LOCUS       NM_031038               2623 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus gonadotropin releasing hormone receptor (Gnrhr),
            mRNA.
ACCESSION   NM_031038
VERSION     NM_031038.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Li,H., Guo,Y., Zhang,G., Deng,J., Fischer,H., Craig,L.B., Yu,X. and
            Kem,D.C.
  TITLE     Gonadotrophin-releasing hormone receptor autoantibodies induce
            polycystic ovary syndrome-like features in a rat model
  JOURNAL   Exp Physiol 106 (4), 902-912 (2021)
   PUBMED   33576068
  REMARK    GeneRIF: Gonadotrophin-releasing hormone receptor autoantibodies
            induce polycystic ovary syndrome-like features in a rat model.
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Kyritsi,K., Meng,F., Zhou,T., Wu,N., Venter,J., Francis,H.,
            Kennedy,L., Onori,P., Franchitto,A., Bernuzzi,F., Invernizzi,P.,
            McDaniel,K., Mancinelli,R., Alvaro,D., Gaudio,E., Alpini,G. and
            Glaser,S.
  TITLE     Knockdown of Hepatic Gonadotropin-Releasing Hormone by
            Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance
            Gene 2 Knockout Mice by Down-Regulation of miR-200b
  JOURNAL   Am J Pathol 187 (7), 1551-1565 (2017)
   PUBMED   28502477
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Nelson,B.S., Black,K.L. and Daniel,J.M.
  TITLE     Circulating Estradiol Regulates Brain-Derived Estradiol via Actions
            at GnRH Receptors to Impact Memory in Ovariectomized Rats
  JOURNAL   eNeuro 3 (6) (2016)
   PUBMED   28032117
  REMARK    GeneRIF: Prevention of estradiol synthesis blocked the ability of
            peripheral estradiol administration in ovariectomized rats to
            enhance hippocampus-dependent memory in a radial-maze task.
            Hippocampal GnRH receptor antagonism blocked the ability of
            peripheral estradiol administration in ovariectomized rats to
            enhance hippocampus-dependent memory.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Bjelobaba,I., Janjic,M.M., Tavcar,J.S., Kucka,M., Tomic,M. and
            Stojilkovic,S.S.
  TITLE     The relationship between basal and regulated Gnrhr expression in
            rodent pituitary gonadotrophs
  JOURNAL   Mol Cell Endocrinol 437, 302-311 (2016)
   PUBMED   27569529
  REMARK    GeneRIF: the age-dependent basal and regulated Gnrhr transcription
            could account for the initial blockade and subsequent activation of
            the reproductive system during development.
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Terashima,R., Laoharatchatathanin,T., Kurusu,S. and Kawaminami,M.
  TITLE     Augmentation of gonadotropin-releasing hormone receptor expression
            in the post-lactational mammary tissues of rats
  JOURNAL   J Reprod Dev 62 (5), 495-499 (2016)
   PUBMED   27349532
  REMARK    GeneRIF: GnRH-R is expressed in the mammary tissues after weaning;
            GnRH is involved in the involution and tissue remodeling of
            post-lactating rat mammary tissues
REFERENCE   6  (bases 1 to 2623)
  AUTHORS   Kudo,A., Park,M.K. and Kawashima,S.
  TITLE     Isolation of rat GnRH receptor cDNA having different 5'-noncoding
            sequence
  JOURNAL   Zoolog Sci 10 (5), 863-867 (1993)
   PUBMED   7764374
REFERENCE   7  (bases 1 to 2623)
  AUTHORS   Perrin,M.H., Bilezikjian,L.M., Hoeger,C., Donaldson,C.J.,
            Rivier,J., Haas,Y. and Vale,W.W.
  TITLE     Molecular and functional characterization of GnRH receptors cloned
            from rat pituitary and a mouse pituitary tumor cell line
  JOURNAL   Biochem Biophys Res Commun 191 (3), 1139-1144 (1993)
   PUBMED   7916600
REFERENCE   8  (bases 1 to 2623)
  AUTHORS   Kaiser,U.B., Zhao,D., Cardona,G.R. and Chin,W.W.
  TITLE     Isolation and characterization of cDNAs encoding the rat pituitary
            gonadotropin-releasing hormone receptor
  JOURNAL   Biochem Biophys Res Commun 189 (3), 1645-1652 (1992)
   PUBMED   1339279
REFERENCE   9  (bases 1 to 2623)
  AUTHORS   Eidne,K.A., Sellar,R.E., Couper,G., Anderson,L. and Taylor,P.L.
  TITLE     Molecular cloning and characterisation of the rat pituitary
            gonadotropin-releasing hormone (GnRH) receptor
  JOURNAL   Mol Cell Endocrinol 90 (1), R5-R9 (1992)
   PUBMED   1338727
REFERENCE   10 (bases 1 to 2623)
  AUTHORS   Marian,J. and Conn,P.M.
  TITLE     Subcellular localization of the receptor for gonadotropin-releasing
            hormone in pituitary and ovarian tissue
  JOURNAL   Endocrinology 112 (1), 104-112 (1983)
   PUBMED   6291912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB775870.1, X68980.1, L07646.1 and JAXUCZ010000014.1.
