LOCUS       NM_021858               1577 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein subunit beta 3 (Gnb3), mRNA.
ACCESSION   NM_021858
VERSION     NM_021858.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1577)
  AUTHORS   Ozdemir,A.C., Wynn,G.M., Vester,A., Weitzmann,M.N., Neigh,G.N.,
            Srinivasan,S. and Rudd,M.K.
  TITLE     GNB3 overexpression causes obesity and metabolic syndrome
  JOURNAL   PLoS One 12 (12), e0188763 (2017)
   PUBMED   29206867
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1577)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   3  (bases 1 to 1577)
  AUTHORS   Kumar,R., Kohli,S., Alam,P., Barkotoky,R., Gupta,M., Tyagi,S.,
            Jain,S.K. and Pasha,M.A.
  TITLE     Interactions between the FTO and GNB3 genes contribute to varied
            clinical phenotypes in hypertension
  JOURNAL   PLoS One 8 (5), e63934 (2013)
   PUBMED   23691120
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1577)
  AUTHORS   Arshavsky,V.Y. and Burns,M.E.
  TITLE     Photoreceptor signaling: supporting vision across a wide range of
            light intensities
  JOURNAL   J Biol Chem 287 (3), 1620-1626 (2012)
   PUBMED   22074925
  REMARK    Review article
REFERENCE   5  (bases 1 to 1577)
  AUTHORS   Hill,C., Goddard,A., Ladds,G. and Davey,J.
  TITLE     The cationic region of Rhes mediates its interactions with specific
            Gbeta subunits
  JOURNAL   Cell Physiol Biochem 23 (1-3), 1-8 (2009)
   PUBMED   19255495
REFERENCE   6  (bases 1 to 1577)
  AUTHORS   Tabara,Y., Kohara,K. and Miki,T.
  TITLE     Polymorphisms of genes encoding components of the sympathetic
            nervous system but not the renin-angiotensin system as risk factors
            for orthostatic hypotension
  JOURNAL   J Hypertens 20 (4), 651-656 (2002)
   PUBMED   11910300
REFERENCE   7  (bases 1 to 1577)
  AUTHORS   Hengstenberg,C., Schunkert,H., Mayer,B., Doring,A., Lowel,H.,
            Hense,H.W., Fischer,M., Riegger,G.A. and Holmer,S.R.
  TITLE     Association between a polymorphism in the G protein beta3 subunit
            gene (GNB3) with arterial hypertension but not with myocardial
            infarction
  JOURNAL   Cardiovasc Res 49 (4), 820-827 (2001)
   PUBMED   11230982
REFERENCE   8  (bases 1 to 1577)
  AUTHORS   Jacobi,J., Hilgers,K.F., Schlaich,M.P., Siffert,W. and
            Schmieder,R.E.
  TITLE     825T allele of the G-protein beta3 subunit gene (GNB3) is
            associated with impaired left ventricular diastolic filling in
            essential hypertension
  JOURNAL   J Hypertens 17 (10), 1457-1462 (1999)
   PUBMED   10526907
REFERENCE   9  (bases 1 to 1577)
  AUTHORS   Liang,J.J., Cockett,M. and Khawaja,X.Z.
  TITLE     Immunohistochemical localization of G protein beta1, beta2, beta3,
            beta4, beta5, and gamma3 subunits in the adult rat brain
  JOURNAL   J Neurochem 71 (1), 345-355 (1998)
   PUBMED   9648884
REFERENCE   10 (bases 1 to 1577)
  AUTHORS   Ray,K. and Robishaw,J.D.
  TITLE     Cloning and sequencing of a rat heart cDNA encoding a G-protein
            beta subunit related to the human retinal beta 3 subunit
  JOURNAL   Gene 149 (2), 337-340 (1994)
   PUBMED   7959013
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086422.1.
