.M.
  TITLE     Cloning of the murine platelet glycoprotein Ibalpha gene
            highlighting species-specific platelet adhesion
  JOURNAL   Blood Cells Mol Dis 23 (2), 292-301 (1997)
   PUBMED   9410473
REFERENCE   8  (bases 1 to 2677)
  AUTHORS   Takahashi,H., Murata,M., Moriki,T., Anbo,H., Furukawa,T.,
            Nikkuni,K., Shibata,A., Handa,M., Kawai,Y., Watanabe,K. et al.
  TITLE     Substitution of Val for Met at residue 239 of platelet glycoprotein
            Ib alpha in Japanese patients with platelet-type von Willebrand
            disease
  JOURNAL   Blood 85 (3), 727-733 (1995)
   PUBMED   7833477
REFERENCE   9  (bases 1 to 2677)
  AUTHORS   Ware,J., Russell,S.R., Marchese,P., Murata,M., Mazzucato,M., De
            Marco,L. and Ruggeri,Z.M.
  TITLE     Point mutation in a leucine-rich repeat of platelet glycoprotein Ib
            alpha resulting in the Bernard-Soulier syndrome
  JOURNAL   J Clin Invest 92 (3), 1213-1220 (1993)
   PUBMED   7690774
REFERENCE   10 (bases 1 to 2677)
  AUTHORS   Miller,J.L., Cunningham,D., Lyle,V.A. and Finch,C.N.
  TITLE     Mutation in the gene encoding the alpha chain of platelet
            glycoprotein Ib in platelet-type von Willebrand disease
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 4761-4765 (1991)
   PUBMED   2052556
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001080712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AI575548.1, CO556293.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00155308, SAMD00155313 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2677
                     /gene="Gp1ba"
                     /note="glycoprotein Ib platelet subunit alpha"
                     /db_xref="GeneID:691992"
                     /db_xref="RGD:1310239"
     exon            1..85
                     /gene="Gp1ba"
                     /inference="alignment:Splign:2.1.0"
     exon            86..2677
                     /gene="Gp1ba"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2245
                     /gene="Gp1ba"
                     /note="glycoprotein 1b, alpha polypeptide; platelet
                     glycoprotein Ib alpha chain; glycoprotein Ib (platelet),
                     alpha polypeptide; glycoprotein Ib platelet alpha subunit"
                     /codon_start=1
                     /product="platelet glycoprotein Ib alpha chain precursor"
                     /protein_id="NP_001103124.1"
                     /db_xref="GeneID:691992"
                     /db_xref="RGD:1310239"
                     /translation="MALLILLFLLPSPLHSQPTCDVSKVTSLLEVNCEDKKLKKLPTD
                     LPADTGILHLSKNQLGTFSTSYLVHFTHLTHLYLSRCELTSLQAHEKLLKLETLDLSH
                     NHLQSLPSLGRALPALTTLDVSFNKLGSLSPGALEGLGQLEELYLQNNDLKSLPPGLL
                     MPTTKLLKLSLANNKLRELPPGLLDGLEDLDTLYLQGNWLSTIPKGFFGSLLLPFVFL
                     HANTWYCDCEILYFRNWLQENPNRVYLWKEGVDVKAMTANVASVRCANLGNAPVYSYP
                     GKGCPTNEGDIDYDDYADTPTTRTEVKFSTNTKAHTTYWGLFYSESSTSPDSQMTSLP
                     PIHEPTKKQPTFAHTEIPGFTTLPDTMESNTAFYSLNNTVPTTTPEPTSTQATPEPSS
                     TPMLTTPVPTPEPSSIPMLTVPVSTPEPSSTPMLTTPVSTPEPSSIPMPTIPVPTPEP
                     SSIPMPTIPVPTPEPSSTPMPTIPVPTPEPSSTPMFTTPVPTPEPSSTPMLTTPTLTT
                     PESSSTPSILVSTIPPVLTTTLAPPESIPKTVLEQFYTLEPTLPRTLESTIIIPEQNS
                     LNSQAVPQASSDTPKSNPFLNSDFCCLLPLGFYVLGLLWLLFASVVLIVLLTWIWHVT
                     PHNLDMDQSAALATSTHTTSLEMQRARQVTMPWAWLLSLQGSLPTFRSSLFLWVRPNG
