LOCUS       NM_053661                725 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus G protein subunit gamma 12 (Gng12), mRNA.
ACCESSION   NM_053661 XM_001067408 XM_578287
VERSION     NM_053661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 725)
  AUTHORS   Ahmed SM, Theriault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS
            and Angers S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   2  (bases 1 to 725)
  AUTHORS   Larson KC, Lipko M, Dabrowski M and Draper MP.
  TITLE     Gng12 is a novel negative regulator of LPS-induced inflammation in
            the microglial cell line BV-2
  JOURNAL   Inflamm Res 59 (1), 15-22 (2010)
   PUBMED   19568691
  REMARK    Erratum:[Inflamm Res. 2009 Oct;58(10):725]
REFERENCE   3  (bases 1 to 725)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 725)
  AUTHORS   Betty M, Harnish SW, Rhodes KJ and Cockett MI.
  TITLE     Distribution of heterotrimeric G-protein beta and gamma subunits in
            the rat brain
  JOURNAL   Neuroscience 85 (2), 475-486 (1998)
   PUBMED   9622245
REFERENCE   5  (bases 1 to 725)
  AUTHORS   Asano T, Morishita R, Ueda H, Asano M and Kato K.
  TITLE     GTP-binding protein gamma12 subunit phosphorylation by protein
            kinase C--identification of the phosphorylation site and factors
            involved in cultured cells and rat tissues in vivo
  JOURNAL   Eur J Biochem 251 (1-2), 314-319 (1998)
   PUBMED   9492299
REFERENCE   6  (bases 1 to 725)
  AUTHORS   Morishita R, Saga S, Kawamura N, Hashizume Y, Inagaki T, Kato K and
            Asano T.
  TITLE     Differential localization of the gamma 3 and gamma 12 subunits of G
            proteins in the mammalian brain
  JOURNAL   J Neurochem 68 (2), 820-827 (1997)
   PUBMED   9003074
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM031435.1 and BG378509.1.
            
            On or before May 12, 2012 this sequence version replaced
            XM_578287.3, XM_001067408.2.
            
            Sequence Note: This RefSeq record was created from transcripts of
            different strains because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF113050.1, BF554406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               FM031435.1         19-498
            481-725             BG378509.1         1-245               c
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..725
                     /gene="Gng12"
                     /gene_synonym="Hg3a"
                     /note="G protein subunit gamma 12"
                     /db_xref="GeneID:114120"
                     /db_xref="RGD:621516"
     exon            1..58
                     /gene="Gng12"
                     /gene_synonym="Hg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            59..111
                     /gene="Gng12"
                     /gene_synonym="Hg3a"
                     /inference="alignment:Splign:2.1.0"
     exon            112..230
                     /gene="Gng12"
                     /gene_synonym="Hg3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..356
                     /gene="Gng12"
                     /gene_synonym="Hg3a"
                     /note="heterotrimeric guanine nucleotide-binding protein
                     3a; guanine nucleotide binding protein (G protein), gamma
                     12"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-12"
                     /protein_id="NP_446113.1"
                     /db_xref="GeneID:114120"
                     /db_xref="RGD:621516"
                     /translation="MSSKTASTNSTAQARRTVQQLRLEASIERIKVSKASADLMSYCE
                     EHARSDPLLMGIPTSENPFKDKKTCIIL"
     exon            231..708
                     /gene="Gng12"
                     /gene_synonym="Hg3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcatatgg gaaggacatt ggggtgagca tcttctctat ttgcagctgg cttttctgat
       61 tcaccctacc atttaaaacc tggaggcact ggcccacaca aagccttgct gatttcagga
      121 aagaagagtc atcaaagatg tccagcaaga cagcgagcac caacagcaca gcccaagcta
      181 ggagaactgt gcagcagctg agattggaag cctccatcga aagaataaag gtctccaaag
      241 catctgcaga cctgatgtca tactgtgagg agcatgcccg gagcgaccct ctgctgatgg
      301 gcataccgac ctcagaaaac ccattcaagg ataagaagac ctgcatcatc ttatagtgga
      361 ccaggaagca ccccttgcct ctcaatgcaa accacagcag caacctgaag agattcatgc
      421 agcttacctg gtaaccacag ctagtaacta aaacaccctt ctcttggcat aacagaccct
      481 caagtctctc tctttcaagt tgtcctttct tcgaccttta ctgatttaat acagaataac
      541 aatcttattt tctatttgga aatatggtat catattgggt tactactgta taaggaaagt
      601 ggcaggggag ttgtgggaag cttgtcttta caatatacta ttgattaaga tatgtcaaga
      661 cctacattgt ctaagcaccg gcaaattaaa atgtcaagaa tcgcttcaaa aaaaaaaaaa
      721 aaaaa
//
