LOCUS       NM_031754               3681 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus G protein subunit gamma 2 (Gng2), transcript
            variant 1, mRNA.
ACCESSION   NM_031754 XM_002725028 XM_002725029
VERSION     NM_031754.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3681)
  AUTHORS   Zhang,X.L., Upreti,C. and Stanton,P.K.
  TITLE     Gbetagamma and the C terminus of SNAP-25 are necessary for
            long-term depression of transmitter release
  JOURNAL   PLoS One 6 (5), e20500 (2011)
   PUBMED   21633701
  REMARK    GeneRIF: Data show that the C-terminus of SNAP-25 is a binding
            target for Gbetagamma necessary for both transient
            transmitter-mediated presynaptic inhibition, and the induction of
            presynaptic LTD.
REFERENCE   2  (bases 1 to 3681)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 3681)
  AUTHORS   Mathur,B.N., Caprioli,R.M. and Deutch,A.Y.
  TITLE     Proteomic analysis illuminates a novel structural definition of the
            claustrum and insula
  JOURNAL   Cereb Cortex 19 (10), 2372-2379 (2009)
   PUBMED   19168664
  REMARK    GeneRIF: We used matrix-assisted laser desorption
            ionization-imaging mass spectrometry to reveal a novel protein
            marker, G-protein gamma2 subunit (Gng2), which is enriched in the
            claustrum but not adjacent structures of the rat forebrain.
REFERENCE   4  (bases 1 to 3681)
  AUTHORS   Khurana,S., Tomar,A., George,S.P., Wang,Y., Siddiqui,M.R., Guo,H.,
            Tigyi,G. and Mathew,S.
  TITLE     Autotaxin and lysophosphatidic acid stimulate intestinal cell
            motility by redistribution of the actin modifying protein villin to
            the developing lamellipodia
  JOURNAL   Exp Cell Res 314 (3), 530-542 (2008)
   PUBMED   18054784
REFERENCE   5  (bases 1 to 3681)
  AUTHORS   Weissman,J.T., Ma,J.N., Essex,A., Gao,Y. and Burstein,E.S.
  TITLE     G-protein-coupled receptor-mediated activation of rap GTPases:
            characterization of a novel Galphai regulated pathway
  JOURNAL   Oncogene 23 (1), 241-249 (2004)
   PUBMED   14712229
REFERENCE   6  (bases 1 to 3681)
  AUTHORS   Zhou,J.Y., Toth,P.T. and Miller,R.J.
  TITLE     Direct interactions between the heterotrimeric G protein subunit G
            beta 5 and the G protein gamma subunit-like domain-containing
            regulator of G protein signaling 11: gain of function of cyan
            fluorescent protein-tagged G gamma 3
  JOURNAL   J Pharmacol Exp Ther 305 (2), 460-466 (2003)
   PUBMED   12606627
REFERENCE   7  (bases 1 to 3681)
  AUTHORS   Betty,M., Harnish,S.W., Rhodes,K.J. and Cockett,M.I.
  TITLE     Distribution of heterotrimeric G-protein beta and gamma subunits in
            the rat brain
  JOURNAL   Neuroscience 85 (2), 475-486 (1998)
   PUBMED   9622245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Apr 1, 2012 this sequence version replaced
            XM_002725028.1, XM_002725029.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.45602.1,
                                           SRR26360194.637370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000015.1  4365408-4365506
            100-140             JAXUCZ010000015.1  4380806-4380846
            141-256             JAXUCZ010000015.1  4446741-4446856
            257-3681            JAXUCZ010000015.1  4462636-4466060
FEATURES             Location/Qualifiers
     source          1..3681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3681
                     /gene="Gng2"
                     /note="G protein subunit gamma 2"
                     /db_xref="GeneID:80850"
                     /db_xref="RGD:69268"
     exon            1..99
                     /gene="Gng2"
                     /inference="alignment:Splign:2.1.0"
     exon            100..140
                     /gene="Gng2"
                     /inference="alignment:Splign:2.1.0"
     exon            141..256
                     /gene="Gng2"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..385
                     /gene="Gng2"
                     /EC_number="3.1.26.4"
                     /note="guanine nucleotide binding protein (G protein),
                     gamma 2 subunit"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2"
                     /protein_id="NP_113942.1"
                     /db_xref="GeneID:80850"
                     /db_xref="RGD:69268"
                     /translation="MASNNTASIAQARKLVEQLKMEASIDRIKVSKAAADLMAYCEAH
                     AKEDPLLTPVPASENPFREKKFFCAIL"
     exon            257..3681
                     /gene="Gng2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgggctgg gctgggctag gctgggcggg ccgagctcac cacccatctg ctccaccagg
