LOCUS       NM_053410               2857 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glyceronephosphate O-acyltransferase (Gnpat),
            mRNA.
ACCESSION   NM_053410
VERSION     NM_053410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2857)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   2  (bases 1 to 2857)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   3  (bases 1 to 2857)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2857)
  AUTHORS   Teigler,A., Komljenovic,D., Draguhn,A., Gorgas,K. and Just,W.W.
  TITLE     Defects in myelination, paranode organization and Purkinje cell
            innervation in the ether lipid-deficient mouse cerebellum
  JOURNAL   Hum Mol Genet 18 (11), 1897-1908 (2009)
   PUBMED   19270340
REFERENCE   5  (bases 1 to 2857)
  AUTHORS   Liu,D., Nagan,N., Just,W.W., Rodemer,C., Thai,T.P. and Zoeller,R.A.
  TITLE     Role of dihydroxyacetonephosphate acyltransferase in the
            biosynthesis of plasmalogens and nonether glycerolipids
  JOURNAL   J Lipid Res 46 (4), 727-735 (2005)
   PUBMED   15687349
REFERENCE   6  (bases 1 to 2857)
  AUTHORS   Thai,T.P., Heid,H., Rackwitz,H.R., Hunziker,A., Gorgas,K. and
            Just,W.W.
  TITLE     Ether lipid biosynthesis: isolation and molecular characterization
            of human dihydroxyacetonephosphate acyltransferase
  JOURNAL   FEBS Lett 420 (2-3), 205-211 (1997)
   PUBMED   9459311
REFERENCE   7  (bases 1 to 2857)
  AUTHORS   Ofman,R. and Wanders,R.J.
  TITLE     Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate
            acyltransferase from human placenta
  JOURNAL   Biochim Biophys Acta 1206 (1), 27-34 (1994)
   PUBMED   8186247
REFERENCE   8  (bases 1 to 2857)
  AUTHORS   Ruyter,B., Lund,J.S., Thomassen,M.S. and Christiansen,E.N.
  TITLE     Studies of dihydroxyacetone phosphate acyltransferase in rat small
            intestine. Subcellular localization and effect of partially
            hydrogenated fish oil and clofibrate
  JOURNAL   Biochem J 282 (Pt 2) (Pt 2), 565-570 (1992)
   PUBMED   1546971
REFERENCE   9  (bases 1 to 2857)
  AUTHORS   Skorve,J., Ruyter,B., Rustan,A.C., Christiansen,E.N., Drevon,C.A.
            and Berge,R.K.
  TITLE     Effect of 3- and 4-thia-substituted fatty acids on glycerolipid
            metabolism and mitochondrial beta-oxidation in rat liver
  JOURNAL   Biochem Pharmacol 40 (9), 2005-2012 (1990)
   PUBMED   2242030
REFERENCE   10 (bases 1 to 2857)
  AUTHORS   Bates,E.J. and Saggerson,E.D.
