LOCUS       NM_175580               1783 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein nucleolar 3 (Gnl3), mRNA.
ACCESSION   NM_175580
VERSION     NM_175580.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Crawford,M., Liu,X., Cheng,Y.L. and Tsai,R.Y.
  TITLE     Nucleostemin upregulation and STAT3 activation as early events in
            oral epithelial dysplasia progression to squamous cell carcinoma
  JOURNAL   Neoplasia 23 (12), 1289-1299 (2021)
   PUBMED   34785448
  REMARK    GeneRIF: Nucleostemin upregulation and STAT3 activation as early
            events in oral epithelial dysplasia progression to squamous cell
            carcinoma.
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Zhang,C., Shi,J., Qian,L., Zhang,C., Wu,K., Yang,C., Yan,D., Wu,X.
            and Liu,X.
  TITLE     Nucleostemin exerts anti-apoptotic function via p53 signaling
            pathway in cardiomyocytes
  JOURNAL   In Vitro Cell Dev Biol Anim 51 (10), 1064-1071 (2015)
   PUBMED   26138242
  REMARK    GeneRIF: In summary, this report suggested that Nucleostemin may
            exert the anti-apoptotic effect through Nucleostemin-p53 signaling
            pathway after myocardial reperfusion injury.
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Katano,M., Ema,M., Nakachi,Y., Mizuno,Y., Hirasaki,M., Suzuki,A.,
            Ueda,A., Nishimoto,M., Takahashi,S., Okazaki,Y. and Okuda,A.
  TITLE     Forced expression of Nanog or Esrrb preserves the ESC status in the
            absence of nucleostemin expression
  JOURNAL   Stem Cells 33 (4), 1089-1101 (2015)
   PUBMED   25522312
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Lassmann,T., Maida,Y., Tomaru,Y., Yasukawa,M., Ando,Y., Kojima,M.,
            Kasim,V., Simon,C., Daub,C.O., Carninci,P., Hayashizaki,Y. and
            Masutomi,K.
  TITLE     Telomerase reverse transcriptase regulates microRNAs
  JOURNAL   Int J Mol Sci 16 (1), 1192-1208 (2015)
   PUBMED   25569094
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Yaghoobi,M.M., Mowla,S.J. and Tiraihi,T.
  TITLE     Nucleostemin, a coordinator of self-renewal, is expressed in rat
            marrow stromal cells and turns off after induction of neural
            differentiation
  JOURNAL   Neurosci Lett 390 (2), 81-86 (2005)
   PUBMED   16139428
  REMARK    GeneRIF: Results suggest that nucleostemin, but not Oct-4 or Nanog,
            is expressed in bone marrow stromal cells where it possibly
            regulates self-renewal cell proliferation.
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Takagi,M., Absalon,M.J., McLure,K.G. and Kastan,M.B.
  TITLE     Regulation of p53 translation and induction after DNA damage by
            ribosomal protein L26 and nucleolin
  JOURNAL   Cell 123 (1), 49-63 (2005)
   PUBMED   16213212
  REMARK    Erratum:[Cell. 2005 Nov 4;123(3):536-7]
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Politz,J.C., Polena,I., Trask,I., Bazett-Jones,D.P. and Pederson,T.
  TITLE     A nonribosomal landscape in the nucleolus revealed by the stem cell
            protein nucleostemin
  JOURNAL   Mol Biol Cell 16 (7), 3401-3410 (2005)
   PUBMED   15857956
  REMARK    GeneRIF: analysis of nucleolar localization of stem cell protein
            nucleostemin
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Tsai,R.Y. and McKay,R.D.
  TITLE     A multistep, GTP-driven mechanism controlling the dynamic cycling
            of nucleostemin
  JOURNAL   J Cell Biol 168 (2), 179-184 (2005)
   PUBMED   15657390
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Tsai,R.Y. and McKay,R.D.
