LOCUS       NM_012571               1998 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus glutamic-oxaloacetic transaminase 1 (Got1), mRNA.
ACCESSION   NM_012571
VERSION     NM_012571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Wei,X.B., Jiang,W.Q., Zeng,J.H., Huang,L.Q., Ding,H.G., Jing,Y.W.,
            Han,Y.L., Li,Y.C. and Chen,S.L.
  TITLE     Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated
            Encephalopathy by Promoting Ferroptosis Through Regulating
            miR-9-5p/TFRC and GOT1 Axis
  JOURNAL   Mol Neurobiol 59 (3), 1954-1969 (2022)
   PUBMED   35038133
  REMARK    GeneRIF: Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated
            Encephalopathy by Promoting Ferroptosis Through Regulating
            miR-9-5p/TFRC and GOT1 Axis.
            Erratum:[Mol Neurobiol. 2022 Aug;59(8):5252. doi:
            10.1007/s12035-022-02931-2.. PMID: 35727437]
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Athmouni,K., Belhaj,D., El Feki,A. and Ayadi,H.
  TITLE     Optimization, antioxidant properties and GC-MS analysis of
            Periploca angustifolia polysaccharides and chelation therapy on
            cadmium-induced toxicity in human HepG2 cells line and rat liver
  JOURNAL   Int J Biol Macromol 108, 853-862 (2018)
   PUBMED   29101047
REFERENCE   3  (bases 1 to 1998)
  AUTHORS   Wang,C., Chen,H. and Ying,W.
  TITLE     Cytosolic aspartate aminotransferase mediates the mitochondrial
            membrane potential and cell survival by maintaining the calcium
            homeostasis of BV2 microglia
  JOURNAL   Neuroreport 29 (2), 99-105 (2018)
   PUBMED   29215467
REFERENCE   4  (bases 1 to 1998)
  AUTHORS   Li,J., Ghazwani,M., Liu,K., Huang,Y., Chang,N., Fan,J., He,F.,
            Li,L., Bu,S., Xie,W., Ma,X. and Li,S.
  TITLE     Regulation of hepatic stellate cell proliferation and activation by
            glutamine metabolism
  JOURNAL   PLoS One 12 (8), e0182679 (2017)
   PUBMED   28797105
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1998)
  AUTHORS   Laloy,J., Lozano,O., Alpan,L., Mejia,J., Toussaint,O., Masereel,B.,
            Dogne,J.M. and Lucas,S.
  TITLE     Can TiC nanoparticles produce toxicity in oral administration to
            rats?
  JOURNAL   Toxicol Rep 1, 172-187 (2014)
   PUBMED   28962237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1998)
  AUTHORS   Sato,A., Nagai,M., Tagami,A., Natori,Y. and Okada,M.
  TITLE     Effect of pyridoxine-deficiency on degradation of cytosolic
            aspartate aminotransferase in rat liver lysosomes
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 37 (4), 419-424 (1991)
   PUBMED   1765846
REFERENCE   7  (bases 1 to 1998)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   8  (bases 1 to 1998)
  AUTHORS   Doyle,J.M., Schinina,M.E., Bossa,F. and Doonan,S.
  TITLE     The amino acid sequence of cytosolic aspartate aminotransferase
            from human liver
  JOURNAL   Biochem J 270 (3), 651-657 (1990)
   PUBMED   2241899
REFERENCE   9  (bases 1 to 1998)
  AUTHORS   Watazu,Y., Uji,Y., Sugiuchi,H., Okabe,H. and Murao,S.
  TITLE     New automated measurement of mitochondrial aspartate
            aminotransferase with use of protease 401
  JOURNAL   Clin Chem 36 (4), 687-689 (1990)
   PUBMED   2182221
REFERENCE   10 (bases 1 to 1998)
  AUTHORS   Pave-Preux,M., Aggerbeck,M., Veyssier,C., Bousquet-Lemercier,B.,
            Hanoune,J. and Barouki,R.
  TITLE     Hormonal discrimination among transcription start sites of
            aspartate aminotransferase
  JOURNAL   J Biol Chem 265 (8), 4444-4448 (1990)
   PUBMED   2307672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK600227.1, FM055803.1, CB578328.1, FN802619.1 and
            JAXUCZ010000001.1.