       61 ggaagctgct ctctaaccaa gcctccggag ccaagcaagt ctgatctgcc agggagcctc
      121 cggccttgaa cactgaccag agtgtctgaa gaccctgtcc agctctccaa tggccagcaa
      181 caacaccgcc agcatagcgc aagccaggaa actggtcgag cagctgaaga tggaagccag
      241 catcgacagg ataaaggtgt ccaaggcagc tgcagacttg atggcctact gtgaggcaca
      301 tgccaaggaa gatcccctgc tgaccccagt cccggcctca gaaaatccct ttcgggagaa
      361 gaagttcttc tgcgccatcc tttaagtctc tgagaggagg ctgaagatgg tcggggctcc
      421 cgggacattg atgtagagtt cctagcagag tgggcgcctt tctcgtccgc agcatttaaa
      481 gagaggaagg agaaccatcc tggacactcc gggctgtgca tgtttaaaga actgtcccct
      541 catgagaatg aaagcttgat tccatgtcct aactttagag atctgaccct gcagaccggc
      601 ctggaggagg ggagtgtata aaaaaaacga gattggtgtc acttcttttc tgctaccccc
      661 ccacccccca ggaccttaca tttctgcttc atatttataa acaaacaaaa taaacattaa
      721 agctggtgtc ctgagctgag atatggctga catcctggga atgagaattg tccttcaagt
      781 accctctgat aagatgtcgc cctgtgtagc cacagtccag tttaatggct tccacgttta
      841 tagtcttttg tgcctttttc ttttccttcc ctttctcttt ctctacccct ctctgttaga
      901 ggactggggg gattaggctg ggtttgtgtg ttagactcac ctccaaggag gagatgttta
      961 gaaagatgtt tccccatggg atttcttcat gagaataacg ataagaaaac aaagaaatca
     1021 taccacacac acgcacatgc acgcacgcac acacaccaca atgccggctc tctgtgtgtc
     1081 cccttaccac tattctcaat atttgtatat gatagtttcg attctgcgag taaaagtaaa
     1141 tcatgtgttg tgaccggtgc tttcatatcc gtggtagttt ttgagtgaca ctgcatgaac
     1201 atgtccctac atcgcatcca ttcagaagtt tcattgttta gctggaaaac taataagaga
     1261 agtgagagaa aaagaggcca gggagtgggg ggaaatcctc tgtactttga taatcgaatc
     1321 acttcaacgc cttagccatg cctgaaatac ctcctagtga cctgtggtgt taagtacccg
     1381 gacccacggc attcgggctc acccgggatc cagggcagct gggttactcc tgcactggag
     1441 accaggcagg tgtccatggt ggcttgggaa ggcactgtca gaatataaca tcagcccgtt
     1501 cccgcttcca ggaaccgtgg aaagcatgtg caaaggaacg ctttccatgt tcatagatag
     1561 ctaggcaacc acagccctct atagttcaag catcagaaga agtaagccca tggctccaag
     1621 ggaggcggcc agccttggga tgcttgttgt ttaagaaaca aagtccccga attgtgctct
     1681 gagcagacct tgtggctgac tcttcttccg gctgacgtgg ccccagtttt tcacttcccc
     1741 aagatttcaa agcattcact gctttcttct ccaccctgtt tctcagagcc tctctgcctt
     1801 acttatagct ccctctggct agtgctctct tcccacaata aggcaccggg agcgagtatt
     1861 tttcattaca gttaaaccct ccgtcagtag cagaaggcct cggctgcctt cagactttct
     1921 gtcacctacg cggtcaagga gagcctctta cacgtacgtc tttttgtttt caaatcctaa
     1981 aaaaccacta aacccaagta aaatttattt cctcctcttg ccattctctt cccattttaa
     2041 aagttggtag tacttctgaa gggaagagac ttcctatggc aaggacacat tttcaaaata
     2101 gatttggtaa gatatttttc ctaactctta tgggttttca gctaaaggag tgaactatgc
     2161 ccatttaaag tttctgccgg gggtgggaga gacgagggta caggactgat tatcaatgag
     2221 caaatgcaat tctgtaacct gaaacttctg ttccggaggg tctagggggg ttgttagagt
     2281 tggtgggatg ctcatgaaga tttaatggtc aaaacaaaca gacaaaaaca aaacaaaaca
     2341 aaacaaaaac caaaccactg tcagcttaca gataatgcaa ttaataacac tgtagaatcc
     2401 ggtaaaagaa tcacattcaa agtgagcaga gacatgaacc tgtgttcaca tgtcaacatc
     2461 cgtgactggg gcactctgtg ctggttgtgg ggtacactag gaggattcca gacttctgtg
     2521 caaatttaga tctctgaagc agttaaaagg ggaacctaat ctttagagtg ccccttgtac
     2581 aggtctagca attaaacatt caggagttgc aaattacttg tgagcatgcc cacaggataa
     2641 aagggcagga agctctgtcc tcttccacac agaagtttca ggaaaatata gtctttttta
     2701 caatttcata tccttcggta tggagctatg gctggaatca gttttgactc attgatgctt
     2761 gtgttaatta aaggggaaaa agggtttgtt tacttggatt ggctccaaag agcttaattc
     2821 tttcgggatg tcaaccacca ttgtcaccag cataatttta tcgtgggtta actaatagga
     2881 aacttcagtt taaccattta agaccctcat ttctctatac caggaaaata attaaaatct
     2941 gccctagaat taataaataa taaatatcat acttataatg caatgtctat taagatacct
     3001 gaaccatttt attatcaact ccaatttaaa atgttttcaa gtttgaaagt aagtgtgatg
     3061 taagtcaaat catcagattt aagaagaagg acaagtatca tacttttccc cacatgcttg
     3121 tactcacatg agttttgaga aaatcaagct ggtgaccttt agcagatttt ttttaatgct
     3181 tttttccccc ttggtgtttg cttctagcca atcctgaaaa tgatgaatta ttatgtgtct
     3241 attgtgtctc acaggccaac aattgtacca cggttcagat cgccacactt ttcctgtata
     3301 agatctgtag aatgtgtctt tgaagaggag aaaacagaaa aaatgggggt gggttatctt
     3361 atgttttgat ggggtttttg cttttggggg tttcttggtt ggctggactt cgttttgttt
     3421 tgtttttgtt tttgtttttg tttttttcaa gacggggtct cactatgtgg ctgtggctgt
     3481 ctggaacttg ttctgtagac caggctggcc tcgaattcaa agattccccc tgcctctgac
     3541 tcttgagtgc ttgggaataa aggcgtgagc tgccacgccc agcttaaaaa cctcggaagc
     3601 agggaaacct gaatgtgatg tgcacacctt tatcccacat gaactgtgtg tttgttttaa
     3661 taaacggaat tttcagattc a
//
