LOCUS       NM_031770               2087 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein subunit beta 5 (Gnb5), mRNA.
ACCESSION   NM_031770 XM_343433
VERSION     NM_031770.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Aguado,C., Orlandi,C., Fajardo-Serrano,A., Gil-Minguez,M.,
            Martemyanov,K.A. and Lujan,R.
  TITLE     Cellular and Subcellular Localization of the RGS7/Gbeta5/R7BP
            Complex in the Cerebellar Cortex
  JOURNAL   Front Neuroanat 10, 114 (2016)
   PUBMED   27965545
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Shamseldin,H.E., Masuho,I., Alenizi,A., Alyamani,S., Patil,D.N.,
            Ibrahim,N., Martemyanov,K.A. and Alkuraya,F.S.
  TITLE     GNB5 mutation causes a novel neuropsychiatric disorder featuring
            attention deficit hyperactivity disorder, severely impaired
            language development and normal cognition
  JOURNAL   Genome Biol 17 (1), 195 (2016)
   PUBMED   27677260
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Tian,M., Zallocchi,M., Wang,W., Chen,C.K., Palczewski,K.,
            Delimont,D., Cosgrove,D. and Peng,Y.W.
  TITLE     Light-induced translocation of RGS9-1 and Gbeta5L in mouse rod
            photoreceptors
  JOURNAL   PLoS One 8 (3), e58832 (2013)
   PUBMED   23555598
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Howlett,A.C., Gray,A.J., Hunter,J.M. and Willardson,B.M.
  TITLE     Role of molecular chaperones in G protein beta5/regulator of G
            protein signaling dimer assembly and G protein betagamma dimer
            specificity
  JOURNAL   J Biol Chem 284 (24), 16386-16399 (2009)
   PUBMED   19376773
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Zhou,J.Y., Siderovski,D.P. and Miller,R.J.
  TITLE     Selective regulation of N-type Ca channels by different
            combinations of G-protein beta/gamma subunits and RGS proteins
  JOURNAL   J Neurosci 20 (19), 7143-7148 (2000)
   PUBMED   11007869
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Witherow,D.S., Wang,Q., Levay,K., Cabrera,J.L., Chen,J.,
            Willars,G.B. and Slepak,V.Z.
  TITLE     Complexes of the G protein subunit gbeta 5 with the regulators of G
            protein signaling RGS7 and RGS9. Characterization in native tissues
            and in transfected cells
  JOURNAL   J Biol Chem 275 (32), 24872-24880 (2000)
   PUBMED   10840031
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Liang,J.J., Cockett,M. and Khawaja,X.Z.
  TITLE     Immunohistochemical localization of G protein beta1, beta2, beta3,
            beta4, beta5, and gamma3 subunits in the adult rat brain
  JOURNAL   J Neurochem 71 (1), 345-355 (1998)
   PUBMED   9648884
REFERENCE   10 (bases 1 to 2087)
  AUTHORS   Betty,M., Harnish,S.W., Rhodes,K.J. and Cockett,M.I.
  TITLE     Distribution of heterotrimeric G-protein beta and gamma subunits in
            the rat brain
  JOURNAL   Neuroscience 85 (2), 475-486 (1998)
   PUBMED   9622245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Sep 23, 2022 this sequence version replaced NM_031770.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089221.1, SRR26360172.644908.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               JAXUCZ010000008.1  84956629-84956847
            220-356             JAXUCZ010000008.1  84968443-84968579
            357-398             JAXUCZ010000008.1  84970867-84970908
            399-475             JAXUCZ010000008.1  84971815-84971891
            476-608             JAXUCZ010000008.1  84973241-84973373
            609-752             JAXUCZ010000008.1  84974875-84975018
            753-844             JAXUCZ010000008.1  84976483-84976574
            845-893             JAXUCZ010000008.1  84979680-84979728
            894-990             JAXUCZ010000008.1  84983267-84983363
            991-1157            JAXUCZ010000008.1  84984144-84984310
            1158-2087           JAXUCZ010000008.1  84984647-84985576
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2087
                     /gene="Gnb5"
                     /note="G protein subunit beta 5"
                     /db_xref="GeneID:83579"
                     /db_xref="RGD:620759"
     exon            1..219
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1169
                     /gene="Gnb5"
                     /note="guanine nucleotide-binding protein, beta-5 subunit;
