LOCUS       NM_030987               1544 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein subunit beta 1 (Gnb1), mRNA.
ACCESSION   NM_030987
VERSION     NM_030987.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1544)
  AUTHORS   Kiefer,K.C., Cremer,S., Pardali,E., Assmus,B., Abou-El-Ardat,K.,
            Kirschbaum,K., Dorsheimer,L., Rasper,T., Berkowitsch,A., Serve,H.,
            Dimmeler,S., Zeiher,A.M. and Rieger,M.A.
  TITLE     Full spectrum of clonal haematopoiesis-driver mutations in chronic
            heart failure and their associations with mortality
  JOURNAL   ESC Heart Fail 8 (3), 1873-1884 (2021)
   PUBMED   33779075
REFERENCE   2  (bases 1 to 1544)
  AUTHORS   Huang,C., Li,R., Yang,C., Ding,R., Li,Q., Xie,D., Zhang,R. and
            Qiu,Y.
  TITLE     PAX8-AS1 knockdown facilitates cell growth and inactivates
            autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in
            osteoporosis
  JOURNAL   Exp Mol Med 53 (5), 894-906 (2021)
   PUBMED   34012023
  REMARK    GeneRIF: PAX8-AS1 knockdown facilitates cell growth and inactivates
            autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in
            osteoporosis.
REFERENCE   3  (bases 1 to 1544)
  AUTHORS   Stott,J.B., Povstyan,O.V., Carr,G., Barrese,V. and Greenwood,I.A.
  TITLE     G-protein betagamma subunits are positive regulators of Kv7.4 and
            native vascular Kv7 channel activity
  JOURNAL   Proc Natl Acad Sci U S A 112 (20), 6497-6502 (2015)
   PUBMED   25941381
  REMARK    GeneRIF: G-protein betagamma subunits are positive regulators of
            Kv7.4 and native vascular Kv7 channel activity.
REFERENCE   4  (bases 1 to 1544)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   5  (bases 1 to 1544)
  AUTHORS   Papal,S., Cortese,M., Legendre,K., Sorusch,N., Dragavon,J.,
            Sahly,I., Shorte,S., Wolfrum,U., Petit,C. and El-Amraoui,A.
  TITLE     The giant spectrin betaV couples the molecular motors to
            phototransduction and Usher syndrome type I proteins along their
            trafficking route
  JOURNAL   Hum Mol Genet 22 (18), 3773-3788 (2013)
   PUBMED   23704327
REFERENCE   6  (bases 1 to 1544)
  AUTHORS   Liang,J.J., Cockett,M. and Khawaja,X.Z.
  TITLE     Immunohistochemical localization of G protein beta1, beta2, beta3,
            beta4, beta5, and gamma3 subunits in the adult rat brain
  JOURNAL   J Neurochem 71 (1), 345-355 (1998)
   PUBMED   9648884
REFERENCE   7  (bases 1 to 1544)
  AUTHORS   Betty,M., Harnish,S.W., Rhodes,K.J. and Cockett,M.I.
  TITLE     Distribution of heterotrimeric G-protein beta and gamma subunits in
            the rat brain
  JOURNAL   Neuroscience 85 (2), 475-486 (1998)
   PUBMED   9622245
REFERENCE   8  (bases 1 to 1544)
  AUTHORS   Wang,X.B., Funada,M., Imai,Y., Revay,R.S., Ujike,H.,
            Vandenbergh,D.J. and Uhl,G.R.
  TITLE     rGbeta1: a psychostimulant-regulated gene essential for
            establishing cocaine sensitization
  JOURNAL   J Neurosci 17 (15), 5993-6000 (1997)
   PUBMED   9221795
REFERENCE   9  (bases 1 to 1544)
  AUTHORS   Macrez-Lepretre,N., Kalkbrenner,F., Morel,J.L., Schultz,G. and
            Mironneau,J.
  TITLE     G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin
            AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein
            myocytes
  JOURNAL   J Biol Chem 272 (15), 10095-10102 (1997)
   PUBMED   9092554
REFERENCE   10 (bases 1 to 1544)
  AUTHORS   von Weizsacker,E., Strathmann,M.P. and Simon,M.I.