  TITLE     A nucleolar mechanism controlling cell proliferation in stem cells
            and cancer cells
  JOURNAL   Genes Dev 16 (23), 2991-3003 (2002)
   PUBMED   12464630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_175580.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY181024.1, BC093602.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000016.1  6219728-6219782     c
            56-114              JAXUCZ010000016.1  6218892-6218950     c
            115-252             JAXUCZ010000016.1  6218377-6218514     c
            253-363             JAXUCZ010000016.1  6218162-6218272     c
            364-444             JAXUCZ010000016.1  6217941-6218021     c
            445-577             JAXUCZ010000016.1  6217412-6217544     c
            578-690             JAXUCZ010000016.1  6216319-6216431     c
            691-808             JAXUCZ010000016.1  6215943-6216060     c
            809-896             JAXUCZ010000016.1  6215649-6215736     c
            897-1071            JAXUCZ010000016.1  6215134-6215308     c
            1072-1214           JAXUCZ010000016.1  6214913-6215055     c
            1215-1351           JAXUCZ010000016.1  6214689-6214825     c
            1352-1509           JAXUCZ010000016.1  6214433-6214590     c
            1510-1576           JAXUCZ010000016.1  6214145-6214211     c
            1577-1783           JAXUCZ010000016.1  6213844-6214050     c
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1783
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /note="G protein nucleolar 3"
                     /db_xref="GeneID:290556"
                     /db_xref="RGD:631354"
     exon            1..55
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1659
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /note="nucleolar GTP-binding protein 3; nucleostemin;
                     guanine nucleotide binding protein-like 3 (nucleolar)"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein-like 3"
                     /protein_id="NP_783170.1"
                     /db_xref="GeneID:290556"
                     /db_xref="RGD:631354"
                     /translation="MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKP
                     KKDPGVPNSAPFKEALLREAELRKQQLEELKQQQKLDRQKEQERKRKLEISPDDEQSN
                     VETQEESDEPKIKKAKSGKQNPKKLHCQELKKVIEASDIVLEVLDARDPLGCRCPQVE
                     EAVIQSGCKKLVLVLNKSDLVPKENLENWLTYLNKELPTVVFKASTNLKNRKKTFKIK
                     KKVVPFQSKLCCGKEALWKLLGGFQQSCGKGVQVGVVGFPNVGKSSIINSLKQERICS
                     VGVSMGLTRSMQIVPLDKQITIIDSPCFIISPCNSPAALALRSPASIEVLRPLEAASA
                     ILSQADSQQVVLKYTVPGYKDSLDFFTKLAQRRGLHQKGGSPNVESAAKLLWSEWTGA
                     SLGYYCHPPASWNHSPHFNENITAIMKRGFNLEELEKNNAHSIQVLKGPHLTNKILFR
                     SSGLTNGILEEKDIPEESPKQTEDQQDGDDQEHVTGEKNAEISDVTPVEETREMSPGQ
                     STASKPSDRSFILDKMSEEDDAYDFTTDYI"
     exon            56..114
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            115..252
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            253..363
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            364..444
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            445..577
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            578..690
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            691..808
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            809..896
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1071
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1214
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1351
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1509
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1576
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1783
                     /gene="Gnl3"
                     /gene_synonym="Ns"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacctgaga cctcttctgc tccagacgcg tccgcggcca ggatgaagag gccgaagtta
       61 aagaaagcaa gtaaacgtat gacctgtcat aagcggtata aaatccagaa aaaggttcga
      121 gaacatcatc gaaaattaag gaaggaagct aaaaagcggg gtcacaagaa gcctaagaag
      181 gacccaggag ttccaaatag tgctcccttt aaagaggctc ttcttcgtga agctgagcta
      241 aggaaacagc agcttgaaga actaaaacag cagcagaaac ttgacaggca aaaagaacaa
      301 gaacgaaaaa gaaaacttga aattagccct gatgatgagc aatctaatgt ggaaactcag
      361 gaggaatctg atgagcccaa aataaagaaa gctaaatcag gcaaacagaa tccaaagaag
      421 ttacattgtc aggaacttaa aaaggtgatt gaagcctcag acattgtgtt agaagttttg
      481 gatgccagag atcctcttgg ttgcaggtgt cctcaagtag aagaagctgt tatccaaagt
      541 ggatgtaaaa aactagtact tgtattaaat aagtcagatc tagtaccaaa agagaatcta
      601 gagaactggc taacttactt gaataaggaa ttgccaacag tggtgttcaa agcctcaaca
      661 aacttaaaga acagaaagaa gacattcaag ataaagaaga aagttgttcc attccaaagt
      721 aaactctgct gtggcaagga agcactgtgg aagctccttg gaggttttca gcagtcctgt
      781 ggaaaaggag ttcaggttgg agtggttggt ttcccaaatg tgggaaaaag cagcatcatt
      841 aatagtttaa aacaagaaag gatttgcagt gttggagttt ccatgggact tacaaggagt
      901 atgcagattg tccctttaga caaacagatc acaatcatag atagtccgtg cttcattatc
      961 tcaccttgta actcccctgc tgcacttgcc ctccgaagtc cagcaagtat tgaagttcta
     1021 agaccattgg aggctgccag tgccatcctg tctcaggctg atagtcaaca ggtggtgtta
     1081 aaatatactg tcccggggta taaggattct ctggattttt ttactaaact tgctcagaga
     1141 agaggtctgc accaaaaagg tggaagccca aatgtcgaaa gtgctgctaa gctgctatgg
     1201 tctgagtgga caggtgcctc attaggttac tactgccatc cccctgcatc ctggaatcat
     1261 tctcctcatt ttaatgagaa tattacagca atcatgaaga ggggctttaa tctagaagaa
     1321 ctagaaaaga ataatgcaca cagcatacaa gtcctcaagg gccctcattt aactaataaa
     1381 atccttttcc ggtcttcggg cctgacaaat ggaatactag aagaaaagga catccccgaa
     1441 gagtcaccaa aacagacaga agaccaacag gatggtgatg atcaagaaca tgttactggt
     1501 gaaaaaaatg cagagatctc agatgtgact cctgtagaag agaccaggga gatgtcacct
     1561 gggcaatcaa cagcaagtaa accatctgac agatccttta tcttggataa aatgagtgaa
     1621 gaagacgatg cctatgactt taccacagat tatatatagc cttctaaatg ttcaagtgtg
     1681 ctctgtacag tgtttctaga ttgctttggt atgatataaa gtgtaaatct tgtgaatatg
     1741 tatcatgttc taaattaaaa acaaaataaa aagtgtttgt ata
//
