LOCUS       NM_013177               2372 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus glutamic-oxaloacetic transaminase 2 (Got2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_013177
VERSION     NM_013177.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Liu,X., Li,X. and Zhou,H.
  TITLE     Changes in glutamic oxaloacetic transaminase 2 during rat
            physiological and pathological cardiomyocyte hypertrophy
  JOURNAL   BMC Cardiovasc Disord 23 (1), 595 (2023)
   PUBMED   38053021
  REMARK    GeneRIF: Changes in glutamic oxaloacetic transaminase 2 during rat
            physiological and pathological cardiomyocyte hypertrophy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Xu,J., Khoury,N., Jackson,C.W., Escobar,I., Stegelmann,S.D.,
            Dave,K.R. and Perez-Pinzon,M.A.
  TITLE     Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial
            Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle
            after Ischemic Injury
  JOURNAL   Transl Stroke Res 11 (3), 418-432 (2020)
   PUBMED   31473978
  REMARK    GeneRIF: Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial
            Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle
            after Ischemic Injury.
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Zhang,Y., Kallenberg,C., Hyatt,H.W., Kavazis,A.N. and Hood,W.R.
  TITLE     Change in the Lipid Transport Capacity of the Liver and Blood
            during Reproduction in Rats
  JOURNAL   Front Physiol 8, 517 (2017)
   PUBMED   28798692
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Yang,L., Shen,Z.Y., Wang,R.R., Yin,M.L., Zheng,W.P., Wu,B., Liu,T.
            and Song,H.L.
  TITLE     Effects of heme oxygenase-1-modified bone marrow mesenchymal stem
            cells on microcirculation and energy metabolism following liver
            transplantation
  JOURNAL   World J Gastroenterol 23 (19), 3449-3467 (2017)
   PUBMED   28596681
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Rodriguez-Cruz,M., Gonzalez,R.S., Maldonado,J., Lopez-Alarcon,M.
            and Bernabe-Garcia,M.
  TITLE     The effect of gestational age on expression of genes involved in
            uptake, trafficking and synthesis of fatty acids in the rat
            placenta
  JOURNAL   Gene 591 (2), 403-410 (2016)
   PUBMED   27317891
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   von Deimling,O.H., Groning,J. and Gaa,A.
  TITLE     Genetic and biochemical characterization of a new chymotrypsin
            isozyme of the house mouse, CTRA-1
  JOURNAL   Biochem Genet 29 (11-12), 545-557 (1991)
   PUBMED   1820020
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Watazu,Y., Uji,Y., Sugiuchi,H., Okabe,H. and Murao,S.
  TITLE     New automated measurement of mitochondrial aspartate
            aminotransferase with use of protease 401
  JOURNAL   Clin Chem 36 (4), 687-689 (1990)
   PUBMED   2182221
REFERENCE   8  (bases 1 to 2372)
  AUTHORS   White,R.A., Birkenmeier,C.S., Lux,S.E. and Barker,J.E.
  TITLE     Ankyrin and the hemolytic anemia mutation, nb, map to mouse
            chromosome 8: presence of the nb allele is associated with a
            truncated erythrocyte ankyrin
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3117-3121 (1990)
   PUBMED   2139228
REFERENCE   9  (bases 1 to 2372)
  AUTHORS   Peters,J. and Nash,H.R.
  TITLE     Polymorphism of esterase 11 in Mus musculus, a further esterase
            locus on chromosome 8
  JOURNAL   Biochem Genet 15 (3-4), 217-226 (1977)
   PUBMED   869894
REFERENCE   10 (bases 1 to 2372)
  AUTHORS   Nichols,E.A. and Ruddle,F.H.
  TITLE     Polymorphism and linkage of glutathione reductase in Mus musculus
  JOURNAL   Biochem Genet 13 (5-6), 323-329 (1975)
   PUBMED   1180875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM056810.1, BC061792.1 and CB607680.1.
