LOCUS       NM_001107631            4246 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus golgi associated PDZ and coiled-coil motif
            containing (Gopc), transcript variant 2, mRNA.
ACCESSION   NM_001107631 XM_001059699 XM_228173
VERSION     NM_001107631.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   Klussendorf,M., Song,I., Schau,L., Morellini,F., Dityatev,A.,
            Koliwer,J. and Kreienkamp,H.J.
  TITLE     The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for
            Synaptic Targeting of mGluR5
  JOURNAL   Mol Neurobiol 58 (11), 5618-5634 (2021)
   PUBMED   34383253
  REMARK    GeneRIF: The Golgi-Associated PDZ Domain Protein Gopc/PIST Is
            Required for Synaptic Targeting of mGluR5.
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   Chen,A., Gossling,E.K., Witkowski,L., Bhindi,A., Bauch,C.,
            Roussy,G., Sarret,P., Kreienkamp,H.J. and Stroh,T.
  TITLE     Regional and subcellular distribution of the receptor-targeting
            protein PIST in the rat central nervous system
  JOURNAL   J Comp Neurol 520 (5), 889-913 (2012)
   PUBMED   21953547
  REMARK    GeneRIF: Distribution of Gopc/PIST suggests that the protein serves
            distinctive roles in specific neuronal populations, establishing
            functionally distinct zones, for instance, in the hippocampus.
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   Catena,R., Ronfani,L., Sassone-Corsi,P. and Davidson,I.
  TITLE     Changes in intranuclear chromatin architecture induce bipolar
            nuclear localization of histone variant H1T2 in male haploid
            spermatids
  JOURNAL   Dev Biol 296 (1), 231-238 (2006)
   PUBMED   16765935
REFERENCE   5  (bases 1 to 4246)
  AUTHORS   Meyer,G., Varoqueaux,F., Neeb,A., Oschlies,M. and Brose,N.
  TITLE     The complexity of PDZ domain-mediated interactions at glutamatergic
            synapses: a case study on neuroligin
  JOURNAL   Neuropharmacology 47 (5), 724-733 (2004)
   PUBMED   15458844
REFERENCE   6  (bases 1 to 4246)
  AUTHORS   Yue,Z., Horton,A., Bravin,M., DeJager,P.L., Selimi,F. and Heintz,N.
  TITLE     A novel protein complex linking the delta 2 glutamate receptor and
            autophagy: implications for neurodegeneration in lurcher mice
  JOURNAL   Neuron 35 (5), 921-933 (2002)
   PUBMED   12372286
REFERENCE   7  (bases 1 to 4246)
  AUTHORS   Cheng,J., Moyer,B.D., Milewski,M., Loffing,J., Ikeda,M.,
            Mickle,J.E., Cutting,G.R., Li,M., Stanton,B.A. and Guggino,W.B.
  TITLE     A Golgi-associated PDZ domain protein modulates cystic fibrosis
            transmembrane regulator plasma membrane expression
  JOURNAL   J Biol Chem 277 (5), 3520-3529 (2002)
   PUBMED   11707463
REFERENCE   8  (bases 1 to 4246)
  AUTHORS   Yao,R., Maeda,T., Takada,S. and Noda,T.
  TITLE     Identification of a PDZ domain containing Golgi protein, GOPC, as
            an interaction partner of frizzled
  JOURNAL   Biochem Biophys Res Commun 286 (4), 771-778 (2001)
   PUBMED   11520064
REFERENCE   9  (bases 1 to 4246)
  AUTHORS   Charest,A., Lane,K., McMahon,K. and Housman,D.E.
  TITLE     Association of a novel PDZ domain-containing peripheral Golgi
            protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive
            fusion protein (NSF) attachment protein receptor) protein syntaxin
            6
  JOURNAL   J Biol Chem 276 (31), 29456-29465 (2001)
   PUBMED   11384996
REFERENCE   10 (bases 1 to 4246)
  AUTHORS   Neudauer,C.L., Joberty,G. and Macara,I.G.