                     RVGPLVAGRRPSALSQGHGQDLLGRVGIRYSGHSL"
ORIGIN      
        1 tggctctcct tggagctagt agagaggagg accgagtcat accctggaag aagctctgtg
       61 ccttcggagg tctttctgcc tgactgttca catggctctc ctcatcttgc tgttcctgct
      121 gccaagtccc ttacactccc agcccacttg tgatgtctcc aaagtgacca gcctgctgga
      181 agtaaactgt gaggacaaga agctgaaaaa attgcctaca gacctgccag ccgacacagg
      241 catcctccac ctgagcaaga accaactggg caccttctcc acatcatacc tggtgcattt
      301 cactcacctt actcacctgt acctgagtag atgtgagctg accagcctgc aggcccatga
      361 gaaactgtta aagctggaaa ccctggactt atcccacaat cacctgcaaa gtctgccctc
      421 cctaggacgg gcactgcctg cactcactac tctagacgtc tccttcaaca agctgggttc
      481 actgtctcct ggtgccctgg aaggcctggg ccaactcgag gaactctact tgcagaacaa
      541 tgatcttaag agtctgcccc ctgggctctt aatgcccaca actaagctgt tgaaactcag
      601 tctggccaac aacaaacttc gtgagctgcc ccctgggctc ctagatggac tagaggatct
      661 tgacaccctc taccttcaag ggaactggct cagcacaata ccaaagggct tctttgggtc
      721 cctcctcttg ccttttgttt ttctccatgc caacacctgg tactgtgatt gtgaaatcct
      781 ctacttccgt aactggctcc aagaaaaccc caaccgtgtc tacttatgga aggagggtgt
      841 agatgtcaag gccatgactg ctaacgtggc cagtgtacga tgtgccaatt tgggcaatgc
      901 gcctgtctac tcctacccag ggaagggctg ccctaccaat gagggtgaca tagactatga
      961 tgactatgct gataccccta ccacaaggac tgaggtgaag ttctctacta acactaaagc
     1021 tcatactacc tactggggcc tattctactc agagtcttcc acttctccag acagccaaat
     1081 gacttctttg cctcccatcc acgaacccac taagaaacaa cctacatttg cccacacaga
     1141 gatcccaggt ttcaccacac tcccagatac catggaatcc aacacagcct tctacagtct
     1201 aaacaatact gtacccacca ccaccccaga gcccacctcc acccaggcta ccccagagcc
     1261 cagcagcacc ccaatgctta ccactcctgt gcctacccca gagcccagca gcatcccaat
     1321 gcttaccgtt cctgtgtcta ccccagagcc cagcagcacc ccaatgctta ccactcccgt
     1381 gtctacccca gagcccagca gcatcccaat gcctaccatt cccgtgccta ccccagagcc
     1441 cagcagcatc ccaatgccta ccattcccgt gcctacccca gagcccagca gcaccccaat
     1501 gcctaccatt cctgtgccta ccccagagcc cagcagcacc ccaatgttta ccacacctgt
     1561 gcctacccca gagcccagca gtaccccaat gcttaccact cccaccctga ctaccccaga
     1621 gtccagcagc accccaagta ttctagtgtc tactatcccc ccagtgctca ctaccaccct
     1681 ggcccctcca gagtctatcc caaagaccgt tttagaacaa ttttataccc tagagcccac
     1741 tttaccccgt accttagaat ccacaataat aatcccagag cagaatagtc taaattccca
     1801 agcggtgcct caagcaagtt ctgatactcc taaaagcaat ccttttctca actctgactt
     1861 ctgttgcctc ctccccctgg gcttctatgt tctgggtctc ctctggctct tatttgcctc
     1921 tgtggtcctc attgtgttgc tgacctggat ctggcatgtg acaccgcaca atctagacat
     1981 ggaccaatct gctgcactgg ccacaagcac acacaccaca agcctggaaa tgcagagagc
     2041 aaggcaagta actatgccct gggcctggct gctctccctt caaggatcac tccctacttt
     2101 ccggtctagc cttttcctgt gggtaaggcc taatgggcgt gtggggcctc tggtagcagg
     2161 acggagaccc tcagctctga gtcagggtca tggtcaggac ctattgggca gagtgggtat
     2221 taggtactca ggccacagtc tgtgacagtg aatgctaaga ctttactgga ctctcctagg
     2281 acctagctag gacaggaggt tgagagcatt acaggacctc ctatttactt ctcgtttatc
     2341 tgaagcccct tctttacatc taggcaccca aatccaaacc ttacaaatca agaggtagtg
     2401 aggtgatgta tccctgtggt cacaggacca acctccctcc gttgcttaga gcattgccag
     2461 gctacatggt cactaccact ttgtgggggg aaaaaagagc tggaaaaagc agataggaat
     2521 agtgtggctc ccaaatgttc acccatggaa gaaaacgtgg aaagtcattc atcaggatgg
     2581 gagcactacc cctaagtatc atgagtactt ttcccttggt taacactctg gttttctacc
     2641 agtgttatca tttgtataat aaaactattt tttaaaa
//