            
            On Aug 31, 2012 this sequence version replaced NM_021858.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1577              BC086422.1         4-1580
FEATURES             Location/Qualifiers
     source          1..1577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1577
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /note="G protein subunit beta 3"
                     /db_xref="GeneID:60449"
                     /db_xref="RGD:708344"
     exon            1..81
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            82..168
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1134
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /note="guanine nucleotide-binding protein, beta-3 subunit;
                     transducin beta chain 3; guanine nucleotide binding
                     protein (G protein), beta polypeptide 3; guanine
                     nucleotide binding protein, beta 3; guanine nucleotide
                     binding protein (G protein), beta 3; G protein
                     beta-subunit; heterotrimeric guanine nucleotide-binding
                     protein 2d"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-3"
                     /protein_id="NP_068630.1"
                     /db_xref="GeneID:60449"
                     /db_xref="RGD:708344"
                     /translation="MGEMEQLKQEAEQLKKQIADARKACADITLAELVSGLEVVGRVQ
                     MRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMT
                     CAYAPSGNFVACGGLDNMCSIYSLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTS
                     SGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTC
                     RQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSHESIICGITSV
                     AFSLSGRLLFAGYDDFNCNVWDSLKCERVGVLSGHDNRVSCLGVTADGMAVATGSWDS
                     FLKIWN"
     exon            169..207
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            208..314
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            315..378
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            379..541
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            542..608
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            609..810
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1027
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1556
                     /gene="Gnb3"
                     /gene_synonym="Hg2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacaggca ggcatcacag ctgagaccgt gaggaggcgc ctgggaagcg gaaacctggg
       61 agaaatccag ctagagccca agagccagga ctacccctcg acctgtgaac catgggggag
      121 atggagcagc tgaagcagga ggcggagcag ctcaagaagc agattgctga tgccaggaaa
      181 gcctgtgcgg acatcactct ggctgagctt gtgtctggcc tggaggtggt gggacgagtc
      241 cagatgcgga cacggaggac gttaagggga cacctggcta agatctatgc catgcactgg
      301 gccactgact ctaagctgct agtaagtgcc tcgcaggatg ggaagctgat cgtgtgggac
      361 acttacacca ccaataaggt gcatgctatc ccgctgcgtt cctcctgggt catgacctgt
      421 gcctatgcac catcagggaa cttcgtggca tgtggggggc tagataacat gtgctcaatc
      481 tacagcctca aatcccgtga gggcaatgtc aaggtcagcc gggaactctc ggctcacaca
      541 ggttatctct cctgttgccg cttcctggat gacaacaaca ttgtgactag ctctggggac
      601 accacgtgtg ccttgtggga cattgagacg gggcagcaga agacagtgtt cgtgggacac
      661 actggtgact gcatgagcct ggctgtgtcc ccagactaca aactcttcat ctcgggagct
      721 tgtgatgcca gcgccaagct ctgggatgtg agggaaggga cctgtcgcca gactttcact
      781 ggccacgagt cagacatcaa tgctatctgt ttctttccca atggggaggc catctgcact
      841 ggctcagatg atgcctcctg ccgcctcttt gacctgaggg cagaccagga actgacagcc
      901 tactcccacg agagcatcat ctgtggcatc acgtccgtag ccttctcact cagtggtcgc
      961 ctgctctttg ctggctatga tgacttcaac tgcaatgtct gggactctct gaagtgtgag
     1021 cgtgtaggcg ttctttctgg ccatgacaac agagtcagtt gcctgggggt cacagctgac
     1081 ggcatggctg tggccactgg atcctgggac agcttcctca agatctggaa ctgaggaggc
     1141 tggaggaaga ggtgggaagc catgaaggct ctcagctgac tcctatgccc tgtctcctta
     1201 gggtcagtct tctataccct ggggccactc ccagtaaact tccttctaag ggcaggtggg
     1261 attatgggag tgtgcctttg ggagtagcag ggacacaagg gcaaagaact gccccatttc
     1321 ctccagggcc tctcctctcc acagtcctca tagcttctcc cttcataaac aagaacagac
     1381 cctccccatc ctagatgact cctgggctac cagcagcctt tgtctggcct gggaatggcc
     1441 agagcgctca gcccatgact ataggtgtca ctcctagtat cctggctccc tcccagccac
     1501 tttctttctg cccttttgtt ctctcttatt acctaataaa atgtagcatc ctggtaaaaa
     1561 aaaaaaaaaa aaaaaaa
//