  TITLE     Diversity among the beta subunits of heterotrimeric GTP-binding
            proteins: characterization of a novel beta-subunit cDNA
  JOURNAL   Biochem Biophys Res Commun 183 (1), 350-356 (1992)
   PUBMED   1543505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078809.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_030987.3.
            
            On Jun 10, 2007 this sequence version replaced NM_030987.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132287, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1544
                     /gene="Gnb1"
                     /note="G protein subunit beta 1"
                     /db_xref="GeneID:24400"
                     /db_xref="RGD:2718"
     exon            1..59
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..108
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..205
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1171
                     /gene="Gnb1"
                     /note="guanine nucleotide-binding protein, beta-1 subunit;
                     transducin beta chain 1; guanine nucleotide binding
                     protein (G protein), beta polypeptide 1; Guanine
                     nucleotide-binding protein beta 1; guanine nucleotide
                     binding protein (G protein), beta 1; guanine nucleotide
                     binding protein, beta 1"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(T) subunit beta-1"
                     /protein_id="NP_112249.2"
                     /db_xref="GeneID:24400"
                     /db_xref="RGD:2718"
                     /translation="MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQ
                     MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT
                     CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS
                     SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC
                     RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSV
                     SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDS
                     FLKIWN"
     exon            206..244
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            245..351
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..415
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..578
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..645
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..847
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1064
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1180
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1513
                     /gene="Gnb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgccagctg ctgaacaact cacccttccc aaagagtaac ttcacctaaa gtaaaccaga
       61 tagacttaca tgtgtgggga accagaccag aaacacttct gagtcaagag cttggattct
      121 gaagtgtgga aagcactgag acgtgaagat gagtgaactt gaccagctgc ggcaggaggc
      181 cgagcaactg aagaaccaaa ttagagatgc ccgtaaagca tgtgcagatg cgactctttc
      241 tcagatcaca aacaacattg atccagtggg aagaatccaa atgcgaacca ggagaacact
      301 gagggggcat ctggcaaaga tttatgccat gcactggggc acagactcaa ggctccttgt
      361 cagcgcctct caggatggga aactcatcat ctgggacagc tataccacaa acaaggttca
      421 tgccatccct ctgcgctcct cttgggtcat gacctgtgca tacgctcctt ctgggaatta
      481 tgtggcctgt ggtggcctgg ataacatctg ctccatttac aatctgaaaa ctcgtgaagg
      541 aaatgtgcgt gtgagtcgtg agctggcagg acatacaggt tatctatcct gttgccggtt
      601 cctggatgac aatcagatag ttaccagttc tggagacacc acatgtgccc tgtgggacat
      661 cgagaccggc cagcagacaa ccacgtttac tggacacact ggagatgtca tgagcctgtc
      721 tcttgctcct gacaccagac tgtttgtctc tggtgcttgc gatgcttcgg ccaagctctg
      781 ggatgtccga gaagggatgt gccggcagac ctttacagga cacgagtctg acatcaatgc
      841 catatgtttc tttcccaatg gcaatgcctt tgccactggc tcagacgatg ctacatgcag
      901 gctgtttgac cttcgtgcag accaggagct catgacctac tcccatgaca acattatctg
      961 tggtatcaca tctgtttcct tctccaagag tggccgcctc ctcctcgctg gctatgacga
     1021 cttcaactgt aatgtctggg atgcactcaa agctgacaga gcaggtgtcc tagctggaca
     1081 tgacaaccga gtcagctgct tgggggtgac tgatgatggc atggctgtgg caacaggatc
     1141 ctgggacagc ttcctcaaga tctggaacta aggccagtag caggtggatg gatgccatgg
     1201 cgactggaag accattccaa ccttgaagcg ttactgcgat agcatatcct atccaaccat
     1261 actaacgtgg acacccacac ctcccctcag aacttcaaaa gggcaagatc ttttttcctt
     1321 cacttattgc tgaaaccaag agcacaactc ccattaagag aaggatctct gtgctgtaaa
     1381 ctaaaacaaa ttgtgcattt ttctggggcc attgtctttg gtttattttg ttttgttttt
     1441 tgtttttgtt ttgttttgtc ttggtcaaat ttttaaagga aatactacaa taaaaatgtt
     1501 aaccagaagg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