            
            On May 14, 2011 this sequence version replaced NM_013177.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18467.1, BC061792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               FM056810.1         1-550
            551-2356            BC061792.1         499-2304
            2357-2372           CB607680.1         2-17                c
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..2372
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /note="glutamic-oxaloacetic transaminase 2"
                     /db_xref="GeneID:25721"
                     /db_xref="RGD:2722"
     exon            1..207
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1411
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /EC_number="2.6.1.1"
                     /EC_number="2.6.1.7"
                     /note="FABP-1; FABPpm; mAspAT; transaminase A; fatty
                     acid-binding protein; plasma membrane-associated fatty
                     acid-binding protein; Glutamate oxaloacetate transaminase
                     2, mitochondrial (aspartate aminotransferase 2);
                     glutamic-oxaloacetic transaminase 2, mitochondrial
                     (aspartate aminotransferase 2); kynurenine
                     aminotransferase 4; kynurenine aminotransferase IV;
                     kynurenine--oxoglutarate transaminase 4;
                     kynurenine--oxoglutarate transaminase IV"
                     /codon_start=1
                     /product="aspartate aminotransferase, mitochondrial"
                     /protein_id="NP_037309.1"
                     /db_xref="GeneID:25721"
                     /db_xref="RGD:2722"
                     /translation="MALLHSGRVLSGMAAAFHPGLAAAASARASSWWTHVEMGPPDPI
                     LGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAGKNLDKEYLPIGGL
                     ADFCKASAELALGENSEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKP
                     SWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFSGALEDISKIPEQSVLLLHACAHNPTG
                     VDPRPEQWKEMAAVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQS
                     YAKNMGLYGERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSP
                     DLRKQWLQEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVE
                     RLTKEFSVYMTKDGRISVAGVTSGNVGYLAHAIHQVTK"
     exon            208..364
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            365..493
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            494..553
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            554..715
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            716..820
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            821..971
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1137
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1288
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..2357
                     /gene="Got2"
                     /gene_synonym="ASPATA; mAAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctagccacg cccagggaag tcactgtctt caccttttag gagcccgcgc ctcggtttca
       61 gcggacgctt cccctgatct ccgttctacc accatccact gccgtcttac cacccaccat
      121 ggccctcctg cactccggtc gcgtcctctc cgggatggct gctgcctttc acccaggcct
      181 tgcagccgca gcctctgcca gagccagctc ctggtggacc catgttgaaa tgggacctcc
      241 agatcccatc ctgggagtga ccgaagcctt caagagagat accaacagca agaagatgaa
      301 cctgggagtt ggtgcctacc gggacgataa cggaaagcct tacgtgctcc ccagtgttcg
      361 gaaggcagag gcccagattg ctgggaaaaa tttggacaaa gaatacctac ccatcggggg
      421 actggctgat ttttgtaagg cttctgcaga actggccctg ggcgagaaca gcgaagtgtt
      481 gaaaagcggc cggtttgtaa ctgtgcagac catttccggg actggagcct tgagggtcgg
      541 agccagcttt ctgcaaagat tttttaagtt cagccgagat gtctttctgc ccaaaccatc
      601 ctggggaaac cacacgccca tcttcaggga tgccggcatg cagctgcaag gttatcgata
      661 ctatgacccc aagacttgcg gctttgactt ctctggagcc ttagaagaca tatcaaaaat
      721 cccagagcag agtgttctcc ttctgcacgc ctgcgctcac aaccccacgg gcgtggaccc
      781 gcgtccagag cagtggaagg aaatggcggc ggtggtgaag aaaaagaatc tcttcgcatt
      841 ctttgacatg gcctaccaag gctttgccag cggcgatggt gataaggacg cctgggccgt
      901 gcggcacttc atcgagcagg gcatcaatgt ctgcctctgc caatcctatg ccaagaacat
      961 gggcctgtac ggtgagcgtg tgggagcctt cactgtggtc tgcaaagatg cagaagaagc
     1021 caaaagggtg gagtcacagc tgaagatcct gatccgcccc ttgtattcca acccgcctct
     1081 caatggagcc cggatcgccg caaccatcct gacttctcca gacttgcgga agcaatggtt
     1141 gcaggaggtg aaaggcatgg ctgaccgcat catcagcatg aggacccagt tggtctccaa
     1201 cctgaagaaa gagggctcgt cccacaactg gcagcacatc accgaccaga tcggcatgtt
     1261 ctgcttcacc ggcctaaagc ctgagcaggt ggagcggctg accaaggagt tctcagtcta
     1321 catgacaaag gatggtcgaa tctctgtggc cggggtcacc tctggcaatg tgggctacct
     1381 ggcccacgcc attcaccagg tcaccaagta atcaccaggt gcaaggaaac agagatcact
     1441 ttcccttcag cctttgctct catgagagtc acgtgcaggg tgagggaggg tggatggtgt
     1501 tgagtagatc ctgttttcaa ccacggtgca taactcctgt cgattgaacg cgttcctcgg
     1561 aaaagaggta gggcagaggc tcccacggct gatatctgga acttcgtcgg ctctaaacca
     1621 aactctccct catccttttg tctccagctt ttctgaaagt ttacacatgc aaaaaaatca
     1681 cagcaccaaa aacctgtcag catggcatag gcacaggtca gaagctttac ctgaagcctc
     1741 aggtggtgtc aggggttccc ctgtggaccc cggtagagcc tctcatatta gaggctgtaa
     1801 gagaagaata actagttctg tcattaacag ttgtcgagtg tgtcctcgtg gtgtggagca
     1861 actgtgtcag cagaccacat tatggaaatt atgctttaca aaaaccaaca gggacagtag
     1921 aagatgtaat gtcttgtcat ggctgttctg tagcctggag tttcatccca ttctactgct
     1981 cggttgacca tcaacctcat ccttaggagt gatctaagaa taaagaatgt agtttttctg
     2041 ttcatgccat aaccttctgt ctcagcaaag agccggggag agtgggaccc tgcccttgat
     2101 ttcagagtcc tcttcagtga ttgattggct cctacggggg tggggcctct gcccagctgg
     2161 acgtcctcat tcatcctgac tgcagcctgt cttcacatga gtcagacatg cagggtagga
     2221 tcggaaggag ctattctggg gtttgtatgc taccagcccg gctcagactc agcccttggg
     2281 aaagataacc accatctgct ctaaccgtgt agacgtacct ggttttctct gttacaataa
     2341 aattactaca gacccagaaa aaaaaaaaaa aa
//
