LOCUS       NM_001013910            1516 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus G protein subunit beta 4 (Gnb4), mRNA.
ACCESSION   NM_001013910 XM_227042
VERSION     NM_001013910.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1516)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   2  (bases 1 to 1516)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   3  (bases 1 to 1516)
  AUTHORS   Mahmoud,S., Yun,J.K. and Ruiz-Velasco,V.
  TITLE     Gbeta2 and Gbeta4 participate in the opioid and adrenergic
            receptor-mediated Ca2+ channel modulation in rat sympathetic
            neurons
  JOURNAL   J Physiol 590 (19), 4673-4689 (2012)
   PUBMED   22711958
  REMARK    GeneRIF: Gnb2 and Gnb4 participate in the opioid and adrenergic
            receptor-mediated Ca2+ channel modulation in rat sympathetic
            neurons
REFERENCE   4  (bases 1 to 1516)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   5  (bases 1 to 1516)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   6  (bases 1 to 1516)
  AUTHORS   Liang,J.J., Cockett,M. and Khawaja,X.Z.
  TITLE     Immunohistochemical localization of G protein beta1, beta2, beta3,
            beta4, beta5, and gamma3 subunits in the adult rat brain
  JOURNAL   J Neurochem 71 (1), 345-355 (1998)
   PUBMED   9648884
REFERENCE   7  (bases 1 to 1516)
  AUTHORS   Betty,M., Harnish,S.W., Rhodes,K.J. and Cockett,M.I.
  TITLE     Distribution of heterotrimeric G-protein beta and gamma subunits in
            the rat brain
  JOURNAL   Neuroscience 85 (2), 475-486 (1998)
   PUBMED   9622245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097370.1.
            
            On Jun 12, 2005 this sequence version replaced NM_001013910.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097370.1, AY552804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1516
                     /gene="Gnb4"
                     /note="G protein subunit beta 4"
                     /db_xref="GeneID:294962"
                     /db_xref="RGD:1359321"
     exon            1..34
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            35..130
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1096
                     /gene="Gnb4"
                     /note="G-protein beta 4 subunit; guanine
                     nucleotide-binding protein subunit beta-4-like; guanine
                     nucleotide binding protein (G protein), beta polypeptide
                     4; transducin beta chain 4; guanine nucleotide binding
                     protein beta 4 subunit; guanine nucleotide binding
                     protein, beta 4; guanine nucleotide binding protein (G
                     protein), beta 4"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein subunit
                     beta-4"
                     /protein_id="NP_001013932.1"
                     /db_xref="GeneID:294962"
                     /db_xref="RGD:1359321"
                     /translation="MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQ
                     MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMT
                     CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDGQIITS
                     SGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPDLKTFVSGACDASSKLWDIRDGMC
                     RQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSV
                     AFSKSGRLLLAGYDDFNCSVWDALKGGRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLRIWN"
     exon            131..169
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            170..276
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            277..340
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            341..503
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            504..570
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..772
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            773..989
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1488
                     /gene="Gnb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcagcagc gcggtggtgg cggccaggct ccagctcttc acttgagact ccggagggaa
       61 gcagccacac aggatgagtg agctggagca gctgaggcag gaggctgaac agctccggaa
      121 tcagatccag gatgctcgga aggcctgcaa cgatgccaca ctggttcaga tcacgtctaa
      181 tatggactcc gtgggccgaa tacaaatgcg aacaaggcgc acgctgcgcg gccacctcgc
      241 caagatctac gccatgcact ggggatacga ttccaggcta ctagtcagtg cttcccaaga
      301 tggaaaatta attatttggg atagctatac aacaaataag atgcacgcca tcccgctgag
      361 gtcctcctgg gtcatgacct gtgcctatgc cccgtctggg aactacgtag cctgtggagg
      421 cttggacaac atctgctcca tatacaacct gaagactcgt gaggggaacg tgagagtgag
      481 ccgggagctg ccagggcaca caggctactt gtcctgctgc cgattcttag atgacggaca
      541 aatcattaca agttctggag acacgacttg tgctttgtgg gacatcgaga ccggacagca
      601 gacgaccacc ttcacaggac actcggggga cgtgatgagc ctctcactga gtcctgactt
      661 gaagaccttt gtttctggtg cttgcgatgc atcttcaaaa ctgtgggata tccgagacgg
      721 gatgtgtaga cagtctttca caggacacat ctcagacatc aatgctgtca gcttcttccc
      781 gagtggatat gcctttgcca ctggttctga tgacgccacc tgccgactct ttgacctccg
      841 tgcagaccag gagctcctgc tgtattccca tgacaatatc atctgtggca tcacttctgt
      901 ggccttctca aagagcgggc gcctcctgct agccggctat gacgacttca actgcagtgt
      961 gtgggacgct ctgaaaggag gtcgggcagg tgtccttgct ggtcatgaca accgtgttag
     1021 ctgcttaggt gtgactgatg acggcatggc tgtggccact ggctcctggg acagttttct
     1081 cagaatctgg aattgagtgc tgtattttct gttctccaat gatatttgga gaaatccgtg
     1141 ctacagccat agctgtgagg aaaaaacccc tctaccttct atttgcagat gaagttcttc
     1201 tattgaggtg actatatata tataaaaagc cactttcaat aaactgtagt ttattgaaac
     1261 tcttctaaca aaaatggtgg tcaaagaaac aatcaagact aagatccctt gctgcggtta
     1321 agcccgtgat attcactgag cggttgtgtt gactttatcc ctatcccgac agactcttgc
     1381 ttgtgctaat tgtttttctg tagattagag tgcacacttt atagcaggac aaccatttgt
     1441 gtttgcattt tgttaaggcc taccattgaa ctttgtatat acaagaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaa
//
