LOCUS       NM_013189               1529 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein subunit alpha z (Gnaz), mRNA.
ACCESSION   NM_013189
VERSION     NM_013189.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1529)
  AUTHORS   Wainford,R.D., Kurtz,K. and Kapusta,D.R.
  TITLE     Central G-alpha subunit protein-mediated control of cardiovascular
            function, urine output, and vasopressin secretion in conscious
            Sprague-Dawley rats
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 295 (2), R535-R542 (2008)
   PUBMED   18525017
  REMARK    GeneRIF: Central Galphaz (inhibitory) and Galphaq (stimulatory)
            activity differentially modulates AVP release to control the
            pattern of diuresis to intracerebroventricular nociceptin.
REFERENCE   2  (bases 1 to 1529)
  AUTHORS   Mannoury la Cour,C., El Mestikawy,S., Hanoun,N., Hamon,M. and
            Lanfumey,L.
  TITLE     Regional differences in the coupling of 5-hydroxytryptamine-1A
            receptors to G proteins in the rat brain
  JOURNAL   Mol Pharmacol 70 (3), 1013-1021 (2006)
   PUBMED   16772521
REFERENCE   3  (bases 1 to 1529)
  AUTHORS   Kimple,M.E., Nixon,A.B., Kelly,P., Bailey,C.L., Young,K.H.,
            Fields,T.A. and Casey,P.J.
  TITLE     A role for G(z) in pancreatic islet beta-cell biology
  JOURNAL   J Biol Chem 280 (36), 31708-31713 (2005)
   PUBMED   16157560
  REMARK    GeneRIF: An endogenous receptor-mediated signaling process in
            pancreatic beta-cells is dependent on G alpha(z) function.
REFERENCE   4  (bases 1 to 1529)
  AUTHORS   Andric,S.A., Zivadinovic,D., Gonzalez-Iglesias,A.E., Lachowicz,A.,
            Tomic,M. and Stojilkovic,S.S.
  TITLE     Endothelin-induced, long lasting, and Ca2+ influx-independent
            blockade of intrinsic secretion in pituitary cells by Gz subunits
  JOURNAL   J Biol Chem 280 (29), 26896-26903 (2005)
   PUBMED   15919662
  REMARK    GeneRIF: endothelin-1 in picomolar concentrations can interrupt
            prolactin release for several hours downstream of spontaneous and
            high K+-stimulated voltage-gated Ca2+ influx. This action occurred
            through the Gz signaling pathway.
REFERENCE   5  (bases 1 to 1529)
  AUTHORS   Carrasco,G.A., Damjanoska,K.J., D'Souza,D.N., Zhang,Y., Garcia,F.,
            Battaglia,G., Muma,N.A. and Van de Kar,L.D.
  TITLE     Short-term cocaine treatment causes neuroadaptive changes in
            Galphaq and Galpha11 proteins in rats undergoing withdrawal
  JOURNAL   J Pharmacol Exp Ther 311 (1), 349-355 (2004)
   PUBMED   15175423
REFERENCE   6  (bases 1 to 1529)
  AUTHORS   Carrasco,G.A., Zhang,Y., Damjanoska,K.J., D'Souza,D.N., Garcia,F.,
            Battaglia,G., Muma,N.A. and Van de Kar,L.D.
  TITLE     A region-specific increase in Galphaq and Galpha11 proteins in
            brains of rats during cocaine withdrawal
  JOURNAL   J Pharmacol Exp Ther 307 (3), 1012-1019 (2003)
   PUBMED   14534355
REFERENCE   7  (bases 1 to 1529)
  AUTHORS   Schuller,U., Lamp,E.C. and Schilling,K.
  TITLE     Developmental expression of heterotrimeric G-proteins in the murine
            cerebellar cortex
  JOURNAL   Histochem Cell Biol 116 (2), 149-159 (2001)
   PUBMED   11685543
REFERENCE   8  (bases 1 to 1529)
  AUTHORS   Yang,J., Wu,J., Kowalska,M.A., Dalvi,A., Prevost,N., O'Brien,P.J.,
            Manning,D., Poncz,M., Lucki,I., Blendy,J.A. and Brass,L.F.
  TITLE     Loss of signaling through the G protein, Gz, results in abnormal
            platelet activation and altered responses to psychoactive drugs
  JOURNAL   Proc Natl Acad Sci U S A 97 (18), 9984-9989 (2000)
   PUBMED   10954748
REFERENCE   9  (bases 1 to 1529)
  AUTHORS   Lounsbury,K.M., Casey,P.J., Brass,L.F. and Manning,D.R.
  TITLE     Phosphorylation of Gz in human platelets. Selectivity and site of
            modification
  JOURNAL   J Biol Chem 266 (32), 22051-22056 (1991)
   PUBMED   1939224
REFERENCE   10 (bases 1 to 1529)
  AUTHORS   Matsuoka,M., Itoh,H., Kozasa,T. and Kaziro,Y.