  TITLE     PIST: a novel PDZ/coiled-coil domain binding partner for the
            rho-family GTPase TC10
  JOURNAL   Biochem Biophys Res Commun 280 (2), 541-547 (2001)
   PUBMED   11162552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Mar 11, 2021 this sequence version replaced NM_001107631.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168160.1, SRR26643299.66953.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               JAXUCZ010000020.1  32319130-32319611   c
            483-647             JAXUCZ010000020.1  32291553-32291717   c
            648-671             JAXUCZ010000020.1  32290152-32290175   c
            672-847             JAXUCZ010000020.1  32287355-32287530   c
            848-1013            JAXUCZ010000020.1  32286204-32286369   c
            1014-1109           JAXUCZ010000020.1  32280050-32280145   c
            1110-1274           JAXUCZ010000020.1  32278645-32278809   c
            1275-1455           JAXUCZ010000020.1  32275568-32275748   c
            1456-4246           JAXUCZ010000020.1  32270314-32273104   c
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..4246
                     /gene="Gopc"
                     /note="golgi associated PDZ and coiled-coil motif
                     containing"
                     /db_xref="GeneID:309774"
                     /db_xref="RGD:1309512"
     exon            1..482
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1586
                     /gene="Gopc"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="Golgi-associated PDZ and coiled-coil
                     motif-containing protein isoform 2"
                     /protein_id="NP_001101101.2"
                     /db_xref="GeneID:309774"
                     /db_xref="RGD:1309512"
                     /translation="MSAGGPCPAGAGSGPGGASCPVGVSPGGVSMFRWLEVLEKEFDK
                     AFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDL
                     RSELTETQAEKVVLEKEVHDQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSMEDLE
                     RELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGR
                     VQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRQDLKRPMQAPPGHDQD
                     SLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVG
                     DAVLAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRY
                     RLYLDELEGGGNSGASCKDSSGEMKVLQGYNKKTVRDAHENGDVGASGESPLDDTAVR
                     AAHPHSLHQKKAY"
     exon            483..647
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            648..671
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            672..847
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1013
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1109
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1274
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1455
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..4246
                     /gene="Gopc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcggtcgc tgttactgcc gcgctacctt tgcggctctg gagctacgct gtcggcgttg
       61 gcggcgcgag ggaagggaag ggacctgcgg ggcgtgtgtg tgcgcgcgcg aggggcgcct
      121 cggtgctagc agttcccctc gcgcggggtg ggcggccaag gtgagcagca gtcggcgagg
      181 ccctggacgg cgccatgtcg gcgggcggcc catgcccggc gggagccggc agcggcccag
      241 ggggcgcctc ctgccctgtt ggggtctccc ctggtggagt gtccatgttt cggtggcttg
      301 aagtgctcga gaaggagttc gacaaggcct ttgtggatgt ggatcttctt ctgggcgaga
      361 tcgatccgga ccaggcggac atcacttatg aggggcgtca gaagatgacc agccttagct
      421 cctgctttgc gcagctttgc cacaaagccc agactgtgtc tcagatcaac cacaagcttg
      481 aggcccagtt ggtggatctg cggtctgaac tgactgagac tcaggcagag aaagttgtcc
      541 tggagaagga agtccacgac cagctcctac agctgcattc cactcagctt cagcttcatg
      601 ccaaaactgg ccaaagcgtt gactctggtg ccattaaggc aaaattgtct gttcactcta
      661 tggaggatct ggaaagagaa cttgaagcaa ataaaacaga aaaggtaaaa gaagctcggc
      721 ttgaagctga agtgaagctg ctaaggaaag agaacgaggc tcttcgcagg cacatagccg
      781 ttctccaggc tgaagtttat ggggcgaggt tggccgccaa gtacttggac aaggagctgg
      841 ctggcagggt ccaacaaata cagttactgg gacgggatat gaagggacct gctcatgaca
      901 agctctggaa ccagttagaa gctgaaatac atttgcatcg ccacaaaaca gtcatccgag