  TITLE     A study of the glycerol phosphate acyltransferase and
            dihydroxyacetone phosphate acyltransferase activities in rat liver
            mitochondrial and microsomal fractions. Relative distribution in
            parenchymal and non-parenchymal cells, effects of N-ethylmaleimide,
            palmitoyl-coenzyme A concentration, starvation, adrenalectomy and
            anti-insulin serum treatment
  JOURNAL   Biochem J 182 (3), 751-762 (1979)
   PUBMED   518562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Dec 3, 2020 this sequence version replaced NM_053410.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217065.1, BC061805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               JAXUCZ010000019.1  69719707-69719967
            262-444             JAXUCZ010000019.1  69727252-69727434
            445-621             JAXUCZ010000019.1  69729937-69730113
            622-751             JAXUCZ010000019.1  69730786-69730915
            752-879             JAXUCZ010000019.1  69733527-69733654
            880-955             JAXUCZ010000019.1  69734078-69734153
            956-1107            JAXUCZ010000019.1  69734919-69735070
            1108-1238           JAXUCZ010000019.1  69735189-69735319
            1239-1462           JAXUCZ010000019.1  69736537-69736760
            1463-1705           JAXUCZ010000019.1  69739528-69739770
            1706-1785           JAXUCZ010000019.1  69741410-69741489
            1786-1926           JAXUCZ010000019.1  69742208-69742348
            1927-2023           JAXUCZ010000019.1  69743187-69743283
            2024-2117           JAXUCZ010000019.1  69743361-69743454
            2118-2179           JAXUCZ010000019.1  69744256-69744317
            2180-2857           JAXUCZ010000019.1  69745567-69746244
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2857
                     /gene="Gnpat"
                     /note="glyceronephosphate O-acyltransferase"
                     /db_xref="GeneID:84470"
                     /db_xref="RGD:620179"
     exon            1..261
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2223
                     /gene="Gnpat"
                     /EC_number="2.3.1.42"
                     /note="DAP-AT; DHAP-AT; glycerone-phosphate
                     O-acyltransferase;
                     acyl-CoA:dihydroxyacetonephosphateacyltransferase;
                     acyl-CoA:dihydroxyacetonephosphate acyltransferase"
                     /codon_start=1
                     /product="dihydroxyacetone phosphate acyltransferase"
                     /protein_id="NP_445862.1"
                     /db_xref="GeneID:84470"
                     /db_xref="RGD:620179"
                     /translation="MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRQV
                     SDFKFAMKCYTPPLYRGITPCKPSDIKSIVLNSEEINYVIKQLSRESLTGVDVLREEA
                     NEILEEMSHKLRIGAIRFFAFVLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVILLPS
                     HRSYIDFLMLSFVLYNYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLY
                     WAVFSEYVKTMLRSGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYF
                     VPISISYDKILEESLYAYELLGIPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLR
                     SLAAGRLSRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVAIL
                     LQNQLCMDFDALVEKTLWLKGLTQVFGGFLLWPDNKLPEEVVQSSILLHSNLATLVKD
                     QVVLKVDSESSQMVNGLVPQHIAFLMCSAYRNQLLNVFARPSLVAVALHMTPGLRKED
                     VFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKTEVMQMTGKDIILTDKGNAVLQ
                     FLTGLFKPFVESYQILSKCLLHEEDYFSEKEYLVTARKFTRQLLDQDASQCYDALSSE
                     LQKNALAAFVRLGVVEKNKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL"
     exon            262..444
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            445..621
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            622..751
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            752..879
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            880..955
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1107