            
            On Oct 18, 2005 this sequence version replaced NM_031038.2.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, Sprague-Dawley and BN/SsNHsdMCW, because no
            single transcript from the same strain was available for the full
            length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68980.1, X76635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB775870.1         57-107
            52-637              X68980.1           2-587
            638-1095            L07646.1           624-1081
            1096-2623           JAXUCZ010000014.1  22228127-22229654
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..2623
                     /gene="Gnrhr"
                     /gene_synonym="GH1; Lhrhr"
                     /note="gonadotropin releasing hormone receptor"
                     /db_xref="GeneID:81668"
                     /db_xref="RGD:70513"
     exon            1..609
                     /gene="Gnrhr"
                     /gene_synonym="GH1; Lhrhr"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1071
                     /gene="Gnrhr"
                     /gene_synonym="GH1; Lhrhr"
                     /note="growth hormone; gnRH-R; gnRH receptor"
                     /codon_start=1
                     /product="gonadotropin-releasing hormone receptor"
                     /protein_id="NP_112300.2"
                     /db_xref="GeneID:81668"
                     /db_xref="RGD:70513"
                     /translation="MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFF
                     LFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWN
                     ITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMT
                     SLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCL
                     FIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFV
                     ICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL"
     exon            610..826
                     /gene="Gnrhr"
                     /gene_synonym="GH1; Lhrhr"
                     /inference="alignment:Splign:2.1.0"
     exon            827..2623
                     /gene="Gnrhr"
                     /gene_synonym="GH1; Lhrhr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagcaac agcgctttgc gttcagttac gataaaaaca tcagcagtaa cagagactcg
       61 actcttgaag cccgtccttg gagaaatatg gctaacaatg cgtctcttga gcaggaccaa
      121 aatcactgct cagccatcaa caacagcatc cccctgacac agggcaagct cccgactcta
      181 accttatctg gaaagatccg agtgacggtg actttcttcc ttttcctact ctctactgcc
      241 ttcaatgcct ctttcttggt aaagctgcag aggtggaccc agaagaggaa gaaaggaaaa
      301 aagctctcaa ggatgaaggt gcttttaaag catttgacct tagccaacct ccttgagact
      361 ctaatcgtca tgccgctgga tgggatgtgg aacatcactg ttcagtggta tgctggagag
      421 ttcctttgca aagttctcag ctatctgaag ctcttctcta tgtatgcccc agccttcatg
      481 atggtggtga ttagcctgga tcgctccctg gccgtcactc agcccttagc tgtccaaagc
      541 aagagcaagc ttgaacggtc tatgaccagc ctggcctgga ttctcagcat tgtctttgcg
      601 ggaccacagt tatatatctt caggatgatc tacctagccg acggctctgg gccagcagtt
      661 ttctcgcaat gtgtgaccca ctgcagcttt ccgcaatggt ggcatgaagc cttctacaac
      721 tttttcacct tcagctgcct gttcatcatc cctcttctca tcatgctaat ctgcaatgcc
      781 aaaatcatct tcgccctcac acgagtcctt catcaggacc cacgcaaact acagctgaat
      841 caatccaaga ataatatccc aagagcacgg ctgagaactc taaagatgac agtggcattt
      901 gccacctcct ttgtcatctg ctggactccc tactacgtcc taggaatctg gtactggttt
      961 gatccggaaa tgttaaacag ggtgtcagag ccagtcaatc acttcttctt tctctttgct
     1021 tttctaaacc cgtgcttcga cccacttata tatgggtatt tctctttgta attgggagac
     1081 tacccaagca cttgtgctga aacccatata cgggataact tatgtcaccg gttgagaata
     1141 agctcaaagc ttgcaacata cctatgtgca agcaaggcag ggtttgggct caggttagca
     1201 gccttgtcca tatacagagt ttgttgttag cgcttcggaa gaccttccaa aataactgaa
     1261 atctgtcctt aatcataagc ttctaaacta gcctcagcct tgtctcatgt tttattgcat
     1321 cccatttggg attctttact tcctccttac ataataatgt atagatactt taaatgacta
     1381 catcctaagg taaaaagtac caaaaagtaa gaccgggaaa gcccaacata ttcacaacat
     1441 cagcttagtt tggggagttg gttttttttt ctcaaagggg gctgagcatc tataacaccc
     1501 catcccaaca cctagagccc acagagagca gaatcgctgc ccatagatca tcagcaaaac
     1561 cagatgctgc tccaagacct aaagcccaga gacagaagga tccctgtcca gaggttagca
     1621 ggaaatactg gctgacacta tcccagccta aggcacagag atagtagact cccttactgc
     1681 ccataggtca gcagcagtag cagctgatgt tatctatccc agcctagagc acagacagaa
     1741 gagaatcact gtccatgggt caaattttaa ctgcaatgac tgaaagactt aattttctat
     1801 tttactttaa aagcctttct gattcttatt cagcaacaaa tccaccagcc caccaggatt
     1861 atttacatga tacaaattaa tcccatttac atgctacatt gcgacacatc cctacatagt
     1921 gggggtattt aaaagggata ggtttttttt catgggctgt tagaatattt cacagactat
     1981 acaacatgtg gggtttatgt caactgactg ccatgaatag tgttttaata taattcagaa
     2041 aatgcctata ataattatct tgcaagcata atatacaatc cactttaaca atatggtgga
     2101 acgtttgtct atcttaactt gccgagtcat gccccacaga taaatgagga aagtcaataa
     2161 aaacagtaag caaatatata aacaaaaaga ggggctttga tgtattaaag gagctcaagg
     2221 caggaagcca tacaatttcc cctatacaga ccaacagcac agaatattag ggaggagaat
     2281 agtaaaactg tacatgtgaa agaaaaaaaa atgcagtccc caaaaatatg tccgcagaat
     2341 accacatact tcattcaact cagctcagat ctttgtcatg aaagaccaga ggtgaagtta
     2401 agattgcgat atccactcac tggggaaagc atatgaacgc acattcaata attatctaat
     2461 agacattgat gtgagctaca taatgccaca ccaggctatg tgtgactata gaaagctgac
     2521 cagaggggtt ggggatttag tttagtggta gagcgcttgc ctagcaagcg caaggccctg
     2581 ggttctgtcc tcagctcaaa agaaagaaag aaagaaagag aga
//
