LOCUS       NM_031037               1670 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus G protein subunit beta 2 (Gnb2), mRNA.
ACCESSION   NM_031037
VERSION     NM_031037.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Hernandez-Castellanos,J.M., Vivas,O., Garduno,J., De la Cruz,L.,
            Arenas,I., Elias-Vinas,D., Mackie,K. and Garcia,D.E.
  TITLE     Gbeta mimics activation kinetic slowing of CaV2.2 channels by
            noradrenaline in rat sympathetic neurons
  JOURNAL   Biochem Biophys Res Commun 445 (1), 250-254 (2014)
   PUBMED   24513289
  REMARK    GeneRIF: Data indicate that verexpression of Gbeta2 subunit mimics
            CaV2.2 kinetic slowing by noradrenaline.
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Mahmoud,S., Yun,J.K. and Ruiz-Velasco,V.
  TITLE     Gbeta2 and Gbeta4 participate in the opioid and adrenergic
            receptor-mediated Ca2+ channel modulation in rat sympathetic
            neurons
  JOURNAL   J Physiol 590 (19), 4673-4689 (2012)
   PUBMED   22711958
  REMARK    GeneRIF: Gnb2 and Gnb4 participate in the opioid and adrenergic
            receptor-mediated Ca2+ channel modulation in rat sympathetic
            neurons
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Zhang,X.L., Upreti,C. and Stanton,P.K.
  TITLE     Gbetagamma and the C terminus of SNAP-25 are necessary for
            long-term depression of transmitter release
  JOURNAL   PLoS One 6 (5), e20500 (2011)
   PUBMED   21633701
  REMARK    GeneRIF: Data show that the C-terminus of SNAP-25 is a binding
            target for Gbetagamma necessary for both transient
            transmitter-mediated presynaptic inhibition, and the induction of
            presynaptic LTD.
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Waragai,M., Nagamitsu,S., Xu,W., Li,Y.J., Lin,X. and Ashizawa,T.
  TITLE     Ataxin 10 induces neuritogenesis via interaction with G-protein
            beta2 subunit
  JOURNAL   J Neurosci Res 83 (7), 1170-1178 (2006)
   PUBMED   16498633
REFERENCE   6  (bases 1 to 1670)
  AUTHORS   Pahner,I., Holtje,M., Winter,S., Takamori,S., Bellocchio,E.E.,
            Spicher,K., Laake,P., Nurnberg,B., Ottersen,O.P. and
            Ahnert-Hilger,G.
  TITLE     Functional G-protein heterotrimers are associated with vesicles of
            putative glutamatergic terminals: implications for regulation of
            transmitter uptake
  JOURNAL   Mol Cell Neurosci 23 (3), 398-413 (2003)
   PUBMED   12837624
  REMARK    Erratum:[Mol Cell Neurosci. 2003 Nov;24(3):850. Numberg, Bernd
            [corrected to Nurnberg, Bernd]]
REFERENCE   7  (bases 1 to 1670)
  AUTHORS   Sharma,S.K. and Das,M.R.
  TITLE     Enhanced expression of heterotrimeric GTP-binding protein subunits
            in Zajdela ascitic hepatoma
  JOURNAL   Indian J Biochem Biophys 39 (3), 148-154 (2002)
   PUBMED   22905384
  REMARK    GeneRIF: analysis of enhanced expression of heterotrimeric
            GTP-binding protein subunits in Zajdela ascitic hepatoma
REFERENCE   8  (bases 1 to 1670)
  AUTHORS   Arnot,M.I., Stotz,S.C., Jarvis,S.E. and Zamponi,G.W.
  TITLE     Differential modulation of N-type 1B and P/Q-type 1A calcium
            channels by different G protein subunit isoforms
  JOURNAL   J Physiol 527 Pt 2 (Pt 2), 203-212 (2000)
   PUBMED   10970423
REFERENCE   9  (bases 1 to 1670)
  AUTHORS   Liang,J.J., Cockett,M. and Khawaja,X.Z.
  TITLE     Immunohistochemical localization of G protein beta1, beta2, beta3,
            beta4, beta5, and gamma3 subunits in the adult rat brain
  JOURNAL   J Neurochem 71 (1), 345-355 (1998)
   PUBMED   9648884
REFERENCE   10 (bases 1 to 1670)
  AUTHORS   Betty,M., Harnish,S.W., Rhodes,K.J. and Cockett,M.I.