                     gbeta5; transducin beta chain 5; guanine nucleotide
                     binding protein (G protein), beta polypeptide 5; guanine
                     nucleotide binding protein, beta 5; guanine nucleotide
                     binding protein (G protein), beta 5"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-5"
                     /protein_id="NP_113958.1"
                     /db_xref="GeneID:83579"
                     /db_xref="RGD:620759"
                     /translation="MATDGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAER
                     VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT
                     MPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACS
                     FTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCD
                     KKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAI
                     YSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS
                     PDGTAFCSGSWDHTLRVWA"
     exon            220..356
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            357..398
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            399..475
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            476..608
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            609..752
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            753..844
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            845..893
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            894..990
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1157
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2087
                     /gene="Gnb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttcggggt cacggaggct gctgctgcgc ccgccctccc gtcgggcccc cgcgtcgatt
       61 cacaatctcc cgctttgcgt ttctctcccg gctgcatccg gacgaagatg gcaaccgatg
      121 ggctgcacga gaacgagacg ctggcgtcgc tgaagagcga ggccgagagc ctcaagggca
      181 agctagagga ggagcgggcg aagctgcatg acgtggagct tcaccaggtg gccgagcggg
      241 tggaggccct gggccagttt gtcatgaaga ccagaaggac cctcaaagga cacgggaaca
      301 aagtcctgtg catggattgg tgcaaagaca agcggaggat cgtgagctcc tcacaggatg
      361 ggaaggtgat tgtctgggat tccttcacta ctaacaagga gcacgcggtc accatgcctt
      421 gcacctgggt gatggcgtgt gcttatgccc catcaggatg tgccattgct tgtggtggtc
      481 tggataataa gtgttccgtg tacccactga catttgacaa gaacgagaac atggctgcca
      541 agaagaagtc tgtcgctatg cacaccaact acctgtctgc ctgcagcttc accaactcag
      601 acatgcagat cctgacagcc agcggtgatg gcacttgcgc cctgtgggat gtggaaagtg
      661 gacagctgtt gcagagcttc catggccatg gggctgacgt cctctgcttg gacctggccc
      721 cctcagaaac tggaaacacc ttcgtgtctg ggggttgtga caagaaggcc atggtgtggg
      781 acatgcgctc tggccagtgt gtgcaagcct ttgaaactca tgaatctgat gtcaacagtg
      841 tccgatacta ccccagtgga gatgcttttg cttccggatc agatgatgcc acgtgtcgcc
      901 tctatgacct gagggcagat agagaggttg ccatctactc caaggagagt attatatttg
      961 gagcatcaag cgtggatttc tccctcagtg gccgcctgct ctttgctggg tacaatgact
     1021 ataccatcaa tgtctgggat gttctcaagg gctcccgggt ctccatcctg tttggacatg
     1081 aaaaccgtgt tagcactctg cgagtgtctc ctgatgggac agcattctgc tcagggtcgt
     1141 gggatcacac cctaagagtt tgggcataat cctctcccag cgtgcaagaa ggacacgtgc
     1201 tctcccgtgt ggatacgacc tcttgatgag cccagggctt cccacaggta gcctatggga
     1261 gcaatcccag tcagcactca ctcacccgtc cagtgtctcc atgaaatccg ccctcccagg
     1321 aaatactcag ataggccctg gctcttcaac tggccctcca agcccttctt tcatctcaaa
     1381 cactctgtga agttttgtcc gtttttgaag ctattccaac caccagaatt ccacgtctgt
     1441 cagcatttca aatgtccctc attgcttcct tgaatccagt ctgtcttcag agcactttaa
     1501 agtctacctt ttcttggtgt cgactgtggt ttctagagcc atcgtctgga catgccggct
     1561 atatggactg tgagagtggc tattcagtgg tctgtaacag aaggaaattt cagttccaaa
     1621 tgtacagaat cacacagaat cactttttaa aactgtttct aggtaaaagt atctttttca
     1681 acctgttcgt tgtctttttt tagatagtat gtttttgttt gggttgattt gtttggttgg
     1741 ttggttggtt ttgttctggg ggaagcttta gaaatgaaat ggacacatgc agaaaacagg
     1801 ctatgtattt gacttgtgaa aaatgcagtc tagggctgag cattccccta cacctgaggg
     1861 gaaaaccagt tgccattcct ggcaccaata ctgccaagag caaacagaac cttctggcat
     1921 gggaacaggt cactaaactg atttaaaagc ctgctagtag tgttatcaga aatgcctaag
     1981 ataatgtgtg tgttgtccct ataaattata ttcgaatgtc ctgcacagca gctgtaccga
     2041 cacagactga tgggcaggcc atgaataata atgtctttgc tacccaa
//