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1238
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1462
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1705
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1785
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1926
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2023
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2117
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2179
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2857
                     /gene="Gnpat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgggcccag cgcgggcctc gggcctggtt aagatggcgg tgcccggcgt cccgtgtggt
       61 ggccgtacgg agtgccactg ccctgggccg atgggagccg ccccgttcga aagaaccgcc
      121 cccagcggct gcaccacagc cgtgtagcag accagtccag gccccgcccg ggacggcagc
      181 cgcgccatgg acgttcctag ctcctccagc tcccgattct cggtcggctc tgccagccct
      241 agcagtgtgc tcctctatgc gaaagacctc aaaaagtggg atgagtttga agacctgttg
      301 gaggagagga gacaggtcag tgatttcaaa tttgcaatga agtgctacac accacccttg
      361 tatagaggaa ttactccctg caagccaagt gatatcaagt ccatcgttct caattctgaa
      421 gagattaact atgtcattaa gcagctttcc agggagtccc tgacgggtgt ggatgtgctc
      481 agagaagagg ccaatgagat cctggaggaa atgagtcaca aactgcgtat aggagccatt
      541 cggttctttg cctttgttct gagcaaagtt tttaaacaga tcttctcaaa ggtgtgtgtg
      601 aatgaagaag gcattcaaaa gctacaacga gcgatccagg agcaccccgt gatcctgctg
      661 cccagccacc ggagctacat cgacttcctc atgctgtcct ttgtcctcta caactatgac
      721 ctgcccgtgc cggtgatcgc agcagggatg gacttcctgg gaatgcgagt ggtgagcgag
      781 ctgctcagga tgtctggggc cttcttcatg cgacgtactt ttggaggaaa taagctctac
      841 tgggccgtat tctcggaata cgtgaagacc atgctacgga gtggttatgc tcctgttgaa
      901 tttttcctcg aagggacaag gagtcgagct gccaagacct tgactcctaa attcggtctc
      961 ctgaatattg tgatggaacc attttttaaa agagaagttt ttgataccta ctttgtccca
     1021 attagcatca gttatgataa aatattggaa gaaagtcttt atgcgtatga gctcctagga
     1081 atccctaagc caaaggaatc cactaccgga ctgttgaaag ctagacggat tctctctgag
     1141 aactttggaa gtatccatgt gtactttgga gaccctgtgt cactgcgctc tctagctgca
     1201 gggcggctca gtcggaacac gtataacttg gtgccaaggt gcatccctca gaagcagcct
     1261 gaggatgtgc aagcctttgt cactgaagtt gcctataaga tgcagctttt gcaaattgaa
     1321 aacctggctc tgagcccatg gcttctggta gttgccattc tgcttcagaa ccagctgtgc
     1381 atggacttcg atgccctggt ggaaaagact ctgtggctga agggcttaac gcaggtgttt
     1441 ggagggttcc tgctttggcc tgataacaaa cttcctgagg aagtggtcca gtcgagcatc
     1501 ctcctgcact ctaacctggc cacccttgtc aaagaccagg tggttctgaa agtggactct
     1561 gaaagctcac agatggtcaa cgggcttgtg ccccaacaca ttgccttcct catgtgctcg
     1621 gcgtacagga accagctgct caacgtgttt gcccgtcctt ccctagtagc tgtggctttg
     1681 cacatgactc ctgggctcag gaaagaggat gtcttcagtt gcttttcctt cctccgcaac
     1741 gtgttttcag atgagttcat cttccttcca ggaaacacac tcagggactt tgaggaaggc
     1801 tgttacttgc tgtgtaaaac tgaggttatg cagatgactg ggaaggacat catcctcaca
     1861 gacaaaggga atgctgtatt acagttcctc acaggactct ttaaaccttt tgtggaatcg
     1921 tatcagatac tttccaaatg cctcttgcat gaagaggact acttcagtga gaaggagtac
     1981 ttggtcacag ccaggaagtt cacccgccag cttctggatc aagatgcctc tcagtgttac
     2041 gacgcgctgt cctctgaact tcagaagaat gccttagcag ccttcgtgag actcggggtg
     2101 gtagaaaaga ataaggtaga cagtaaatat gtgtattatg tcaacgggcc tgccacaagc
     2161 aagttagaag aaatgctcgg atgtaagaag ccaataggaa aaccagccac tgcaaaacta
     2221 tgataatcat ggagcagtta cagaaaacac agttccataa tgacagtcac aaaggactta
     2281 ctctgccaca aatgggcgct gagaggaaga tgtgacgtct gtctccttga gacccgtgag
     2341 ccgtgcttct gccaggagga ggagagcatg ggaatgtcag tgtgactgtc ccaccatgat
     2401 ggctgccagc ggcattcatg gcactgtgtt gtctaataaa gcagtcttga aaatgttctt
     2461 ggacagcaga gctcaggccc tccctgttta ctccactcac ttcccacacc tactccattc
     2521 tcaggctgac ctacgaggta tagaacagca gcagcactga ccacgtactt atctgtgcag
     2581 gaagacactg aagaaaggac accggtgagt gttcctaacc cagcctgaag ctgggagtgg
     2641 gagtgtgcag agttctctgc tgagctccat gagggtccca gtcaaaacac aggtgcacta
     2701 agaatgctgt gttgggtgta cacaaaacag aggaagttca tgtctacatt agctcaaatc
     2761 tctagggcac tttgtttgga taagcagacc ttccaaaatc taaaaagcac ccagctcact
     2821 tctttgtcag tgttttcaat aaacttctta caaacaa
//