  TITLE     Distribution of heterotrimeric G-protein beta and gamma subunits in
            the rat brain
  JOURNAL   Neuroscience 85 (2), 475-486 (1998)
   PUBMED   9622245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC065579.1.
            
            On Feb 1, 2004 this sequence version replaced NM_031037.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065579.1, SRR8487230.16983.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1670
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /note="G protein subunit beta 2"
                     /db_xref="GeneID:81667"
                     /db_xref="RGD:69319"
     exon            1..139
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            140..285
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1251
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /note="guanine nucleotide-binding protein, beta 2;
                     transducin beta chain 2; g protein subunit beta-2; guanine
                     nucleotide binding protein, beta polypeptide 2; guanine
                     nucleotide binding protein beta 2 subunit; heterotrimeric
                     guanine nucleotide-binding protein 2c1; guanine nucleotide
                     binding protein (G protein), beta 2; guanine nucleotide
                     binding protein (G protein), beta polypeptide 2"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-2"
                     /protein_id="NP_112299.1"
                     /db_xref="GeneID:81667"
                     /db_xref="RGD:69319"
                     /translation="MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQ
                     MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT
                     CAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITS
                     SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMC
                     RQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSV
                     AFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLKIWN"
     exon            286..324
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..431
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..658
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..725
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..927
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1144
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1624
                     /gene="Gnb2"
                     /gene_synonym="Hg2c1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagctgcg ctggacggtt gagttggggt gactgaggaa atccatccgc gtcgccgccg
       61 ctgccgcctc cgccgcggag gaagacagga cctcccgcgc tcctccaagc gaccccttgg
      121 cagagtccca ccacctcagg cctcgggcca gcggccagga gctgcctccc ccagcccccg
      181 tcccgcggcc cccagccgcc cccaaccccg ccccacgggc ccggcgccat gagtgagctg
      241 gagcaactga gacaggaggc tgagcagctc cggaaccaga tccgggacgc cagaaaagca
      301 tgcggggatt ccacactgac ccagatcaca gctgggctgg acccagtggg gcgaattcag
      361 atgagaacac ggaggaccct ccgtggacac ctggcaaaaa tctatgccat gcactggggg
      421 acagactcaa ggctgctggt cagcgcctcc caggacggaa agctcatcat ttgggacagc
      481 tacaccacta acaaggtcca cgccatccct ctgcgctcct cctgggtcat gacctgtgcc
      541 tacgccccct cggggaactt cgtggcctgt gggggtttgg acaacatctg ctccatctat
      601 agtctcaaga cccgagaggg caatgtcagg gtcagcagag agctgcctgg ccatactggg
      661 tacctctcct gctgccgctt cctggacgac aaccaaatca tcaccagctc tggggacacc
      721 acctgtgccc tgtgggacat tgagacaggc cagcagacag tgggatttgc tggacacagt
      781 ggggatgtga tgtccctgtc cctggccccc gatggccgca cctttgtgtc aggtgcctgc
      841 gatgcctcca tcaagctgtg ggatgttcgg gattccatgt gccgacagac attcataggt
      901 cacgaatcgg acatcaatgc tgtggctttc ttccccaatg gttatgcctt caccacggga
      961 tcagatgatg ccacatgtcg cctgtttgac ctgcgggctg atcaggagct gctcatgtat
     1021 tcccacgaca acatcatctg cggcatcacc tcggttgcct tctcacgcag cggccggctg
     1081 ctgctcgctg gctatgacga cttcaactgc aacatctggg atgccatgaa gggtgaccgt
     1141 gcaggtgtcc tcgctggcca tgataaccgt gtgagctgcc ttggggtcac agatgatggg
     1201 atggctgtgg ctacaggctc ctgggactcc ttcctcaaga tctggaacta acctccccaa
     1261 ccccagatgg gcccaggcag ggagcagccc tgcccatgcc cacactacag gcccggagct
     1321 ttggggctgg gcacacatgc caagcctccc tccctgggct acagggcctt gggtcctgct
     1381 cccataccca ggtttggttc ctctcggggg ggcccccact gtggagataa aagtcgggga
     1441 tggaatgggg gaagaggaag ggcaggaaag ccctcaccct ttgctgccct ggggccaggg
     1501 cctcacccct ctggagggcc agaggcagga ggtggaaact ccaggggctg gcttttttaa
     1561 ctggttttat tttaattttt attatatttt cagtttttcc ataaaggaac cacttccaac
     1621 tctgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