  TITLE     Sequence analysis of cDNA and genomic DNA for a putative pertussis
            toxin-insensitive guanine nucleotide-binding regulatory protein
            alpha subunit
  JOURNAL   Proc Natl Acad Sci U S A 85 (15), 5384-5388 (1988)
   PUBMED   2456569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J03773.1.
            
            On Jun 10, 2007 this sequence version replaced NM_013189.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03773.1, BP486875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1529
                     /gene="Gnaz"
                     /gene_synonym="GXA; Hg1h"
                     /note="G protein subunit alpha z"
                     /db_xref="GeneID:25740"
                     /db_xref="RGD:2717"
     exon            1..737
                     /gene="Gnaz"
                     /gene_synonym="GXA; Hg1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1082
                     /gene="Gnaz"
                     /gene_synonym="GXA; Hg1h"
                     /note="gz-alpha; g(x) alpha chain; guanine nucleotide
                     binding protein (G protein), alpha z polypeptide; Guanine
                     nucleotide binding protein alpha; guanine nucleotide
                     binding protein, alpha z polypeptide; guanine nucleotide
                     binding protein, alpha z subunit; heterotrimeric guanine
                     nucleotide-binding protein 1h"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(z) subunit
                     alpha"
                     /protein_id="NP_037321.1"
                     /db_xref="GeneID:25740"
                     /db_xref="RGD:2717"
                     /translation="MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNS
                     GKSTIVKQMKIIHSGGFNLEACKEYKPLIIYNAIDSLTRIIRALAALKIDFHNPDRAY
                     DAVQLFALTGPAESKGEITPELLGVMRRLWADPGAQACFGRSSEYHLEDNAAYYLNDL
                     ERIAAPDYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEG
                     VTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLS
                     EKIRRIPLSVCFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQ
                     FVFDAVTDVIIQNNLKYIGLC"
     exon            738..1529
                     /gene="Gnaz"
                     /gene_synonym="GXA; Hg1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctgccg gaccatggga tgtcggcaaa gctcagagga aaaagaggca gcgcggcggt
       61 cgaggagaat tgaccgccac ctgcgctcgg agagccagcg gcagcgccgt gagatcaaac
      121 ttctcctgct gggcaccagc aactcgggca agagcaccat cgtcaagcag atgaaaatca
      181 tccacagcgg tggtttcaac ctggaggcct gcaaggagta caagcccctc atcatctaca
      241 acgccatcga ctcgctgacc cgcatcattc gggccctggc tgccctgaag attgatttcc
      301 acaaccctga ccgtgcctac gacgccgtgc agctctttgc cctgactggc ccggcagaga
      361 gcaagggtga gatcacgccc gagctgctgg gtgtcatgcg acggctctgg gctgaccccg
      421 gggcccaggc ctgcttcggc cgctccagcg agtaccacct ggaggacaac gccgcttact
      481 acctgaatga cctggagcgc atcgcggcgc ccgactatat ccccacggtg gaggacatcc
      541 tgcgctctcg ggacatgacc acgggcattg tggaaaacaa gttcaccttc aaggagctta
      601 ccttcaagat ggtggatgtg ggagggcaga ggtcagagcg caaaaaatgg atccactgct
      661 ttgagggcgt gacggccatc atcttctgtg tggagctcag tggctatgac ctgaagcttt
      721 atgaggacaa ccagacgagc cgaatggcgg agagcctgcg tctttttgac tccatctgca
      781 acaacaactg gttcatcaac acctccctca tcctcttcct gaacaagaag gacctcctgt
      841 cggagaagat tcggcgtatc ccgctcagcg tctgcttccc cgagtacaag ggtcagaaca
      901 cgtacgagga agccgcggtc tacatccagc gtcagttcga ggacctaaac cgaaacaagg
      961 agaccaagga gatctactcg cactttacct gtgccaccga caccagtaac atccagtttg
     1021 tcttcgacgc agtgacagat gtcatcatac agaacaatct caagtacatt ggcctttgct
     1081 gaggagccgg gcgcagcctg cttgcctgcg gtgaaaaccc acggggtgtc acaccccaca
     1141 cctcatgctg gagaggcccg acccaggggc aggaaacggg gggagtggct tgaagagtgt
     1201 gtccccaccc ccagcctctc tcgcctcctt ggccccacgt ctctgcaaac ataaatatat
     1261 ttggatagat tgctaggtag gtagacacac agacacacgc acacgcacac gcacacgcgc
     1321 acgcacgtct ggagacggca acgctctccg gcggtcaagg tttcctgaaa ttttcagaag
     1381 ctgctgtcac aatttcattc tgaggccatc ttgccccccc accccccatc cactctgagt
     1441 cggcccccgc tctgcacggg agggagggtc cacgtttgac tgccgaggag gggccggcgg
     1501 ggctggggcc agggccggcc agctgtgcc
//