      961 cctgcagagg acgccaggac ctgaagcggc ccatgcaggc acccccaggc cacgatcaag
     1021 actctttgaa gaaaagccag ggagttggtc caattagaaa agttctcctc cttaaggaag
     1081 atcatgaagg ccttggcatt tctattacag gtgggaagga gcacggtgtc cccattctca
     1141 tctcggagat ccatccagga cagcctgcgg ataggtgtgg agggctccat gtcggagatg
     1201 ctgttctggc agtaaatggc gttaacctaa gggacacaaa gcacaaagaa gccgtgacca
     1261 tactttccca gcagagagga gagattgaat ttgaagtagt ctacgtggcc cctgaagtgg
     1321 attctgatga tgaaaatgtc gagtatgaag acgagagtgg gcaccgctac cgtttgtatc
     1381 ttgatgagtt agaaggcggt ggtaattctg gtgctagttg caaagacagc agtggtgaaa
     1441 tgaaagtgtt acaaggatat aacaagaaga cggtgaggga tgcccatgag aatggggacg
     1501 tgggggcttc gggtgaaagc cctctggacg acactgctgt gagagcagct catccgcaca
     1561 gcctccatca gaagaaggcc tactaatcct tcccagacac gctgctgtca gactcgtgga
     1621 atgtggggca ctggagaaga tggtggcaag gactgcacaa gatcagggag gctgtgtgtt
     1681 gcctagagta aggcgggaac ctcagggctt catgtgaaca attctaagtg cataaacccc
     1741 tgttttctgt ggtacacctt aattagctat tgcatggaag gcaattttga ttttcctgaa
     1801 atctaagcac caaagcatgt gtttcccaaa ggggtattac caggccgagt ggatgctgtt
     1861 tcctttggct ccttttcata tttaacagga cagtgctaac tggaattttc taagttccct
     1921 ttaaatacag cagagtaaat gatgccatag attccctaag ggtaactgtg gaatttcaga
     1981 tgatagaact tgactcagtg aattgcaaaa atctaggttg acatttttgc ttaattgaaa
     2041 aatttgttcc aggtttttta aagaagtata ttgtacattc ctgatatctg aattaactct
     2101 ttgtacctaa attactatct aaatcattat gccgagctca ctctccgttt actcagctgc
     2161 ggtatagact agtttcttta ggcaatcttg tatcaatcag tgctgcacta gaatagtctg
     2221 ggaaagcaac tggacatttc actttagatt gtgaaaggaa gcgcagagga gcggaaatgc
     2281 ctgttttcaa ttatgttgat ctgtgtgcat ggtgttggag cattacactg ttagtgtctg
     2341 gaatccacga aagacagttt tatacatttt tgagttgttc ctaagctttg acatgtgata
     2401 gtcgggaacc ttactatgtc atggaataca ttgtgttcaa acagcagttg gctttacgta
     2461 cctgacttgc cagtcattta acaagccggg gccaaggtgg gcaagatgag gtacagacag
     2521 tttggcacag tgagcacatc gattttcata tcagtatatg ttggactaaa gcaatactcg
     2581 cgtgcaagct ctgtaaatgt gttagttctc tcgtgtcaga actaagcaga ctgcctgctc
     2641 ccttctttcc tgacctacag gccattgcac cctgccaggc aaagtcaaaa tactgtattt
     2701 aaagaggtga tttttgcaaa gtcactgttt taaaggattt atacctaagg gaattgtaag
     2761 taggagaagc cttcatataa ggctttcaca gtatcagtat ctcttccttg gtatgcttgt
     2821 ttttcccaga tgcattatat atttgttcaa agttgaatct ataaaatgta tatactttat
     2881 tttgtgattt tgctatttat aaatttactt aactgttgcc cattcatggt ctgtggtggt
     2941 tcttcctggt gtcaccatgt taacggtggc tggcagtgca ctttgtctgt atcttgttcc
     3001 tcgtgctgag atgccttgta gtgtaacatt gcctgtaaac aaggttagca tttcaattgt
     3061 acaaatgaat aaacacctta catattactg tttgctcctg acaggctagg cctcttaaaa
     3121 gaaggattgt tttttcctca cgtattcctc ccacaccgaa tacatacccc agtgcatgac
     3181 ctgagacctt caaagtaggt ggtagccaat gtgttcattt aggaaaaagt atccatggta
     3241 acagatctga aaccattttt gctttgacct gaaaccatgt tgctcctata tcctttcaac
     3301 ctttcaatgt tgcctgggaa tgaccatggc cgttttcttc tcctttttct tcaaacatta
     3361 tatgccttat atacgatgat tgaatcacta ggaaatgtaa gctataaccc tttgaattct
     3421 tcaagatctt cacagtaaac atggaagcag aattttagag aaacagattg aacatttctg
     3481 tgcgctgcct gtgagggatt gtgtgaaatg ggtacggagt atatttagaa agagtagttt
     3541 atggttccgc gggtcagtct tcacatctct ctctgctttg gaagcacatg cgagctcagt
     3601 ggcgggagtg ctgctctgaa agagagcatc tggtattctc ccaggcctag ctgggagttc
     3661 acttgagagt gtgtgatcac tagggatgaa ctaggtagtc aaacccttcc caaagcattt
     3721 aatgaaaaat agtttttata tttcatagga aagacgccca tataacactg aatcttactg
     3781 aacaaagcca aaaagtgggc ggaaagccgt tgcaaagcca ttacaatgaa aacgtgttga
     3841 gtagaacttg agaggtatgt gtgcagacgc agtcacactt actgtgcaga attgtcttct
     3901 gcagttctct aacgagcatg atagaagcga cacatttgag ttagggatta ttgttaaatt
     3961 aaattaagag agatgaagag cttgcgtgtc tgttggttag aattgagcaa tgacaaatag
     4021 cctgtccatg gtgctggaat aggccccaca gcagtgggct tccgttttca tagtttaaaa
     4081 caaaaatata ttgattcaca tataaggtga tttatgataa ttgtattata tctagttaag
     4141 tttcatattc ttaattagcc tgtaaataaa aatgacatct tcaacattaa agtggtattg
     4201 atcagatttg aaggaaaata aatgttttct ctttcattca cttaaa
//