            
            On Aug 16, 2012 this sequence version replaced NM_012571.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061877.1, J04171.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               CK600227.1         20-447
            429-674             FM055803.1         351-596
            675-1060            CB578328.1         239-624
            1061-1677           FN802619.1         106-722
            1678-1998           JAXUCZ010000001.1  252306541-252306861 c
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1998
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /note="glutamic-oxaloacetic transaminase 1"
                     /db_xref="GeneID:24401"
                     /db_xref="RGD:2721"
     exon            1..203
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1327
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /EC_number="2.6.1.1"
                     /EC_number="2.6.1.3"
                     /note="cytosolic aspartate aminotransferase; transaminase
                     A; glutamate oxaloacetate transaminase 1, soluble;
                     cysteine transaminase, cytoplasmic; cysteine
                     aminotransferase, cytoplasmic; aspartate aminotransferase
                     1; glutamic-oxaloacetic transaminase 1, soluble"
                     /codon_start=1
                     /product="aspartate aminotransferase, cytoplasmic"
                     /protein_id="NP_036703.2"
                     /db_xref="GeneID:24401"
                     /db_xref="RGD:2721"
                     /translation="MAPPSFFAQVPQAPPVLVFKLIADFRDDPDPRKVNLGVGAYRTD
                     DSQPWVLPVVRKVEQKIANDHSLNHEYLPILGLAEFRSCASQLVLGDNSPALRENRVG
                     GVQSLGGTGALRIGADFLGRWYNGTDNKNTPVYVSSPTWENHNGVFSAAGFKDIRSYR
                     YWDAEKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTEEEWKQIAAVMKRRFL
                     FPFFDSAYQGFASGDLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGK
                     EHDSVLRVLSQMEKIVRITWSNPPAQGARIVATTLSNPELFKEWKGNVKTMADRILTM
                     RSELRARLEALKTPGTWSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLMPSGRINMCG
                     LTTKNLDYVATSINEAVTKFQ"
     exon            204..385
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            386..509
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            510..622
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            623..727
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            728..878
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1044
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1187
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1998
                     /gene="Got1"
                     /gene_synonym="AAT1; ASAT; Aspat; cAspAT; cCAT; Gaspat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagagtct cctccagtca caggtccccg caccgcacgg agcagctccc agctcgtgct
       61 cgaggtcccc tcagattcca tcgcgatggc ccctccatca ttctttgccc aggttccaca
      121 ggccccgccg gttctggtct ttaagctcat tgcggacttc cgggatgatc ccgatccccg
      181 caaggttaac ctcggcgtgg gagcgtaccg cacagatgac tctcagccct gggttttgcc
      241 agtagtgagg aaggtcgaac agaagattgc taacgaccac agtctcaacc acgagtactt
      301 gcccatcctg ggcctggcgg agttccggag ctgtgcttct cagctagtac ttggggacaa
      361 cagcccagct ctcagggaga atcgggttgg gggtgtgcag tctttgggag ggaccggtgc
      421 acttcgaatt ggagctgact tcttagggcg atggtacaat ggcacagaca acaagaacac
      481 gcccgtctac gtatcatcgc cgacctggga gaaccataat ggcgtgtttt ctgccgctgg
      541 ttttaaagac attcggtcct atcgctactg ggatgcagag aagagaggac ttgatctcca
      601 gggtttcctg aatgatctgg agaatgctcc tgagttctcc atctttgtcc tccacgcctg
      661 tgcacacaac ccaacgggga ccgacccaac tgaagaggag tggaagcaga tcgccgccgt
      721 catgaagcgc cgttttctgt tccccttctt tgactcagcc tatcagggct ttgcatctgg
      781 agacctagag aaagatgcct gggctattcg ctattttgtg tctgaaggct tcgagctctt
      841 ctgtgcccag tccttctcca agaacttcgg gctctacaat gagagagtgg ggaatctgac
      901 cgtggtcgga aaagagcatg acagcgtcct gcgggtcctt tcccagatgg agaagattgt
      961 acgaatcacc tggtccaatc cccctgccca gggagctcgg atcgtggcca ccaccctctc
     1021 caaccctgag ctctttaagg agtggaaagg aaacgtgaag acaatggctg accggattct
     1081 gaccatgaga tccgaactca gggcgcgact agaagctctc aagactcccg ggacttggtc
     1141 tcacatcact gagcagattg gaatgttcag ctttactggg ttgaacccca agcaggtcga
     1201 gtatttggtc aacgagaagc acatctatct gatgccgagc ggtcggatca acatgtgcgg
     1261 cttgaccacc aagaacctag attacgtggc tacctccatc aatgaagctg tcaccaaatt
     1321 ccagtgaaga aacaccgagt agttcatacc accaaagcag ttcctgtcac agctttcctg
     1381 cctgcgcaaa cctagccgta catgttgttt attagagatg accaccatgg ggaggcagcc
     1441 gctgtttagc tggccccaca agagaagaca tttcttgaaa tgaacctggg tcgggtgggg
     1501 ggatgactgg ggttagggcc ttttggaaac cagagcagat taaagttatt taagaataaa
     1561 aaaccctttg atatgagatg taatcacctt gccttcctct gtagtattct gcaggagtgt
     1621 tgcccacgaa gccgtgggct tctgcacgtt gcttgagtct gtacagagtc ctgtccccaa
     1681 aatcaagttg tctgaggagc cagctgtgac tgtggatgtt ggcattaaaa ctcaccattt
     1741 ccatcgtctc tgtctctcgg ccccctgatc tttccgcatg gttgtgaccc tggtcttgga
     1801 acattagttt tttaaggcca ctgtggccag tatttatatc atgacacaca agtggattta
     1861 catatttaac tgagatgaaa gttccgctaa acggtatttg ctcttgtgat acgtggcaca
     1921 ttgtgacatt ttcttagtct cttctgtcgt gttctgtttc atttaaaaaa ataaaaatgc
     1981 tgatcaagac aaagggaa
//
